University Of Texas Southwestern Medical Center

This study tests whether adding a precise form of radiation (SABR) to the drug osimertinib can help people with a specific type of advanced lung cancer (EGFR mutant) live longer without their cancer growing. About 41 adults with stage 4 non-small cell lung cancer that cannot be r…

This study tests whether the drug tofacitinib can slow tumor growth in people with recurrent glioblastoma, a fast-growing brain cancer. About 17 adults whose cancer has returned after standard treatment will take tofacitinib pills twice daily. The main goal is to see how long the…

This study tests a precise, high-dose radiation treatment called SABR for small kidney tumors (≤5 cm) that are growing. The goal is to stop tumor growth without surgery. Sixteen adults with biopsy-proven kidney cancer are participating. The study tracks tumor response, side effec…

This study tests an automated system that uses patient risk levels to send reminders for follow-up appointments. About 1,000 adults with inflammatory bowel disease (IBD) will be randomly assigned to either usual care or the reminder tool. The goal is to see if the tool reduces mi…

This study looks at whether giving higher doses of focused radiation (stereotactic radiosurgery) to brain tumors is safe and effective, without also radiating the whole brain. It involves 135 adults with up to 10 brain tumors that have not been treated with radiation before. The …

This study tests a precise, 5-session radiation treatment called stereotactic partial breast irradiation (S-PBI) using a special device called GammaPod for women with early-stage breast cancer. The goal is to control the cancer while improving cosmetic results and reducing side e…

This study tests whether adding an immunotherapy drug called APX005M to standard treatment helps more people with advanced rectal cancer achieve a complete response, meaning no cancer cells remain after treatment. About 58 adults with stage II or III rectal cancer will be randoml…

This study looks at whether people with relapsing-remitting or active secondary progressive multiple sclerosis can safely switch from natalizumab to cladribine tablets. The goal is to see if cladribine can control the disease with fewer infusions. The study involves 40 adults age…

This study looks at whether adding methadone to the usual morphine pain medicine can better control severe mouth pain in children aged 6 to 18 who are getting a stem cell transplant for conditions like leukemia or aplastic anemia. The mouth pain is a common side effect of the che…

This early-phase study tests a special light therapy designed to reset the body's internal clock and reduce fatigue in people with progressive multiple sclerosis. About 20 adults with stable disease will receive the light treatment, and researchers will monitor safety and any cha…

This study looks at how obesity affects children's breathing and exercise ability over 6 years. Researchers will re-test 90 kids (some with obesity, some without) who were first studied between ages 8-12. They will measure lung function, exercise tolerance, and shortness of breat…

This study looks back at the medical records of 20,000 people with lung or gastrointestinal cancer who also have cachexia (severe weight loss and muscle wasting). Researchers want to understand how doctors currently manage this condition and what factors affect patient outcomes. …

This study looks at how depression changes the way people process emotions and make decisions. Researchers will compare 120 adults with major depression to 120 healthy adults, all aged 21 to 80. Participants will complete thinking tests and brain scans to understand these differe…

This study looks at how bones might influence citrate levels in urine, which is important for preventing kidney stones. Researchers will measure bone density and turnover in 25 people with untreated osteoporosis before and after they take osteoporosis medications. The goal is to …

This study follows 9 people with transverse myelitis who previously received an experimental nerve cell treatment called Q-Cells®. Researchers will monitor them for 10 years to check for side effects and see if any benefits last. The goal is to understand the long-term safety of …

This study looks at how well people with short bowel syndrome tolerate fiber from green beans. Researchers will track symptoms, weight, and changes in gut bacteria. 60 adults will participate, comparing those with the condition to healthy controls.

This study reviews medical records of up to 10,000 people with lung or gastrointestinal cancers to see if PET scans can identify tumors that cause cachexia—a condition of severe weight loss and weakness. Researchers will compare PET scan results with patients' weight and performa…

This study follows 852 adults with liver cirrhosis who are scheduled for a TIPS procedure—a shunt placed in the liver to reduce dangerous pressure. Researchers will collect real-world data over 5 years to answer key questions about when and how to use TIPS most safely. The goal i…

This study looks at how the brain manages actions like stopping or switching tasks in people with Parkinson's disease. Researchers will record brain activity during deep brain stimulation (DBS) surgery in 125 patients. The goal is to understand the brain circuits involved, not to…

This study was designed to see if two different standard treatments for severe hemophilia A affect joint health and bleeding differently in children. Researchers planned to use ultrasound and blood tests to look for early joint changes. However, the study was withdrawn before enr…

This study follows 150 people with rare inflammatory conditions affecting the brain, spinal cord, and optic nerves. Researchers collect medical data and biological samples over time to understand what causes these diseases and why some patients respond to treatments while others …

This study looks at how extra body fat affects muscles and blood vessels in people with a type of heart failure called HFpEF. Researchers will measure changes before and after participants lose at least 7% of their body weight using standard weight-loss medications. The goal is t…