University Of Utah

This study tests a 'go-slow' treatment for ultra-frail patients newly diagnosed with multiple myeloma. Instead of starting all drugs at once, patients begin with just two medications and add a third after two months. The goal is to see if this gentle approach helps patients stick…

This early-phase trial tests whether combining two drugs—cabozantinib (a targeted therapy) and 177Lu-PSMA-617 (a radioactive molecule that seeks out cancer cells)—is safe and effective for men with advanced prostate cancer that no longer responds to hormone therapy. About 33 part…

This study tests whether the diabetes drug metformin can help older adults regain muscle after a period of disuse, such as bed rest. Fifty healthy adults aged 60 and older will take either metformin or a placebo during recovery. The goal is to see if metformin improves muscle reg…

This study looks at whether giving sex hormone therapy to men with low hormone levels can help their shoulder tendons heal better after surgery. About 58 men will be randomly assigned to receive either hormone pills or placebo. The goal is to see if the treatment improves tendon …

This early-phase study tests a new type of CAR-T cell therapy for people with certain blood cancers (like leukemia and lymphoma) that have not responded to other treatments. The therapy uses a patient's own immune cells, modified to attack cancer cells, and is made with a new man…

This early-stage study tests a new device that uses focused ultrasound waves guided by MRI to partially destroy breast tumors. About 34 women with breast cancer will have half of one tumor ablated before their standard surgery. The goal is to see if the procedure is safe, tolerab…

This study looks at how well the levonorgestrel 52 mg IUD works as emergency contraception (after unprotected sex) or when started later in the menstrual cycle. About 1,400 people from Planned Parenthood clinics across the U.S. will choose to get the IUD as part of their regular …

This study tests a mobile app called MyChildCMC that helps parents of children with complex medical conditions spot early warning signs of illness. The goal is to prevent emergency room visits and hospital stays. About 360 children ages 1-18 and their parents will use the app dai…

This study tests a daily oral drug called XL092 in 32 adults with metastatic castration-resistant prostate cancer that has worsened after treatment with 177Lu-PSMA-617. The main goal is to see if the drug can stop the cancer from growing for at least 16 weeks. Researchers will al…

This study looks at whether Swedish massage or light touch can reduce anxiety symptoms in people with Generalized Anxiety Disorder (GAD). About 46 adults will receive either massage or light touch twice a week for 6 weeks. Researchers will use brain scans (fMRI) and questionnaire…

This study tests whether brief guided meditation sessions during daily radiation therapy can help reduce anxiety in people with breast or gynecologic cancers. About 34 adults will be randomly assigned to either listen to a guided meditation during treatment or receive standard ca…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, skin melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. Abo…

This study compares a shorter course of internal radiation (vaginal cuff brachytherapy) to the standard longer course for people with stage I-II endometrial cancer. The goal is to see if the shorter treatment improves quality of life and reduces financial burden. About 188 partic…

This study tests a home-based program that combines exercise, nutrition advice, and coaching for people with lymphoma or myeloma who are receiving CAR-T cell therapy. The program uses a tablet and wearable sensors to guide patients safely through personalized workouts and track t…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. About 19 women with persistent pain will receive rTMS treatments…

This study tests a behavioral (non-medication) treatment to reduce nightmares in adults with REM Sleep Behavior Disorder (RBD). Twenty people with RBD and their family members will join video sessions to learn techniques. The goal is to see if this approach can lower nightmare fr…

This study tests whether a 5-minute guided meditation played during each radiation session can lower anxiety in people with brain tumors. About 30 adults will either listen to the meditation or receive standard care. Researchers will measure anxiety levels before and after each t…

This study tests two strategies to help people with osteoarthritis (OA) get more active and manage pain. Researchers will compare different text-message approaches to see which one gets more people to join physical activity counseling, and then whether joining a walking program h…

This study tests whether a tretinoin cream can lessen the acne-like rash that often appears on the face during treatment with certain cancer drugs (panitumumab or cetuximab). About 25 adults with advanced solid tumors will apply tretinoin to one side of their face and a placebo c…

This study is testing whether a headband with tiny semiconductors can help with memory and thinking problems (often called 'brain fog') after breast or gynecological cancer treatment. About 50 people who finished chemotherapy within the last 90 days will wear the headband for 18 …

This study tests whether guarana, a natural plant extract, can improve fatigue in people with neuroendocrine tumors or gynecologic cancers. About 86 adults will take guarana or a placebo for up to 42 days, and researchers will measure changes in fatigue and quality of life. The g…

This study is testing a new decision support tool for parents and doctors of children with neuromuscular scoliosis (a curved spine due to nerve or muscle problems). About 110 parent-child pairs will either use the tool or receive usual care. The goal is to see if the tool helps f…

This study tests a new video game designed to help teenagers with congenital heart disease learn skills to manage their own healthcare, like talking to doctors and keeping track of appointments. About 150 teens, their parents, and doctors will try the game and give feedback. The …

This study looks at how different light patterns and meal timing change the way your body processes food when you are sleep-deprived. Researchers will track 120 healthy adults aged 18-35 over several months using surveys, medical tests, and three overnight clinic stays. The goal …

This study is testing whether tiny electrodes placed in the arm nerves of people with amputations can record nerve signals and provide a sense of touch and movement. Three participants will have the electrodes implanted for up to 30 days to see if they can control a prosthetic ha…

This study follows 100 people with high-risk smoldering myeloma, a pre-cancerous blood condition, to learn how it naturally progresses. Participants receive close monitoring with advanced MRI scans and standard care over two years. The goal is to better understand when and how th…

This study tests whether offering personalized financial incentives can help people with obesity stick to a weight-loss program. Eighty adults will receive tailored rewards for tracking their food intake and weighing themselves regularly. The goal is to see if this approach impro…

This study is testing whether a digital chatbot can help women who have had a mammogram better understand their results and follow through with recommended next steps. Researchers will enroll 2,700 women who recently had a mammogram at the University of Utah. Half will get the us…

This study looks at how mindfulness meditation can help people with chronic low back pain who take opioids. Researchers will use brain scans to see how meditation changes pain signals. The goal is to understand the brain mechanisms behind pain relief, not to test a new treatment.…

This study looks at how muscles recover after a period of not being used. Researchers will immobilize one leg of healthy volunteers for two weeks, then measure muscle size and strength changes. The goal is to understand how aging and metabolic health affect muscle recovery. The s…