Could a natural hormone ease menopausal depression?
NCT ID NCT03505905
First seen Jan 23, 2026 · Last updated May 01, 2026 · Updated 16 times
Summary
This study tested whether a natural hormone called pregnenolone could help reduce depression in women going through menopause or perimenopause. 73 women aged 40-67 with major depression took either pregnenolone or a placebo. Researchers measured changes in mood, anxiety, thinking, and quality of life to see if the hormone offered relief.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
Conditions
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