University Of Texas Southwestern Medical Center

This early-phase study tested whether switching HIV medications to doravirine (with emtricitabine and tenofovir alafenamide) could reduce heart disease risk in 26 adults with well-controlled HIV and high cholesterol. Researchers measured how the change affected HDL function and o…

This study tested whether Tenapanor, a drug already approved for kidney disease, can reduce oxalate absorption from food and lower the amount of oxalate in urine. Oxalate is a key component of many kidney stones. The study involved 18 healthy adults without a history of kidney st…

This study looked at 25 kidney transplant patients to see if a blood test (AlloSure) could help them safely switch from several anti-rejection drugs to just one, Belatacept. The goal was to keep the new kidney healthy while reducing medication side effects. Researchers checked fo…

This study tested a new way to give radiation for head and neck cancer. Instead of treating the whole neck, doctors used artificial intelligence to focus radiation only on the cancer and nearby suspicious spots. The goal was to see if this approach could control the cancer while …

This study tested whether the diabetes drug pioglitazone, weight loss, or both could raise urine pH in overweight adults with uric acid kidney stones. Higher urine pH makes it harder for stones to form. Twenty-nine participants followed a fixed diet and took either the drug, a pl…

This study tested whether regularly warming the lower legs in hot water could help older women with high blood pressure lower their numbers. 134 women aged 60-85 either soaked their legs in warm water (42°C) or neutral water (33°C) four times a week for 8 weeks, while all took a …

This study tested whether a single daily pill containing three heart failure medications could help people with weak hearts who often miss out on standard treatments. The trial included 212 adults from low-income and racially diverse backgrounds. Researchers measured changes in h…

This study tested a program called Walk Together that helps African American adults with high blood pressure manage their condition with support from a family member. The program involved 62 participants and their family partners. Researchers wanted to see if the program was prac…

This study tested whether a natural hormone called pregnenolone could help reduce depression in women going through menopause or perimenopause. 73 women aged 40-67 with major depression took either pregnenolone or a placebo. Researchers measured changes in mood, anxiety, thinking…

This study looked at whether a higher dose of vitamin D (4000 IU daily) improves physical and mental health in adults who had a major burn injury and are vitamin D deficient. 48 participants were randomly assigned to take either a standard low dose or a higher dose for a period o…

This study looked at whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people who still have concussion symptoms months after a mild head injury. Twelve adults with persistent post-concussion syndrome received either real or sham treatmen…

This study tested whether ketamine, a fast-acting medication, can reduce suicidal thoughts and behaviors in teenagers more quickly than a standard sedative (midazolam). Fifty teens aged 13-18 who had recently attempted suicide or had strong suicidal thoughts received either ketam…

This study looked at whether adding a nerve block in the armpit to the standard shoulder block can reduce pain, opioid use, and recovery room time after total shoulder replacement. Twelve adults having shoulder replacement took part. The goal was to see if the extra block helps w…

This study tested whether a non-invasive brain stimulation technique called HD-tDCS could improve memory in 26 older adults with mild memory problems and a history of traumatic brain injury. Participants received 10 sessions of stimulation to a brain area linked to memory. The go…

This study tested whether using the UroLift system before targeted radiation is safe for men with both prostate cancer and an enlarged prostate (BPH). Fifteen men participated, and researchers monitored side effects within 90 days of treatment. The goal was to see if this combina…

This study tested a 10-session therapy program delivered over the phone or video to help adults with depression increase their physical activity. The goal was to see if the program was practical, well-liked, and could reduce depressive symptoms. Sixty-five adults with moderate-to…

This study looked for proteins in the blood that can predict how well liver cancer patients will respond to standard treatments like TACE or ablation. Researchers collected blood samples before and after treatment from 17 adults with liver cancer. No new treatments were tested; t…

This study looked at 86 people with very high or very low cholesterol removal ability (cholesterol efflux) to find genes, proteins, and fats that affect this process. The goal is to discover new targets for preventing heart disease. Participants came from the Dallas Heart Study a…

This study looked at how blood pressure medications affect brain blood flow and thinking skills in older adults with high blood pressure. Researchers gave 27 participants either a drug or a placebo for 1-2 weeks and measured brain blood flow, nerve activity, and cognitive perform…

This study looked at how healthy older adults (65+) respond to heat wave conditions compared to younger adults. Researchers measured changes in core body temperature and heart function. The goal was to understand the risks of extreme heat on the aging body.

This study talked to 15 children and teens aged 12-21 with bleeding or clotting disorders to learn how their condition affects their daily life, emotions, and future plans. Researchers used interviews and questionnaires to understand their experiences and quality of care. No new …

This study asked 65 African American adults who use cocaine or other drugs for their ideas on how to make clinical trials more welcoming. The goal was to create a manual (I-DREM) that researchers can use to recruit and keep more Black participants in substance use studies. Partic…

This study brought together 50 international experts to agree on what training doctors need to safely manage airways in critically ill patients. Using a structured survey method, the team identified key skills and knowledge areas. The goal is to improve patient outcomes by standa…

This study looked at whether changing how genetic testing is offered can encourage more at-risk relatives to get tested for hereditary cancer. Researchers compared a new choice-based approach to usual care in 108 adults with a known cancer gene mutation. The goal was to see if th…

This study created a registry of 149 cancer patients who received a precise type of radiation called SBRT. The goal was to track how doctors use this treatment in different situations, such as for cancer that has spread, to shrink tumors before chemotherapy, or for repeat radiati…

This study looked at how a 3-day course of hydrocortisone (a corticosteroid) affects memory and the hippocampus, a brain region key for learning. Researchers used advanced MRI scans and memory tests in 66 healthy adults and people with depression. The goal was to understand which…

This study looked at how natural changes in sex hormones (like estrogen and progesterone) during the menstrual cycle affect muscle reflexes and brain signals in healthy women. Researchers also compared women using birth control pills to those not using them, and included men for …

This study looked at 101 adults having elective spine surgery to compare two medicines (norepinephrine and phenylephrine) used to keep blood pressure stable. The goal was to see which one works better and whether either affects kidney function after surgery. Results help doctors …