OPIOID USE DISORDER

This study tests whether a smartphone app featuring a friendly, animated virtual coach can help people stay in treatment for opioid use disorder. The app is designed to support patients taking buprenorphine, a medication that reduces cravings and withdrawal. Researchers will trac…

This study tests a program called Youth Opioid Recovery Support (YORS) that helps young adults aged 18-28 with opioid use disorder stick to their medication and avoid relapse. Participants receive extra support from family or friends and work with a care team to overcome barriers…

This study tests whether adding buprenorphine-naloxone to the standard extended-release naltrexone shot helps people with opioid use disorder stay in treatment longer and reduce cravings. About 180 adults aged 18–65 who want to prevent relapse will receive either the combination …

This study is testing a smartphone app that rewards people for staying on track with their recovery from opioid and alcohol use disorders. The app uses digital check-ins and biochemical tests to verify progress. Researchers want to see if this approach is practical and acceptable…

This study tests whether personalized, step-by-step treatment plans can help adults with opioid use disorder stay on buprenorphine longer after an emergency visit. About 500 participants will be assigned to different treatment strategies to see which works best. The goal is to re…

This study tests if low intensity focused ultrasound (LIFU) can help people with severe opioid addiction that hasn't improved with other treatments. The ultrasound targets brain areas linked to addiction. 34 participants will receive either real or sham (fake) ultrasound to see i…

This study tests two monthly buprenorphine shots (Sublocade and Brixadi) in 60 incarcerated adults with opioid use disorder who are about to be released from prison. The goal is to see which shot helps them stay in treatment longer after returning to the community, and whether le…

This study compares a technology-enhanced therapy program (including a mobile app) to simple medication monitoring for pregnant people taking buprenorphine for opioid use disorder. About 37 participants will be randomly assigned to either four therapy sessions plus app access or …

This study tests if a monthly injection of buprenorphine works better than daily tablets for people with opioid use disorder who are leaving jail. 240 adults will receive either the injection or the tablets while in jail and for 6 months after release. The goal is to see which ap…

This study compares two medications—methadone and buprenorphine—given in a doctor's office to treat opioid use disorder. Researchers want to see which one helps people stay in treatment longer. The study involves 600 adults starting a new treatment episode. Results could improve …

This study tests if e-cigarettes can help people with opioid use disorder cut down on smoking regular cigarettes. Researchers will compare e-cigarettes to standard nicotine patches and gum, along with counseling. The goal is to see which approach works better for reducing smoking…

This study tests a new care model for women who have opioid use disorder, have experienced intimate partner violence, and have PTSD symptoms. The program starts with present-centered therapy and adds extra support if needed. The goal is to help women stay in their medication trea…

This study tests a computer tool that helps emergency room doctors follow best practices for starting buprenorphine in patients with opioid use disorder. About 300 adults with moderate to severe opioid use disorder will take part. The goal is to see if the tool increases the numb…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid addiction who still use illegal opioids despite being on methadone. About 240 participants will receive either a high, medium, or low dose of psilocybin and…

This study aims to reduce racial gaps in opioid overdose deaths by training peer recovery coaches using a video-based program and an AI texting tool. The coaches will support 180 Black and Latinx adults with opioid use disorder in New York City, helping them connect to treatment …

This study tests whether semaglutide (the drug in Ozempic/Wegovy) can reduce cravings and prevent relapse in people with opioid use disorder who are already taking buprenorphine. About 46 adults will receive either semaglutide or a placebo injection weekly for 12 weeks. Researche…

This study tests whether a special clinic that combines infectious disease and addiction care can reduce the number of infection-related hospital readmissions in people who inject opioids or stimulants. About 304 adults hospitalized with an infection linked to recent injection dr…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) can help people with opioid use disorder reduce drug use and stick with their medication. Thirty-six adults on stable medication for opioid use will receive either a high or low dose o…

This study tests a program called Youth Opioid Recovery Support (YORS) to help teens aged 13-21 with opioid use disorder stay on their medication and avoid relapse. The program includes family support, outreach, and rewards for sticking with treatment. Researchers want to see if …

This study tests a smartphone app that lets people with severe opioid use disorder take methadone at home while being remotely monitored. The goal is to see if the app helps people stay in treatment longer, reduces opioid cravings, and lowers healthcare costs. About 100 adults wi…

This study tests a new way to start treatment for opioid use disorder using a single long-acting injection of buprenorphine. Thirty adults who use opioids will stay in the hospital for 3 days, receive the injection, and be closely monitored for withdrawal symptoms. The goal is to…

This study tests a program called THRIVE, where a trained peer support specialist meets with people in the hospital and sends weekly texts for 12 weeks after discharge. The goal is to see if this support reduces the risk of non-fatal overdoses and skin infections compared to just…

This study tests whether giving a higher-than-standard dose of buprenorphine (32 mg instead of 12 mg) is safe and helps more people with opioid addiction start comprehensive treatment within 7 days. About 140 adults with moderate to severe opioid use disorder who test positive fo…

This study tests whether a once-monthly injection of buprenorphine is better than the standard daily tablet at keeping veterans with opioid use disorder in treatment and free from opioids. About 952 veterans will be followed for a year to compare outcomes like overdose, quality o…

This study tests whether a once-monthly injection of buprenorphine works better than daily pills for people who use fentanyl or other strong synthetic opioids. About 60 adults aged 18-65 with opioid use disorder will be randomly assigned to one of the two treatments. Researchers …

This study tests a community program called Young HEROES that helps young people with opioid use disorder. The program combines medication, counseling, and peer support to keep them in treatment and reduce opioid use. Researchers will track how many youth stay in treatment and st…

This study tests a combination of services—telehealth check-ins, a peer support specialist, the medication buprenorphine, and help connecting to long-term care—for people who have had an opioid overdose and visited the emergency department. The goal is to keep participants in tre…

This study tests whether mailing buprenorphine to people with opioid use disorder after a hospital stay helps them stay in treatment. The goal is to overcome barriers like transportation and pharmacy access. Twenty adults who started buprenorphine in the hospital will receive the…

This study looks at whether giving a monthly buprenorphine shot to people in jail who already take daily buprenorphine helps them stay on treatment after they leave. About 200 adults entering jail with an active prescription will be randomly assigned to either switch to the month…

This study tests whether special alerts in electronic health records can help doctors prescribe opioids more safely for patients at high risk of overdose. About 1,350 adults who have taken opioids in the past year will take part. Doctors will see a flag or a best-practice alert n…

This study tests a health systems strategy to help people with opioid use disorder stay in treatment after leaving jail. Researchers will work with jails and clinics to improve care coordination and follow-up. About 4,186 adults on Medicaid who receive opioid treatment while inca…

This study looks at whether a combination of THC and CBD (cannabis compounds) can help people who have both opioid use disorder and chronic pain. Participants are on methadone therapy and will take the study drug by mouth. Researchers will measure pain sensitivity and opioid crav…

This study tests whether adding tirzepatide (a drug used for diabetes and weight loss) to standard buprenorphine treatment helps people with moderate to severe opioid use disorder stay in treatment longer and reduce opioid use. About 310 adults who recently started buprenorphine …

This study tests whether a smartphone tool can help people being treated for opioid addiction avoid using illicit opioids. The app predicts a patient's risk of relapse in the next week and adjusts their medication dose accordingly. Researchers will compare relapse rates between 2…

This study looks at whether a short-term stabilization center (SASC) can help people who have had an opioid overdose. Participants are adults in Seattle who are stable enough to be transferred to the center for less than 24 hours, where they receive monitoring, medication for opi…

This study tests whether starting buprenorphine at a low dose is safe and works well for people with opioid use disorder. About 70 adults will take part, and the main goal is to see if patients are willing to join this type of study. The approach aims to make treatment easier to …

This study compares a higher daily dose of buprenorphine (24 mg) to the standard dose (16 mg) in 250 adults with opioid use disorder who have used fentanyl. The goal is to see if the higher dose helps people stay in treatment longer and reduces cravings and overdose risk. Partici…

This study tests a new method called SINI to help people with opioid use disorder start taking buprenorphine. Participants receive small doses of naloxone until mild withdrawal symptoms appear, then take buprenorphine under the tongue. The goal is to see if this approach is safe …

This study looks at whether mobile health clinics and peer support specialists can help people with opioid use disorder start and stay on medication treatment. Researchers will follow 750 adults in rural South Carolina for 6 months. The goal is to increase treatment success and p…

This early study tests whether deep brain stimulation (DBS) can help people with severe opioid addiction who keep relapsing despite standard treatments. Only 3 participants will receive DBS to a brain region linked to reward and craving. The goal is to see if it is safe and can r…

This study looks at whether follow-up care for opioid use disorder works better through telehealth or in-person visits after starting treatment in the emergency department. About 528 adults who received buprenorphine in the ER will be assigned to either telehealth or in-person cl…

This study looks at whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can help people with opioid use disorder who are already on buprenorphine maintenance. Researchers will measure changes in brain connectivity and t…

This study looks at whether support from trained peers who have personal experience with addiction and recovery can help people stick with their medication treatment for opioid use disorder. About 218 adults starting treatment will either get standard care alone or standard care …

This study tests a vaccine that targets oxycodone, a commonly abused prescription opioid. The vaccine works by training the body to produce antibodies that bind to the drug in the blood, preventing it from reaching the brain and reducing its pleasurable effects. Researchers will …

This study tests whether adding a new drug called brenipatide to standard opioid-use-disorder treatment (buprenorphine) helps people stay off opioids longer. About 465 adults with opioid use disorder will receive either brenipatide or a placebo injection for up to 144 weeks. The …

This study is testing whether a private Facebook group can help Native American women in Minnesota stay free from opioid use. Participants are women already on medication for opioid use disorder and have been abstinent for at least one month. The study will measure how well the F…

This study aims to expand medication-assisted treatment (MAT) for opioid use disorder in Kazakhstan, Kyrgyzstan, and Tajikistan. By increasing access to MAT, researchers hope to reduce HIV infections among people who inject drugs and their partners. The study involves 900 partici…

This study tests whether a program that includes HIV self-testing, quick access to HIV prevention pills (PrEP), and addiction treatment (MOUD) plus peer coaching helps people who inject opioids stay on these medications. About 284 participants will be randomly assigned to the pro…

This study tests a digital health program for women involved in the criminal justice system who have opioid use disorder. The goal is to help them start and stick with PrEP (a daily pill that prevents HIV) and medication for opioid use. Researchers will compare the eHealth tool t…

This study tests whether offering counseling, advocacy, and support services at a drop-in center can prevent opioid use disorder in homeless youth aged 14 to 24. About 300 participants will be split into groups receiving different combinations of services, and researchers will tr…

This study tests whether a low-intensity focused ultrasound device can safely help treat opioid and other substance use disorders. About 29 adults aged 18–60 who are already in outpatient treatment will receive the ultrasound as an add-on therapy. The main goal is to check for si…

This study is developing and testing a mobile app to help people recovering from opioid use disorder sleep better. The app uses proven sleep therapy techniques and is designed for those starting medication-assisted treatment. Researchers will enroll 40 adults who are stable on bu…

This study tests whether bright light therapy can improve sleep and brain function in people recovering from opioid use disorder. About 105 adults on stable opioid medication will receive either bright or dim light for 30 minutes each morning over two weeks. Researchers will meas…

This study looks at whether taking methadone once a day or twice a day works better for people who have both chronic pain and opioid use disorder. About 150 adults currently on methadone treatment will take part. Researchers will track pain levels and pain tolerance over 12 weeks…

This early-stage study tests whether adding lacosamide, a seizure medication, to standard opioid therapy is safe and tolerable for people with chronic pancreatitis and ongoing abdominal pain. About 24 adults who have been on opioids for at least 4 weeks will take lacosamide for 7…

This study tests if adding Acceptance and Commitment Therapy (ACT) and a care management smartphone app can help people with opioid use disorder and chronic pain who are already taking buprenorphine. About 127 adults will be enrolled to see if these tools reduce pain interference…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms in pregnant women starting treatment for opioid use disorder. About 40 participants will use the patch during the required withdrawal period before switching to standard under-the-tongue buprenorphine. …

This study is testing whether a non-invasive brain stimulation technique (tDCS combined with ultrasound) can reduce drug use and improve well-being in people with opioid use disorder and chronic pain. About 126 adults on methadone treatment will receive either real or sham stimul…

This study tests a therapy program called HOPE for adults who have both opioid use disorder and PTSD. Participants must already be on stable medication for opioid use (like Suboxone or methadone) and will attend 10-12 weeks of therapy sessions. The goal is to see if HOPE reduces …

This study explores whether MDMA-assisted therapy can help new mothers (6 to 12 months after childbirth) who struggle with both post-traumatic stress disorder (PTSD) and opioid use disorder. Fifteen participants will receive the therapy alongside their usual medication for opioid…

This study tests if addressing loneliness can help people with opioid use disorder. Researchers will enroll 300 adults who feel lonely and have opioid use disorder. Participants will attend six weekly sessions designed to reduce loneliness. The study will measure changes in lonel…

This study looks at whether doing yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their usu…

This early-stage study tests whether adding two doses of psilocybin (the active ingredient in magic mushrooms) is safe for people being treated for opioid use disorder with buprenorphine/naloxone. Ten adults will be closely monitored for side effects and changes in withdrawal, cr…

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce withdrawal symptoms in people with opioid use disorder. About 100 participants will stay in a hospital for one week, receive either real or sham stimulation, and complete surveys and brain s…

This study looks at whether cannabidiol (CBD) is safe and can help with pain and opioid cravings in people who are already on medication (methadone or buprenorphine) for opioid use disorder. About 34 adults with chronic pain will take CBD or a placebo in a random order over four …

This study tests whether low-intensity focused ultrasound (LIFU) can safely reduce pain, cravings, and anxiety in adults with chronic back pain, opioid use disorder, and anxiety. About 25 participants will receive the ultrasound and be monitored for side effects and changes in mo…

This pilot study tests whether a group-based behavioral therapy delivered over Zoom can help 30 adults with both chronic pain and opioid use disorder. The therapy focuses on emotional awareness and expression to reduce pain, disability, depression, and anxiety. Researchers will m…

This study tests whether low doses of ketamine can reduce cravings for opioids in people who have just started methadone treatment for opioid use disorder. Researchers will compare two low doses of ketamine given four times over two weeks. The goal is to see if ketamine helps wit…

This pilot study tests a smartphone app called Mindful Journey that teaches mindfulness skills to adults recovering from opioid use disorder who also have chronic pain. The study aims to see if the app is easy to use and helpful for this group. Ten participants will use the app a…

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the patch or a placebo, along with standard pain care…

This early-stage study tests whether cannabis can reduce withdrawal symptoms in people with opioid use disorder who are not currently seeking treatment. Researchers will measure how cannabis affects withdrawal severity, drug liking, and breathing. The goal is to see if cannabis c…

This study tests whether buspirone, a medication used for anxiety, can reduce withdrawal symptoms and cravings in people with opioid use disorder. About 100 adults will stay in a clinic for 10-12 days while their opioid dose is slowly reduced. The goal is to see if buspirone make…

This study tests whether a special type of talk therapy for PTSD, delivered by video at syringe service programs, is practical and helpful for adults who are also taking medication for opioid use disorder. Researchers want to see if the therapy reduces PTSD symptoms and helps par…

This study is adapting an existing texting chatbot, Penny, to better support pregnant and postpartum women who are dealing with opioid use disorder. The new chatbot, called Penny COPILOT, will send supportive texts and respond to messages to help reduce loneliness and keep women …

This study looks at how different e-cigarette flavors are perceived by adults who have opioid use disorder and are taking buprenorphine. Participants will smell and rate 11 flavors on sweetness, coolness, strength, harshness, liking, and how likely they would be to use them again…

This study is building a Canada-wide registry of people who come to emergency departments after an opioid overdose. Researchers will track treatments and outcomes for 7,200 patients to find the best ways to save lives and prevent future overdoses. The goal is to create a tool tha…

This study looks at 80 adults with opioid use disorder who are starting buprenorphine and want to quit. Researchers will use MRI scans to see if brain markers can predict who stays opioid-free, and test whether real or sham magnetic brain stimulation (rTMS) helps them quit. Parti…

This study observes 200 people already taking psychedelics in other trials to understand how these drugs alter brain information processing. Researchers will use brain scans, computer tasks, and interviews to measure changes in perception, belief flexibility, and electrical activ…

This study uses PET scans to measure cannabinoid receptors in the brains of healthy volunteers and people with conditions like schizophrenia, cannabis dependence, PTSD, and opioid use disorder. Researchers aim to understand how these receptors differ across groups and how they ch…

This study is for people who take buprenorphine for opioid use and also drink alcohol. Researchers want to see if a short, tailored counseling session is acceptable and practical. About 60 adults will try the program for four weeks. The goal is to gather information to plan a lar…

This study is creating a new tool to measure opioid cravings in people receiving treatment for opioid use disorder. Researchers will show participants opioid-related images and objects, then interview them about their feelings and thoughts. The goal is to develop a more accurate …

This study aims to create a lab test to measure resilience in people with opioid use disorder. Researchers will see if tasks that test thinking and emotional control match how people rate their own resilience. The study involves 125 adults who currently use opioids or are in trea…

This study is developing and testing a simple tool to help people with opioid use disorder make informed decisions about starting buprenorphine treatment in the emergency department. About 20 adults who meet criteria for moderate-to-severe opioid use disorder and are not currentl…

This study uses brain scans to look at a specific receptor (CB1) in people with opioid use disorder who are on methadone treatment, compared to healthy volunteers. The goal is to understand how the endocannabinoid system works in opioid addiction. About 30 adults will participate…

This pilot study is testing whether connecting people who take medication for opioid use disorder to recovery community centers (RCCs) leads to better recovery outcomes. Researchers will compare two groups: one that visits an RCC and one that does other recovery activities. The s…

This study looks at whether a 12-session parenting program can change brain activity in mothers recovering from opioid use disorder. Researchers will use EEG to measure brain responses to baby faces and cries before and after the program. The goal is to see if the program helps m…

This study tests two types of reward programs to help people with opioid, cocaine, or methamphetamine use disorders stay abstinent. Participants use a smartphone app that tracks drug tests and offers incentives that either increase or decrease over time. The goal is to find the b…

This study follows 100 pregnant women with opioid use disorder who are already receiving standard treatment. Researchers will track whether mothers relapse and whether their babies develop withdrawal symptoms (NOWS). The goal is to better understand and eventually prevent these o…

This study looks at how past childhood experiences might affect memory and brain function in people with opioid use disorder. Researchers will compare three groups: people with opioid use disorder on buprenorphine, people without the disorder on buprenorphine, and healthy adults.…

This study tests whether wearable devices like smartwatches can detect physical signs of opioid withdrawal and cravings. Twenty adults with opioid use disorder will wear sensors for 14 days while their symptoms are tracked. The goal is to find better ways to monitor and manage wi…

This study looks at how opioid use disorder during pregnancy affects both mothers and their babies over time. Researchers will follow 600 pregnant women taking buprenorphine to understand which factors lead to better or worse outcomes, including the baby's risk of withdrawal (neo…

This study looks at how opioid use disorder (OUD) affects thinking skills like decision-making and self-control. Researchers will use brain scans, computer tests, and surveys to find patterns that predict who might struggle with recovery. The goal is to improve treatment and prev…

This study looks at how opioid withdrawal symptoms vary from person to person. Researchers will monitor 60 adults with opioid use disorder as they go through a medically supervised medication taper. The goal is to better understand withdrawal patterns, not to test a new treatment…

This study looks at whether a patient navigation program called NavSTAR helps people with opioid use disorder start treatment after leaving the hospital. Researchers will first test it with 32 people across four hospitals, then with 720 participants to see if it reaches those who…

This study is testing how well a culturally tailored screening and brief intervention works for chronic pain and opioid misuse in three clinics serving American Indian and Alaska Native people. About 225 participants who have chronic pain or opioid problems will take part. The go…

This study looks at how psilocybin (a psychedelic drug) changes brain activity related to motivation and self-control in people with opioid use disorder. Researchers will use brain scans (fMRI) to compare low and high doses in 24 adults aged 18-60. The goal is to understand brain…

This study looks at how stress changes the way opioid pain medications work in people with long-term back pain. Researchers want to understand if high stress levels make these drugs more likely to be misused. The study involves 120 adults and uses questionnaires and lab tests to …

This study tests whether a telehealth platform can help people with opioid use disorder, especially those in vulnerable groups, start and stay on treatment. Researchers will enroll 250 adults who are beginning or restarting buprenorphine therapy. The main goal is to see if the pr…

This study tests whether a program that pairs people in the ER with a trained peer recovery specialist helps them connect to addiction treatment and support services. Researchers will follow 400 adults who came to the ER for a substance use-related issue, comparing those who get …

This study looks at how social interactions and relationships impact treatment for opioid use disorder. Researchers will collect daily reports from 230 patients and their close friends or family members to understand links between social behaviors, cravings, and medication adhere…

This study looks at how to help people with opioid use disorder stay in treatment longer. Staying on medications like methadone or buprenorphine improves outcomes, but many leave early. Researchers will compare two approaches—giving clinics quality measures and a toolkit, with or…

This study follows 20,000 adolescents aged 12-17 who receive opioid painkillers after major surgery. Researchers want to identify early warning signs that could lead to opioid use disorder within the first year. Participants complete surveys and allow access to their medical reco…

This study looks at why people taking medications for opioid use disorder often have trouble sleeping. Researchers will test special light-sensitive cells in the eye that help control sleep and body rhythms. The goal is to find new ways to improve sleep and reduce relapse. About …

This study tests whether a telemedicine program is practical and well-received for treating substance use disorders in people living with HIV in Alabama. About 30 participants who misuse opioids or stimulants will receive care via video or phone. The main goal is to see if they a…