University Of Texas Southwestern Medical Center

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This study will test three different forms of potassium citrate—a medication that helps prevent kidney stones by making urine less acidic. Twenty adults who have had kidney stones will take each form for one week, with a week off in between. Researchers will measure changes in ur…

This study tests whether adding deucravacitinib to standard therapy helps adults with psoriatic arthritis that is not well controlled. About 128 participants will receive the combination and be monitored for 48 weeks. The goal is to reduce skin and joint symptoms and improve qual…

This study tests whether giving two drugs (ateganosine and cadonilimab) before surgery can safely shrink liver tumors in people with resectable hepatocellular carcinoma. About 60 participants will receive either one or both drugs before their operation. The main goal is to see if…

This early-stage study tests whether the investigational drug BMS-986353 is safe in adults with a specific type of neuromyelitis optica (NMOSD). Participants, who are already stable on standard treatments, will receive the study drug and continue their current therapy. The study …

This study tests whether a mobile app (DynamiCare) combined with patient navigation can help people recently released from jail or prison reduce their use of stimulants like methamphetamine or cocaine, and start or restart HIV prevention (PrEP) or treatment (ART). The pilot phase…

This study aims to see if a new radioactive dye can detect early signs of a heart condition called amyloidosis in people who carry a TTR gene mutation but have no heart failure symptoms. About 80 adults aged 30-80 will receive an injection of the dye and then have a PET/CT scan t…

This study looks at whether a powder containing potassium, magnesium, and citrate can help prevent or treat high blood pressure in African Americans. About 45 African American adults with slightly high blood pressure will take the supplement daily for several weeks. The goal is t…

This study tests whether a low dose of the drug erlotinib can prevent liver cancer in people with advanced liver scarring (fibrosis or cirrhosis). About 60 adults at high risk will receive either erlotinib or a placebo for a set time. Researchers will check if the drug changes a …

This study tests whether wearing compression garments on the legs can increase the amount of blood the heart pumps during exercise in adults with Fontan circulation. Twenty participants will undergo exercise tests with and without the garments, and a subset will wear them for two…

This study tests two types of brain stimulation for people with depression that hasn't improved with medication. About 247 adults will receive either a precise, guided form of stimulation, a standard form, or a fake (sham) procedure. The goal is to see if these treatments can saf…

This study tests whether people hospitalized for acute heart failure can safely go home early and continue treatment with a portable, under-the-skin diuretic instead of staying in the hospital for IV diuretics. About 250 adults will be randomly assigned to either early discharge …

This study tests whether a device called Lymphatic Enhancement Technology (LET) can reduce pain and improve quality of life in women with fibromyalgia. Forty participants will receive either active or sham LET treatments once a week for four weeks. Researchers will measure change…

This study compares two methods of giving surfactant, a medicine that helps premature babies breathe. One method uses a thin tube, the other uses a small airway device. The goal is to see which method causes fewer breathing problems and complications in infants born at 29 weeks o…

This study tests if giving a long-lasting numbing medicine in two different places around the ribs and chest wall can reduce pain and the need for strong painkillers after robotic lung surgery. About 300 adults having this surgery will be randomly assigned to receive the numbing …

This study looks at two methods for giving a lung-helping medicine called surfactant to very premature babies (born at 22 to 28 weeks). One method uses a video camera to guide the procedure, the other uses direct sight. The goal is to see which method works better on the first tr…

This study looks at 300 adults with a type of brain bleed called aneurysmal subarachnoid hemorrhage. Researchers want to see if a non-invasive headband can accurately monitor brain pressure and blood flow, replacing the need for invasive probes. They will also test two nerve stim…

This early-phase study tests whether the drug Cobenfy KarXT can change brain activity linked to memory in 50 adults with epilepsy who are already scheduled for brain surgery. Participants will take either the drug or a placebo on separate days and perform memory tasks while their…

This study compares over-the-counter and prescription alkalinizing agents to see how well they change urine chemistry and reduce kidney stone risk. Fifteen adults with or without a history of stones will follow a strict diet and take different medications. The goal is to find eff…

This study tests whether sending automated messages to cancer patients after they leave the hospital can help them use urgent oncology care instead of the emergency room. About 200 patients will receive reminders via MyChart and text in English or Spanish. Researchers will track …

This study will observe 300 adults in the intensive care unit with serious brain conditions like bleeding, stroke, or injury. Researchers will use noninvasive monitors to track brain activity and blood flow, linking this data to patients' recovery. The goal is to better understan…

This early study tests whether applying low-intensity electric fields (TTFields) to the chest before lung cancer surgery is safe and affects cancer-related genes. About 18 adults with stage I-IIIA non-small cell lung cancer will wear a non-invasive device for a short time before …

This early-phase trial will test how Acetadote, a drug that affects cell damage, changes metabolism in people with newly diagnosed glioblastoma. Ten participants will receive Acetadote before surgery, and researchers will use MRI scans and tumor tissue analysis to measure metabol…

This study looks at how data from an Operating Room Black Box can be used to create virtual training that helps surgical teams work better and safer. About 30 experienced operating room staff will test the simulator. The goal is to improve teamwork and safety checklists during re…

This study looks at whether showing real-time visual feedback to emergency medical workers helps them deliver the right amount of air when giving rescue breaths during CPR. About 80 trained EMS responders will practice on a mannequin with and without feedback, using two different…

This study helps doctors get better at talking to teenagers and their parents about birth control. Doctors will practice conversations with computer-generated teens and parents that look and act like real people. The goal is to see if this training makes doctors more confident an…

This study looks at how heart rate variability (a measure of stress response) relates to emotional control and parent-teen relationships in 74 adolescents with depression. Teens will wear a Fitbit while sleeping for a week and fill out questionnaires. The goal is to better unders…

This study looks at how the brain works in 200 children with hard-to-treat epilepsy who are already scheduled for brain monitoring. Researchers will measure brain activity during tasks like learning and decision-making. The goal is to better understand thinking and memory, which …

This study tests whether an automatic pop-up alert in electronic medical records helps primary care doctors screen patients for HIV, hepatitis B, and hepatitis C all at once. About 50 doctors will participate, and their encounters will be randomly assigned to either see the alert…

This study watches brain activity in 300 adults during high-risk surgeries like heart or spine operations. Researchers use special monitors to track brain waves and pressure, linking them to patient outcomes. The goal is to understand why some people develop confusion or brain in…