University Of Texas Southwestern Medical Center

This study tests whether giving higher doses of focused radiation (stereotactic radiosurgery) to brain tumors is safe and effective, without also radiating the whole brain. About 135 adults with certain types of cancer that have spread to the brain will receive escalating radiati…

This study tests whether tafamidis, a drug that stabilizes a protein called transthyretin, is safe and effective in 25 people who have had a heart transplant for ATTR amyloidosis. Participants take tafamidis daily for 12 months. The goal is to see if it can slow or prevent amyloi…

This phase 1 trial is testing a precise, high-dose radiation technique called SABR for men with high-risk prostate cancer. The goal is to find the highest safe dose to the prostate and pelvic lymph nodes while monitoring side effects. Sixty participants will receive five radiatio…

This study tests a shorter, more intense course of radiation therapy given after surgery for head and neck cancer. The goal is to see if it is safe and if it can help preserve swallowing function compared to the standard longer radiation schedule. About 59 adults with certain typ…

This study tests whether combining two drugs, domvanalimab and zimberelimab, can shrink or control advanced liver and bile duct cancers that have stopped responding to earlier treatments. About 58 adults with these cancers will receive the drug combination. The main goal is to se…

This phase 2 trial is testing whether combining immunotherapy drugs (pembrolizumab, ipilimumab, nivolumab) with a freezing technique called cryoablation before standard surgery can improve outcomes for women with triple-negative breast cancer. The study enrolls 51 women who have …

This phase 2 trial is testing a combination of three drugs—ATRA (a vitamin A derivative), bevacizumab (a blood vessel growth blocker), and atezolizumab (an immunotherapy)—in 22 people with advanced colorectal cancer that has not responded to prior treatments. The goal is to see i…

This study tests whether semaglutide, a once-weekly injectable diabetes drug, improves blood sugar control in people with type 2 diabetes who are on chronic dialysis. About 43 participants will be randomly assigned to receive either semaglutide or a placebo for just over a year. …

This early-phase study tests a single, powerful dose of radiation given before surgery for early-stage breast cancer. The goal is to find the highest safe dose that can destroy the tumor in one session, potentially shortening treatment from weeks to one day. The study involves 45…

This study tests a precise, non-invasive radiation treatment called SABR for people with small kidney tumors that are growing. The goal is to stop tumor growth without surgery. Sixteen adults with tumors 5 cm or smaller are participating.

This study tests a precise, 5-session radiation treatment called stereotactic partial breast irradiation (S-PBI) using a special device (GammaPod) for women with early-stage breast cancer. The goal is to see if this approach keeps the breast looking good (cosmesis) while controll…

This study looks at whether switching from natalizumab to cladribine tablets is safe and effective for people with relapsing forms of multiple sclerosis. About 40 adults aged 18-60 will take cladribine after stopping natalizumab. Researchers will track immune cell changes, relaps…

This study tested whether combining two drugs, afatinib and prednisone, can help people with advanced squamous non-small cell lung cancer who have already tried other treatments. The goal was to see if the combination could slow cancer growth. The trial enrolled 12 adults and mea…

This study tests whether a special form of calcium and magnesium (effervescent calcium-magnesium citrate) can slow down harmful calcium buildup in the heart and blood vessels of people with end-stage kidney disease on dialysis. About 269 adults will take either this supplement or…

This study tests giving focused radiation to a tumor clot in the main vein before surgery for kidney cancer. The goal is to see if this approach is safe and helps prevent the cancer from coming back within a year. About 25 people with newly diagnosed kidney cancer and a clot in t…

This study tests whether Tofacitinib, a drug used for arthritis, can slow tumor growth in people with recurrent glioblastoma (a type of brain cancer). About 17 adults whose cancer returned after standard treatment will take Tofacitinib pills twice daily. The goal is to see if it …

This study tests whether adding a precise type of radiation (SABR) to the targeted drug osimertinib can help people with advanced EGFR-mutant lung cancer live longer without their disease getting worse. About 41 adults with this specific genetic type of lung cancer will receive b…

This study tests whether a new type of cage (with nanoLOCK coating) used in neck fusion surgery leads to better swallowing and bone healing than standard cages. About 200 adults with neck nerve problems will be randomly assigned to get either the new cage or a regular one. The go…

This study tests an automated tool that uses patient risk levels to remind people with inflammatory bowel disease (IBD) when they need follow-up appointments. Researchers will compare how often patients are overdue for visits and whether this leads to fewer emergency room trips o…

This study tests whether sending personalized screening invitations based on a person's race, ethnicity, and diabetes risk, plus offering phone navigation for those who don't respond, leads to more people getting tested for diabetes compared to generic invitations or usual care. …

This study tested a program to help bladder cancer patients recover better after bladder removal surgery. The program included extra monitoring and support before, during, and after the operation to catch problems early. The goal was to reduce complications within 90 days after s…

This study tests whether a precise type of radiation (SAbR) that avoids the nerves near the prostate can help men with localized prostate cancer keep their ability to have erections. About 124 men will be randomly assigned to standard SAbR or a nerve-sparing version. The goal is …

This early-phase study tests whether a special light therapy is safe and can help reduce fatigue in people with progressive multiple sclerosis. About 20 adults with this condition will receive the light treatment. The goal is to see if it is well-tolerated and to gather initial d…

This study looks at whether adding methadone to standard morphine pain medicine can better control severe mouth pain (mucositis) in children aged 6 to 18 who are getting a stem cell transplant for conditions like leukemia or aplastic anemia. The mouth pain happens because chemoth…

This study looks at whether a simple writing therapy called Written Exposure Therapy (WET) can help pregnant and postpartum teens and young adults (ages 15-24) with PTSD. The goal is to see if the therapy is easy to use and if it reduces PTSD symptoms. About 30 participants will …

This study is building a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will track their health over time to better understand these conditions and develop ways to predict outcomes. The goal is to improve care and prevent s…

This study follows 90 children (some with obesity, some without) who were first tested between ages 8-12. After about 6 years, researchers will measure lung function, exercise tolerance, and breathlessness during exercise. The goal is to understand how obesity affects breathing a…

This study follows 150 people with rare neuroimmune disorders like neuromyelitis optica and transverse myelitis. Researchers collect medical data and blood samples over time to understand what causes inflammation and why some patients respond to treatments while others do not. Th…

This study follows 852 adults with liver cirrhosis who are scheduled for a TIPS procedure, a shunt placed in the liver to relieve dangerous high blood pressure. Researchers will collect information from standard medical care over 5 years to learn how to best use TIPS and reduce c…

This study looks at how alcohol triggers the liver to create new fat, especially in women. Healthy volunteers drink a small amount of vodka and heavy water, then give blood samples to track fat production. Researchers want to see if adding sugar to alcohol increases this effect. …

This study looks at how depression changes the way people process emotions and make decisions. Researchers will compare 120 adults with depression and 120 healthy adults, all aged 21 to 80, using brain scans and thinking tests. The goal is to understand the brain circuits involve…

This study looks back at the medical records of 20,000 people with lung or gastrointestinal cancer who also have cachexia (severe weight loss and muscle wasting). The goal is to learn how doctors currently treat cachexia and what factors affect patient outcomes. No new treatments…

This study records brain activity from 125 Parkinson's patients during deep brain stimulation (DBS) surgery. While patients perform tasks involving decision-making, stopping, or switching actions, researchers measure signals from the brain's surface and deep areas. The goal is to…

This study looks at how well people with short bowel syndrome (a condition where the small intestine is too short to absorb nutrients normally) can tolerate fiber from green beans. Researchers will track symptoms, weight, and changes in gut bacteria. 60 adults from UT Southwester…

This study aimed to compare two standard treatments for severe hemophilia A in children: extended half-life factor VIII and non-factor VIII therapies. Researchers planned to measure how well each treatment prevented bleeding and protected joint health using ultrasound. However, t…

This study looks at how bone contributes to citrate levels in urine, which may help explain why some people have low urine citrate. Researchers will study 25 adults with untreated osteoporosis, giving them potassium citrate and measuring changes in urine citrate and bone markers.…

This study follows 9 people with transverse myelitis who previously received an experimental cell therapy called Q-Cells®. Researchers will monitor them for 10 years to check for side effects and see if the treatment continues to have any effect. Participants will have regular ex…

This study looks at how precise radiation (stereotactic radiosurgery) affects memory and thinking in people with 6 or more brain tumors that have spread from other cancers. About 80 adults will take part to find the safest radiation dose and measure any decline in memory over 4 m…

This study follows 1,500 young people aged 10-24 for up to 10 years to learn what helps them stay mentally strong and avoid depression and anxiety. Researchers will look at things like lifestyle, brain scans, and personal history. No treatments or medications are given—this is pu…

This study looks at whether using a Pedi-Cap, a device that changes color to show carbon dioxide levels, can shorten the time newborns need breathing help in the delivery room. About 632 infants born at 30 weeks or later who need face mask ventilation will be included. The resear…

This study looks at whether healthcare providers can use skills learned on mannequins when helping real newborns breathe. About 120 respiratory therapists will be observed in both a simulation lab and the delivery room. The goal is to see if their ability to manage a baby's mask …

This study is creating a collection of blood samples and health information from 250 adults with very high or very low cholesterol or related lipid problems. Researchers will analyze these samples to learn more about the genetic and biological causes of these extreme lipid disord…

This study looks at why some children and teens feel short of breath or have trouble exercising after their first blood clot in the leg (deep vein thrombosis) or lung (pulmonary embolism). Researchers will measure exercise capacity and breathing using special tests. The goal is t…

This study looks at how social media use impacts the emotions of 100 teenagers (ages 13-18) who already have depression or suicidal thoughts. Participants will use a smartphone app to report their feelings and social media use twice a day for 30 days. The goal is to better unders…

This study reviews medical records of 10,000 people with lung or gastrointestinal cancers to see if PET scans can identify tumors that cause cachexia—a condition of severe weight loss and weakness. Researchers will compare PET scan results with patients' weight and performance st…

This study looks at how extra body fat affects muscles and blood vessels in people with a type of heart failure called HFpEF. Researchers will measure muscle health and blood flow before and after participants lose at least 7% of their body weight using standard weight-loss medic…