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Armpit block may ease shoulder replacement pain

NCT ID NCT06042608

Symptom relief Sponsor: University of Texas Southwestern Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether adding a nerve block in the armpit to the standard shoulder block can reduce pain and opioid use after total shoulder replacement. Twelve adults having shoulder replacement surgery received both blocks. Researchers measured recovery room time, pain scores, and how much opioid medication they needed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intercostobrachial nerve block (local anesthetic injection)
What this could lead to
If effective, this simple addition could reduce pain and opioid use after shoulder replacement, making recovery more comfortable.
What could go wrong
This is a very small, early study with only 12 participants. Results may not apply to everyone, and the added block carries rare risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

12 people

The number who actually took part.

Started

Sep 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients 18-80 years old * Adult patient's BMI \<= 35 * Individuals presenting for primary total shoulder arthroplasty or reverse total shoulder arthroplasty * Anticipated discharge home same day of surgery * Patient is able to provide informed consent to participate in the study. Exclusion Criteria: * Patient presenting for revision shoulder surgery * Allergy to amide local anesthetic, liposomal bupivacaine or other medication involving liposomal formulation * Preexisting neurological deficits involving or potentially involving the ipsilateral brachial plexus * Preexisting contralateral vocal fold paralysis or recurrent laryngeal paralysis * Psychiatric or cognitive disorders that could interfere with perioperative evaluation including drug or alcohol abuse * Chronic pain conditions * Preoperative opioid use * Moderate to severe pulmonary disease * Moderate to severe sleep apnea * Planned postoperative admission. * Unplanned postoperative admission * Any contraindication to interscalene or intercostobrachial nerve block including any local disorder of the skin where blockade is to be performed which would prevent safe performance of the block * Any coagulation abnormality which would be a contraindication for block placement * Preoperative chronic renal dysfunction requiring renal replacement therapy or CrCl \< 60 * Sulfa allergy (or other reason patient cannot receive celecoxib) * Allergy or intolerance to any medication in the protocol * Body mass index \>35 * Pregnancy * Incarceration * ASA classification greater than 3 * Inability to provide informed consent * Refusal to participate in the study

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative Shoulder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain, acute Shoulder pain

Contacts and locations

Locations

  • University of Texas Southwestern Medical Center

    Dallas, Texas, 75390, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.