University Of Texas Southwestern Medical Center

This study tested a combination of the immunotherapy drug durvalumab and precise, high-dose radiation for people with advanced non-small cell lung cancer. The goal was to see if this approach could improve quality of life and control tumors. However, the trial was terminated earl…

This study tested whether medically tailored meals and a behavior-change app (Noom) could help people keep off weight after stopping GLP-1 medications like Wegovy. It enrolled 39 adults who had lost at least 10% of their body weight on GLP-1s and recently stopped. The trial was t…

This study aimed to compare two standard treatments for people with large intermediate-stage liver cancer that cannot be surgically removed. One group would receive a combination of two immunotherapy drugs (atezolizumab and bevacizumab), while the other would receive local treatm…

This early-phase study tested a drug called abiraterone acetate (normally used for prostate cancer) in 4 children with congenital adrenal hyperplasia (CAH). The goal was to see if it could lower high male hormone levels and reduce the need for strong steroid medications that can …

This study looked at whether Hiprex, a medication that turns into formaldehyde in the urine, can help women aged 50-85 who get frequent urinary tract infections (UTIs). The goal was to see if it lowers the number of infections and reduces the need for antibiotics over one year. T…

This study tested whether a wearable device and digital care plan could help people with systolic heart failure get better medical treatment. The plan was to enroll 150 adults, but the study was stopped early. Participants would have used the device for 90 days to track their hea…

This study looked at how older adults (65+) with COPD handle heat, and whether spraying water on their bodies can keep their temperature and heart rate down. Only one person took part before the study was stopped early. The findings are too limited to draw firm conclusions.

This study looked at whether a special type of MRI, called Arterial Spin Labeling, can measure blood flow changes in kidney cancer tumors as early as two weeks after starting treatment. The goal was to see if this could help doctors know sooner whether a treatment is working. The…

This study looked at how anesthesia changes brain activity in people with Parkinson's disease or essential tremor who were already scheduled for deep brain stimulation (DBS) surgery. Researchers recorded brain signals during a short period of anesthesia to understand which circui…

This study tested whether a special type of MRI can detect early signs of heart damage caused by radiation therapy. It included people with left-sided breast cancer or other chest cancers receiving standard radiation. The goal was to see if changes in heart cell energy use could …