ENDOMETRIAL CANCER

This study aims to improve fertility-sparing treatment for young women (ages 18-45) with endometrial cancer by tailoring therapy to the tumor's genetic profile. Participants will receive either hormone therapy (progestins) or a combination with an immunotherapy drug (sintilimab),…

This early-stage trial tests an experimental drug called ADU-1805, alone or combined with the immunotherapy Keytruda, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and find the right dose. About 130 pa…

This early-stage trial is testing an experimental drug called BL0175, a nano-medicine designed to deliver treatment directly into tumors. It is for postmenopausal women with advanced or metastatic hormone-receptor-positive breast, ovarian, or endometrial cancer that has progresse…

This Phase 2 trial is testing an experimental drug called lorigerlimab in about 80 people with advanced ovarian or other gynecologic cancers that have stopped responding to platinum chemotherapy. Lorigerlimab is a bispecific antibody designed to boost the immune system by blockin…

This early-stage trial tests the safety of combining two drugs, ONC201 and atezolizumab, in 58 women with advanced or recurrent endometrial cancer. The study includes both obese and non-obese participants to see if body weight affects treatment. The goal is to find the best dose …

This study tests a new drug called MORAb-202 that targets a protein (folate receptor alpha) found on some cancer cells. It is for people with ovarian, endometrial, non-small cell lung, or triple-negative breast cancer. The trial has two parts: first to find the safest dose, then …

This program offers early access to the investigational drug selinexor for people with certain advanced cancers, such as multiple myeloma, lymphoma, sarcoma, and others, who have no other treatment options. Patients must not qualify for any ongoing clinical trial and must have ex…

This early-stage trial tests an experimental oral drug called CSCJC3456 in 102 people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for any signs that the drug can shrink tumors. Participants take the table…

This Phase 3 trial tests whether the drug BNT323 (trastuzumab pamirtecan) works better than standard chemotherapy for people with recurrent endometrial cancer that expresses HER2. About 480 participants will be split into two groups based on their HER2 levels. The study measures …

This early-stage trial is testing an experimental drug called MOv18 IgE in people with advanced ovarian, endometrial, or triple-negative breast cancers that have a specific protein (folate receptor alpha) on their cells. The study has two parts: first, finding the safest dose, an…

This early-stage trial tests NRM-823, a drug designed to help the immune system fight cancer, in 150 people with advanced solid tumors like lung, breast, and ovarian cancer. The study gives NRM-823 alone or with another immunotherapy to see if it is safe and tolerable. The main g…

This study is testing whether a short, 1-week course of radiation therapy combined with standard chemotherapy (carboplatin and paclitaxel) is practical for people with stage III endometrial cancer. The usual radiation takes 5 weeks, so this shorter schedule could be more convenie…

This early-phase trial is testing a new drug called PHST001, which helps the immune system attack cancer cells by blocking a protein called CD24. The study will first test PHST001 alone, then in combination with standard chemotherapy, in adults with advanced solid tumors (includi…

This study tests a new drug called AZD8205, alone or with other cancer drugs, in people with advanced solid tumors like breast, ovarian, lung, or bile duct cancer that have spread or come back. About 460 adults will take part to find safe doses and see if the drug shrinks tumors.…

This study tests a new drug, TER-2013, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and can shrink tumors. About 205 participants will receive th…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer or other solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety, find the best dose, and see if it helps shrink tumors. About 470 adults will tak…

This early-stage study tests a new drug called HWK-007 in people with advanced solid tumors, including certain ovarian, endometrial, and lung cancers. The drug is designed to target a protein (PTK7) found on cancer cells and deliver a chemotherapy-like payload directly to them. T…

This study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their…

This study tests a less invasive weight-loss procedure called endoscopic suture gastroplasty (ESG) in 74 obese women who have had curative treatment for endometrial cancer. The goal is to see if ESG is safe and effective for helping these women lose weight, since obesity raises t…

This study tests a new drug called TCC1727 combined with other medicines (benmelstobart, olaparib, or topotecan) in people with advanced solid tumors, including lung, stomach, endometrial cancer, and melanoma. The goal is to find the safest dose and see if the combination helps s…

This early-stage study tests a new treatment using a patient's own immune cells, engineered to recognize and attack cancer cells with a specific KRAS mutation (G12D). It is for adults with advanced solid tumors like lung, colorectal, pancreatic, or endometrial cancer that have no…

This study tests a combination of two drugs, nab-sirolimus and letrozole, in 29 people with advanced or recurrent endometrioid endometrial cancer that cannot be removed by surgery. The goal is to see if the combination shrinks tumors or slows cancer growth. Participants take both…

This study tests a new drug called ubamatamab, alone or with another drug (cemiplimab), in people with ovarian or uterine cancer that has come back. The main goals are to check safety, find the best dose, and see if the drugs can shrink tumors. About 890 participants will take pa…

This early-phase study tests a new drug called XMT-1660 in about 319 people with advanced solid tumors, including breast, ovarian, and endometrial cancers. The main goals are to find the safest dose and check for side effects. Researchers will also see if the drug shrinks tumors.…

This study tests an experimental drug called AZD5335, alone or with other cancer medicines, in people with advanced ovarian, lung, or endometrial cancers that have not responded to standard treatments. The main goals are to check the drug's safety and find the right dose. About 5…

This study tests whether combining targeted drugs with the immunotherapy atezolizumab can shrink tumors or slow cancer growth in people with endometrial cancer that has come back or persists. About 148 participants whose cancer has progressed after at least one prior treatment wi…

This study tests whether injecting a lab-made collagen into the uterus, along with daily hormone pills, can help shrink early-stage endometrial cancer or precancerous growths. The goal is to preserve fertility in women aged 45 or younger. Thirty participants will either receive t…

This study tests a drug called relacorilant combined with chemotherapy (nab-paclitaxel) and another drug (bevacizumab) in people with ovarian, fallopian tube, peritoneal, or endometrial cancers. The goal is to see if the combination can slow cancer growth. About 270 participants …

This phase II trial is testing whether giving the PD-1 blocker TSR-042 (dostarlimab) before standard chemoradiation and surgery can improve outcomes for people with advanced mismatch repair deficient (dMMR) solid tumors. The study will enroll 212 adults with locally advanced rect…

This phase 2 trial tests a personalized cell therapy called lifileucel (TIL) in 60 people with advanced endometrial cancer that has been treated before. Doctors take a sample of the patient's tumor, grow immune cells from it in a lab, and then infuse them back after a short cours…

This early-phase trial tests MGC026, a biologic drug given by IV, in 250 adults with advanced solid tumors that have not responded to standard treatments. The study has two parts: first, finding a safe dose, then expanding to see if the drug shrinks tumors. Participants receive u…

This study tests whether a 24-week digital wellness platform, combined with online coaching from a dietitian, exercise expert, and therapist, can help endometrial cancer survivors reduce waist size and improve overall health. About 148 survivors will participate. The goal is to f…

This early-stage trial tests a modified virus called KD01 that is designed to infect and kill cancer cells in women with gynecologic cancers like cervical or endometrial cancer. The study has two parts: first, to find a safe dose, and second, to see if the virus can shrink tumors…

This early-stage trial is testing a new drug called BL-M07D1 in 280 adults with advanced solid tumors that have a protein called HER2. The cancers include breast, lung, stomach, and others that have not responded to at least two prior treatments. The study aims to find a safe dos…

This phase 3 trial is testing whether a targeted drug (trastuzumab deruxtecan) combined with immunotherapy (rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with advanced or recurrent endometrial cancer that has a specific prot…

This early-stage trial tests a new drug called LY4175408, which is designed to seek out and attack cancer cells that have a specific marker (PTK7). The study includes 240 people with advanced lung, endometrial, or triple-negative breast cancers that have not responded to standard…

This phase 2 trial is testing a drug called zanidatamab in 200 adults with advanced HER2-positive solid tumors, including breast, stomach, lung, and other cancers that have worsened after at least one prior treatment. The drug is given by IV and aims to shrink or control tumor gr…

This study tests whether taking a daily targeted therapy pill (olaparib) for one year after standard chemoradiation can prevent endometrial cancer from coming back in patients with a specific genetic change (p53 abnormal). About 554 participants will be randomly assigned to recei…

This early-phase trial tests an experimental drug called IPH5301, which targets a protein called CD73 on cancer cells. The study involves 27 people with advanced solid tumors, including breast, lung, and pancreatic cancers. In the first part, IPH5301 is given alone to find a safe…

This early-phase trial is testing a new drug called 177Lu-RAD204, which is a radioactive antibody designed to seek out and attack cancer cells that have a protein called PD-L1 on their surface. The study will involve about 30 adults with advanced solid tumors (like lung, breast, …

This early-phase study tests a new drug called 177LuBetaBart in people with advanced solid tumors that have stopped responding to standard treatments. The drug is a radioactive antibody designed to seek out and destroy cancer cells. The study will enroll about 61 participants and…

This early-stage study tests a new drug called DAY301 in people with advanced solid tumors that have not responded to standard treatments. The drug is designed to deliver a powerful toxin directly to cancer cells while sparing healthy ones. The study aims to find the safest dose …

This early-phase study tests a new drug called CTIM-76 in people with ovarian, testicular, or endometrial cancer that has come back or stopped responding to standard treatments. The drug is designed to help the body's immune cells find and attack cancer cells that have a specific…

This study is for people with early-stage endometrial cancer whose tumors have certain genetic markers (POLE-mutated or p53 wildtype/NSMP). It tests whether using less intense treatment after surgery can still prevent cancer from coming back while reducing side effects. About 393…

This early-phase study tests an experimental oral drug, RGT-490, in adults with advanced solid tumors (including breast, ovarian, and endometrial cancers) that have a specific PIK3CA gene change. The main goals are to check safety, find the right dose, and see if the drug shrinks…

This study tests whether adding an immunotherapy drug (camrelizumab) to standard chemotherapy before surgery can eliminate or shrink advanced endometrial cancer (stage III-IV). About 39 participants will receive the combination, then have surgery to see if no cancer cells remain.…

This phase 2 trial is testing two immunotherapy drugs, durvalumab and tremelimumab, alone or together, in people with colorectal or endometrial cancer. The study includes patients with different tumor types (MSI and MSS) to see who responds best. About 60 participants will receiv…

This study tests whether adding sacituzumab tirumotecan (Sac-TMT) to pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without the cancer getting worse. About 1,100 participants with a specific type of endometrial cancer (pMMR) will receive eith…

This study tests a new drug called EIK1005, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to other treatments. The goal is to find a safe dose and see if the drug shrinks tumors. About 160 adults with certain cancer types…

This early-stage study tests a new drug, TORL-1-23, in 90 people with advanced solid tumors like ovarian, endometrial, or lung cancer. The main goals are to find a safe dose and check for side effects. Researchers will also see if the drug can shrink tumors or slow cancer growth.

This study is for women with a specific type of endometrial (uterine) cancer that is mismatch repair deficient (MMR-D) or has high microsatellite instability (MSI-H). After surgery, they will receive radiation therapy combined with the immunotherapy drug Dostarlimab. The goal is …

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This study looks at how well the drug T-DXd works in adults with advanced HER2-positive solid tumors (like certain breast, lung, or stomach cancers) that have spread and no longer respond to other treatments. About 100 people will be followed in real-world settings to see if thei…

This study is checking how safe and effective durvalumab (with or without olaparib) is for people with endometrial cancer in everyday medical practice in Korea. About 50 patients will be followed for up to a year. The goal is to see how well the drugs work outside of a controlled…

This early-phase study tests a new drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with another d…

This study tests an experimental drug called INV-6452 in adults with advanced breast cancer (HR+/HER2-) or other solid tumors that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 201 participants wil…

This early-stage study tests a new drug called PF-08046054/SGN-PDL1V, alone or with another drug (pembrolizumab), in people with advanced solid tumors like lung, head and neck, esophageal, breast, stomach, endometrial, pancreatic, or liver cancer. The main goals are to find safe …

This early-phase study tests a new drug, LNCB74, in people with advanced solid tumors (ovarian, breast, endometrial, bile duct, or lung cancer) that have not responded to standard treatments. The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main…

This study tests whether combining two drugs—avelumab (an immunotherapy) and M1774 (a targeted therapy)—can help control recurrent endometrial cancer in people with a specific gene change (ARID1A mutation). About 25 participants who have already tried immunotherapy will receive t…

This early-phase trial tests whether combining chemotherapy with radiation, followed by a maintenance drug called dostarlimab, is safe and can help control stage IIIC endometrial cancer that has spread to lymph nodes. About 21 participants will receive the treatment and be monito…

This study tests an experimental drug called REGN5668, alone or with other cancer drugs, in people with ovarian, fallopian tube, peritoneal, or endometrial cancers. The goal is to find the safest dose and see if the combination can shrink tumors. About 612 adults will take part i…

This study compares a new drug called Rina-S to standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has returned or worsened after platinum-based chemo and immunotherapy. About 660 participants will be randomly assigned to receive either Rina-…

This study tests a combination of an immune-boosting drug (TQB2450) and a high-dose hormone (progestin) to treat young women (ages 18-45) with a specific type of early-stage endometrial cancer (MMRd). The goal is to eliminate the cancer while preserving the uterus so patients can…

This study tests a new drug called BC3195 combined with pembrolizumab (an immunotherapy) in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if the combination can shrink tumors. About 111 adults with certain cancers will take part.

This study tests an experimental drug called patritumab deruxtecan (HER3-DXd) in people with advanced solid tumors that have not responded to standard treatments. The drug targets a protein called HER3 found on many cancer cells. About 740 participants with various cancers (inclu…

This study tests a personalized vaccine plus three other drugs in 60 adults with advanced HER2-positive endometrial cancer that returned after treatment. The vaccine is made from each patient's own blood cells and targets the HER2 protein. The goal is to see if this combination c…

This early-phase study tests an experimental drug called CGT6297 in about 90 adults whose advanced solid tumors (including certain breast and endometrial cancers) have a specific genetic change called PIK3CA. The main goals are to find a safe dose and see if the drug can shrink o…

This early-phase study tests a new drug called SLV-154 in about 70 people with advanced solid tumors (like head and neck, lung, breast, or ovarian cancer) that have spread. The main goal is to find a safe dose and check for side effects. Researchers will also watch for any signs …

This early-stage study tests a new oral drug, MOMA-341, alone or with other treatments, in people with advanced solid tumors that have specific genetic changes (MSI-H or dMMR). The main goal is to check safety and find the best dose. About 132 adults whose cancer has not responde…

This study tracks 150 women with advanced or returning endometrial cancer to see how well a first treatment of chemotherapy plus durvalumab works, followed by maintenance durvalumab (with or without olaparib). It collects real-world data from German hospitals to measure how long …

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors (like liver, lung, or skin cancer) that have stopped responding to standard therapies. The main goal is to check the drug's safety in a small group of 10 patients. It is not a cure, but …

This study tests a new targeted therapy, puxitatug samrotecan, against standard chemotherapy for people with advanced or metastatic endometrial cancer that has worsened after platinum-based chemo and immunotherapy. About 800 participants will be randomly assigned to receive eithe…

This early-phase study tests a new drug called zanzalintinib combined with standard chemotherapy (paclitaxel) in people with recurrent high-grade uterine or endometrial cancer. The main goal is to find the safest and most effective dose of the combination. About 36 participants w…

This study tests new treatments for endometrial cancer based on the genetic makeup of each person's tumor. About 1,615 participants will be assigned to one of four trials depending on their cancer's molecular profile. The goal is to see if these tailored therapies can prevent the…

This study tests if the drug elacestrant, alone or with abemaciclib, can shrink or control advanced or recurrent ER+ endometrial cancer. About 75 adults who have already had chemotherapy and immunotherapy will take part. The goal is to see how well the treatment works and if it i…

This study tests a new drug called ivonescimab in 50 people with advanced endometrial or cervical cancer that has worsened after standard chemotherapy. The drug targets two proteins (PD1 and VEGF) to help the immune system fight cancer and block tumor blood supply. Researchers wi…

This study tests a new combination of drugs (sapanisertib and serabelisib, together called PIKTOR) plus standard chemotherapy (paclitaxel) in people with advanced or recurrent endometrial cancer that has not been cured by prior treatments. The goal is to see if this combo can shr…

This study tests a new oral drug, AVZO-021, in people with advanced solid tumors that have not responded to other treatments. The goal is to find safe doses and see if the drug can shrink tumors or slow cancer growth. The trial includes patients with certain breast, ovarian, and …

This early-phase study tests a new drug called HWK-016 in people with advanced ovarian or endometrial cancers that have not responded to other treatments. The drug is designed to deliver a toxic payload directly to cancer cells that carry a specific marker (MUC16). The main goals…

This study looks at whether a simple blood test (ctDNA) can help doctors decide if it's safe to stop maintenance immunotherapy after one year in people with advanced or recurrent endometrial cancer. About 30 participants will receive standard treatment, and if their ctDNA test is…

This study tests an experimental drug called ART0380 in people with advanced or metastatic solid tumors (cancers that have spread). The goal is to find a safe dose and see if it works alone or with chemotherapy drugs gemcitabine or irinotecan. About 442 participants will take par…

This study tests whether combining two drugs—cabozantinib and dostarlimab—can help women with a rare and aggressive gynecologic cancer called carcinosarcoma that has come back after initial treatment. About 37 participants will receive the combination therapy. The main goal is to…

This study tests a new combination of drugs (BL-B01D1, pembrolizumab, and possibly bevacizumab) in people with cervical or endometrial cancer that has come back or spread. The goal is to see if the treatment can shrink tumors and control the disease. About 96 adults aged 18-75 wi…

This early-phase study tests a new oral drug, NKT5097, in adults with advanced solid tumors, especially breast cancer and tumors with a specific genetic change (CCNE1 amplification). The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. Ab…

This study tests a drug called belzutifan in people with a rare, hard-to-treat type of gynecologic cancer called clear cell carcinoma. The goal is to see if the drug can shrink tumors or stop them from growing. About 32 participants will receive the drug, and researchers will mon…

This phase 3 trial tests whether a targeted drug called trastuzumab deruxtecan (T-DXd) works better than standard chemotherapy (with or without radiation) to prevent endometrial cancer from coming back after surgery. The study enrolls 710 adults with HER2-expressing endometrial c…

This study tests a new drug, Rina-S, in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to see if Rina-S is safe and how well it works against cancers like ovarian, lung, and breast cancer. About 884 participants will receive the dru…

This study tests whether two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from getting worse. About 32 people with a specific type of estrogen-sensitive cancer will take these pills daily after initial treatment. The goal is to see if t…

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have already tried at least one other treatment. The main goals are to find a safe dose and see if the drug can shrink tumors. About 27 adults w…

This early-phase study tests a new drug called DR-0202 in people with advanced solid tumors (like breast, lung, or prostate cancer) that have not responded to at least two prior treatments. The main goal is to check the drug's safety and find the right dose. About 96 participants…

This study tests a new drug called Dato-DXd, given alone or with other cancer drugs, in people with advanced solid tumors that have spread. The goal is to see if it can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gastric, prostate, ovarian…

This early-stage study tests a new drug called CTX-10726 in about 70 people with advanced cancers of the stomach, liver, uterus, or kidney that have not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. Participants will receive…

This early-stage study tests a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to other treatments. The main goal is to see if the drug is safe and find the best dose. About 282 adults will take part, and researche…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific change in the TP53 gene (Y220C mutation). The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment …

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with obesity-driven endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare cancer cell activity in t…

This study is testing a new imaging agent called 18F-T2, which is designed to highlight tumors that produce a protein called CAIX. About 200 adults with various cancers (like kidney, lung, or breast cancer) will receive an injection of 18F-T2 and then undergo a PET/CT scan. The g…

This study looks at whether DNA markers in urine, vaginal, and cervical samples can better identify endometrial cancer risk in women with postmenopausal bleeding. About 600 participants will provide samples and undergo standard ultrasound. The goal is to see if these non-invasive…

This study is testing a new, non-invasive way to detect endometrial cancer using DNA methylation testing on urine and vaginal samples collected by patients themselves. Researchers will compare samples from 120 women—half with endometrial cancer and half healthy—to see if the test…

This study tests whether people with Lynch syndrome can use a self-collected vaginal swab at home to detect early signs of uterine cancer. Researchers will check if participants find the process easy and acceptable, and whether DNA from the swab can predict cancer risk. The goal …

This study compares two methods—OSNA and ultrastaging—for finding cancer in lymph nodes removed during surgery for early-stage endometrial cancer. About 1,900 women will be randomly assigned to one of the two detection techniques. The goal is to see which method finds more cancer…

This study is collecting vaginal fluid samples from 4,200 people to develop a new test for endometrial cancer. Participants include those with abnormal uterine bleeding or a recent endometrial cancer diagnosis. The goal is to find biomarkers that could lead to a simple, non-invas…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study looks at whether a menstrual cup can collect enough uterine tissue to screen for endometrial cancer, especially in women with Lynch syndrome who are at higher risk. About 25 participants will use a menstrual cup at home and also have a standard biopsy, then compare the…

This study is testing a new type of PET scan that targets a protein called Trop2, found on many solid tumors. The goal is to see if this scan can find and stage cancers like lung, bladder, ovarian, and others more accurately than current methods. About 400 adults with confirmed o…

This early-stage study tests whether a dye called CYTALUX (pafolacianine) can make endometrial cancer cells glow under a special camera during surgery. The goal is to help surgeons find and remove all cancer. Ten adults with endometrial cancer who are already scheduled for surger…

This study aims to find a gentler way to detect uterine cancer early in people with abnormal bleeding. Instead of relying only on a biopsy, researchers will use a health questionnaire and a self-collected vaginal swab to look for cancer-related genetic changes and microbiome patt…

This study explores whether a tampon can be used to collect samples for detecting endometrial (uterine) and ovarian cancer. Researchers will analyze DNA and proteins from tampons and compare them to tissue samples from 1,500 women undergoing surgery. The goal is to develop a simp…

This study aims to create a test that can find endometrial, ovarian, and cervical cancers by looking at specific DNA markers in vaginal fluid or blood. Researchers will collect samples from about 3,110 women to see how accurate the test is. The goal is to make cancer detection ea…

This study looks at whether the things people buy at stores—like pain relievers or digestive aids—could be early warning signs of cancer. Researchers will compare the shopping habits of 2900 people, some diagnosed with cancer and some not, to see if certain purchases happen more …

This study is creating a shared decision-making tool to help women and their doctors talk about using a levonorgestrel IUD to prevent endometrial cancer. Researchers will survey 270 women, both with and without the condition, to understand their preferences. The goal is to make i…

This study offers free genetic testing to 5,000 women, trans men, and non-binary people with female reproductive organs, regardless of family history. The goal is to find hidden gene changes that raise the risk of breast, ovarian, bowel, and womb cancers. Participants use a smart…

This study tests whether a pre-surgery program of exercise and a dietary supplement called Ocoxin can improve recovery for 100 women undergoing surgery for gynecologic cancers like endometrial, ovarian, or cervical cancer. Participants will follow an enhanced recovery protocol (E…

This study tests whether a 16-week, virtually supervised aerobic and resistance exercise program can help patients with ovarian or endometrial cancer maintain leg function and reduce chemotherapy-induced nerve pain. Thirty newly diagnosed patients receiving first-line chemotherap…

This study is testing whether a shorter course of pelvic radiation after surgery works as well as the standard longer schedule for people with cervical or endometrial cancer. The shorter schedule means fewer hospital visits and less time in treatment. About 120 participants will …

This study looks at two standard radiation treatments for early-stage endometrial cancer to see which one causes less sexual dysfunction. About 258 women who have had surgery for early-stage endometrial cancer will receive either 3 or 6 sessions of vaginal brachytherapy. The main…

This study tests whether a personalized, automated physical activity program using a Fitbit can help women with advanced ovarian or endometrial cancer exercise more and improve their quality of life. Researchers will compare the program to standard exercise advice in 120 particip…

This study tests whether patients having robotic hysterectomy for benign conditions or endometrial cancer can safely go home the same day instead of staying overnight. 300 patients will be randomly assigned to day-care or overnight stay. Researchers will measure quality of life a…

This study is testing whether a shorter course of pelvic radiation (called hypofractionation) is safe for women with endometrial cancer. The researchers will find the best dose and see if it reduces bowel and urinary side effects. About 100 women who have already had surgery will…

This study tests whether Reiki therapy can reduce anxiety and pain in people receiving brachytherapy for gynecologic cancers like endometrial or cervical cancer. About 70 participants will either receive Reiki or standard care during their treatment wait time. Researchers will co…

This study tests whether a personalized activity coaching program can help women feel less tired during pelvic radiation therapy for endometrial cancer. Sixteen participants will be randomly assigned to receive coaching or usual care. The main goal is to see if the program is pra…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study tests whether weight loss drugs like tirzepatide and semaglutide are practical and safe for endometrial cancer patients who are overweight, obese, or have diabetes and are undergoing chemotherapy. About 36 participants will take weekly doses for 24 weeks. Researchers w…

This study tests whether a program of exercise, nutrition advice, and mental support before surgery helps gynecological cancer patients recover faster and feel better. About 64 women with ovarian or endometrial cancer will be randomly assigned to either standard care or the preha…

This study compares robot-assisted keyhole surgery to standard keyhole surgery for removing the uterus in people with early-stage endometrial cancer. The goal is to see which approach offers better value for money and quality of life after recovery. About 1,680 participants will …

This study is testing a precise type of radiation (proton beam) given to the pelvis after surgery for cervical, uterine, or endometrial cancer. The goal is to see if it causes fewer bowel side effects than standard radiation. About 25 adults who need pelvic radiation after surger…

This study compares a new barbed stitch (SYMMCORA®) to a standard one for closing the vaginal cuff during laparoscopic hysterectomy. The goal is to see if the new stitch can close the area faster without causing more complications. About 132 women having elective hysterectomy wil…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help people with endometrial or cervical cancer use fewer opioid painkillers. About 120 participants will be randomly assigned to use the app or not. The goal is to see if mindful…

This study looks at whether alternate day fasting (eating very little every other day) before chemotherapy can help reduce side effects and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start c…

This study tests a personalized physical activity program for women over 60 with gynecologic cancers who are receiving chemotherapy or other systemic treatments. The program includes a wearable activity tracker and a smartphone app, plus optional features like an exercise partner…

This observational study is looking at 350 women with early-stage endometrial cancer to see if doctors can better predict who really needs lymph node removal during surgery. Participants receive standard care and are followed for three years. The goal is to find out if some patie…

This study is observing about 1,715 people with early-stage endometrial cancer to see how often the cancer comes back and how often lymphedema (swelling) happens after standard treatment. Participants will have regular check-ups for 36 months. The goal is to gather real-world dat…

This pilot study looks at whether educational videos can increase the number of ovarian and endometrial cancer patients who get genetic testing. About 30 participants will watch a short video about genetic testing relevant to their cancer and then fill out a survey. Researchers w…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study looks at whether changing the dose and how a green dye (indocyanine green) is stored can help doctors find cancer in lymph nodes more accurately during surgery for cervical, endometrial, and vulvar cancers. The goal is to make the procedure safer, more effective, and l…

This study is collecting live tumor samples from 2,000 cancer patients undergoing standard biopsies. Researchers will analyze these samples to understand how tumors respond to immunotherapy drugs outside the body. The goal is to develop a method to predict which patients will res…

This study is a German registry that will follow about 2,000 people with advanced ovarian or endometrial cancer. Researchers will collect information on the treatments patients actually receive, how well they work, and how patients feel. The goal is to understand real-world care …

This study surveys about 264 Italian hospitals that treat endometrial cancer to find out how often they use POLE testing. POLE testing helps doctors know which patients have a very low risk of cancer returning and may not need extra treatment. The goal is to understand current pr…

This study looks at the best times to send messages that encourage physical activity to older cancer survivors (65+) who have chronic pain. About 50 participants will wear an activity tracker and rate their pain four times a day using a smartphone app. The goal is to see if certa…

This study looks at whether a special hospital visit with a team of experts can help women who finished treatment for ovarian or endometrial cancer get more of the supportive care they need. About 268 women in remission will be split into groups: some get the extra hospital asses…

This study tests whether giving gynecologic cancer patients a list of questions to ask their doctor improves their confidence, reduces distress, and builds trust. About 70 adults with newly diagnosed or suspected gynecologic cancer will either receive the question list or usual c…

This study looks at tumor samples from 2,100 Chinese patients with lung, gynecologic, bile duct, or bladder cancers. Researchers will compare different HER2 testing methods to see how well they agree with each other. The goal is to improve the accuracy of HER2 testing, which help…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancer. Ten participants will receive brachytherapy with a personalized 3D-printed mold. Th…

This study aims to collect tissue samples, medical data, and family histories from 1,120 adults who are being screened for colorectal or endometrial cancer. Researchers hope to discover new genes and immune system responses that could lead to better prevention and targeted treatm…

This early-phase study is testing a new substance called RAD301 in 9 healthy volunteers and people with certain cancers (pancreatic, lung, esophageal, cervical, endometrial, or ovarian). The goal is to see how safe it is and how radiation from it spreads through the body. Partici…

This study looks at whether it is safe for women with endometrial cancer to fast overnight before their surgery. Many women with this cancer have high blood sugar and inflammation, which may help the cancer grow. The study will check if fasting is doable and liked by patients, an…

This study is testing whether a web and mobile phone program can help Hispanic women who have had breast, uterine, or ovarian cancer, along with their adult daughters, eat better and be more active. The program includes 8 online modules. The main goal is to see if the program is …

This study looks at whether using a uterine manipulator during minimally invasive surgery for early-stage endometrial cancer causes cancer cells to appear in the abdominal fluid. About 278 women will be randomly assigned to have surgery with or without the manipulator. The goal i…

This study looks at whether giving chemotherapy before surgery helps older adults (over 55) with advanced ovarian or endometrial cancer become fitter for their operation. Researchers will measure changes in frailty using a special score from medical records. The goal is to see if…

This study looks at the genetic makeup of advanced endometrial cancer in 500 women in Russia. Researchers will test tumor samples for specific gene changes to see how common they are and what treatments patients receive. The goal is to gather information, not to test a new treatm…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study talks to women with and without endometrial cancer to learn what they know about risk factors and prevention options. Researchers hope to create a tool that helps women make informed decisions. About 45 women will take part at MD Anderson Cancer Center.

This study looks at women who had radiation therapy for cervical or endometrial cancer to see how often they experience long-term side effects in the bowel or bladder. Researchers will review medical records of 300 patients treated at Tata Memorial Hospital. The goal is to unders…

This study is testing whether an artificial intelligence (AI) tool can help match cancer patients with the right clinical trials. Researchers will enroll up to 50,000 people with various cancers to see if the AI improves trial enrollment rates and patient outcomes. The goal is to…

This study is testing a computer model called ENDORISK that helps doctors predict whether endometrial cancer has spread to lymph nodes. About 735 patients with early-stage endometrial cancer will use the model to guide decisions about lymph node surgery. The goal is to see if the…

This study is testing whether tumor tissue from endometrial cancer patients can be successfully turned into organoids (tiny lab-grown models) after being transported from other hospitals. About 20 adults with endometrial cancer will provide a sample during their standard surgery.…

This study is observing how well a new robotic surgery system (da Vinci SP) works for staging endometrial cancer. About 564 patients will be followed to see if the surgery meets guideline standards and to track complications and survival. The goal is to gather information, not to…

This study looks at 625 women with endometrial cancer to compare two surgical methods for checking lymph nodes: selective staging versus removing all nodes. The goal is to see which approach leads to better cancer-free survival. Participants will be followed over time to track re…

This study tests whether a special ultrasound can measure changes in vaginal tissue caused by radiation therapy for endometrial cancer. Ten participants will have ultrasound scans before and after treatment to see if the method works. The goal is to better understand and monitor …

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecologic cancers (cervical, endometrial, ovarian, or vulvar). Researchers will track CRP levels in 120 women receiving immunotherapy plus chemo…