Brain neoplasm

Researchers at the University of Minnesota are testing whether a single extra dose of radiation, given about four weeks after standard chemotherapy, is safe and practical for adults with newly diagnosed glioblastoma. Participants first receive standard surgery, radiation, and che…

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …

This early-stage trial tests whether using focused ultrasound with microbubbles can temporarily open the blood-brain barrier, allowing the immunotherapy drug nivolumab to reach brain tumors more effectively. It includes 30 children and young adults with relapsed diffuse midline g…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests a new approach for a rare and aggressive brain tumor called butterfly glioblastoma, which crosses both sides of the brain and has a very poor outlook. The treatment combines open surgery to remove as much tumor as possible from one side, followed by a minimally i…

This early-phase study tests the safety of a new cell therapy called B7-H3 CAR T cells for children and young adults whose brain tumors have come back or are growing despite standard treatment. The therapy uses the patient's own immune cells, modified to target a protein (B7-H3) …

This study looks at whether removing a brain tumor and the nearby area where seizures start can help people with tumor-related epilepsy. About 100 people aged 8 and older with brain tumors and seizures will have surgery and be followed for up to a year. The goal is to see if seiz…

This study tests a drug called zotiraciclib in people with a certain type of brain tumor (glioma) that has come back after treatment. The tumor must have a specific gene mutation (IDH1 or IDH2). Participants take the drug by mouth in cycles. The goal is to see if the drug can slo…

This study is testing proton radiation as a treatment for adults with benign or slow-growing brain tumors. Researchers want to see how well it controls tumor growth and how it affects quality of life and side effects. About 100 participants will receive proton radiation and be fo…

This study tests whether a focused ultrasound device can safely open the blood-brain barrier in people with non-small cell lung cancer that has spread to the brain. About 30 participants will receive standard immunotherapy plus the ultrasound procedure. The goal is to see if this…

This early-phase trial tests whether letrozole, a drug normally used for breast cancer, can reach and concentrate in recurrent high-grade gliomas (aggressive brain tumors). About 39 adults will take letrozole pills daily along with standard temozolomide chemotherapy. Researchers …

This study tests a more precise way to place electrodes on the scalp of glioblastoma patients receiving tumor treating fields (TTFields) therapy. Using advanced MRI that maps cancer spread, researchers aim to deliver stronger electrical doses to the tumor. The goal is to slow can…

This phase 2 trial tests whether sitagliptin, a diabetes drug, can improve the immune system's ability to attack glioblastoma, an aggressive brain tumor. The study will enroll 48 adults with grade 4 glioma who are scheduled for surgery. Some participants will receive sitagliptin …

This study tests a new treatment called BCB-276 for children and young adults with diffuse intrinsic pontine glioma (DIPG), a rare and aggressive brain tumor. BCB-276 is made from a patient's own immune cells, which are modified in a lab to recognize and attack the cancer. The tr…

This study is tracking 600 people with brain tumors who receive GammaTile therapy during surgery. GammaTile is a device that delivers radiation directly to the tumor site to help prevent regrowth. Researchers are measuring how long tumors stay under control and how patients feel …

This study tests whether metformin, a diabetes drug, and wearable activity trackers can help prevent memory and thinking problems after cranial radiation for brain tumors. About 100 patients will take metformin or not, and complete remote cognitive tests and wear a device. The ma…

This study looks at how safe and effective temozolomide (brand name Amitzo) is for people with aggressive brain tumors (grade III and IV gliomas). Researchers are tracking 100 patients to see how often liver injury occurs and to monitor other side effects. The goal is to better u…

This study tests whether using advanced brain network mapping (connectome-guided navigation) during surgery can better preserve functions like speech and movement in people with brain tumors in critical areas. Two hundred participants will be randomly assigned to either this new …

This early-phase study tests the safety of delivering the chemotherapy drug topotecan directly to the brain using a pump and catheter system (convection-enhanced delivery) in 6 people with a recurrent, aggressive type of brain tumor called IDH-mutant malignant glioma. The treatme…

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This early-stage trial tests a new combination treatment for children and young adults (ages 3-39) with recurrent malignant brain tumors that can be surgically removed. The treatment uses two genetically modified viruses injected into the tumor site, plus an oral anti-herpes drug…

This study tests whether adding the chemotherapy drug capecitabine to the standard temozolomide regimen can help people with newly diagnosed glioblastoma live longer without their tumor growing. About 67 adults who have completed initial radiation and chemo will take both pills a…

This trial tests a new way to treat glioblastoma, an aggressive brain cancer. The drug cetuximab, which blocks a protein that helps tumors grow, is infused directly into the brain's arteries after temporarily opening the blood-brain barrier. Up to 33 newly diagnosed patients will…

This early-stage trial is testing whether the drug sotorasib can get into KRAS G12C+ brain tumors and how safe and effective it is. Sixteen adults with these tumors who are already scheduled for brain surgery will receive the drug. Researchers will measure how much drug reaches t…

This phase II trial tests whether adding a cannabis-based mouth spray (nabiximols) to standard chemotherapy helps people with recurrent glioblastoma live longer. About 120 adults whose brain tumor has returned after initial treatment will receive either the cannabis spray or a pl…

This study tests a two-step treatment for people with newly diagnosed high-grade gliomas, a type of aggressive brain cancer. First, doctors use a laser to heat and destroy tumor tissue, then follow up with a shorter course of radiation. The goal is to see if this approach is safe…

This study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove for guided exercises or do standard home therapy. The goal is …

This study tests a new drug called TNG456, alone or with another drug (abemaciclib), in people with advanced cancers that have lost a gene called MTAP. The trial has two parts: first finding a safe dose, then testing how well it shrinks tumors. Up to 191 adults with lung cancer, …

This phase 2 trial tests a new way to deliver the cancer drug cetuximab directly into the brain's arteries, along with mannitol to open the blood-brain barrier, plus targeted radiation. It is for adults with recurrent glioblastoma or other aggressive brain tumors that have high l…

This Phase 3 trial tests whether combining the drug Avastin with a focused ultrasound system (NaviFUS) can improve outcomes for people with recurrent glioblastoma, an aggressive brain cancer. The ultrasound temporarily opens the blood-brain barrier to let more drug reach the tumo…

This study tests a shorter course of high-dose proton radiation for people with non-cancerous brain tumors like meningiomas and schwannomas. The goal is to see if fewer treatments can still control tumor growth while reducing side effects and being more convenient. About 70 adult…

This phase 3 trial tests whether brain tumor patients who have been seizure-free for 6 months on levetiracetam can safely stop the drug earlier than the standard 2-3 years. 604 adults with primary brain tumors and controlled seizures will be randomly assigned to stop levetiraceta…

This early-phase trial tests a new approach for people with recurrent high-grade astrocytomas, a type of aggressive brain cancer. During surgery to remove the tumor, doctors inject a modified virus directly into the brain cavity, followed by targeted radiation. The main goal is t…

This trial tests the drug entrectinib (Rozlytrek) in people with rare cancers that have a specific genetic change called ROS1 fusion. The drug is already approved for some lung cancers, but researchers want to see if it works for other tumor types. About 30 adults, teens, and chi…

This study looks at a special type of stitch (STRATAFIX) already approved by the FDA for closing wounds after brain or spine surgery. Researchers want to see if it helps wounds heal better and with fewer problems. About 160 adults having brain or spine surgery will take part. The…

This early-phase trial tests the drug troriluzole in 27 adults with recurrent IDH wild-type glioblastoma, an aggressive brain cancer. Participants take the drug before surgery, and researchers measure brain activity and glutamate levels in the removed tumor tissue. The goal is to…

This study is testing a new, quick MRI technique called Magnetic Resonance Fingerprinting (MRF) to better tell the difference between a brain tumor coming back and damage from radiation therapy (radiation necrosis). About 90 people will take part, including healthy volunteers, pa…

This study tests a special MRI technique to help doctors tell whether an enlarged spot in the brain after radiation is the tumor growing back or harmless scar tissue from the radiation. About 100 adults with brain metastases who had radiation will get this MRI before any surgery.…

This study tests a radioactive tracer called FET that lights up brain tumor cells on a PET scan. Researchers want to see if FET can better detect whether a brain tumor has come back after treatment, and help tell high-grade from low-grade tumors. About 199 people with known or su…

This study is testing whether a new MRI technique using a substance called hyperpolarized pyruvate gives consistent results in people with solid tumors. About 109 participants will have two special MRI scans to see if the images are reproducible. The goal is to improve how doctor…

This study tests a special dye that makes brain tumor cells glow during surgery. The dye is given before surgery, and a special camera helps surgeons see the glowing tumor tissue. The goal is to help surgeons remove more of the tumor while protecting healthy brain tissue. The stu…

This study tests whether a special brain scan (PET-MRI) done within 48 hours after glioblastoma surgery is safe and practical. Fifteen adults who just had their first surgery for a suspected glioblastoma will get this scan, which uses a radioactive tracer and contrast dye. The go…

This phase 2 trial at Mayo Clinic is testing whether adding an amino acid PET/CT scan (using a radioactive tracer called FDOPA) to standard imaging can improve clinical management for people with brain tumors. The study will enroll 47 adults with brain tumors to see if the extra …

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with neurological conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based computer tests wi…

This early-phase trial tests a fluorescent dye called ABY-029 to help surgeons better see high-grade gliomas (a type of brain tumor) during surgery. About 33 adults with suspected high-grade glioma will receive a small amount of the dye before surgery. The goal is to find the rig…

This phase 3 study is testing an improved PET/CT imaging method using a radioactive tracer called 18F-DOPA. Researchers want to see if it can better detect small lesions and reduce image artifacts in patients with conditions like congenital hyperinsulinism, neuroblastoma, neuroen…

This study tests a new MRI sequence that aims to make brain tumors (metastases) more visible after a standard contrast injection. Researchers will compare the new method to the usual MRI in 100 adults with known or suspected brain tumors. The goal is to see if the new scan finds …

This study is testing whether a simple ultrasound of the optic nerve can quickly detect brain swelling and inflammation in ICU patients with conditions like meningitis, encephalitis, or stroke. Researchers will measure the optic nerve sheath diameter in 200 adults and compare it …

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults w…

This trial tests two digital platforms, one for children with cancer and one for their parents, designed to improve communication with healthcare providers and address physical, emotional, social, and spiritual needs during treatment. Researchers will recruit 120 families of chil…

This study tests whether a 12-week tele-exercise program called RISE-YA can help reduce cancer-related fatigue in young adults (ages 18-39) who are brain tumor survivors. Participants receive energy conservation counseling, behavior coaching, and exercise training via video calls…

This study tests whether virtual reality can make cognitive training more engaging and effective for children aged 8-22 who are receiving radiation for brain tumors. About 45 participants will be randomly assigned to do brain exercises on an iPad or in virtual reality. Researcher…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This pilot study tests whether brodalumab, a drug used for autoimmune conditions like psoriasis, can safely reduce immune-related side effects caused by cancer immunotherapy. About 11 adults with advanced solid tumors who developed these side effects will receive brodalumab injec…

This study compares a single dose of methadone to the standard drug remifentanil for pain control after brain surgery. About 40 adults having elective brain surgery will be randomly assigned to one of the two drugs. The goal is to see if methadone provides better pain relief and …

This study tests whether a smart board device can help people with arm weakness from brain disorders (like stroke or brain injury) do rehab at home. Forty adults will either use the smart board or a workbook for 4 weeks. The goal is to see if the smart board improves arm function…

This study compares two 8-week virtual programs for adults with brain tumors who have thinking or memory issues. One program combines cognitive rehab with mindfulness (C-SMART), the other provides educational videos (BE Well). Researchers want to see if these programs are practic…

This study tests whether a non-invasive technique called transcranial magnetic stimulation (TMS) can help people recover movement after brain tumor surgery. Six patients will receive TMS once daily for three days, and their muscle strength will be measured before and after treatm…

This study tests whether a 5-minute guided meditation played during each radiation session can help reduce anxiety in people with brain tumors. About 30 adults will either listen to the meditation or receive standard care. Researchers will measure anxiety levels before and after …

This study tests if a drug called tranexamic acid (TXA) can reduce blood loss during brain tumor surgery. About 102 adults having a craniotomy will receive either TXA or a placebo. Researchers will measure blood loss and check for bleeding-related complications within 30 days aft…

This study tests whether a 6-week occupational therapy group programme can improve quality of life and daily functioning in adults with primary brain tumours who are on active treatment. Participants are randomly assigned to either the group programme or usual care (written infor…

This study tests whether brain tumor patients can safely receive radiotherapy without wearing an immobilization mask. Instead, a surface imaging system tracks the patient's position and movement. Twenty adults will try one session without a mask and report their comfort, anxiety,…

This study tests a home-based program called HOBSCOTCH-CA for brain cancer survivors who struggle with memory and thinking. The program involves weekly virtual sessions with a coach, teaching problem-solving and relaxation techniques. Researchers will compare two groups: one that…

This study tests whether wearing special glasses that emit bright light can help reduce fatigue and improve thinking speed and attention in children and teens who have been treated for a brain tumor. The study will include 40 survivors and compare the bright light glasses to dim …

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study tests the safety of placing a small device called an Ommaya reservoir under the scalp during brain tumor surgery. The device allows doctors to collect spinal fluid samples over time to study biomarkers. Researchers at Mayo Clinic will enroll 100 adults with brain tumor…

This study looks at whether placing a small device called an Ommaya reservoir under the scalp during a brain tumor biopsy allows doctors to safely collect fluid samples from the brain over time. Researchers want to see if this method works better than repeated spinal taps for tra…

This study tests whether artificial intelligence can predict muscle loss (sarcopenia) in intensive care patients with serious brain conditions like stroke, bleeding, or tumors. Researchers will measure thigh muscle thickness with ultrasound and track nutrition markers over the fi…

This study aims to map the brain regions essential for language and cognition in people with epilepsy or brain tumors. Participants perform language-based tasks while their brain activity is recorded using fMRI or electrical stimulation. The goal is to compare brain organization …

This study explores whether planning radiation therapy to avoid key brain regions can reduce thinking and learning problems in children with brain or head and neck tumors. Participants include children receiving radiation, survivors who completed radiation at least two years ago,…

This study looks at whether training paramedics with simulations can make brain tumor patients more satisfied with their care. About 250 adults with a newly discovered brain tumor will fill out a questionnaire after their hospital stay. The goal is to see if this training helps p…

This study tests a handheld microscope called CONVIVO that gives surgeons real-time, high-resolution images of brain tissue during surgery. The goal is to see if it can easily tell healthy tissue from tumor tissue in 30 patients with brain tumors. If it works, it could help surge…

This study follows 1,400 children and teens (ages 3-21) in Southern Europe with acute lymphoblastic leukemia or certain brain tumors. Researchers will track their diet, lifestyle, and quality of life over time to see how these factors relate to treatment side effects and survival…

This study uses a special microscope called intravital microscopy to look at blood vessels inside solid tumors while patients are in surgery. Researchers want to see how these vessels work and how well they let blood and dye flow through. The goal is to learn whether tumor vessel…

This study looks at a new CT scan technology to see if it produces clearer images of brain tumors. About 120 adults with diagnosed brain tumors will have their scans reviewed by radiologists. The goal is to improve image quality and diagnostic confidence, not to test a treatment.

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks happen and what makes them more likely. The goal is to find ways to prevent leaks and help people recover faster. No new treatment is being tested—just careful observation.

After brain surgery, many patients need a breathing machine in the ICU. This study will follow 220 such patients to see how the natural bacteria in their lungs change over time. Researchers will collect airway samples and use advanced lab tests to link those changes to the risk o…

This study aims to understand why some people with meningioma, the most common type of brain tumor, have worse outcomes than others. Researchers will look at factors like race, income, education, and medical history in 3,000 adults. The goal is to identify social and health-relat…

This study tests whether a non-invasive sound wave technique (transcranial focused ultrasound) can successfully image brain tumors before surgery. About 15 adults scheduled for brain surgery will have ultrasound scans taken and compared to standard MRI images. The goal is to see …

This study is testing a new computer program that helps doctors see which parts of the brain control important functions like language and movement. The goal is to help surgeons plan brain tumor removal more safely. About 1,720 adults with brain tumors who need surgery will take …

This study gives patients with a new brain mass a safe, non-radioactive sugar tracer before surgery to see how their tumor uses energy. Researchers will analyze the tumor tissue and compare it with MRI scans to find patterns that could help identify aggressive tumor cells. The go…

This study tests a special brain-mapping grid placed during surgery to better identify areas that control movement and speech. Researchers will compare this method with standard techniques in 75 adults with brain tumors. The goal is to see if the new grid helps surgeons avoid dam…

This study involves 20 people undergoing awake brain surgery for tumors near the hand movement area. Surgeons will test different electrical stimulation frequencies (10 to 250 Hz) to see which ones best identify or even improve hand movement. The goal is to develop a more precise…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This study aims to find biological markers in the blood that may help explain brain development disorders like autism, epilepsy, and brain tumors. Researchers will compare children with and without these conditions to identify unique patterns. Up to 500 children will participate …

This pilot study is testing whether a special MRI scan can measure a substance called 2-hydroxyglutarate (2HG) in brain tumors (gliomas) without needing surgery. Researchers will compare the MRI results with measurements from actual tumor tissue removed during surgery. If the MRI…

This study at MD Anderson Cancer Center tests whether advanced MRI (AMRI) can help doctors better target brain tumor biopsies. About 62 adults with brain lesions will get an AMRI scan before standard surgery. Researchers compare biopsy results from AMRI-guided spots to those from…

This study looks at how radiation to the brain affects memory in children who had a brain tumor. Researchers will test memory and thinking skills in 130 children ages 4 to 12, starting 2 years after radiation and again 2 years later. The goal is to learn which parts of the brain …

This study follows children and teens who had radiation to the brain before age 16 to check for hormone problems. Researchers will measure hormone levels and track fatigue to create better follow-up guidelines. About 230 participants in remission from cancer will be monitored for…

This study uses magnetoencephalography (MEG), a non-invasive brain scan, to compare brain signals in 1,500 children with neurodevelopmental disorders (like epilepsy, autism, ADHD) and healthy children. The goal is to improve diagnosis and understanding of these conditions. No tre…

This study uses a smartphone app to track how patients feel before and after neurosurgery for conditions like disc disease, spine instability, brain tumors, or aneurysms. Researchers aim to understand normal recovery patterns and how complications affect well-being. 400 adults wh…

This study is creating a large database of brain tumor patients (70,000 people) to help doctors better understand, diagnose, and treat these cancers. It collects medical images, lab results, and patient outcomes over time. The goal is to improve prediction of tumor behavior and g…

This study investigates whether brain surface recordings can decode Mandarin Chinese speech, including tones, from imagined speech. About 50 participants with brain tumors or epilepsy will have temporary electrodes placed during surgery, and 10 people with severe speech loss will…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study is testing whether a mobile app called 'Iskhaa' can help brain tumor patients perform their own neurological exams at home. Six hundred participants will use the app to record videos of tasks like speaking and walking, which an AI will analyze. The goal is to see if th…

This study looks at the bacteria and fungi in the gut and tumors of 100 children aged 3–18 who are suspected of having a brain tumor. Researchers want to see if changes in these microbes are linked to the tumor's presence or growth. The goal is to learn more, not to test a new tr…

This study aims to standardize care for people with rare brain tumors by using artificial intelligence to analyze patient data and predict recovery after surgery. Researchers will collect information on symptoms, brain scans, and cognitive function from 200 adults undergoing tumo…

This study aims to create immune organoids—tiny lab-grown models of the immune system—using cells from children and young adults with brain tumors, kidney tumors, neuroblastoma, or sarcoma. Researchers will mix these organoids with tumor cells to see how they interact. The goal i…

This observational study aims to find blood markers that show brain injury caused by cancer treatments in children with brain tumors. Researchers will collect plasma samples from 560 children before and after surgery, during radiation or chemotherapy, and up to three years later.…

This study uses focused ultrasound to temporarily open the blood-brain barrier during brain tumor surgery. Researchers will place tiny catheters to sample fluid from different brain areas to see how the barrier affects the tumor environment. Only 6 adults with large brain tumors …

This study looks at 100 adults with newly diagnosed glioblastoma, the most common and aggressive brain tumor. Researchers will measure certain proteins (MMP2 and MMP9) in blood and tumor tissue, and compare them with MRI scans. The goal is to better understand how these proteins …

This study aims to collect and store biological samples (like tumor tissue and blood) from 500 adults with brain tumors. The samples will be used to build a research collection to help scientists better understand brain tumors. Participants do not receive any treatment as part of…

This study collects brain tumor tissue samples from 4,000 children and adults undergoing brain surgery. The samples are stored in a tissue bank at the University of Florida for future research. The goal is to help scientists find better treatments and cures for brain tumors.

This study looks at whether platelets—small blood cells that help with clotting—are found inside brain and spinal cord tumors. Researchers want to see if the presence of platelets in these tumors is linked to how long patients survive. The study will involve 50 adults who are hav…

This study tests if analyzing waste from surgical suction devices can help detect brain tumor cells during surgery. About 8 adults with suspected high-grade gliomas or other brain tumors will take part. The goal is to see if this method improves tumor removal compared to standard…

This study compares two common anesthesia methods—inhaled gases (sevoflurane or desflurane) versus intravenous propofol—in 84 adults having brain tumor surgery. Researchers will measure brain oxygen levels, swelling, and thinking skills after surgery to see which approach better …

This study explores whether electrical brain stimulation can be personalized using a patient's own brain activity. Researchers will work with 25 epilepsy patients who already have electrodes implanted for medical monitoring. They aim to develop a system that tracks depression sym…

This study tests whether a digital website called Careverse can help caregivers of people with serious illnesses engage more in advance care planning. About 200 caregivers will be randomly assigned to use the website or receive usual care. Researchers will measure how involved ca…