Vanderbilt University Medical Center

This study tests whether a drug called 2-HOBA can reduce immune system overactivity in people with Long COVID-related POTS, a condition causing fatigue, dizziness, and rapid heartbeat. Researchers will give 50 participants either 2-HOBA or a placebo for 28 days and measure change…

This study tests whether semaglutide, a drug already approved for diabetes and weight loss, can improve asthma control in adults with obesity who still have symptoms despite using inhaled steroids. About 100 participants will receive either semaglutide or a placebo for up to 24 w…

This study compares two sedative medications—dexmedetomidine and midazolam—in children aged 44 weeks to 11 years who are on breathing machines in the ICU. The goal is to see which drug reduces delirium (a form of temporary brain dysfunction) and improves recovery, including time …

This study looks at whether a high-dose flu vaccine works better than the standard-dose vaccine for lung transplant recipients, who are at high risk for infections due to lifelong anti-rejection drugs. About 60 participants who were in a previous flu vaccine study will receive ei…

This study tests whether teaching parents about safe gun storage while their child is in the hospital can prevent firearm injuries. About 400 caregivers of hospitalized children will receive either the Be SMART counseling or usual care. The goal is to see if this approach increas…

This study tests a smartphone app called VoiceLove that lets mothers of babies in the NICU record voice messages for their baby and care team. The goal is to see if using the app reduces symptoms of postpartum depression and anxiety compared to standard care. About 150 mothers wi…

This study looks at whether adding a supplement called CoQ10 to a special exercise program can help people with end-stage kidney disease build muscle and move better. Many patients on dialysis become frail, and exercise alone often doesn't help enough. The trial will test if CoQ1…

This study tests a remote program called Empowered Relief to help people recover after lumbar spine surgery. About 100 adults will take part, comparing the program to standard education. The goal is to see if it reduces pain and improves daily function.

This study is testing whether a single-port robotic system can be used safely for DIEP flap breast reconstruction, a procedure that uses a patient's own belly tissue to rebuild the breast. Four women who are candidates for this surgery will be enrolled. The goal is to see if the …

This study tests whether a gel containing a human growth factor (rhPDGF-BB) can help surgical wounds heal faster after skin cancer removal on the head or neck. About 40 adults whose wounds are too large to stitch closed will receive either the gel or a placebo. The goal is to see…

This study tests whether taking a combination of two natural antioxidants (glycine and N-acetyl-cysteine, or GlyNAC) before and after knee replacement surgery can lower the risk of long-term chronic pain. About 148 adults aged 50 and older with knee osteoarthritis will be followe…

This study aims to see if low-dose buprenorphine, a partial opioid, can provide similar pain relief to oxycodone but with less risk of abuse. Researchers will give 60 healthy adults different doses of buprenorphine, oxycodone, or a placebo, then measure pain response and drug lik…

This study aims to understand why some people develop pulmonary arterial hypertension (PAH), a serious lung condition, while others with genetic risk factors do not. Researchers will follow 150 participants, including patients with PAH, healthy people with a BMPR2 gene mutation, …

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may be underactive. They will measure immune cell activity and inflammation in 150…

This study surveys 2000 people with fibromuscular dysplasia (FMD), a rare artery disease that can cause serious complications like stroke or heart attack. Many patients are told to avoid certain physical activities, but there are no clear guidelines. The survey aims to understand…

This study looks at whether using an extra medication (an SGLT2 inhibitor) to lower insulin levels can improve heart and blood sugar health in people with type 1 diabetes. Researchers will compare three groups: people with type 1 diabetes, people with a mild genetic form of diabe…

This study collects tissue, blood, urine, and stool samples from 5,000 people undergoing colonoscopy or endoscopy. Researchers want to find new biomarkers that could help detect colorectal, esophageal, stomach, and pancreatic cancers earlier. Participants include both healthy vol…

This study tests a new augmented reality tool that shows trainee surgeons where expert surgeons look during kidney stone surgery. The goal is to help trainees learn to see the entire kidney, which may reduce the need for repeat surgeries. Ten urology residents will use the tool o…

This study looks at how newer weight loss medications (like semaglutide or tirzepatide) compare to gastric bypass surgery in people with severe obesity. Researchers want to see how each treatment affects muscle loss, metabolism, and side effects like nausea or fatigue. About 60 a…

This study looks at 200 adults with early-onset atrial fibrillation (before age 60) who also have certain genetic changes. Researchers will use cardiac MRI and electrical mapping during a scheduled heart procedure to see if they can identify who is at high risk for dangerous fast…

This study looks at how hormones and metabolism are linked to pulmonary arterial hypertension (PAH), a serious lung condition. Researchers will measure things like sex hormone levels and insulin resistance in up to 1,899 people with PAH, their family members, and healthy voluntee…

This study explores whether targeted brain stimulation can reduce cannabis cravings in people with schizophrenia or schizoaffective disorder. Researchers will use a non-invasive technique called rTMS to stimulate specific brain networks and measure changes in craving and brain ac…

This early-stage study is testing whether swabbing the noses of healthy C-section-born babies with their mother's vaginal secretions can safely change the bacteria in their upper airways. Twenty babies will be randomly assigned to get either the real swab or a sterile sham swab. …

This study looks at how stress changes the way opioid pain medications work in people with chronic low back pain. Researchers will measure pain relief and drug liking under different conditions to understand why some people may be at higher risk for misusing these medications. Th…

This study is creating a large, diverse group of 1,000 older adults in Tennessee to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will be followed yearly with tests and scans. The goal is …