Which potassium citrate works best for kidney stones? new study aims to find out
NCT ID NCT06819111
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will test three different forms of potassium citrate—a medication that helps prevent kidney stones by making urine less acidic. Twenty adults who have had kidney stones will take each form for one week, with a week off in between. Researchers will measure changes in urine acidity and ask participants about side effects and preferences.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Potassium citrate (slow-release tablet, powder, and tablet forms)
- What this could lead to
- If successful, this could show which form of potassium citrate works best and is most tolerable for preventing kidney stones.
- What could go wrong
- This is a small, early-phase study with only 20 participants, so results may not apply to everyone. It compares existing drugs, not a new breakthrough.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Oct 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * adults, 18 years or older * recurrent stone formers or first-time stone formers at high risk for recurrence * have a baseline 24-hour urine within six months from study enrollment * have the ability to adhere to a directed diet Exclusion Criteria: * minors (age \<18 years) * mentally incapacitated and/or unable to provide consent * prisoners * pregnant or breastfeeding individuals * concurrent potassium citrate therapy * concurrent thiazide therapy * chronic kidney disease (eGFR \<60) * solitary kidney * unable to take any of the study medications due to a prior adverse reaction or other health-related reason (ex: severe renal impairment, hyperkalemia, or severe acidosis or alkalosis).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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