Vanderbilt University Medical Center

This study tests a drug called 2-HOBA in 12 adults with pulmonary arterial hypertension (PAH), a condition where high blood pressure in the lungs strains the heart. The goal is to see if the drug is safe and can improve heart function and blood vessel health. Participants must be…

This study tests a drug called 2-HOBA in 20 adults with salt-sensitive high blood pressure. The drug aims to calm overactive immune cells that may worsen blood pressure when salt is eaten. Researchers will measure blood pressure changes and blood vessel health after taking 2-HOBA…

This study looks at whether antibiotics are truly needed for mild diverticulitis. One hundred adults with uncomplicated diverticulitis will receive either antibiotics or a placebo for 10 days. Researchers will track recovery, side effects, and whether avoiding antibiotics is safe…

This study tests two methods of removing blood clots from the brain in people having a stroke. About 500 adults will be randomly assigned to either a cyclic suction technique or a steady suction method. The goal is to see which approach restores blood flow more effectively after …

This study tests whether combining gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups, receiving either active or placebo sti…

This study looks at whether adding Botox injections to the jaw and temple muscles can improve symptoms of facial synkinesis, a condition where facial muscles move involuntarily after nerve injury. About 50 adults who already get standard Botox for synkinesis will try both their u…

This study tests whether a gel containing carbon dioxide (carboxytherapy) can reduce redness and swelling after microneedling, a cosmetic skin treatment. About 20 adults will receive the gel on one side of their face and a placebo on the other. Researchers will compare healing an…

This study tests whether giving patients a lidocaine drip during and after major non-cardiac surgery helps them recover faster. About 2,290 adults having planned surgeries will be randomly assigned to receive either lidocaine or a placebo. The goal is to see if lidocaine reduces …

This study looks at whether people who have weight-loss surgery can safely go home the same day instead of staying overnight in the hospital. About 200 adults having either sleeve gastrectomy or gastric bypass will be randomly assigned to go home right away or stay at least one n…

This study is creating a decision aid for people with a rare heart condition where a coronary artery comes from the wrong side of the aorta (R-AAOCA). The goal is to help patients and families weigh the risks of surgery versus monitoring, reduce anxiety, and feel more confident i…

This study looks at two common ways to help people recover after a stroke: having physical and occupational therapists work with the patient one at a time, or having both therapists work together. About 567 stroke patients will be randomly assigned to one approach. The goal is to…

This study will test a new type of eye imaging called OCT in 24 adults who have had a cornea transplant. The goal is to see if the new method can take clearer pictures of the eye to help doctors better detect eye diseases. Participants will have their eyes scanned with the new de…

This study looks at a new way to check if the bowel is healing properly after surgery. Instead of using a dye that can cause allergies, doctors will measure oxygen levels in the tissue. The goal is to see if low oxygen can predict leaks or narrowing of the bowel. About 80 adults …

This study tests whether an electronic decision support system can help doctors identify and refer high-risk patients with metabolic-dysfunction associated steatotic liver disease (MASLD) to liver specialists. About 7,200 adults will take part, and the tool will be used during ro…

This study will test a new device called the Magnetic Flexible Endoscope (MFE) in 6 adults with stable inflammatory bowel disease (IBD). The MFE uses a magnet at its tip, guided by an external robotic arm, to move through the colon. Researchers want to see if it can reach the end…