University Of Texas Southwestern Medical Center

This early-phase study tested a shorter, more intense radiation schedule (completed in 3 weeks instead of the usual 6) combined with chemotherapy for people with HPV-related throat cancer. The goal was to find the safest dose that still controls the cancer. Only 24 patients took …

This study looked at 25 kidney transplant patients to see if a blood test measuring donor DNA could help them safely reduce their immunosuppressant medications to just one drug, belatacept. The goal was to see if this approach could prevent kidney rejection while simplifying trea…

This completed Phase 2 trial tested whether a single daily polypill (containing a statin, aspirin, and a blood thinner) could improve medication adherence in 140 patients who had a heart attack and received a stent. The study compared the polypill to usual care with separate pill…

This study tested whether providing medically tailored meals or fresh produce boxes to heart failure patients after hospital discharge could improve their health and reduce return visits to the hospital. 150 adults who were recently hospitalized for heart failure were randomly as…

This study tested whether giving focused radiation to leftover cancer spots after CAR-T cell therapy could help control non-Hodgkin lymphoma. Fourteen adults who had incomplete responses to CAR-T received the extra radiation. The goal was to see if it was safe and could improve t…

This study looked at whether the drug pioglitazone, weight loss, or both could help prevent uric acid kidney stones in overweight people. 29 adults with a history of these stones were randomly assigned to one of three groups for 24 weeks. The main goal was to see if these treatme…

This study tested a method called LISA (Less Invasive Surfactant Administration) in extremely preterm infants (22-25 weeks). Instead of inserting a breathing tube, doctors gave lung medication through a thin catheter while the baby continued on CPAP. The goal was to see if this a…

This completed early-phase trial tested whether switching HIV medications to doravirine (with emtricitabine and tenofovir alafenamide) could improve cholesterol and reduce early signs of artery hardening compared to staying on integrase inhibitors. Twenty-six adults with well-con…

This study tested a once-daily 'polypill' containing three heart failure drugs (metoprolol, empagliflozin, spironolactone) in 212 adults with reduced ejection fraction. The goal was to see if this simpler approach could help low-income and minority patients get the proven therapi…

This study tested a program called Walk Together, which helps African American adults with high blood pressure and their family members work as a team to manage the condition. The program included training on using a blood pressure cuff, setting health goals, and improving commun…

This study tested whether a combination of two extended-release medications (naltrexone and buprenorphine) could help adults reduce cocaine use. Over 400 people who wanted to cut back or quit cocaine took part. The approach uses monthly injections to manage cravings and use, aimi…

This study tested whether adding lower leg heat therapy (soaking legs in warm water) to a standard blood pressure pill helps older women with high blood pressure more than the pill alone. 134 women aged 60-85 participated, either soaking in 42°C water or neutral 33°C water for 8 …

This study tested a remote video monitoring system to help people with opioid use disorder safely take their methadone at home. Fifteen adults already on methadone treatment used a smartphone or computer camera to record each dose. The goal was to see if this method could track a…

This study tested whether Tenapanor, a drug approved for kidney disease, can reduce oxalate absorption from food and lower the risk of kidney stones. Eighteen healthy adults without a history of stones took the drug or a placebo, and their urine oxalate levels were compared. The …

This study tested a new treatment called Magnetic Seizure Therapy (MST) for people with severe depression that hasn't improved with medication. MST uses magnets to trigger a small, controlled seizure in the brain, similar to electroconvulsive therapy (ECT) but potentially with fe…

This study tested whether adding an immunotherapy drug called APX005M to standard treatment helps people with advanced rectal cancer achieve a complete response (no cancer left after treatment). 58 adults with stage II or III rectal cancer at high risk took part. The goal was to …

This study tested a new way to give radiation for head and neck cancer. Instead of treating the whole neck, doctors used artificial intelligence to focus radiation only on the cancer spots. 67 patients took part to see if this approach could reduce side effects without increasing…

This study tested whether taking probiotic capsules (Lactobacillus GG and Bifidobacteria) for 24 weeks could prevent people from being re-hospitalized for mania after a recent manic episode. 67 adults who were hospitalized for mania took either the probiotic or a placebo. The mai…

This study tested whether real-time remote blood sugar monitoring and secure texting could help teens (ages 13-18) with poorly controlled type 1 diabetes improve their blood sugar levels. Twenty teens wore a continuous glucose monitor that shared their readings with the study tea…

This study tested whether giving two medicines (atropine and fentanyl) before a less invasive breathing treatment helps preterm babies have fewer dangerous drops in heart rate and oxygen levels. Fifty-eight babies born at 29 weeks or later took part. The goal is to see if premedi…

This study tested whether a device that delivers a very mild electrical current to the scalp could improve memory in 26 older adults with mild cognitive impairment and a past traumatic brain injury. Participants received ten sessions of either real or fake stimulation to a brain …

This study tested a combination of light and laser treatments on 15 adults with skin pigmentation and texture issues from sun damage. Participants received up to two treatments using the Sciton Joule System, which combines broad-based light, fractionated laser, and dual-wavelengt…

This study tested whether ketamine, a fast-acting drug, can reduce suicidal thoughts in teenagers more quickly than standard treatments. Fifty teens aged 13-18 who had recently attempted suicide or had severe suicidal thoughts received either ketamine or a sedative (midazolam) tw…

This study tested a special movie system called PROMISE to help children aged 3-11 stay still during radiation treatment for cancer, so they might not need general anesthesia. The system uses an interactive movie that pauses if the child moves, encouraging them to stay still. The…

This study tested a new type of radiation therapy that adjusts the treatment beam each day based on the patient's current anatomy. The goal was to see if this daily adaptive approach could reduce chronic dry mouth (xerostomia) compared to standard radiation in 50 people with head…

This study tested a 10-session therapy program delivered by phone or video to help adults with moderate-to-severe depression become more physically active. The goal was to see if the program was practical and liked by participants, and if it could reduce depressive symptoms. 65 a…

This study tested whether a natural substance called pregnenolone can help reduce depression in women going through menopause or perimenopause. 73 women took either pregnenolone or a placebo for several weeks. Researchers measured changes in mood, anxiety, thinking, and quality o…

This pilot study tested whether a non-invasive brain stimulation technique (HD-tDCS) could improve memory and word recall in 27 older adults with mild cognitive impairment (MCI). Participants received 10 sessions targeting a brain region linked to memory. The goal was to see if t…

This study looked at 205 pairs of caregivers with major depression and their children (ages 7-17) with asthma. Researchers tracked whether improving the caregiver's depression symptoms led to better asthma control, fewer flare-ups, and improved quality of life for the child over …

This study looked at whether adding an extra nerve block in the armpit to the standard shoulder block can better control pain after shoulder replacement surgery. 12 adults having shoulder replacement were enrolled. The goal was to see if the extra block reduces time in recovery, …

This study tested a special laser (1927nm) to reduce dark spots on the face in 15 adults with Fitzpatrick Skin Types V and VI (darker skin). The goal was to see if the laser works and to find the best skin care routine before and after treatment to avoid side effects like scarrin…

This small pilot study tested whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) could help people with persistent symptoms after a mild concussion. Twelve adults who had symptoms for 3 to 12 months after their injury received either real or fake (…

This study looked at whether a higher daily dose of vitamin D (4000 IU) is better than the standard dose (400 IU) for adults who had a major burn injury and are vitamin D deficient. 48 people took part, and researchers measured changes in their physical and mental health, as well…

This study tested whether it is safe to place a UroLift implant (a device that opens the urethra) before giving precise, high-dose radiation to men with both prostate cancer and an enlarged prostate (BPH). Fifteen men took part. The main goal was to see if the combination caused …

This study looked at how natural changes in sex hormones (like estrogen and progesterone) during the menstrual cycle affect muscle reflexes and brain signals in women. Researchers tested 102 healthy women and men using simple muscle and brain measurements. The goal was to underst…

This completed study brought together 50 international experts to agree on what training doctors need to safely manage airways in critically ill patients. Using a structured method called Delphi, the team aimed to create a standard curriculum. The study did not test any drug or d…

This completed study interviewed 15 children aged 12 to 21 who have bleeding or clotting disorders. The goal was to learn how their condition affects their quality of life, confidence, and care. Researchers used questionnaires and open-ended interviews to gather insights, aiming …

This study tested a virtual reality simulator (VLaHHS) designed to train general surgery residents on laparoscopic hiatal hernia repair. Eight residents practiced on the simulator for up to 15 sessions over three weeks. Researchers measured their skill improvement and whether the…

This completed study worked with 65 African American adults who use cocaine or other illicit substances and want to cut back or stop. Researchers gathered their feedback to create a manual called I-DREM, designed to improve how clinical trials recruit and keep Black participants.…

This study looked at how a short course of corticosteroids (hydrocortisone) affects memory and brain areas involved in learning. Researchers gave 66 healthy adults and people with depression either the steroid or a placebo for three days, then used memory tests and advanced MRI s…

This study tested a simple idea: send at-home genetic testing kits directly to relatives of people who have a hereditary cancer gene. The goal was to see if this approach gets more relatives tested compared to usual care. The study involved 108 adults in Texas who had a cancer-re…

This completed Phase 2 trial gave postmenopausal women with hormone-sensitive breast cancer a short course of letrozole (7-30 days) before their scheduled surgery. The goal was to measure changes in a tumor marker called Ki67 to see which cancers are highly hormone-dependent. 61 …

This study created a registry of 149 cancer patients who received a precise type of radiation called SBRT. The goal was to track how doctors use SBRT in four situations: for cancer that has spread to a few spots, after chemotherapy, before starting chemotherapy, or when cancer re…

This study looked at whether inflammation in the body is linked to suicidal thoughts and behaviors in teenagers. Researchers took blood samples and surveyed 225 teens aged 12-18, including those with recent suicidal behavior, those at risk for depression, and healthy controls. No…

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This study looked at why people with a certain type of heart failure (HFpEF) have trouble exercising and feel short of breath. Researchers tested whether different exercise programs (using the whole body or just one leg) could improve fitness. The study involved 93 adults aged 60…

This study looked at 29 children with brain injuries to test two new methods for checking how well the brain controls its own blood flow. The goal was to see if these methods could help doctors better understand and treat brain injuries. The study did not test a treatment, but ai…

This study looked at how radiofrequency ablation (using heat) affects adenomyosis tissue in 15 women who were already scheduled for a hysterectomy. The goal was to see how well the treatment destroys the abnormal tissue by examining it under a microscope after surgery. The study …

This study looked at how heat waves impact the heart and body temperature in healthy older adults (65+) compared to younger people. Researchers measured core body temperature and heart function during simulated heat wave conditions. The goal was to understand the risks so we can …

This study looked at how blood pressure medications affect brain blood flow and the nervous system in older adults with high blood pressure. Researchers gave 27 participants either a drug or a placebo for 1-2 weeks and measured brain blood flow, cognitive function, and nerve acti…

This study looked at 86 people with very high or very low cholesterol efflux—how well the body removes cholesterol from cells. Researchers analyzed their genes, proteins, and fats to find clues that could lead to new heart disease treatments. The goal was to gather knowledge, not…

This study tested a special vest designed to protect central venous catheters (CVCs) in children aged 0-12. Researchers wanted to see if the vest was practical and how satisfied parents and nurses were with it. 30 children participated, and parents and nurses provided feedback th…

This study enrolled 17 adults with liver cancer who were scheduled for standard treatments like TACE, ablation, or Y90. Researchers took blood samples before and after treatment to search for proteins (biomarkers) that might predict how well a patient responds. No new treatment w…

This study looked at 101 adults having elective spine surgery to compare two medicines (norepinephrine and phenylephrine) used to keep blood pressure stable during the operation. The main goal was to see how much of each drug was needed. Researchers also checked if either drug le…