University Of Utah

This study tests whether a two-shot pneumonia vaccine series (PCV20 and PPSV23) can help people with chronic lymphocytic leukemia (CLL) build a stronger immune defense against pneumococcal infections. About 61 adults with CLL who have not yet had treatment, or who are on a specif…

This early-stage trial tests whether using special scans (FMISO-PET and MRI) to find low-oxygen areas in esophageal tumors can help doctors give a higher, more effective radiation dose to those areas while keeping standard treatment for others. The study involves 16 adults with e…

This early-phase study tests whether a drug combination (loncastuximab tesirine and rituximab) given after precise radiation (stereotactic radiosurgery) is safe for people with central nervous system lymphoma. The trial includes patients whose cancer has returned or who cannot ta…

This early-phase study tests a new device that uses focused ultrasound waves guided by MRI to partially destroy breast tumors in 34 women with breast cancer. The goal is to see if the procedure is safe and feasible before standard surgical removal. Participants will have half or …

This study tests a personalized approach called Functional Precision Oncology (FPO) for people with triple-negative or HR-low/HER2- breast cancer at high risk of early return. Researchers will analyze each person's tumor and grow it in mice to find the best treatments. The goal i…

This early-phase study tests whether giving radiation therapy before a bispecific antibody (epcoritamab or glofitamab) is safe for people with diffuse large B-cell lymphoma that has come back or not responded to at least two prior treatments. The main goal is to check for serious…

This study tests whether taking nicotinamide (a form of vitamin B3) twice daily can reduce the number of new non-melanoma skin cancers in people with chronic lymphocytic leukemia (CLL) who have already had at least one such skin cancer. About 86 participants will be randomly assi…

This study tests whether giving two drugs (loncastuximab tesirine and rituximab) before standard CAR-T cell therapy can improve outcomes for people with relapsed or hard-to-treat large B-cell lymphoma. About 29 adults will receive this bridging treatment to see if it makes the CA…

This study tests a daily oral drug called XL092 in 32 men with advanced prostate cancer that has spread and is no longer responding to a specific type of radiation therapy (Lu-177-PSMA-617). The main goal is to see if the drug can stop the cancer from growing for at least 16 week…

This early-phase study tests a new type of CAR-T cell therapy for people with certain blood cancers (like leukemia and lymphoma) that have not responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and attack cancer cells. The main goa…

This study tests a 'go-slow' treatment plan for ultra-frail patients newly diagnosed with multiple myeloma. Instead of starting all drugs at once, patients first receive two medications (isatuximab and dexamethasone) and then slowly add a third (lenalidomide) after two months. Th…

This study tests whether taking creatine supplements along with a home-based resistance training program twice a week can help men with metastatic prostate cancer maintain muscle mass and reduce fatigue. About 200 participants will be followed for 52 weeks. The goal is to improve…

This study looks at whether the diabetes drug metformin can help older adults regain muscle strength after a period of disuse, like bed rest. Researchers will give metformin or a placebo to 50 healthy adults aged 60 and older during recovery. The goal is to see if metformin impro…

This early-stage trial tests whether adding Tumor Treating Fields (TTFields) to standard chemoradiation and immunotherapy is safe for people with stage III non-small cell lung cancer that cannot be removed by surgery. About 30 participants will receive TTFields alongside their us…

This study tests whether two drugs, pirtobrutinib and rituximab, can shrink or eliminate tumors in people newly diagnosed with marginal zone lymphoma. About 23 adults will receive the combination and be checked for response after several cycles. The goal is to control the disease…

This study tests two drugs, cabozantinib and atezolizumab, in 33 men with a type of advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to see if the combination can stop or shrink tumors. Participants must have non-measurable disease o…

This study tests the drug bortezomib in 22 men with a specific genetic change (PTEN deletion) in their advanced prostate cancer that has stopped responding to hormone therapy. The main goal is to see if the drug can lower PSA levels by at least 30%. Participants receive bortezomi…

This study tests two or three drugs (defactinib, avutometinib, and possibly encorafenib) in people with advanced melanoma that has spread to the brain. The goal is to see if these combinations can shrink brain tumors and how safe they are. About 33 adults whose melanoma worsened …

This study tests a personalized program to help people who have lost weight keep it off. About 30 adults who lost at least 7% of their body weight in the past 6 months will receive weekly texts, surveys, and possibly health coaching over 26 weeks. The goal is to see if this appro…

This study tests whether offering personalized financial incentives can help 80 adults with obesity stick to a weight-loss program. Participants attend virtual group classes, log their calories, and weigh themselves regularly. The goal is to see if tailored rewards improve diet t…

This study aims to see if a shorter, lower-dose radiation treatment after robotic surgery can improve quality of life for people with HPV-related throat cancer. About 42 adults who have had robotic surgery will receive a reduced radiation schedule. The main goal is to see if thei…

This study tests if men with metastatic hormone-sensitive prostate cancer who have a strong initial response to hormone therapy can safely take breaks from one of their medications (relugolix) to reduce fatigue. About 160 participants will either continue standard daily therapy o…

This study tests a drug called pemigatinib in adults with certain types of B-cell non-Hodgkin lymphoma that have come back or not responded to at least two prior treatments. The goal is to see if the drug can shrink tumors and help control the disease. About 27 people will take p…

This study looks at whether adding a special balloon pump (called LV unloading) to a standard heart-lung machine (VA ECMO) helps people with severe cardiogenic shock. About 104 adults will be randomly assigned to get the balloon pump or not. Researchers will measure heart functio…

This study tests giving two doses of immunotherapy (ipilimumab and nivolumab) before standard surgery for people whose melanoma returned after or during previous treatment. About 25 adults with resectable stage III or IV melanoma will take part. The goal is to see if this approac…

This early-phase study tests whether adding pegylated interferon alfa-2a after a stem cell transplant can help control myelofibrosis, a type of bone marrow cancer. About 18 adults with primary or secondary myelofibrosis will receive the drug after their transplant to find the saf…

This study looks at whether giving sex hormone therapy to men with low hormone levels can help their shoulder tendons heal better after surgery. About 58 men will receive either hormone pills or a placebo after rotator cuff repair. The goal is to see if the therapy improves tendo…

This study tests how well a levonorgestrel IUD works as emergency contraception (within 5 days of unprotected sex) or when started later in the menstrual cycle. About 1,400 people at Planned Parenthood clinics will choose to get the IUD and be followed for one month to see if the…

This study is testing whether changes in platelet RNA can help doctors diagnose ovarian cancer earlier and more accurately. Researchers will collect blood samples from 245 women—those with ovarian masses and healthy volunteers—to see if this new approach works. If successful, it …

This study tests if a tretinoin cream can help reduce the acne-like rash that often appears on the face during treatment with certain cancer drugs (panitumumab or cetuximab). About 25 adults with advanced solid tumors will join. Each person will apply tretinoin to one side of the…

This study is testing a new lightweight, motorized prosthetic leg for people who have lost a leg above the knee. The goal is to see if it helps them walk, climb stairs, and move more easily compared to their current prosthesis. About 40 adults who already use a prosthetic leg wil…

This study tests a 12-week home-based rehabilitation program for men with advanced prostate cancer living in rural areas. The program includes exercise and support delivered via video calls to help manage side effects from hormone therapy and improve quality of life. About 30 par…

This study tests whether a gentle ultrasound device aimed at the brain can reduce pain and improve daily life for people with fibromyalgia. Fifty adults with fibromyalgia will receive six 45-minute treatments over two weeks. Researchers will measure pain levels and symptoms using…

This study tests a culturally adapted program called Nuestro Sueno for Latino couples where one partner has sleep apnea and is starting CPAP therapy. The goal is to see if the program helps the patient use CPAP more consistently and improves sleep quality for both partners. Resea…

This study tests whether a single, quick radiation session can effectively treat painful bone metastases without the usual planning steps. About 40 adults with one or two painful bone spots will receive this streamlined treatment in just one visit. The goal is to see if this simp…

This study aims to help people with chronic arm weakness after a stroke control a robotic brace more naturally. Researchers will test advanced computer algorithms and many small sensors that read muscle signals. The goal is to make the brace respond more accurately, improving eve…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study is testing whether a headband with special semiconductors can help with memory and thinking problems (often called "chemo brain") after chemotherapy. About 50 women with breast or gynecological cancer will wear the headband for 18 hours a day for 3 weeks, then switch t…

This study tests whether acupuncture can help relieve symptoms of Gulf War Illness, a condition affecting many veterans. Two hundred veterans will receive either biweekly acupuncture for six months or a shorter waitlist followed by weekly sessions. Researchers will measure change…

This study looks at whether Swedish massage or light touch can reduce anxiety symptoms and change brain activity in people with generalized anxiety disorder. About 46 adults will receive one of two types of touch therapy twice a week for six weeks. Brain scans and questionnaires …

This study tests whether guarana, a natural plant extract, can reduce fatigue in people with neuroendocrine tumors or gynecologic cancers. About 86 participants will take guarana or a placebo for up to 42 days, and researchers will measure changes in fatigue using a standard ques…

This study tests whether a 12-week, home-based exercise program (aerobic and resistance training) can reduce cancer-related fatigue in 80 adults with metastatic breast cancer who are already taking the drug Enhertu. Participants will exercise on their own and report changes in fa…

This study tests whether a 5-day course of whole breast radiation works as well as a 9-day course for women with early-stage breast cancer. About 144 participants will be randomly assigned to one of the two schedules. The main goal is to see if the shorter treatment leads to simi…

This study tests whether brief guided meditation during daily radiation therapy can help reduce anxiety in people with breast or gynecologic cancers. About 34 participants will either listen to a guided meditation or receive standard care during their radiation sessions. The goal…

This study tests a non-drug behavioral treatment to reduce nightmares in adults with REM sleep behavior disorder (RBD). Twenty people with RBD and their family members will join video sessions to learn techniques. The goal is to see if this approach can lower nightmare frequency …

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study tests whether a personalized exercise program, delivered through telehealth, is practical for people with stage II or III lung cancer who are receiving treatments like chemotherapy or immunotherapy. Researchers will track how many patients join and stick with the progr…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. About 19 women who have persistent pain after chemo will receive…

This study is testing a home-based exercise and nutrition program for people with lymphoma or myeloma who are about to receive CAR-T cell therapy. The program uses a web portal and touch-screen technology to guide patients through personalized workouts and meal plans, with remote…

This study tests whether a medication called budesonide can prevent severe diarrhea in people with multiple myeloma who are receiving a stem cell transplant. About 120 adults will be randomly assigned to get either budesonide or a placebo alongside standard care. The goal is to s…

This study looks at whether text message reminders and physical activity coaching can help more people with osteoarthritis start and stick with a walking program. Researchers will enroll 346 adults aged 45 and older who have knee, hip, or spine arthritis. The goal is to reduce pa…

This study compares a shorter course of internal radiation (vaginal cuff brachytherapy) to the standard longer course for people with early-stage endometrial cancer. The goal is to see if the shorter treatment improves quality of life and reduces financial stress. About 188 parti…

This study will follow 10,000 adults with joint or tendon problems (like knee, hip, or shoulder arthritis, tennis elbow, or plantar fasciitis) who have not gotten better with other treatments. Participants will receive a platelet-rich plasma (PRP) injection and be tracked for one…

This study is for people with brain tumors that started elsewhere in the body (brain metastases) who have not had brain radiation before. Researchers want to find the highest safe dose of a precise radiation treatment called stereotactic radiosurgery. About 50 participants will r…

This study tests if a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) can safely reduce widespread pain in people with lupus. About 30 adults with lupus and fibromyalgia will attend 8 weekly online sessions. Researchers will check if pain and other s…

This study tests whether Reiki, a gentle touch therapy, can reduce anxiety and pain in people receiving brachytherapy for gynecologic cancers like endometrial or cervical cancer. About 70 participants will be randomly assigned to receive either Reiki or usual care during their tr…

This study tests a powered neck exoskeleton in 10 people with ALS who have neck weakness. Participants will wear the device and perform tasks like tracking objects on a screen and daily activities. Researchers will measure head movement and ask about comfort and satisfaction. The…

This study tests whether a 5-minute guided meditation played during each radiation session can help reduce anxiety in people with brain tumors. About 30 adults will either listen to the meditation or receive standard care. Researchers will measure anxiety levels before and after …

This study is testing whether low-dose metformin, a drug typically used for diabetes, can safely improve symptoms of fibromyalgia. Researchers believe it may work by reducing inflammation in the nervous system. The trial will involve 72 adults with fibromyalgia, comparing metform…

This study tests whether short, educational videos can help childhood cancer survivors ages 18-26 complete their HPV vaccine series. About 55 participants will watch the videos and answer surveys. The goal is to see if this approach is feasible and acceptable for improving vaccin…

This study is looking for the genetic mutation that causes polycythemia (too many red blood cells) and thrombocytosis (too many platelets). Researchers will collect blood samples from 200 people with these conditions to analyze their DNA. Finding the gene could lead to new treatm…

This study tests a mobile app called MyChildCMC that helps parents of children with complex medical needs (ages 1-18) spot early signs of health problems before they become emergencies. About 360 families will use the app daily for 6 months or receive usual care, then be followed…

This study tests a video game designed to help teenagers with congenital heart disease learn skills to manage their own healthcare, like talking to doctors and handling medications. About 150 teens, their parents, and doctors will try the game and give feedback. The goal is to se…

This study looks at how immune cells in the blood change as we get older and how they cause inflammation. Researchers will compare healthy young adults (18-35) with healthy older adults (65+) to understand this process. The goal is to find new ways to reduce age-related inflammat…

This study looks at the best ways to offer HPV self-collection kits to women who are overdue for cervical cancer screening. About 1,000 women aged 25-65 can get a kit to use at home or in the clinic. The goal is to see if offering this option helps more women complete screening a…

This study aims to improve how quickly injured children receive care in Tanzania. Researchers will work with health centers and hospitals to identify delays and create a better triage process. About 284 patients, family members, and healthcare providers will help develop and test…

This early-stage study tests whether tiny electrode arrays implanted in the arm nerves of three amputees can record nerve signals and provide a sense of touch. The goal is to see if these signals can be used to control a prosthetic hand more naturally. The study focuses on measur…

This study aims to understand how muscles recover after a period of disuse. Researchers will immobilize the leg of 45 healthy adults (ages 18-35 and 60-85) for 2 weeks and then monitor recovery. The goal is to learn more about muscle loss and regrowth, which could help develop fu…

This study looks at how different light patterns and meal timing affect your body's ability to process food when you're not sleeping enough. Researchers will track 120 healthy adults aged 18-35 over 4-6 months with overnight stays and tests. The goal is to understand how these li…

This study is testing a new decision support tool for parents and doctors of children with neuromuscular scoliosis who are considering surgery. About 110 parent-child pairs will either use the tool or receive usual care. Researchers will measure how the tool affects decision qual…

This study tests a 4-session virtual coaching program to help young adult cancer survivors (ages 26-39) better understand their health insurance, reduce financial stress, and improve follow-up care for cancer recurrence. About 300 participants who have finished initial cancer tre…

This study is creating a large database of information about children with hydrocephalus (a condition where fluid builds up in the brain). Researchers will collect details on diagnosis, treatments, and outcomes from multiple hospitals. The goal is to better understand the disease…

This study follows 600 people with leukodystrophy, a rare genetic brain disorder, to learn how the disease progresses and affects patients over time. Researchers will use medical exams, brain scans, and genetic testing to track changes and outcomes. The goal is to improve diagnos…

This study looks at how immune cells from premature babies respond to certain signals that may lead to necrotizing enterocolitis (NEC), a severe gut disease. Researchers will collect blood from the umbilical cord of both premature and healthy full-term newborns to analyze their i…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…

This study uses machine learning to analyze real-world data from over 144,000 people with advanced non-small cell lung cancer. The goal is to find which existing treatments work best for different patient groups, helping doctors make more personalized choices. Participants' healt…

This study looks at how mindfulness meditation helps people with chronic low back pain who take opioids. Researchers will use brain scans to see how meditation changes pain signals. The goal is to understand the brain mechanisms behind pain relief, not to test a new treatment. Ab…

This study looks at whether using behavioral nudges—like gentle reminders or small prompts—in recruitment emails can encourage more healthy adults to join a short interview study. About 120 English-speaking adults aged 18 and older will be randomly assigned to receive either stan…

This study tests whether watching a short educational video about safe opioid use helps breast reconstruction patients use fewer pain pills after surgery. About 68 women having breast reconstruction after mastectomy will be randomly assigned to either watch the video or receive s…

This study looks at how teenagers with a history of self-harm learn and use coping skills in daily life. About 200 teens and a parent will practice two skills during discussions while their heart rate, sweat, and brain activity are measured. The goal is to understand what helps s…

This study follows 100 people with high-risk smoldering myeloma, a condition that may turn into active cancer. Researchers use advanced MRI scans and regular check-ups to track how the disease changes over two years. The goal is to better understand who progresses and how to impr…

This study is testing whether a digital chatbot can help underserved women better understand their mammogram results and follow through with recommended care. About 2,700 women who recently had a mammogram will be randomly assigned to get usual care or usual care plus the chatbot…

This study watches how early damage in age-related macular degeneration (AMD) grows over time. Researchers will use special eye scans to measure changes in the retina and see how they affect vision and daily life. The goal is to find better ways to detect and track the disease ea…

This study tests a web-based platform called LEAD that helps people in the early stages of Alzheimer's or mild cognitive impairment talk about and write down their end-of-life wishes. About 120 participants and their care partners will use the tool to see if it improves decision-…