OPIOID USE DISORDER

This early-phase study tests whether suvorexant, a sleep aid, can lower the desire for opioids in people with moderate to severe opioid use disorder. Researchers will measure how much drug participants choose at different prices and track sleep quality. The study is currently sus…

This study looks at whether using a smartphone app that gives rewards for negative drug tests works for older adults with opioid, cocaine, or methamphetamine use disorders. Researchers will compare how well younger and older participants engage with the app and stay abstinent. Th…

This study tests a collaborative care model where doctors, nurses, and support staff work together to help pregnant women with opioid use disorder. Researchers will track whether more women start and stay on medication, have fewer overdoses, and keep their children out of foster …

This study tests two approaches to help people with chronic pain who also misuse opioids. One group gets telemedicine and collaborative care, while the other adds a pain education and self-management program. The goal is to see which method better reduces pain interference and op…

This study tests whether a mobile app called KIOS can help people with opioid use disorder stay in treatment longer and use fewer opioids. About 116 adults in Texas who recently started medication for opioid use will use the app or get standard care for 13 weeks. The goal is to s…

This study tests whether a smartphone app can help people who are already on methadone treatment reduce their use of opioids and cocaine. About 240 adults who use both drugs will either get standard methadone care or also use an app that rewards them with money for drug-free test…

This study tests a program called SC-POWR for 204 people with opioid use disorder and long-term chronic pain. Participants receive medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction techniques for 24 weeks, then are followed for another 24 weeks. The g…

This study tests a program where people with opioid or stimulant use disorder earn small cash rewards for attending doctor visits and providing drug-free urine samples. The goal is to see if this approach helps them stay in treatment and reduce drug use. The study involves 56 adu…

This study tests a program called ED LINC, which provides coordinated care starting in the emergency department for people with opioid use disorder. The program helps connect patients to medication and support services to reduce illicit opioid use and emergency visits. About 500 …

This study looks at the best ways to add mental health care for depression into clinics that provide methadone treatment for opioid use disorder. About 1,350 patients from 12 clinics across Ukraine will be followed for two years. The goal is to see if training doctors and offerin…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medications like methadone or buprenorphine will be randomly assigned to eith…

This study looks at whether giving e-cigarettes to adults aged 50 and older who are in treatment for opioid use disorder can help them cut down on smoking. Participants are not trying to quit smoking at the start. The study will see if switching to e-cigarettes is a practical and…

This study tests whether a smartphone app that connects people recovering from opioid use disorder with peer support can help them stay in treatment and feel more supported. About 1,300 adults who own a smartphone and are in recovery or treatment for opioid use disorder will use …

This study tests a program called CHaRRM-CN designed to help people with opioid use disorder stay in medication-assisted treatment (MAT) and reduce harm from drug use. About 136 adults from the Cherokee Nation who are new to MAT will either receive the program or standard care fo…

This study tests a program called MIAPP that combines a patient navigator, a smartphone app, and small rewards to help people who use both opioids and methamphetamine stay connected to addiction treatment after leaving the hospital. About 40 adults who started buprenorphine while…

This study tests whether keeping people with opioid use disorder in the emergency department for a longer observation period helps them start medication (like buprenorphine) and connect to follow-up care. About 170 adults from four hospitals will be randomly assigned to standard …

This study was designed to see if adding a single high dose of psilocybin (30 mg) to standard buprenorphine treatment helps people with opioid use disorder stay off illicit opioids. Participants would have received either psilocybin or a very low dose, and researchers planned to …

This study tests whether giving a long-acting buprenorphine shot (BRIXADI) via telemedicine to 30 jailed adults with opioid use disorder helps them stay on treatment after release. Participants switch from daily pills to weekly and then monthly injections before leaving jail, the…

This study tests a community program in Houston that combines outreach, medication, counseling, and peer support to help people with opioid use disorder start and stay in treatment. About 3,000 adults who test positive for opioids and want to stop using will take part. The goal i…

This study tests whether offering medication for opioid use disorder (MOUD) via telehealth, with or without a peer navigator, helps women in jail start and continue treatment after release. About 900 women in Kentucky jails will take part. The goal is to increase treatment initia…

This study compares two long-acting injectable medications—extended-release naltrexone and extended-release buprenorphine—for people with opioid use disorder who are leaving jail. About 240 participants from Maryland jails will receive one of the two medications monthly for six m…

This study tests a 24-week program that uses rewards and support services to help people with opioid use disorder who inject drugs take their daily HIV prevention pill (PrEP) consistently. The goal is to reduce HIV risk in this group. 526 participants will be followed for a year …

This study tests whether a mobile peer support app can reduce loneliness and improve social support for 90 adults with opioid use disorder recently released from jail or prison. Participants must have taken medication for opioid use disorder while incarcerated. The app aims to he…

This study looks at whether combining exercise (like cycling) with psychotherapy can reduce drug cravings in adults with opioid use disorder who also have chronic pain. About 198 people in residential treatment will take part. The goal is to see if these activities help with crav…

This study tests whether a mobile mindfulness app can help people being treated for opioid use disorder who also have a history of childhood trauma. Researchers want to see if participants will use the app daily for 30 days and if it lowers stress levels. Sixty adults already in …

This early-phase study explores whether hyperbaric oxygen therapy (HBOT) can reduce the physical and emotional discomfort of opioid withdrawal when people slowly lower their methadone dose. About 36 adults in a supervised treatment program will receive either real HBOT at differe…

This study tests a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) for veterans with chronic pain who are taking buprenorphine for opioid use disorder. The goal is to see if this approach reduces how much pain interferes with daily l…

This study tests a new under-the-tongue film (BXCL501) to help reduce the unpleasant symptoms of opioid withdrawal, like anxiety, pain, and nausea. It involves 160 adults with opioid use disorder who will receive the study drug, a placebo, or an existing non-opioid medication dur…

This study tests a small device that stimulates a nerve in the ear to see if it helps people with both PTSD and opioid use disorder stay on their buprenorphine medication. Twenty participants will use either the active device or a placebo for 12 weeks. Researchers will check if t…

This study tests an experimental medicine called BI 1356225 to see if it can help people with opioid use disorder control their impulses. About 60 adults aged 18 to 65 who are already taking buprenorphine for opioid addiction will be randomly assigned to receive either the study …

This study tests whether a Pain Self-Management (PSM) program helps people with chronic pain and opioid misuse or opioid use disorder (OUD) better manage their pain and stay engaged in treatment. About 204 adults from primary care clinics will either take part in the 12-week PSM …

This study tests a device called NET to see if it can reduce opioid withdrawal symptoms and help people stay off opioids without using medication. 108 adults who want to quit opioids but avoid standard drug treatments will use either the real device or a sham version. The main go…

This study tests a treatment that combines two therapies—Acceptance and Commitment Therapy (ACT) and Mindfulness-Based Relapse Prevention (MBRP)—for people with both chronic pain and opioid use disorder. About 160 adults already stable on buprenorphine will either receive this in…

This study aimed to compare two approaches to pain management after surgery in people taking buprenorphine for opioid use disorder. One group would continue their usual dose, while the other would temporarily reduce their dose before and after surgery. The goal was to see which a…

This early-stage study tests a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to people with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. 17 adults currently in tre…

This study aimed to compare two pain medicines given during spinal anesthesia for cesarean delivery in patients with opioid use disorder who take buprenorphine. The goal was to see which provides better pain relief after surgery. However, the study was withdrawn before enrolling …

This study tests two approaches to help people with opioid use disorder and chronic pain who are taking buprenorphine. One approach is a pain self-management program with coaching and peer support. The other allows patients to adjust their buprenorphine dose based on their pain l…

This study tests whether educating prenatal care providers can increase the use of medication-assisted treatment (MAT) for opioid use disorder during pregnancy. Researchers will track treatment use and health outcomes for about 1,000 pregnant women using electronic health records…

This study looks at 350 people with opioid use disorder to understand how social life, mental health, and body chemistry work together to affect addiction severity. Researchers will collect blood samples and detailed personal information to find patterns that could help predict h…

This pilot study uses special PET scans to see where and how opioids attach to receptors in the brain and body. Researchers will study up to 60 adults, including some with opioid use disorder and some healthy volunteers. The goal is to better understand opioid binding, not to tes…

This study follows 1,600 adults with opioid use disorder over the long term by collecting monthly online surveys and yearly phone interviews. Researchers will track substance use, mental health, treatment involvement, and daily functioning. The goal is to better understand how pe…

This study explores whether transcranial magnetic stimulation (TMS) can change how people with opioid use disorder make risky or uncertain decisions. About 60 adults (some with opioid use disorder, some healthy) will receive both real and fake TMS while having brain scans. The go…

This study is testing a mobile app designed to teach pregnant women who are in treatment for opioid use disorder how to care for newborns with Neonatal Abstinence Syndrome (NAS). The app provides early education on NAS symptoms and caregiving strategies. Researchers will assess w…

This study involves 3,650 adults in 20 opioid treatment programs who are starting medication for opioid use disorder. Participants will use digital tools to regularly track their symptoms and share results with their providers. The goal is to see if this measurement-based care ap…

This study looks at whether fun, short smartphone games can help measure and improve thinking skills like memory and focus in adults aged 55 and older who are receiving methadone treatment for opioid use disorder. About 30 participants will play these brain-training games on thei…

This study aimed to understand how patients and clinic staff feel about using long-acting injectable medications to treat both HIV and opioid use disorder together. Researchers planned to enroll 30 patients and 5-10 staff, giving patients the combined injectable treatment and fol…

This study looks at how combining public health and medical data can improve care for pregnant women with opioid use disorder. The goal is to help more women get the right treatment and reduce health problems for both mothers and babies, such as neonatal withdrawal syndrome. Ten …

This study looks at whether an online support program called HOPE can help people with opioid use disorder learn about and ask for medication treatment. Researchers will track how many participants request information or help scheduling an appointment. The study involves 640 adul…

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. The researchers will compare a team-based problem-solving approach (Participatory S…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve treatment outcomes for people with opioid use disorder. Researchers will look at how stress affects drug cravings and decision-making. 32 adults on methadone or buprenorphine will receive …