University Of Utah

This study will test different strategies to help adults with obesity (BMI 30 or higher) enroll in evidence-based weight management programs at community health centers. About 5,354 participants will be offered digital tools, text reminders, and support to join these programs. Th…

This study tests two drugs, mosunetuzumab and pirtobrutinib, given together to people with Waldenstrom macroglobulinemia (a rare blood cancer) that has returned or not responded to prior therapy. The goal is to find a safe dose and see how well the combination controls the diseas…

This study tests whether a Patient Navigator—a personal guide—can help pregnant women with opioid use disorder stay in care, stick with medication, and reduce drug use. About 429 participants will be randomly assigned to usual care or extra support from a navigator. The study las…

This study looks at whether estrogen patches can help post-menopausal women recover better from rotator cuff surgery. About 58 women will receive either estrogen or placebo patches after their operation. The goal is to see if estrogen improves shoulder pain, strength, and functio…

This study tests two drugs, loncastuximab tesirine and rituximab, as a first treatment for a rare blood cancer called post-transplant lymphoproliferative disorder (PTLD) that can occur after an organ transplant. The first part finds the safest dose, and the second part checks how…

This study compares two emergency contraception pills: levonorgestrel plus piroxicam (an anti-inflammatory drug) versus levonorgestrel alone. About 1,458 women aged 16-35 who had unprotected sex within 72 hours will participate. The goal is to see if adding piroxicam reduces preg…

This early-phase study tests whether adding the drug ropeginterferon alfa-2b to the standard treatment ruxolitinib is safe for people with myelofibrosis, a type of bone marrow cancer. About 15 adults already on a stable dose of ruxolitinib will receive the combination. The main g…

This study tests a new blood test that looks at RNA in platelets to see if it can accurately detect lung cancer and tell the difference between harmless and cancerous lung nodules. Researchers will collect blood samples from 240 adults with lung cancer or suspicious lung nodules.…

This study will test a chatbot called LIFT-UP designed to help people living in poverty quit smoking. Researchers will interview 22 adults who smoke at least 3 cigarettes daily and want to quit within 30 days. The chatbot offers tailored support in English or Spanish, and the stu…

This study tests whether having a paracentesis (draining fluid from the belly) at home can improve symptoms in women with cancer-related ascites. Twenty women who have already had the procedure in a clinic will receive it at home. Researchers will measure symptom changes and trac…

This early-stage study tests whether high doses of Vitamin C are safe for adults with two rare inherited blood disorders—Pyruvate Kinase Deficiency (PKD) and a type of G6PD deficiency. These conditions cause red blood cells to break down too quickly, leading to anemia. Participan…

This study tests whether a non-drug therapy called Imagery Rehearsal Therapy can help reduce nightmares in adults with narcolepsy. About 80 people with narcolepsy will take part, along with their romantic partners. Everyone gets the therapy, but half start right away and half wai…

This study tests a new chatbot that gives cancer patients and their caregivers clear information about insurance, travel costs, and other financial aspects of cancer care. About 60 adults from rural areas in five states will use either a hybrid or AI-only chatbot and then rate ho…

This study will test a new breathing support system in 25 healthy volunteers. The goal is to see how accurately the system measures breath volume, rate, and carbon dioxide levels, and how comfortable it is to use. This is not a treatment study—it aims to gather information to imp…

This study aims to find the best ways to encourage people to get screened for lung cancer using low-dose CT scans. About 19,000 adults aged 50-80 who smoke or used to smoke will be invited to participate. Researchers will compare different methods like text messages and phone cal…

This study tests whether a new educational tool helps patients on blood thinners (anticoagulants) better understand their medication. About 68 adults who are new to or currently taking these drugs will use either the new materials or standard ones and then answer surveys. The mai…

This observational study follows 50 people aged 65-90 with geographic atrophy (a form of dry age-related macular degeneration) who are already receiving pegcetacoplan injections as part of their routine care. Researchers want to see if a specialized vision test called lesion-tail…

This study looks at the best ways to tell people about their exposure to radon (long-term risk) and indoor air pollution (short-term risk). About 112 enrolled tribal members will have monitors placed in their homes and answer questions about steps they take to reduce exposure. Th…

This study looks at three ways to give oxygen during colonoscopy sedation to prevent breathing pauses and low oxygen levels. About 280 adults will be randomly assigned to standard continuous oxygen, a device that delivers oxygen only when they inhale, or a mask that keeps the air…

This study explores whether a non-invasive, painless skin measurement called electrical bioimpedance can help monitor acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). About 25 adults who are already scheduled for a bone marrow biopsy will also receive this skin te…