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Scientists probe Brain's 'Off Switch' under anesthesia

NCT ID NCT07644663

Knowledge-focused Sponsor: Fudan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will give 120 surgery patients one of three anesthetics—propofol, dexmedetomidine, or esketamine—and use high-density EEG to measure brain activity while they are unconscious. The goal is to understand how each drug disrupts brain communication and to find markers that could help anesthesiologists monitor consciousness during surgery. Participants are healthy adults undergoing elective non-cardiac surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propofol, dexmedetomidine, and esketamine
What this could lead to
If successful, this could lead to better ways to monitor consciousness during surgery, helping doctors ensure patients are properly anesthetized.
What could go wrong
This is an early-phase study focused on brain activity patterns, not on treating a disease. It may not directly change clinical practice, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients scheduled for elective non-cardiac surgery; * American Society of Anesthesiologists (ASA) physical status classification I-II; * Aged 18 to 65 years, regardless of gender; * Body mass index (BMI) greater than 18 kg/m² and no more than 31 kg/m²; * Written informed consent voluntarily signed by the patient or legal authorized representative for participation in this study. Exclusion Criteria: Subjects meeting any one of the following items will be excluded from this study: * Presence of severe cardiovascular diseases or hepatic and renal insufficiency; * Hearing impairment; * History of psychiatric disorders or communication disorders; * Anticipated difficult airway; * Pregnant or lactating women; * History of allergic reaction or contraindication to any of the three anesthetic drugs used in this trial; * Participation in other clinical trials within the past 3 months.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Electroencephalogram (EEG)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fudan University Shanghai Cancer Center

    Shanghai, Shanghai Municipality, 200032, China

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