University Of Utah

This study tests ways to help more parents in rural areas get their children (ages 9-17) the HPV vaccine, which prevents certain cancers. About 1,455 parents and caregivers are taking part. The goal is to see if simple clinic-based reminders and conversations can increase vaccina…

This study looks at whether combining two types of minimally invasive glaucoma surgeries (MIGS) works better than cataract surgery alone for lowering eye pressure. Researchers will review records of 100 people with open-angle glaucoma who had both procedures plus cataract surgery…

This study tests a program called Share plus for adults aged 60+ with type 1 diabetes and their care partners. The program helps them better use continuous glucose monitor data together. Researchers want to see if it improves blood sugar control and reduces diabetes-related stres…

This early-phase study tests a combination of three drugs (tremelimumab, durvalumab, and belinostat) in people with advanced bladder cancer that has spread or cannot be removed surgically. The main goal is to find the safest dose and understand side effects. About 9 adults who ha…

This study aimed to see if the drug N-803 is safe to give as maintenance therapy after CAR T-cell treatment for people with relapsed or refractory B-cell non-Hodgkin lymphoma. It was designed for adults who had already responded to CAR T therapy. However, the trial was withdrawn …

This study tests a combination of two drugs, nivolumab and axatilimab, in adults with classical Hodgkin lymphoma that has returned or not responded to prior treatments, including anti-PD-1 therapy. The main goal is to see if the combination shrinks tumors. Nine participants are e…

This study tests two different timing schedules of a drug combination (durvalumab, pemetrexed, and carboplatin) in adults with advanced non-squamous non-small cell lung cancer. The goal is to see if staggering the doses improves how long the cancer is controlled. 43 participants …

This early-phase study tested a combination of two drugs—nivolumab (an immunotherapy) and Radium-223 (a radioactive drug)—in 39 men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bones. The main goals were to check safety and see if…

This study tests a combination of two drugs—cabozantinib (a targeted therapy) and 177Lu-PSMA-617 (a radioactive drug)—in men with advanced prostate cancer that no longer responds to hormone therapy. The goal is to find the safest dose and see if the combination can slow cancer gr…

This study tests whether adding the immunotherapy drug ipilimumab to the standard targeted therapy osimertinib is safe and effective for people with a specific type of advanced lung cancer (EGFR-mutated NSCLC). About 24 adults whose cancer is stable on osimertinib will receive th…

This study tests whether surgery and radiation can help men whose prostate cancer has returned or spread to a few spots in the body. About 20 participants will receive targeted treatments to remove or destroy these cancer spots. The main goal is to see if this approach can signif…

This study tests a drug called cobimetinib in people with a rare blood cancer (CMML) that has certain gene mutations. The goal is to see if the drug can shrink or control the cancer. Fourteen adults with either new or treatment-resistant CMML will take the drug daily in 3-week-on…

This study tests a drug called enfortumab vedotin, alone or with other medicines, in men with advanced prostate cancer that no longer responds to hormone therapy. The goal is to see if the drug can shrink tumors, lower PSA levels, or improve cancer markers. About 34 men who have …

This early-stage trial tests whether combining three drugs—tazemetostat, zanubrutinib, and an anti-CD20 antibody—is safe for people with indolent B-cell non-Hodgkin lymphoma that has come back or stopped responding to treatment. About 24 adults with certain lymphoma types will re…

This study tests whether the immunotherapy drug nivolumab, given after standard chemo-radiation, can help prevent bladder cancer from coming back. About 200 adults with localized muscle-invasive bladder cancer who cannot have bladder removal surgery are taking part. The main goal…

This study tests a program called FAMS-T1D that helps young adults (ages 18-24) with type 1 diabetes set goals and get support from a friend or family member. The goal is to see if this approach improves blood sugar control, reduces diabetes distress, and helps the support person…

This early-phase study tests whether adding the blood pressure drug losartan to a shorter, stronger course of radiation therapy can help treat pancreatic cancer that is either borderline removable or has spread locally. Losartan may improve blood flow and oxygen in the tumor, mak…

This study tests whether metformin, a common diabetes medicine, can prevent muscle loss and insulin resistance in healthy older adults (60+) during 5 days of bed rest. Researchers will measure changes in muscle size and insulin sensitivity. The goal is to find a simple way to pro…

This study tests a program called "Paso a Paso" designed to help Spanish-speaking adults at risk for diabetes prevent the disease. About 45 participants will follow the program to see if it helps with weight loss and blood sugar control. The goal is to make sure the program works…

This study tests an 8-week remote program for couples where one partner has had a stroke. The program uses positive psychology techniques to help both the survivor and their carepartner manage anxiety and depression. Researchers hope it will improve emotional well-being and quali…

This study looks at whether a special painkiller injection given around the knee during surgery can lower pain after a tibial plateau fracture (a type of knee break). About 150 adults with this injury will receive the injection, and their pain scores will be tracked. The goal is …

This study tests a shoulder pacemaker device in 20 people with scapular dyskinesia or posterior shoulder instability. The device is used during rehabilitation to see if it reduces pain and improves shoulder function. The goal is to ease symptoms, not to cure the condition.

This study looks at whether watching short videos with coping strategies can help people feel less pain and distress after surgery for abdominal cancer. About 95 adults will be assigned to one of three video-based approaches, including mindfulness or other support methods. They w…

This study is testing whether a device called the Shoulder Pacemaker can help people recover better after shoulder replacement surgery. About 100 adults aged 18 to 80 having their first shoulder replacement will either use the device or follow standard rehab. The goal is to see i…

This small study tests a procedure called radiofrequency ablation for people with chronic shoulder pain that hasn't improved with standard treatments like physical therapy or injections. The treatment uses heat to calm the nerves that send pain signals from the shoulder joint. Te…

This study compares two ways to numb the arm before setting a broken wrist: a hematoma block (injecting numbing medicine into the fracture site) and a Bier block (using a tourniquet and IV medicine). 500 adults with a displaced distal radius fracture will rate their pain during t…

This study tests a new device (Trident cannula) against a standard one for treating neck pain caused by small joints in the spine. About 80 adults with long-term neck pain will receive a procedure using either device. The goal is to see if the new device works just as well but wi…

This study looks at whether 30 sessions of UVA-1 light therapy can improve daily life for people with scleroderma, morphea, or skin hardening from graft-versus-host disease. About 30 adults will report how their symptoms change using questionnaires. The goal is to see if this tre…

This small pilot study tests whether memantine, a drug already used for Alzheimer's, can improve arm and leg movement after a stroke. About 20 people who had a stroke and have arm weakness will be randomly assigned to receive memantine or a placebo for several weeks. Researchers …

This study follows 150 adults who received the Intracept Procedure, a treatment that uses heat to disable a nerve in the spine thought to cause chronic low back pain. Researchers are tracking how much pain and disability improve over three months using patient questionnaires. The…

This pilot study looks at whether the diabetes drug metformin can help older adults regain thigh muscle and function after a hip fracture. Sixty people aged 60 and older who had surgery for a hip fracture will take either metformin or a placebo daily for 4 months. The goal is to …

This study planned to test a computer game that children control by breathing in and out. The goal was to make anesthesia induction less frightening and encourage good breathing. The study was withdrawn before any children took part.

This study looks at whether people who start putting weight on their leg 6 weeks after surgery for a certain type of knee fracture recover better than those who wait 10-12 weeks. Researchers will measure walking patterns, patient satisfaction, and how quickly people return to wor…

This study tests whether a local injection of multiple pain medicines works as well as regional anesthesia (numbing a larger area) for controlling pain after ankle fracture surgery. Researchers will compare pain scores, complications, and costs in 200 adults with rotational ankle…

This study tests whether a new type of screw (Bone Bolt) can reduce pain better than standard screws after surgery for a specific pelvic fracture (LC-1). About 100 adults aged 18-80 who need surgery for this injury will be enrolled. Pain levels will be measured using a 0-10 scale…

This study looks at a shoulder replacement surgery that avoids cutting a major muscle (the subscapularis) in patients with shoulder arthritis. Researchers want to see if this approach leads to better pain relief, movement, and strength. About 50 adults having this surgery at the …

This study looks at whether non-drug treatments like physical therapy or counseling, delivered through telehealth, can help people with chronic back pain feel better and rely less on opioids. About 500 adults from community health centers in Utah are taking part. The goal is to f…

This study looks at how skin temperature changes in people with a leg amputation and diabetes, especially while walking. Researchers will measure walking patterns, blood flow, and skin temperature to understand what raises the risk of tissue damage. The goal is to find ways to im…

This study looks at how the body's inflammatory response after a broken knee or ankle joint may lead to post-traumatic arthritis. Researchers will measure inflammatory markers in blood and joint fluid from 60 adults with a specific type of leg fracture. They will combine this wit…

This study looks at whether special MRI scans can be used safely during surgery to remove brain tumors called gliomas. Researchers will try two advanced imaging techniques before and during the operation. The goal is to see if these scans are possible and to track any complicatio…

This study tracks the physical stress on orthopedic surgeons during surgery by measuring their heart rate. Researchers will compare heart rates before and during operations to see how demanding the work is. The study includes up to 8 surgeons and reviews charts of up to 750 patie…

This study compares genetic differences and muscle gene activity in people who develop acute compartment syndrome after a leg fracture versus those who do not. Researchers will measure a protein called myostatin in muscle tissue. The goal is to better understand why some people g…

This study aims to find genetic factors that may increase the risk of infection after hip or knee replacement surgery. Researchers will analyze DNA from 150 people from families with a history of such infections. The goal is to use this information to create personalized care pla…

This study compares four different approaches to managing suicide risk in 120 adults who have had suicidal thoughts and past suicide attempts. Participants are randomly assigned to one of four interventions, and researchers measure changes in suicidal thoughts and behaviors befor…

This study looks at how well a new hip replacement stem (Insignia) fits and stays in place over time. Researchers will review X-rays from 100 adults getting a first-time hip replacement to check for any signs of loosening. The goal is to see if the stem is safe and effective for …

This study looks at whether massage and light touch therapies can change brain activity and help reduce anxiety. About 46 healthy adults will be randomly assigned to receive either Swedish massage or light touch therapy twice a week for six weeks. Brain scans (MRI) before and aft…

This study looks at how sleep and daily body rhythms impact memory and thinking skills in couples where one partner has mild memory problems. Researchers will track 340 couples over time using smartphone tests and surveys. The goal is to understand if poor sleep in one partner af…

This study looks at how a hip condition called femoroacetabular impingement (FAI) changes the way the hip joint moves. Researchers will compare 36 people with FAI to those without it. The goal is to better understand the mechanics behind the condition, which may help improve futu…

This study looks at whether a web-based decision aid can help parents of unborn or newborn babies with life-threatening congenital heart disease make informed choices and feel less stressed. About 135 parents will be randomly assigned to use the decision aid alone or with an extr…

This study is testing a new computer tool called ORRCDS that helps pharmacists screen for opioid risks when dispensing pain medications. About 80 pharmacies in Ohio will either use the tool or continue with usual care. The goal is to see if the tool helps lower patients' risk of …

This study looks at whether Fitbit activity monitors can help measure physical function in people with cervical myelopathy (a spine condition) before and after decompression surgery. Researchers will compare Fitbit step counts with standard questionnaires to see if the monitors p…

This study looks at whether a certain type of blood vessel that grows under the retina in age-related macular degeneration (AMD) might actually help preserve vision, rather than harm it. Researchers will measure how well the retina works in areas with and without these vessels in…

This study looks at cells from spine surgery patients to find which ones are best at making bone. The goal is to improve healing after spinal fusion and lower the chance of needing another surgery. About 60 adults having spine surgery will take part, and a small piece of their bo…

This study follows children who had a hip socket fracture to see how they recover over many years. Researchers will collect information from medical records and patient questionnaires to understand which fracture patterns lead to better or worse outcomes. The goal is to create a …

This study looks at how a single session of Swedish massage or light touch therapy changes brain activity, heart rate, blood pressure, breathing, and mood in healthy adults. Thirty participants will be randomly assigned to receive either massage or light touch. Brain scans (MRI) …

This study was designed to see if a drug called abatacept could improve blood vessel function in older adults by targeting immune cells called T cells. It planned to enroll adults aged 55-75 without major health problems. However, the study was withdrawn before any participants w…

This study looks at whether using two metal implants instead of one to fix a broken thigh bone near the knee helps older adults (over 60) recover better. About 80 participants will be tracked for a year to see how well they heal and move. The goal is to find out if a stronger fix…

This study looks at whether rotator cuff disease runs in families. Researchers will collect DNA and health information from 400 people, including those with shoulder pain and their close relatives. The goal is to find genetic factors that increase risk, which could help with futu…

This study looks at how to bring a proven childhood obesity program to rural areas. About 150 families will take part to see if extra support helps communities use the program more effectively. The goal is to find the best way to help kids in small towns achieve a healthier weigh…

This study looks at whether special vocal fold stretching exercises can help people expand their pitch range and make their voice more stable. Researchers will test 120 adults with no current voice problems, comparing those who use their voice a lot versus those who don't. The go…

This study was designed to test whether giving methadone during breast reconstruction surgery could lower the amount of opioids patients need afterward. It was planned for women having breast reconstruction after mastectomy. However, the study was withdrawn before enrolling any p…

This study tests whether giving oxygen only when a patient breathes in (on-demand) works better than constant-flow oxygen during medical procedures with sedation. Researchers will measure blood oxygen levels and exhaled oxygen and carbon dioxide in about 100 relatively healthy ad…

This study tests whether a hospital-customized plan (ROAD Home) reduces unnecessary antibiotic use at discharge for adults with pneumonia or urinary tract infections. Forty hospitals are randomly assigned to either use this tailored approach or continue their usual practices. The…

This study looks at 116 adults who had glaucoma stent surgery up to 2 years ago. Researchers use a special eye scan (OCT) to see if the tiny stents are correctly positioned and how that affects eye pressure. The goal is to understand what makes the surgery work best long-term.

This study aims to understand how diet affects the eyes and skin by measuring natural pigments called carotenoids. Researchers will use non-invasive methods to check levels in the eye and skin, and also test blood in some participants. Anyone age 7 or older having a routine eye e…

This study looks at three common stress tests used to check ankle joint stability after a specific type of ankle fracture (Weber B). The goal is to see if these tests give different measurements of how much the ankle joint space widens. Sixty adults with this fracture will have a…

This pilot study tests whether leaving the placenta in place after delivery (conservative management) is a safe and effective alternative to hysterectomy for women with placenta accreta spectrum, a condition where the placenta grows too deeply into the uterine wall. Four particip…

This study looks at whether reusing parts of walking boots is safe for people recovering from foot or ankle injuries. About 60 patients will be randomly assigned to receive either new or reused boot components. The goal is to see if reused parts cause skin problems like blisters …