University Of Texas Southwestern Medical Center

This study compares early discharge with a subcutaneous (under-the-skin) diuretic called furosemide against standard hospital care for 250 adults with acute heart failure. Participants are enrolled within 48 hours of admission and must have a safe home environment. The goal is to…

This study tests whether a smartphone app (DynamiCare) plus personal support can help people recently released from jail or prison cut down on stimulant use and start HIV medication or prevention. About 40 participants will use the app and receive guidance for 6 months. The goal …

This study tests whether giving two drugs (ateganosine and cadonilimab) before surgery can help treat liver cancer that can be removed. About 60 adults with resectable hepatocellular carcinoma will receive the drugs and then have surgery. The main goal is to see if the treatment …

This study tests whether a low dose of the drug erlotinib can prevent liver cancer in people with advanced liver scarring (fibrosis or cirrhosis). About 60 adults will receive either erlotinib or a placebo for a period of time. Researchers will check if the drug changes a blood t…

This study aims to improve laser therapy for port-wine birthmarks in children aged 2 months to 18 years. Researchers will test different laser methods to see which works best to lighten the birthmark with fewer treatments and less need for general anesthesia. The goal is to make …

This study compares two ways of giving surfactant, a medicine that helps premature babies breathe better. One method uses a thin tube (LISA), and the other uses a small airway device (SALSA). The goal is to see which method causes fewer breathing problems and complications in inf…

This study tests a non-invasive device that delivers low-intensity electric fields (TTFields) to people with early-stage lung cancer before they have surgery. The main goal is to see how these fields affect certain genes in the tumor, not to treat the cancer. About 18 participant…

This study looks at whether wearing compression garments (like tight leggings) can improve how well the heart pumps blood during exercise in people with Fontan circulation, a rare heart condition. Twenty adults will do exercise tests in an MRI and on a bike, with and without the …

This study looks at how social media use impacts the emotions of 100 teens aged 13-18 who already have depression or suicidal thoughts. Participants will answer quick surveys twice a day for 30 days and monthly check-ins for 6 months. The goal is to better understand the link bet…

This study tests whether showing emergency medical workers a real-time visual display helps them deliver the right amount of air during CPR on a mannequin. About 80 trained responders will give breaths with and without the feedback, using two different CPR techniques. The goal is…

This study looks at whether an FDA-approved automated device can safely drain small amounts of spinal fluid in people aged 60 and older with normal pressure hydrocephalus. The device monitors pressure continuously and reduces the need for manual checks by nurses. Ten participants…

This study looks at three different forms of potassium citrate—a common medication to prevent kidney stones—to see which one works best and is easiest to take. Twenty adults with kidney stones will try each form for one week, then provide urine samples and fill out surveys. The g…

This study helps doctors get better at talking with teenagers and their parents about birth control. Doctors will practice these conversations with computer-generated avatars that act like real teens and parents. The goal is to see if this training boosts doctors' confidence and …

This study looks at how heart rate variability (a measure of nervous system health) relates to emotional control and parent-teen relationships in 74 adolescents with major depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to u…

This study looks at how the drug Cobenfy KarXT changes brain activity related to memory. About 50 adults with epilepsy who are already having brain surgery for seizure monitoring will take either the drug or a placebo. Researchers will measure brain signals to see if the drug boo…

This study looks at whether sending automated MyChart messages and texts to cancer patients after they leave the hospital can steer them toward urgent oncology care instead of the emergency room. About 200 adults with active cancer who recently had chemotherapy and an ER visit wi…