University Of Texas Southwestern Medical Center
Clinical trials sponsored by University Of Texas Southwestern Medical Center, explained in plain language.
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Could a common antidepressant tame severe asthma?
Disease control Recruiting nowThis study tests whether escitalopram, an antidepressant, can reduce severe asthma flare-ups in people with frequent attacks. Researchers will give either the drug or a placebo to 105 adults with moderate-to-severe asthma. The goal is to see if the drug lowers the number of attac…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 20:47 UTC
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Can a Weight-Loss drug tame deadly high blood fats?
Disease control Recruiting nowThis study tests orlistat, a drug that blocks fat absorption, in people with type 1 hyperlipoproteinemia—a rare condition causing extremely high blood fats. Researchers want to see if orlistat can safely lower triglyceride levels over the long term. The trial enrolls 28 participa…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 20:34 UTC
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New hope for kidney stone sufferers: supplement may stop painful recurrences
Disease control Recruiting nowThis study tests whether hydroxycitrate, a molecule similar to citrate, can reduce the recurrence of calcium phosphate kidney stones. Researchers will give 25 stone formers either hydroxycitrate, potassium citrate, or a placebo, and measure how well their urine prevents stone for…
Phase: PHASE4 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 12:00 UTC
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New radiation combo may let some rectal cancer patients skip surgery
Disease control Recruiting nowThis early-phase trial is testing a new way of giving radiation therapy (ultra-fractionated, short course) along with standard chemotherapy for people with locally advanced rectal cancer. The goal is to see if this combination can shrink the tumor enough to avoid surgery. The stu…
Phase: PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 11:59 UTC
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Virtual checkups could save new Mothers' lives
Disease control Recruiting nowThis study compares two telemedicine programs for new mothers after they leave the hospital. One sends scheduled health tips and reminders, while the other lets moms reach out for care when needed. Researchers hope to see which approach helps diagnose and treat complications like…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 11:57 UTC
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New drug combo aims to slow cervical cancer growth
Disease control Recruiting nowThis study is testing whether two drugs, pembrolizumab (Keytruda) and lenvatinib (Lenvima), can slow tumor growth in people with cervical cancer that has spread or come back. About 30 participants will receive the combination. The main goal is to see how many people's tumors shri…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 11:57 UTC
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HIV-Positive hearts for HIV-Positive patients: a lifesaving match?
Disease control Recruiting nowThis study looks at whether heart transplants from HIV-positive donors are as safe and effective for HIV-positive recipients as those from HIV-negative donors. Fifty participants with advanced heart failure and HIV will receive a heart from either an HIV-positive or HIV-negative …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 11:57 UTC
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New radiation schedule could cut treatment time for throat cancer patients
Disease control Recruiting nowThis phase II trial compares a new, shorter radiation schedule (LT-SABR, given over 1-2 weeks) to standard radiation (over 5-6 weeks) for early-stage laryngeal cancer. The goal is to see if the shorter schedule causes fewer severe side effects in the first 3 months. About 67 adul…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 11:56 UTC
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New hope for cystic fibrosis bone disease: denosumab trial launches
Disease control Recruiting nowThis study looks at bone health in people with cystic fibrosis (CF) and tests a drug called denosumab to treat bone disease. Up to 100 participants, including both CF patients and healthy volunteers, will have bone scans and blood tests. A smaller group of 10 CF patients with bon…
Phase: PHASE4 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 11:55 UTC
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New drug duo takes on tough liver cancers
Disease control Recruiting nowThis phase 2 trial is testing whether a combination of two immune-boosting drugs, ligufalimab and cadonilimab, can shrink advanced liver or bile duct cancers that have stopped responding to prior treatments. About 64 adults will receive the drugs by IV every three weeks. The main…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 23, 2026 11:54 UTC
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New hope for women suffering from recurrent UTIs: daily antibiotic vs. bladder procedure
Disease control Recruiting nowThis study looks at two ways to manage recurrent urinary tract infections (UTIs) in women. One group takes a daily antibiotic called nitrofurantoin. The other group has a minor procedure to burn away tiny spots in the bladder (electrofulguration) and also takes the daily antibiot…
Phase: PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 22, 2026 12:08 UTC
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Nerve block may stall prostate cancer spread in High-Risk patients
Disease control Recruiting nowThis study tests whether blocking nerve signals to the prostate can slow or stop cancer growth in men with high-risk prostate cancer. Researchers will give one or two injections of a nerve-blocking agent before surgery to see if it reduces nerve activity around the tumor. The goa…
Phase: PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 22, 2026 12:08 UTC
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Nerve zap tech aims to give amputees a more natural hand feel
Disease control Recruiting nowThis study is testing whether temporarily implanting small electrodes in arm nerves can help people with hand or arm amputations control a prosthetic hand more naturally and feel sensations like touch. About 25 adults will have the electrodes placed for around 18 months. Research…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 22, 2026 12:05 UTC
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Smartphone rehab for heart failure: a new hope for rural patients?
Disease control Recruiting nowThis study tests a 12-week home-based cardiac rehabilitation program delivered through a smartphone app for 332 adults with heart failure who cannot attend in-person rehab. Participants are split into two groups: one uses the app program, the other receives standard attention. Th…
Phase: PHASE3 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 22, 2026 12:04 UTC
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Lung cancer showdown: surgery or radiation – which saves more lives?
Disease control Recruiting nowThis study compares two treatments for early-stage lung cancer in patients who are high-risk for surgery: removing part of the lung (sublobar resection) versus precise, high-dose radiation (stereotactic ablative radiotherapy). About 272 participants will be randomly assigned to o…
Phase: PHASE3 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 22, 2026 12:00 UTC
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Could ketamine help people quit meth? new trial aims to find out
Disease control Recruiting nowThis study tests whether intravenous ketamine can help adults with moderate to severe methamphetamine use disorder reduce their drug use. Over 12 weeks, 120 participants will receive either ketamine or an active placebo (midazolam) in a double-blind design. The main goal is to se…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 22, 2026 12:00 UTC
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New program aims to lower cholesterol in blood donors
Disease control Recruiting nowThis study tests a support program for blood donors who have very high cholesterol (familial hypercholesterolemia). The program includes notifications, online resources, and a care navigator to help them and their doctors manage cholesterol. Researchers will compare LDL cholester…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 22, 2026 11:59 UTC
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Radiation boosts CAR-T: new hope for tough lymphoma?
Disease control Recruiting nowThis study tests whether giving a targeted radiation drug (Iomab-B) before standard CAR-T cell therapy can safely improve outcomes for people with relapsed or refractory diffuse large B-cell lymphoma. About 30 participants will receive the radiation dose followed by CAR-T cells. …
Phase: PHASE1, PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 22, 2026 11:56 UTC
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Could vitamin d ease sarcoidosis? new trial investigates
Disease control Recruiting nowThis study looks at whether vitamin D supplements can help people with sarcoidosis who have low vitamin D levels. Researchers will give some participants vitamin D2 and others a placebo, then measure changes in lung function and quality of life. The goal is to see if correcting v…
Phase: PHASE4 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 22, 2026 11:55 UTC
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New hope for kids with tough tumors: drug combo trial launches
Disease control Recruiting nowThis study is for children whose solid tumors have returned or not responded to standard therapy. It combines an immunotherapy drug (atezolizumab) with three chemotherapy drugs to see if the mix is safe and can shrink tumors. About 23 children will take part, and the main goals a…
Phase: PHASE1, PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 18, 2026 11:53 UTC
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Turmeric compound tested to stop prostate cancer growth
Disease control Recruiting nowThis study tests whether curcumin, a natural compound found in turmeric, can slow or stop the progression of low-risk prostate cancer in men who are not receiving immediate treatment. About 291 men with early-stage prostate cancer will take either curcumin or a placebo daily for …
Phase: PHASE3 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 17, 2026 12:09 UTC
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New combo aims to shrink bladder tumors before surgery for cisplatin-ineligible patients
Disease control Recruiting nowThis study tests a combination of the drug enfortumab vedotin and targeted radiation before bladder removal surgery in people with muscle-invasive bladder cancer who cannot take the standard chemotherapy drug cisplatin. The goal is to see if this approach is safe and can eliminat…
Phase: PHASE1, PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 17, 2026 12:06 UTC
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Healthy kids program aims to tame childhood obesity
Disease control Recruiting nowThis study looks at whether a community program that teaches families about healthy eating, physical activity, and sleep can help children who are overweight or obese. About 160 children will be randomly assigned to either join the program right away or be placed on a waitlist. T…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 16, 2026 12:52 UTC
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Dietician-Guided program targets obesity in spinal cord injury patients
Disease control Recruiting nowThis study looks at whether a 9-week program led by a dietician can help people with chronic spinal cord injury lose body fat and improve how their body uses insulin. Twenty adults who use wheelchairs will take part in telehealth sessions and have their body composition and insul…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 16, 2026 12:51 UTC
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Kidney cancer patients who progress on standard dose may benefit from higher dose
Disease control Recruiting nowThis study tests whether a higher dose of the drug cabozantinib can help people with advanced kidney cancer whose disease got worse while on the standard dose. About 18 adults whose cancer had been controlled by cabozantinib for at least 6 months will receive a higher dose. The g…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 16, 2026 12:49 UTC
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Home visits may beat clinic care for chronic disease
Disease control Recruiting nowThis study compares home visits to standard clinic visits for managing high blood pressure and type 2 diabetes. Researchers will track changes in blood pressure and blood sugar over 6 months in 100 adults aged 18-60. The goal is to see if home-based care leads to better control o…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 15, 2026 19:07 UTC
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Could a single dose of radiation before surgery replace weeks of treatment?
Disease control Recruiting nowThis study tests a new way to treat early-stage ER+ breast cancer using a single, strong dose of radiation before surgery. It also explores using a special ultrasound with microbubbles to check lymph nodes without a surgical biopsy. The goal is to see if this approach can elimina…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 15, 2026 19:07 UTC
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New prostate cancer trial aims to personalize treatment and reduce side effects
Disease control Recruiting nowThis study tests a personalized approach to radiation therapy for men whose prostate cancer has returned after surgery. Instead of giving everyone the same treatment, doctors will adjust the plan based on how well the cancer responds to initial radiation. Those who respond well m…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 15, 2026 19:05 UTC
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Triple attack on kidney cancer: immune booster, radiation, and immunotherapy
Disease control Recruiting nowThis study tests whether adding an immune-boosting drug (IMSA101) and targeted radiation to standard immunotherapy can help control metastatic kidney cancer that has started to grow again. About 15 adults with clear cell kidney cancer that has progressed in up to 5 spots will rec…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 15, 2026 18:56 UTC
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Brain type may predict who benefits from clozapine in psychosis
Disease control Recruiting nowThis study tests whether the antipsychotic clozapine works better than risperidone for people with schizophrenia, schizoaffective disorder, or bipolar I with psychosis, based on a specific brain biotype (B1). About 524 adults will be randomly assigned to receive either drug for 1…
Phase: PHASE4 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 15, 2026 18:54 UTC
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Texts to parents may prevent teen suicide after ER visit
Disease control Recruiting nowThis study tests whether text messages can help parents lock up guns and medications after their teen's suicide-related emergency room visit. About 129 teens aged 12-17 and their parents will be followed for 12 weeks. The goal is to see if simple reminders can reduce access to da…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 12, 2026 12:06 UTC
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Could tiny corneal inserts save your sight without a transplant?
Disease control Recruiting nowThis study tests INTACS prescription inserts—tiny plastic implants placed in the cornea—to reduce vision problems caused by keratoconus, a condition that thins and bulges the cornea. About 25 adults who can no longer see well with glasses or contacts and are facing a corneal tran…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 11, 2026 11:57 UTC
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Smart scans guide Ultra-Precise radiation for tough prostate cancers
Disease control Recruiting nowThis study tests a personalized approach to radiation therapy for high-risk prostate cancer. Using special PET scans that highlight cancer cells, doctors will adjust the timing and dose of radiation to each patient's tumor. The goal is to improve treatment effectiveness while red…
Phase: PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 09, 2026 12:10 UTC
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One pill to rule them all? new study tests polypill for heart attack patients
Disease control Recruiting nowThis study tests whether combining three standard heart medications (aspirin, a blood thinner, and a statin) into a single daily pill helps people who've had a heart attack take their medicine more consistently. About 1,000 adults who recently had a heart attack and a stent place…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 09, 2026 12:07 UTC
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Can a diabetes drug replace surgery for a rare hormone disorder?
Disease control Recruiting nowThis study looks at two treatments for mild autonomous cortisol secretion (MACS), a condition where the body makes too much cortisol. Researchers want to see if removing the adrenal gland (surgery) or taking semaglutide (a weight-loss drug) better improves insulin resistance and …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 09, 2026 12:07 UTC
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Can cooling Newborns' brains prevent Long-Term problems?
Disease control Recruiting nowThis study looks at whether cooling therapy helps babies born with mild brain injury (HIE) develop better as they grow. About 460 full-term newborns will be enrolled within 6 hours of birth. Researchers will compare cooling to standard care and measure development at age 2, as we…
Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 08, 2026 13:18 UTC
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Experimental drug offers hope for Tough-to-Treat amyloidosis
Disease control Recruiting nowThis study tests a drug called belantamab mafodotin in people with a rare blood disease called AL amyloidosis that has come back or not responded to other treatments. The goal is to find the safest and most effective dose. The study has two parts: first, different doses are teste…
Phase: PHASE1, PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 08, 2026 13:13 UTC
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Tailored radiation: new trial aims to personalize cancer treatment
Disease control Recruiting nowThis study tests personalized radiotherapy approaches for people with lung cancer, brain metastases, or other solid tumors. It aims to see if adapting radiation based on how a patient responds is safe and effective. About 45 adults will participate, receiving either extra radiati…
Phase: PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 08, 2026 13:12 UTC
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First-Ever vagus nerve gene therapy trial launches for rare fatal nerve disease
Disease control Recruiting nowThis early-stage trial tests a gene therapy injected directly into the left vagus nerve for people with giant axonal neuropathy (GAN), a rare and fatal nerve disease. The study enrolls 4 participants who previously received the same gene therapy via spinal injection. The main goa…
Phase: PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 08, 2026 13:08 UTC
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New study explores less invasive prostate cancer treatments
Disease control Recruiting nowThis study is testing ablative therapies—treatments that destroy cancer cells with heat or cold—for men with localized prostate cancer. Researchers want to see how well these treatments control cancer and affect quality of life, including urinary and sexual function. The study wi…
Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 03, 2026 12:07 UTC
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New radiation approach aims to safely treat Hard-to-Reach lung tumors
Disease control Recruiting nowThis early-stage study tests a personalized radiation technique called PULSAR for lung cancers located near the center of the chest. The goal is to make treatment safer while still effectively controlling the tumor. About 30 adults with primary or metastatic lung cancer will rece…
Phase: EARLY_PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated May 29, 2026 14:19 UTC
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Could less radiation be better for head and neck cancer?
Disease control Recruiting nowThis study is for people with head and neck cancer. It compares two types of radiation therapy: one that treats only the cancer and nearby lymph nodes (INRT) and one that treats a larger area (ENI). The goal is to see if the smaller treatment area works just as well and causes fe…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated May 26, 2026 12:07 UTC
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Routine urine tests could spot bladder cancer early in smokers and factory workers
Diagnosis Recruiting nowThis study is testing whether regular urine tests every 6 months can find bladder cancer earlier in people at high risk, such as smokers over 50 and those with long-term workplace chemical exposure. Researchers will enroll 1,000 participants and track how many cancers are detecte…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Diagnosis
Last updated Jun 23, 2026 20:33 UTC
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New scan could spare thousands from unnecessary kidney surgery
Diagnosis Recruiting nowThis study is testing whether a combined PET/MR scan can better tell aggressive kidney cancers from harmless or slow-growing tumors. About 20% of kidney masses found by chance are not cancer, yet many are still treated. Researchers will scan 97 adults with suspicious kidney masse…
Sponsor: University of Texas Southwestern Medical Center • Aim: Diagnosis
Last updated Jun 23, 2026 11:57 UTC
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Glow stick for cancer: new dye helps surgeons spot hidden tumors
Diagnosis Recruiting nowThis study tests a dye called pegsitacianine that makes cancer cells glow during surgery. It is for 120 adults with head and neck cancer, including those with an unknown primary tumor. The goal is to see if the dye helps surgeons find and remove all cancer tissue safely.
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Diagnosis
Last updated Jun 22, 2026 12:05 UTC
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Heart scan breakthrough: new MRI spots living tissue without radiation
Diagnosis Recruiting nowThis study tests a new type of MRI that uses a safe, natural substance to measure how well the heart is producing energy. By looking at two simple molecules, the scan can tell which parts of the heart are still alive and working. The goal is to help doctors decide who will benefi…
Sponsor: University of Texas Southwestern Medical Center • Aim: Diagnosis
Last updated Jun 08, 2026 13:13 UTC
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Green tea compound tested to stop liver cancer before it starts
Prevention Recruiting nowThis study tests whether a green tea extract called EGCG can lower the risk of liver cancer in people with liver cirrhosis. Sixty adults with cirrhosis but no prior liver cancer will take either EGCG or a placebo for several months. Researchers will measure changes in a blood-bas…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Prevention
Last updated Jun 23, 2026 11:59 UTC
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New screening strategy aims to catch heart failure risk early in diabetes patients
Prevention Recruiting nowThis study tests a heart failure screening strategy for people with type 2 diabetes. Doctors use a blood test (NT-proBNP) and a risk score to identify high-risk patients, then recommend preventive treatments. The trial involves 300 patients and their primary care providers. The g…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Prevention
Last updated Jun 23, 2026 11:56 UTC
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Warm legs, healthy pregnancy? new study tests heat therapy for Moms-to-Be
Prevention Recruiting nowThis study tests whether regularly warming the legs with a portable sauna blanket can improve blood vessel health and lower the risk of high blood pressure disorders in pregnant women with obesity. About 118 women will use the blanket at home for 16 weeks, starting early in pregn…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Prevention
Last updated Jun 22, 2026 12:07 UTC
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Jail-Based program aims to cut HIV risk after release
Prevention Recruiting nowThis study tests a program in the Dallas County Jail that identifies people at high risk for HIV and offers them testing and education about PrEP, a daily pill that prevents HIV. A patient navigator helps interested individuals connect with PrEP providers after they are released.…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Prevention
Last updated Jun 22, 2026 11:58 UTC
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Blood pressure trial aims to stop dementia before it starts
Prevention Recruiting nowThis study tests whether helping doctors manage high blood pressure more aggressively can prevent cognitive decline and dementia in adults aged 70 and older. 4,000 participants will be randomly assigned to either a special decision-support tool for their doctors or usual care. Th…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Prevention
Last updated Jun 22, 2026 11:56 UTC
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Sugar pill could slash recurrent UTIs in Post-Menopausal women
Prevention Recruiting nowThis study tests whether taking a daily supplement of D-mannose, a type of sugar, can prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Over 12 months, 90 women will receive either D-mannose or a placebo to see if it reduces the number …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Prevention
Last updated Jun 17, 2026 12:07 UTC
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ERs now offering instant HIV protection pills to At-Risk patients
Prevention Recruiting nowThis study aims to help people who are at risk for HIV start prevention medication (PrEP) right away in the emergency department. Participants will receive a same-day prescription for oral PrEP and a follow-up appointment to continue care, with options for long-acting injectable …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Prevention
Last updated Jun 15, 2026 19:06 UTC
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New pill may stop COVID-19 after exposure – trial underway
Prevention Recruiting nowThis study tests whether a pill called mitoquinone can prevent COVID-19 in healthy adults who have had close contact with someone who has COVID-19. About 112 participants will receive either the pill or a placebo. The goal is to see if it stops infection and reduces symptoms.
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Prevention
Last updated Jun 15, 2026 19:03 UTC
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New study uses peer coaches to bring HIV prevention to formerly incarcerated
Prevention Recruiting nowThis study tests whether adding a peer health coach to existing re-entry services can help people with a history of justice involvement learn about and start taking PrEP, a daily pill that prevents HIV. Researchers will work with 100 clients of Unlocking Doors in Dallas to see if…
Sponsor: University of Texas Southwestern Medical Center • Aim: Prevention
Last updated Jun 08, 2026 13:07 UTC
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Nasal spray could ease stent pain after kidney stone surgery
Symptom relief Recruiting nowThis study compares a nasal spray form of ketorolac (Sprix) to oral diclofenac pills for managing pain from ureteral stents placed after kidney stone surgery. Researchers will enroll 80 adults to see if the nasal spray provides faster pain relief and reduces unplanned doctor visi…
Phase: PHASE1, PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 23, 2026 20:47 UTC
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Can remote exercise and weight loss boost heart failure Patients' stamina?
Symptom relief Recruiting nowThis study tests whether a tailored, home-based exercise program (with or without weight loss medications) can improve exercise capacity and quality of life in 120 adults with heart failure with preserved ejection fraction (HFpEF). Participants will follow exercise videos and mee…
Phase: PHASE2, PHASE3 • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 23, 2026 20:46 UTC
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Could a common gout drug help heart failure patients breathe easier?
Symptom relief Recruiting nowThis study tests whether a low dose of colchicine, an anti-inflammatory drug, can improve exercise capacity in people with heart failure and chronic inflammation. Sixty participants will be randomly assigned to receive either colchicine or a placebo for three months. Researchers …
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 23, 2026 11:54 UTC
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Ear stimulation device may cut opioid use after back surgery
Symptom relief Recruiting nowThis study tests whether a gentle, non-invasive device placed on the ear can help reduce pain after lumbar (lower back) surgery. The device stimulates nerves in the ear to change how the brain processes pain. Researchers will enroll 20 adults having back surgery to see if this ap…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 22, 2026 12:04 UTC
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Smartphone app could take the guesswork out of water pill dosing for kidney patients
Symptom relief Recruiting nowThis study tests whether a smartphone app can help people with kidney problems control body swelling by guiding daily adjustments to their water pill (diuretic) dose. Thirty adults with advanced kidney disease or nephrotic syndrome who have swelling will use the app for 90 days, …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 22, 2026 12:04 UTC
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Could a gentle brain zap improve social skills in anorexia?
Symptom relief Recruiting nowThis pilot study tests whether a gentle electrical current applied to the back of the brain (cerebellum) can improve social behaviors and mental flexibility in 15 women and girls aged 15-30 with anorexia nervosa. Participants receive two types of stimulation (anodal and cathodal)…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 22, 2026 12:01 UTC
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Could freezing your throat stop a chronic cough?
Symptom relief Recruiting nowThis study tests a new treatment for people with a long-lasting cough caused by nerve issues. Doctors will freeze a small area in the throat to see if it reduces coughing and improves quality of life. 28 adults will be tracked for 6 months after the procedure.
Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 18, 2026 11:49 UTC
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Art and education: a new social approach to eating disorders
Symptom relief Recruiting nowThis study looks at whether social therapy can improve symptoms in people with eating disorders and anxiety. 60 participants aged 18-30 will join either an educational group or an interactive group that also does a collaborative art task. Researchers will track changes in eating,…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 18, 2026 11:48 UTC
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New study aims to make anesthesia safer for endoscopy patients
Symptom relief Recruiting nowThis study tests two different mixtures of common anesthesia drugs (propofol and etomidate) to see which one keeps blood pressure more stable and causes fewer side effects during endoscopy. About 200 adults with higher health risks will take part. The goal is to find a safer way …
Phase: PHASE3 • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 18, 2026 11:47 UTC
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New laser strategy could cut anesthesia rounds for kids with birthmarks
Symptom relief Recruiting nowThis study looks at how to improve laser therapy for port-wine birthmarks in children. The goal is to reduce the number of treatments needed and make the therapy work better, especially for stubborn cases. About 200 children aged 2 months to 18 years will take part. Researchers w…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 15, 2026 19:09 UTC
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Wet T-Shirt trick could save heart failure patients from heat danger
Symptom relief Recruiting nowThis study tests whether keeping the skin wet—by wearing a damp T-shirt or wetting the skin—can help people with heart failure stay cooler and reduce stress on the heart during extreme heat. About 88 participants (half with heart failure, half healthy) will be exposed to simulate…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 15, 2026 19:09 UTC
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Ear-Zap therapy could calm brain inflammation after injury
Symptom relief Recruiting nowThis study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for patients in the ICU who have a traumatic brain injury. The researchers will check if the device can reduce inflammation in the blood and monitor changes in vital signs li…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 15, 2026 19:04 UTC
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Cool relief: wet skin may help burn survivors beat the heat during workouts
Symptom relief Recruiting nowThis study tests whether wetting the skin can prevent dangerous rises in body temperature during exercise in hot conditions for burn survivors. Researchers will compare cooling methods in 40 adults, including those with and without burn injuries. The goal is to find a simple way …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 15, 2026 19:03 UTC
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Could a mild brain zap help kids with autism? new study investigates.
Symptom relief Recruiting nowThis study tests whether a safe, non-invasive brain stimulation technique called tDCS can reduce certain autism symptoms, such as repetitive behaviors and hyperactivity, in children and young adults aged 4 to 17. Researchers will apply a mild electrical current to a part of the b…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 15, 2026 18:57 UTC
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New online program aims to curb teen suicide after hospital discharge
Symptom relief Recruiting nowThis study tests whether an online recovery program with trained teen peers and support specialists can help teens aged 15-18 who recently left a psychiatric hospital after suicidal thoughts or attempts. Participants are split into two groups: one gets the online program plus sta…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 12, 2026 12:04 UTC
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Which breathing aid best heals lungs after heart surgery?
Symptom relief Recruiting nowThis study compares three breathing treatments (IPPB, EzPAP, and Metaneb) to see which one helps lungs expand and recover best after heart surgery. About 324 adults who had coronary bypass or valve surgery will take part. The goal is to find the most effective therapy to improve …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 11, 2026 11:57 UTC
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Ankle zaps may curb bladder leaks in kids with spina bifida
Symptom relief Recruiting nowThis study tests a treatment called transcutaneous tibial nerve stimulation (TTNS) for children aged 8-18 with spina bifida who still leak urine despite regular catheter use. TTNS uses mild electrical pulses at the ankle to stimulate a nerve that helps control the bladder. Partic…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Symptom relief
Last updated Jun 01, 2026 18:08 UTC
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Sugar tracer sheds light on brain tumors during surgery
Knowledge-focused Recruiting nowThis study looks at how brain tumors use energy by giving patients a harmless, non-radioactive form of sugar before surgery. Researchers will analyze the tumor tissue to understand its metabolism and compare it with imaging scans and genetic tests. The goal is to learn more about…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 20:48 UTC
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Could a tiny pin on the head replace brain surgery for pressure monitoring?
Knowledge-focused Recruiting nowThis study is testing a new device that measures pressure inside the skull without needing surgery. The device uses a small pin on the head to detect tiny skull movements with each heartbeat. Researchers want to see if this non-invasive method can give useful information similar …
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 20:47 UTC
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Immune system secrets may improve breast cancer therapy
Knowledge-focused Recruiting nowThis study aims to understand how the immune system reacts to a common breast cancer treatment combination of letrozole and abemaciclib. Researchers will collect tumor and blood samples from 60 postmenopausal women with hormone receptor-positive breast cancer before and after two…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 20:33 UTC
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Breathing Helium-Oxygen may unlock exercise secrets for heart failure patients
Knowledge-focused Recruiting nowThis study looks at whether breathing a low-density helium-oxygen gas mixture can reduce breathlessness and improve exercise capacity in people with heart failure with preserved ejection fraction (HFpEF) and obesity. Researchers will measure how much oxygen the body uses during b…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 12:09 UTC
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Can a phosphate diet test improve kidney disease care?
Knowledge-focused Recruiting nowThis pilot study is testing how different levels of dietary phosphorus affect people with chronic kidney disease (stages 3-4). Participants will follow a controlled meal plan with increasing phosphorus intake over 21 days. The goal is to find new biomarkers and create a better wa…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 11:59 UTC
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Scientists use special MRI to peek inside brain tumors
Knowledge-focused Recruiting nowThis observational study uses a special MRI technique with hyperpolarized carbon-13 pyruvate to see how brain tumors use energy. Researchers will measure metabolic byproducts in 25 adults with brain tumors before any treatment. The goal is to learn more about tumor metabolism, no…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 11:59 UTC
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Ketamine may be safe for severe brain injury, tiny study hints
Knowledge-focused Recruiting nowThis early-phase study will give a single dose of ketamine to 10 adults with severe traumatic brain injury who already have monitors measuring brain pressure and oxygen levels. Researchers want to see if ketamine changes these readings, challenging the old belief that it raises b…
Phase: EARLY_PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 11:58 UTC
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AI reads brain scans to spot Parkinson's early
Knowledge-focused Recruiting nowThis study is testing whether artificial intelligence (AI) can analyze brain scans to help diagnose Parkinson's disease and related conditions like multiple system atrophy. Researchers will also see if the scans can predict how fast the disease will progress. The study involves 9…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 11:58 UTC
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Robot drain could ease hydrocephalus treatment
Knowledge-focused Recruiting nowThis study tests a new automated device called Intellidrop that drains spinal fluid in people with normal pressure hydrocephalus (NPH). The device aims to be safer and more comfortable than current manual methods. Ten adults aged 60 and older with suspected NPH will use the devic…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 11:58 UTC
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Can a multidisciplinary clinic improve life for MSA patients?
Knowledge-focused Recruiting nowThis study follows 200 people with Multiple System Atrophy (MSA) to see if receiving care from a team of specialists every four months improves their quality of life and eases the burden on their caregivers. Participants and their doctors will complete questionnaires about daily …
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 23, 2026 11:56 UTC
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Can a voice test prevent vocal cord damage?
Knowledge-focused Recruiting nowThis study looks at how voice sounds change when people strain their vocal cords. Researchers will measure specific voice features in 100 adults, some with and some without vocal cord injury. The goal is to find early warning signs that could help prevent voice damage before it h…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 22, 2026 12:08 UTC
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Spinal zaps may help stroke patients regain leg control
Knowledge-focused Recruiting nowThis study tests whether a gentle electrical current applied to the spine (called tsDCS) can improve reflexes, walking, and balance in people who have leg weakness after a stroke. Researchers will measure changes in movement and adaptation over 15 sessions. The goal is to underst…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 22, 2026 12:03 UTC
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AI spots silent heart failure in diabetics before symptoms start
Knowledge-focused Recruiting nowThis study tests whether an AI-powered tool can help doctors detect a type of heart failure (HFpEF) that often goes undiagnosed in people with type 2 diabetes. Researchers will use echocardiogram results and an AI algorithm to flag patients at risk, then alert their doctors. The …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 22, 2026 11:59 UTC
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New registry aims to unlock secrets of rare skin disease morphea
Knowledge-focused Recruiting nowThis study is creating a registry of 500 children and adults with morphea (localized scleroderma) to track how the disease behaves over time, what complications arise (like arthritis), and whether it has an autoimmune cause. Participants provide medical history and skin assessmen…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 22, 2026 11:59 UTC
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1,000 lupus patients join hunt for skin disease genes
Knowledge-focused Recruiting nowThis study aims to collect genetic and protein data from 1,000 people with cutaneous lupus (skin lupus) to better understand what causes it. Researchers hope to find specific genes and proteins that could lead to improved diagnosis and new drug development. Participants must be 1…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 22, 2026 11:57 UTC
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Massive MS registry aims to unlock disease secrets
Knowledge-focused Recruiting nowThis long-term study follows up to 50,000 people with multiple sclerosis to learn how the disease changes over time and what factors affect it. Participants fill out surveys twice a year online or by mail. No treatment or medication is given; the goal is to gather information for…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 22, 2026 11:55 UTC
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Study reveals burn survivors may struggle to cool down after exercise
Knowledge-focused Recruiting nowThis study looks at how a simulated burn injury affects how quickly the body cools down after exercise in hot conditions. Researchers will compare the same person's recovery with and without a special material on the skin that mimics a burn. The goal is to understand if burn surv…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 22, 2026 11:54 UTC
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New MRI method tracks sugar burning in lung tumors
Knowledge-focused Recruiting nowThis study aims to develop a better way to image lung tumors using MRI and a natural, slightly modified sugar solution. Researchers will look at how tumors burn sugar for fuel by analyzing tumor samples after surgery. The goal is to understand the metabolic pathways of lung cance…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 18, 2026 11:51 UTC
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Hormones and the spine: scientists probe Estrogen's role in nerve flexibility
Knowledge-focused Recruiting nowThis study looks at how the female sex hormone estradiol might change the way the spinal cord adapts. Researchers will use mild electrical stimulation to test nerve responses in 50 healthy young adults. The goal is to understand basic biology, not to treat any disease.
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 18, 2026 11:49 UTC
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New biorepository aims to unlock secrets of kidney disease in sickle cell patients
Knowledge-focused Recruiting nowThis study is building a special collection of blood and urine samples from 800 adults with sickle cell disease or sickle cell trait, along with some healthy volunteers. Researchers will use these samples and medical records to learn how kidney disease starts and gets worse in pe…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 18, 2026 11:47 UTC
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Can we spot heart amyloidosis before it strikes?
Knowledge-focused Recruiting nowThis study aims to find early signs of a heart condition called transthyretin cardiac amyloidosis in Black adults who carry a specific genetic change (V122I TTR) but have no heart failure symptoms. Researchers will use advanced heart scans and blood tests to detect amyloid buildu…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 17, 2026 12:16 UTC
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Heart health info: does more detail help or hurt?
Knowledge-focused Recruiting nowThis study looks at the best way to share personalized heart health information with 1500 adults from the Dallas Heart Study. Participants will receive letters with their heart risk results, presented either in a detailed or simple format. Researchers will track whether people wa…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 16, 2026 12:53 UTC
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Massive liver cancer screening showdown: ultrasound vs. blood test
Knowledge-focused Recruiting nowThis study will enroll 5500 adults with liver cirrhosis or chronic hepatitis B to compare two screening methods for liver cancer. Half will get standard ultrasound plus a blood test (AFP) every six months, and the other half will get a newer blood test (GALAD) alone. The goal is …
Phase: PHASE4 • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 16, 2026 12:53 UTC
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Brain study aims to unlock secrets of movement in Parkinson's
Knowledge-focused Recruiting nowThis study looks at how Parkinson's disease affects the brain's ability to control actions, like stopping or switching tasks. Researchers will have 50 people with Parkinson's do joystick tasks while on their usual dopamine medication. The goal is to better understand these brain …
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 16, 2026 12:52 UTC
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What's a normal pupil? new study aims to find out in ICU patients
Knowledge-focused Recruiting nowThis study collects data from 1,000 intensive care patients to determine normal pupil size and reactivity using a pupillometer device. The goal is to help doctors better understand what healthy pupil readings look like in critically ill people. Participants are adults already rec…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 16, 2026 12:50 UTC
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Do heart meds make seniors overheat? new study aims to find out.
Knowledge-focused Recruiting nowThis study looks at whether two common heart medications, propranolol and metoprolol, cause older adults to get hotter than normal during extreme heat. Researchers will measure body temperature and sweat rate in 22 healthy volunteers aged 65 and older over 3 hours of heat exposur…
Phase: PHASE4 • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 16, 2026 12:49 UTC
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Massive radiation registry aims to unlock better cancer care
Knowledge-focused Recruiting nowThis study is a large registry that collects health information from up to 10,000 people who received or were evaluated for radiation therapy at UT Southwestern since 2000. Researchers will analyze quality of life and compare outcomes with national data to better understand the b…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:07 UTC
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Money for travel and childcare may boost diversity in cancer trials
Knowledge-focused Recruiting nowThis study looks at whether offering money for things like travel, parking, and childcare helps more people from different backgrounds join and stay in cancer clinical trials. About 1,200 adults already in a cancer trial can take part. Researchers will compare those who use the f…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:04 UTC
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Scientists track Cancer's diet in real time during surgery
Knowledge-focused Recruiting nowThis study looks at how kidney and bladder cancers use nutrients like sugar and fat to grow. Participants receive a harmless nutrient tracer during surgery or biopsy, and researchers collect blood and tissue samples to analyze cancer metabolism. The study does not change standard…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:03 UTC
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Blood test may track heart drug effectiveness in rare amyloid disease
Knowledge-focused Recruiting nowThis study measures levels of amyloid proteins in the blood of 50 adults with transthyretin amyloid cardiomyopathy (ATTR-CM) who are taking standard TTR-stabilizing medications like tafamidis or acoramidis. Researchers want to see if these drugs lower amyloid levels over three mo…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:02 UTC
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New tool helps parents with bipolar disorder spot early mental health signs in kids
Knowledge-focused Recruiting nowThis study aims to improve early detection of mental health issues in children (ages 7-21) who have a parent with bipolar disorder. Researchers are testing a video decision aid to help parents understand genetic risks and make informed choices about screening their kids. The stud…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:02 UTC
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New MRI could reveal hidden heart damage
Knowledge-focused Recruiting nowThis study is testing a new type of MRI scan that looks at how the heart uses energy. It involves 15 people: 6 healthy volunteers and 9 patients with severe heart disease who are scheduled for bypass surgery. The goal is to see if this new scan can better measure heart muscle hea…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 15, 2026 18:57 UTC
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Scientists track fuel use in melanoma to uncover spread secrets
Knowledge-focused Recruiting nowThis study looks at how melanoma tumors use energy (sugar) to grow and spread. Researchers will give a special sugar infusion during surgery to track it in the tumor. 400 adults with melanoma will join to help find clues about which tumors are more likely to spread.
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 15, 2026 18:54 UTC
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Brain zap & blood test probe link between old concussions and memory decline
Knowledge-focused Recruiting nowThis study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to biological changes in people with mild memory problems. Researchers will use a gentle brain stimulation technique and blood tests to explore this connection. The study involves 7…
Phase: PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 12, 2026 12:02 UTC
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Scientists use epilepsy patients to peek inside Memory's brain code
Knowledge-focused Recruiting nowThis study looks at how a drug called scopolamine affects brain areas involved in memory. Sixty adults with epilepsy who are already having brain surgery for seizure monitoring will take part. They will receive either the drug or a saltwater solution and perform memory tasks whil…
Phase: EARLY_PHASE1 • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 11, 2026 12:11 UTC
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Shaking off stigma: brain procedure may ease social burden of hand tremors
Knowledge-focused Recruiting nowThis study looks at whether a brain treatment called focused ultrasound can reduce the social stigma that people with essential tremor often face. About 220 adults with essential tremor will have their tremor treated and then be followed for one year. Researchers want to see if l…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 11, 2026 12:10 UTC
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Scientists test Anti-Aging drugs in seniors to unlock healthier lifespans
Knowledge-focused Recruiting nowThis study looks at how two drugs, sirolimus and everolimus, work in healthy adults aged 65 and older. Researchers want to measure how the body processes these drugs and their effects on aging-related markers. The goal is to gather essential data to design future trials that coul…
Phase: PHASE1, PHASE2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 11, 2026 12:09 UTC
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Scientists develop new way to watch brain fuel use
Knowledge-focused Recruiting nowThis study aims to develop a new imaging technique using a special substance called hyperpolarized pyruvate to measure how the brain uses energy and makes neurotransmitters. Researchers will scan 28 healthy adults aged 18 to 60 to create detailed maps of brain metabolism. This is…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 08, 2026 13:17 UTC
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Can a CT scan predict lung cancer treatment success?
Knowledge-focused Recruiting nowThis study looks at CT scans from 2,000 people to see if computer models can better predict how lung cancer will respond to treatment. Researchers will review past patient records and data from a national screening trial. The goal is to improve screening and treatment decisions f…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 08, 2026 13:12 UTC
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Can a cool towel save your heart in a heat wave? study seeks answers for seniors.
Knowledge-focused Recruiting nowThis study tests how well different cooling methods (like cold towels or fans) protect the heart and body of healthy older adults during simulated heat waves. Researchers will measure body temperature and heart function in 100 volunteers aged 65 and older. The goal is to find sim…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 08, 2026 13:08 UTC
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Brain scan registry aims to uncover secrets of schizophrenia
Knowledge-focused Recruiting nowThis study creates a registry of brain scans, thinking tests, and blood samples from 1,000 people with schizophrenia, schizoaffective disorder, or no mental illness. Researchers use MRI to compare brain activity and connections between groups while performing memory tasks. The go…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 08, 2026 13:05 UTC
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Could your diet be secretly sapping your stamina? new study investigates phosphate overload.
Knowledge-focused Recruiting nowThis study looks at whether eating too much phosphate—common in many US diets—can reduce your ability to exercise and increase belly fat. Researchers will measure oxygen use during cycling and energy production in muscles. About 124 healthy adults will take part to see if finding…
Phase: NA • Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated Jun 01, 2026 17:55 UTC
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New scanner aims to spot prostate cancer as well as standard PET
Knowledge-focused Recruiting nowThis study checks if a new PET-CT scanner (RefleXion X1) can see prostate cancer tumors as well as the standard scanner does. About 25 men with prostate cancer who are already getting a standard PET scan will get an extra scan on the new machine. The goal is to see if the new sca…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated May 26, 2026 12:04 UTC
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Nerve block may reveal hidden eye changes in brain injury patients
Knowledge-focused Recruiting nowThis study looks at how a nerve block (stellate ganglion block) changes tiny blood vessels in the eye. Researchers will use a special camera to take pictures of the retina before and after the procedure in 50 adults who are already receiving the block for pain. The goal is to und…
Sponsor: University of Texas Southwestern Medical Center • Aim: Knowledge-focused
Last updated May 26, 2026 12:00 UTC