OPIOID USE DISORDER

This study tested whether offering hepatitis C treatment right at methadone clinics helps more people get cured than sending them to other clinics. Over 600 adults on opioid addiction therapy took part across 13 clinics in Ukraine. Some clinics provided on-site care with or witho…

This study tested a pharmacist-led program for people with opioid use disorder who are about to be released from jail. Participants received overdose training, Narcan nasal spray, motivational counseling, and help connecting to medication treatment after release. The goal was to …

This study tested different combinations of counseling, rewards, and text reminders to help people on methadone reduce their methamphetamine use and improve HIV control. 667 participants from methadone clinics in Vietnam took part. The goal was to find the best approach to suppor…

This study tested a collaborative care model for adults with opioid use disorder (OUD) and depression, anxiety, or PTSD in primary care. 567 participants received medication for OUD along with mental health support. Researchers measured changes in opioid use, psychiatric symptoms…

This study looked at whether adding mindfulness-based relapse prevention (MBRP) to standard medication-assisted treatment (MAT) helps people with opioid use disorder stick with their medication and avoid drug use after leaving a residential treatment program. About 105 adults in …

This early-phase study tested whether adding a medication called AUVELITY (a mix of dextromethorphan and bupropion) to standard buprenorphine/naloxone treatment is safe for people with opioid use disorder. 18 adults on stable buprenorphine treatment took part. Researchers monitor…

This study tested a program to help people in Chicago start medication for opioid use disorder after a naloxone-reversed overdose. 251 adults who had an overdose and were not in treatment were randomly assigned to either the new program or standard referral. The program provided …

This study tested a telehealth platform designed to help people with opioid use disorder get treatment and avoid overdoses. 33 people who had already experienced an opioid overdose took part. The goal was to see if the platform could help them start and stay on medication for the…

This early-stage study tested a small implant placed under the skin that slowly releases naltrexone, a medicine used to treat opioid use disorder. The implant stays in for 3 months and is then removed. The goal was to check safety and how much medicine gets into the blood in 16 h…

This study tested a remote video monitoring system to help people with opioid use disorder take their methadone safely at home. Fifteen adults already on methadone treatment used a web-based platform to record each dose. The goal was to see if this approach could improve adherenc…

This study tested whether cannabidiol (CBD) can help people with opioid use disorder reduce cravings and prevent relapse. 35 adults already taking standard medications (buprenorphine or methadone) were randomly given either CBD or a placebo for 28 days. Researchers measured safet…

This study tested a new way to help people with opioid use disorder who use fentanyl switch to standard oral opioid therapy. Participants received medically supervised IV fentanyl until comfortable, then started daily oral medication tailored to their needs. The goal was to see i…

This study tested whether a mobile health unit could help people who inject drugs get treatment for opioid use disorder and HIV prevention or treatment all in one place. 447 adults with opioid use disorder joined the study. The goal was to see if this approach increased the use o…

This study tested two ways to connect people recently released from jail or prison to community-based care for HIV, hepatitis C, STIs, and opioid use disorder. Over 600 adults took part. The goal was to see which method worked better for starting and staying on treatment or preve…

This study tested a new non-opioid medication called INDV-2000 in 300 adults with moderate to severe opioid use disorder who had recently started or completed withdrawal treatment. The goal was to see if the drug could help people stay opioid-free for 3 months without needing ong…

This study tested whether people with opioid use disorder and severe injection-related infections could be treated safely at home instead of in the hospital. Participants received antibiotics through an IV along with medication for addiction. The goal was to see if this combined …

This study tested a program to help people with opioid addiction stay on their medication after being hospitalized for serious infections like heart or bone infections. 40 adults took part to see if the program was easy to use and helpful. The goal is to improve long-term recover…

This study tested a smartphone app made just for women with opioid use disorder. The goal was to see if the app was easy to use and helpful for staying on medication treatment. 39 women who had recently started medication took part. The results will show if this digital tool can …

This study tested two types of counseling to help people with opioid use disorder stick to their prescribed medication (buprenorphine-naloxone). 48 adults were randomly assigned to either a reward-based program or a mindfulness and activity session. The goal was to see if these a…

This study tested a program to help women involved in the criminal justice system get and stay in treatment for opioid addiction. The program included peer support, housing help, overdose training, and childcare. Half of the 42 women also joined a trauma support group. The goal w…

This study tested whether a low dose of cariprazine, a medication used for bipolar disorder, could help people with both opioid and cocaine use disorders reduce cocaine use. Participants were already stable on buprenorphine-naloxone for opioid use. The trial lasted about 11 weeks…

This early-phase trial tested a virtual reality (VR) intervention designed to help people in early recovery from opioid use disorder think more about their future and reduce drug use. 104 participants who had been abstinent for at least 14 days but less than a year were split int…

This early-phase study tested whether a combination of brief therapy sessions and a mobile app could help pregnant women with opioid use disorder stay on their buprenorphine medication. Fifteen women participated, attending therapy appointments during pregnancy and after birth, a…

This study looked at whether having a peer support specialist (a trained person who has been through similar struggles) helps people with opioid use disorder begin and continue taking buprenorphine, a medication for opioid use disorder. Ninety adults from rural South Carolina who…

This study tested whether a trained peer recovery specialist could help low-income, minority individuals stick with their medication for opioid use disorder. 200 people in Baltimore took part, comparing the peer-led program to standard care over six months. The goal was to see if…

This study tested a web-based program that combines cognitive behavioral therapy with pain self-management for 160 adults who have both opioid use disorder and chronic pain and are taking methadone or buprenorphine. The program teaches coping skills and uses daily text surveys to…

This study followed 480 adults with opioid use disorder who were taking SUBLOCADE, a long-acting medication to control cravings and withdrawal. Researchers watched participants for up to 4 years to see how their drug use, health, and daily life changed over time. The goal was to …

This study tested an online parenting program called Family Check-Up Online for rural families where a parent may misuse opioids or other substances. About 356 parents of young children (18 months to 5 years) took part. The program aimed to improve parenting skills, reduce stress…

This study tested a pop-up clinic inside a van to help women who inject drugs and exchange sex get HIV prevention medicine (PrEP), treatment for opioid use disorder, and quick testing for sexually transmitted infections. Fifty women took part in Seattle. The goal was to see if th…

This study looked at how cannabidiol (CBD) affects the brain in people with opioid use disorder who are stable on methadone. Researchers gave 66 participants either CBD or a placebo and used brain scans to measure changes in brain activity related to craving and anxiety. The goal…

This study tested an online program called Empowered Relief to help people with chronic pain who misuse prescription opioids. 234 adults used either the pain relief skills program or a general health education program. The goal was to see if the digital program could lower pain, …

This study tested whether CBD (a compound from cannabis) can help people reduce their use of painkillers and opioids, while also easing pain and anxiety. 126 adults with opioid use disorder who wanted to cut back on opioids took either CBD or a placebo for 12 weeks. Researchers m…

This study tested whether suvorexant, a sleep medication, could help reduce drug use and cravings while improving sleep and stress in 20 adults being treated for both opioid and stimulant use disorders. Participants were already stable on methadone or buprenorphine. The study mea…

This study tested a walking program for veterans with both opioid use disorder and chronic pain. The program included pain education and a pedometer to track steps. Researchers wanted to see if this approach was practical and liked by participants. The goal was to offer a non-dru…

This study looked at whether adding lofexidine to the standard opioid-use treatment buprenorphine could improve symptoms of both PTSD and opioid use disorder in veterans. 84 veterans on a stable dose of buprenorphine were given either lofexidine or a placebo. The goal was to see …

This early-phase study tested whether palmitoylethanolamide (PEA), a natural molecule available as a supplement, could help people with opioid use disorder manage stress, craving, and pain. Twelve adults already on stable medication (buprenorphine or methadone) took PEA or a plac…

This study tested a non-invasive brain stimulation technique called theta burst stimulation (TBS) in 23 adults with both opioid and tobacco use disorders who were stable on buprenorphine. Participants received four sessions of TBS or a sham (fake) treatment in one day. Researcher…

This study looked at whether a heart rate variability biofeedback (HRVB) program is practical and helpful for adults recovering from opioid use disorder in a residential treatment center. Thirty-two participants used a portable device for daily breathing exercises over three week…

This study tested whether a mobile app could help reduce anxiety and depression in 63 adults who were already receiving medication for opioid use disorder. Participants used the digital program for four weeks alongside their usual care. The goal was to see if the app was easy to …

This small pilot study tested whether blocking a nerve cluster called the SPG can reduce withdrawal symptoms in people with opioid use disorder. Only 3 people took part, and the goal was to see if the approach is feasible and safe, not to provide treatment. The study did not invo…

This study tested a pain-relief method for adults having open-heart surgery. Half received a numbing medicine (ropivacaine) through small tubes placed near the breastbone, while the other half got a saltwater placebo. The goal was to see if the nerve block could lower the amount …

This study looked at whether a sleep medication called suvorexant can improve sleep and reduce stress in people recovering from opioid use disorder. About 138 adults on medication-assisted treatment (like methadone or buprenorphine) took either suvorexant or a placebo for 8 weeks…

This study tested whether wearing a bright light device could improve sleep and reduce cravings in people receiving medication for opioid use disorder. 23 adults who had trouble sleeping took part. The goal was to see if this simple, wearable therapy is practical and helpful alon…

This study looked at whether a 12-week supervised aerobic exercise program can help mid-life adults with opioid use disorder feel less pain and move better. Only 6 people took part, so the main goal was to see if such a program is possible to run. The results will help design lar…

This pilot study looked at whether providing overnight infant care (respite) could help new mothers with substance use disorder get better sleep and feel better. 41 mothers living in residential treatment programs took part. The goal was to see if this approach is feasible and ac…

This pilot study tested whether adding exercise and pain-focused therapy to residential drug treatment is practical for adults with opioid use disorder and chronic pain. 63 participants were enrolled to see if they would stick with the program. The goal was to explore if this app…

This small study tested whether people with chronic pain and opioid problems would actually do art on their own at home, and if it helped their pain and mood. Thirty-one adults completed surveys before and after up to four art sessions. The results suggest that self-guided artmak…

This study tested a patient decision aid for adults with opioid use disorder. Over 7,500 participants used the tool to help choose medication-assisted treatment. Researchers tracked drug use, treatment retention, and healthcare use for up to 24 months to see if the aid improved o…

This study tested whether training VA staff with computer simulations (called participatory system dynamics) improves how quickly and effectively veterans with PTSD, depression, or opioid use disorder receive proven treatments. About 720 staff from 24 VA health systems participat…

This study tested whether people early in heroin addiction treatment could learn to lower their cravings by matching their brain activity to that of people further along in recovery. Using real-time brain scans, 28 participants watched drug-related videos and got feedback on how …

This study looked at the brains of 45 pregnant women with opioid use disorder (OUD) who were taking medication therapy, compared to pregnant women without OUD. Researchers used MRI scans to see if OUD and the medication change how different brain regions connect. The goal was to …

This study looked at whether people who inject opioids can safely complete their IV antibiotic treatment at home instead of in a hospital. Ten participants received addiction medications and extra support like case management. The goal was to see if this approach is feasible and …

This study looked at how vitamin D (calcitriol) affects dopamine activity in the brains of people with opioid use disorder. Researchers used brain scans to compare dopamine levels between those with the disorder and healthy volunteers. The goal was to understand if vitamin D coul…

This study looks at a program called NavSTAR that helps people with opioid use disorder start treatment after leaving the hospital. The program is designed to reduce differences in treatment access that affect racial minority groups the most. Researchers will first test the progr…

This study looked at how opioid use and withdrawal change the way people make choices. Twelve adults with opioid use disorder played a gambling task while their brains were scanned. The goal was to understand the brain processes behind poor decision-making in addiction.

This study tested a group well child care model for mothers in treatment for opioid use disorder and their babies. About 49 mother-infant pairs took part, comparing group care to individual care over 18 months. The goal was to see if group care improves health visits, parenting k…

This small pilot study tested a program where trained peer recovery specialists provide regular support to people receiving medication for opioid use disorder. The goal was to see if the program was practical and well-liked by patients. Thirteen adults who recently started treatm…

This study examined how doctors and nurses in 12 Colorado hospitals treat patients with opioid use disorder. Researchers surveyed 400 healthcare workers to understand current practices and track changes in prescribing medications like buprenorphine and methadone. The goal was to …

This study tested a computer tool that helps primary care doctors identify and treat patients with opioid use disorder. Over 10,000 adults from 30 clinics took part. The tool gave personalized treatment suggestions based on each patient's health records. The goal was to see if it…

This study tested whether coaching and electronic tools could help addiction treatment clinics improve care for people with opioid use disorder. Nearly 8,000 patients from clinics in New York took part. The goal was to increase use of addiction medications, keep patients in treat…

This study looked at how opioid maintenance therapy affects sensation, balance, walking, posture, and reaction time in people with opioid use disorder. Researchers compared 80 men aged 18-65 on maintenance therapy with healthy individuals. The goal was to understand these physica…

This study tested a web-based toolkit to help jails provide better care for pregnant people with opioid use disorder. Jail staff used the toolkit and gave feedback through surveys and interviews over 12 months. Pregnant individuals in custody also shared their experiences. The go…

This study looked at how the body processes buprenorphine, a medication used to treat opioid use disorder, when given by mouth in different doses. Eighteen healthy adults who had used opioids in the past took part. The goal was to gather information on drug levels in the blood to…

This study looked at whether listening to music can lower cravings for opioids when people see drug-related images. Twenty-eight adults on stable medication for opioid use disorder took part. Researchers compared cravings before and after exposure to cues, with some participants …

This study looked at how people with opioid use disorder react to pain and whether that affects their craving for opioids. 89 adults with both opioid use disorder and chronic pain took part. They received a brief education session and then had their pain response and cravings mea…

This study tested whether involving a person's family and friends can help them stay on methadone treatment for opioid use disorder and take their HIV medication regularly. Researchers adapted a UK program for use in Tanzania and tried it with 20 people receiving methadone and up…

This study tested a method called measurement-based care in opioid treatment programs. It involved 35 clinic leaders and providers who used patient surveys to guide treatment. The goal was to see if this approach could improve patient attendance and reduce opioid use. The study d…

This study tested whether a team-based care model (Collaborative Care) can help people with both opioid use disorder and mental health conditions like depression or anxiety. 254 adults from primary care clinics took part. The goal was to see if treating both conditions together w…

This study looked at how the brain chemical glutamate changes in people who use both opioids and cocaine. Researchers tested whether a supplement called N-acetylcysteine (NAC) could reduce cravings for cocaine during opioid withdrawal. Twelve adults with opioid and cocaine use di…

This study looked at how to best offer digital treatments (smartphone apps called reSET and reSET-O) to people with opioid, alcohol, or other substance use disorders during their regular primary care visits. Over 18,000 adults in Washington State took part. The goal was to see if…

This study followed 12 adults with opioid use disorder who had been stable on SUBLOCADE for at least 9 months and decided with their doctor to stop treatment. Researchers tracked whether participants could successfully taper off without relapsing or needing to restart long-term m…

This study tested different methods to help emergency room doctors start medication (buprenorphine) for patients with opioid use disorder. Over 1,100 patients took part. Researchers compared tools like nurse prompts and patient resources to see which best increased treatment rate…