OPIOID USE DISORDER

This study tests the safety of a long-acting naltrexone implant (OLANI) in 250 adults with opioid use disorder who want to prevent relapse. The implant is placed under the skin in the belly and releases medicine slowly to block opioids for weeks. Participants will receive up to f…

This study tests a program called CROSSROADS for adults who recently survived an opioid or stimulant overdose. Participants are randomly assigned to standard paramedic care or that care plus a medical-legal partnership that helps with issues like housing or benefits. Researchers …

This study tests a new implant called iSTEP-N that releases naltrexone over many months to block the effects of opioids. It involves 33 healthy adults aged 18-55 who will receive either a low-dose implant, high-dose implant, or monthly injections of an approved medication. The go…

This study aims to develop and test a telehealth program to make it easier for people with opioid use disorder to get treatment with buprenorphine. The researchers will enroll 60 adults, including some already in treatment and some not yet in treatment, to try the telehealth appr…

This study tests a digital tool called FamilyCHESS that uses text messages and a website to help people with opioid use disorder begin and continue medication treatment, with support from a family member or close friend. About 338 participants (a person with opioid use disorder a…

This study compares two methods for starting buprenorphine treatment in adults with opioid use disorder who use fentanyl. Participants will be randomly assigned to either a low-dose or direct-to-inject approach and will track their symptoms for 90 days. The goal is to see which m…

This study tests a new care model for veterans with opioid use disorder that combines infectious disease screening and treatment with their regular medication-assisted therapy in a single clinic visit. The goal is to make it easier for veterans to get tested and treated for infec…

This study tests whether treating opioid use disorder with buprenorphine via telemedicine works as well as in-person care. About 50 adults seeking treatment will be randomly assigned to receive medication and counseling either remotely or in a clinic. The main goal is to see how …

This study tests a new approach called 'Methadone Rapid Restart' for people with opioid use disorder who use fentanyl. Current methadone guidelines are based on less potent opioids, so restarting treatment can be slow and frustrating. The study will enroll 25 adults to see if ret…

This study tests whether completing the methadone clinic intake process while still in the hospital helps people with opioid use disorder stay in treatment after discharge. Researchers will compare usual care (referral at discharge) to a hospital-based approach where staff help f…

This study tests whether adding mindfulness training to ketamine-assisted therapy helps people with opioid use disorder reduce drug use and cravings. About 88 adults currently on buprenorphine will be randomly assigned to receive either the combined therapy or ketamine with a sup…

This study tests new ways to help people with opioid use disorder stay on their buprenorphine medication after starting it in the emergency department. About 3,500 adults will take part across multiple hospitals. The goal is to see if better coordination between the ER and outpat…

This study tests whether emergency medical services (EMS) can safely start buprenorphine treatment for opioid use disorder right in the ambulance or at the scene. About 495 adults who agree to the protocol will receive the medication and be followed to see if they stay in treatme…

This study will test a telehealth platform called RecoveryPad in 470 adults with moderate to severe opioid use disorder. The goal is to see if using the platform helps people get their first buprenorphine prescription faster and stay on medication for longer. Participants will us…

This study tests whether offering medication for opioid use disorder (buprenorphine) in community settings, along with coaching, helps people stay in treatment longer than standard clinic care. About 400 adults with opioid use disorder will take part. The goal is to improve treat…

This study tests whether offering gift cards can help people leaving jail stay on their medication for opioid use disorder. Participants earn rewards for attending appointments and counseling sessions for up to three months after release. The goal is to see if this approach is pr…

This study tests whether personalized treatment plans, guided by machine learning, can improve care for people with opioid use disorder. Researchers will enroll 75 adults receiving care at behavioral health centers to find the best sequence of treatments that lowers overdose risk…

This study tests a program for people with opioid use disorder who have had an overdose. After leaving the emergency room, participants get telehealth visits, a peer support specialist, and medication (buprenorphine) to help them stay in treatment. The goal is to reduce repeat ov…

This pilot study will see if giving monthly extended-release buprenorphine injections from a mobile pharmacy clinic is acceptable and practical for people with opioid use disorder. Sixty adults who want to start this treatment will receive injections for 6 months. The main goal i…

This study tests a clinical decision support tool that reminds doctors to follow CDC guidelines when reducing opioid doses in patients. About 200,000 primary care patients will be included. The goal is to lower the risk of withdrawal, overdose, and poisoning by encouraging safer …

This study tests whether long-acting HIV prevention shots and opioid use disorder medications work well for people in prison who are close to release. About 300 adults will receive these treatments and be followed to see how well they stick with them and whether they reduce HIV r…

This study works with 300 women in Kentucky jails who have opioid or stimulant use disorder. The goal is to lower their risk of overdose when they return to rural communities after release. The program offers support and connects them to treatment options during this high-risk tr…

This study tests whether two FDA-approved cannabis-based drugs, dronabinol and epidiolex, can help people with opioid use disorder who have just started buprenorphine treatment. The goal is to see if these drugs improve treatment retention and reduce opioid use during the early, …

This pilot study tests whether Emotional Brain Training (EBT), a method that teaches skills to shift mood from negative to positive, can help manage stress, anxiety, and cravings in adults being treated for substance use disorders. About 54 participants will either receive standa…

This study tests whether a non-invasive brain stimulation technique called TMS can improve recovery in 60 adults with opioid and alcohol use disorder. Participants will receive TMS alongside their usual treatment program. The goal is to see if TMS reduces cravings, withdrawal sym…

This study tests whether a ketone supplement taken three times daily for seven days can lower opioid cravings and ease withdrawal symptoms like low mood and pain. Fifty adults with opioid use disorder who are in a supervised detox program will receive either the supplement or a p…

This study looks at two pain medicines, buprenorphine and oxycodone, to see which works better and is safer for people with serious injuries. About 282 adults with injuries to at least two body areas will take part. The goal is to improve pain control while reducing the risk of o…

This study tests a digital treatment program that veterans can use at home to manage chronic pain and opioid addiction. About 250 veterans who take buprenorphine for opioid use disorder will participate. The program aims to reduce how much pain interferes with daily life and impr…

This study tests a computer tool that helps emergency room doctors follow best practices for starting buprenorphine in patients with opioid use disorder. About 300 adults with moderate to severe opioid use disorder will take part. The goal is to see if the tool increases the numb…

This study looks at whether using no opioids during knee replacement surgery can help prevent patients from becoming dependent on painkillers later. Researchers will compare two groups: one that gets standard opioid anesthesia and one that gets opioid-free anesthesia with other p…

This study is testing a new program that helps people receiving medication for opioid use disorder connect with recovery community centers. The goal is to see if this program is practical, acceptable, and helpful for improving recovery. About 145 adults in Massachusetts who are o…

This study looks at whether federal rule changes made during the COVID-19 pandemic helped more veterans get and stay on medications for opioid or alcohol use disorder. Researchers will compare treatment use, retention, and outcomes before and after the policy changes using data f…

This study looks at whether a special training program for supervisors, called COSTARS, helps keep caseworkers and peer mentors in their jobs longer and improves services for families. About 200 supervisors, caseworkers, and family peer mentors in Ohio's START program will take p…

This study tests a web-based toolkit that helps healthcare providers screen for intimate partner violence and mental health issues in patients receiving treatment for opioid use disorder. About 792 patients and their providers across three clinics will use the toolkit during rout…

This study tests whether a computer alert can help primary care doctors identify patients with opioid use disorder and guide them to prescribe effective medications like buprenorphine. About 200,000 patients will be involved, with some clinics getting the alert and others not. Th…

This study looks at how a type of brain stimulation (rTMS) and a stress-inducing drug affect thinking, cravings, and stress responses in 20 people with opioid use disorder who are not seeking treatment. Participants will complete tasks measuring attention, memory, and decision-ma…

This study tests whether an 8-session telehealth program can help people who inject drugs in the rural South build coping skills and resilience. The goal is to make it easier for them to access HIV prevention (PrEP) and hepatitis C care. The study will enroll 50 participants and …

This study tests whether an AI tool called Compl-AI can predict which adults with opioid use disorder are likely to stop their medication early. Researchers will observe 295 people receiving their usual treatment and track medication visits and adherence. Participants complete a …