University Of Texas Southwestern Medical Center

This study tests whether combining three standard heart attack medications into one daily pill can help patients stay on track and avoid future heart problems. About 1000 adults who recently had a heart attack and received a stent will take either the single pill or their usual s…

This study tests whether the drug tafamidis can safely stop or slow the progression of ATTR amyloidosis in people who have already had a heart transplant. About 25 adults who received a heart transplant at least a year ago will take tafamidis for 12 months. Researchers will measu…

This study compares two treatments for early-stage non-small cell lung cancer in patients who are high-risk for surgery. One group gets a precise, high-dose radiation treatment (SAbR), while the other has surgery to remove the tumor. The goal is to see which approach helps patien…

This study tests whether adding the immunotherapy drug atezolizumab to standard chemotherapy can help children whose solid tumors have come back or not responded to treatment. About 23 children with relapsed or refractory solid tumors (including rhabdomyosarcoma) will receive the…

This early-stage trial tests a gene therapy injected directly into the left vagus nerve for people with giant axonal neuropathy (GAN), a rare and fatal nerve disease. Only 4 participants who previously received a spinal injection of the same therapy are eligible. The main goal is…

This study tests a combination of the drug enfortumab vedotin and targeted radiation before bladder removal surgery in people with muscle-invasive bladder cancer who cannot receive standard chemotherapy. About 19 participants will receive different schedules of the drug and radia…

This study is testing temporary nerve implants (FAST electrodes) in people with hand or arm amputations to improve control of a prosthetic hand and restore some feeling. About 25 participants will have the implants for around 18 months. Researchers will measure how well they can …

This study tests whether hearts from HIV-positive deceased donors work as well as hearts from HIV-negative donors for HIV-positive patients who need a heart transplant. About 50 HIV-positive adults with advanced heart failure will receive either type of heart, whichever becomes a…

This study tests whether nurse home visits can help people with high blood pressure and type 2 diabetes manage their conditions better than standard clinic visits. Researchers will measure changes in blood pressure and blood sugar over 6 months. The study enrolls 100 adults aged …

This early-stage trial is testing whether personalized radiotherapy can be safely adapted to each patient's response. It involves 45 adults with extensive-stage small cell lung cancer, brain metastases, or other solid tumors. The goal is to see if adjusting radiation doses based …

This study looks at how vitamin D levels relate to sarcoidosis severity and whether vitamin D supplements can improve lung function and quality of life. About 90 adults with sarcoidosis and low vitamin D will get either standard vitamin D or a placebo. People with normal vitamin …

This study looks at whether taking a daily antibiotic (nitrofurantoin) alone works as well as combining it with a procedure that burns off tiny bladder sores (electrofulguration) to prevent repeat urinary tract infections in women. About 104 women aged 18-85 with frequent UTIs wi…

This study looks at whether cooling therapy helps babies born with mild brain injury (HIE) develop better as they grow. About 460 full-term newborns will be enrolled within 6 hours of birth. The goal is to see if cooling reduces the risk of developmental delays and to check for a…

This study tests whether injecting a nerve-blocking agent around the prostate can slow or stop cancer growth in men with high-risk prostate cancer. About 21 participants will receive one or two injections before their scheduled prostate removal surgery. The goal is to see if redu…

This study compares clozapine to risperidone in 320 adults with schizophrenia, schizoaffective disorder, or bipolar I with psychosis. Participants are grouped by a biological subtype (Biotype-1 or Biotype-2) to see if clozapine works better for certain brain types. The main goal …

This study compares two ways of caring for new mothers after they leave the hospital: telemedicine (video or phone visits) versus standard in-person clinic visits. The goal is to see which approach helps find and treat problems like high blood pressure, wound infections, or blood…

This study tests whether a low dose of ketamine, given through an IV, can help adults with moderate to severe methamphetamine use disorder reduce their drug use. 120 participants will receive either ketamine or a placebo over six weeks, and researchers will check urine samples to…

This study is testing ablative therapies—treatments that destroy cancer cells using heat, cold, or other methods—for men with localized prostate cancer. Researchers will track how well these treatments control cancer, and how they affect urinary and erectile function. The goal is…

This study tests whether a higher dose of the drug cabozantinib can help people with advanced kidney cancer whose disease has gotten worse while on the standard dose. About 18 adults will receive the higher dose to see if it slows cancer growth. The goal is to control the cancer,…

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can slow or stop tumor growth in women with cervical cancer that has returned or spread. About 30 participants will receive the treatment to see if tumors shrink or stabilize. The goal is to find a better…

This early-phase study tests a personalized radiation approach for high-risk prostate cancer. It uses special PET scans to see how tumors respond to hormone therapy, then adjusts the radiation dose to target remaining cancer spots. The goal is to improve treatment precision and r…

This study tests whether a single, strong dose of radiation given before surgery can eliminate early-stage ER+ breast cancer tumors. About 53 women will receive the radiation, and if the tumor disappears on scans and biopsy, they may avoid surgery. The study also explores using a…

This study looks at whether a 9-week dietician-guided program, adapted from the National Diabetes Prevention Program, can reduce body fat and improve how the body uses insulin in people with chronic spinal cord injury. Twenty adults who use wheelchairs will participate in telehea…

This study tests whether combining two drugs, ligufalimab and cadonilimab, can shrink advanced liver or bile duct cancers that have stopped responding to previous treatments. About 64 adults will receive the combination and be monitored for tumor response. The goal is to see if t…

This study tests a new type of MRI that looks at how the heart uses energy to find areas of damage. Researchers want to see if this scan can help doctors better choose which patients with heart disease will benefit from bypass surgery. About 30 adults with coronary artery disease…

This study tests whether a blood test (GALAD) is better than standard ultrasound for catching liver cancer early in 5500 people with cirrhosis or chronic hepatitis B. Participants are randomly assigned to one of two screening methods and followed for about 5.5 years. The goal is …

This study tests whether taking a daily supplement called D-mannose (a type of sugar) can help prevent recurrent urinary tract infections (UTIs) in post-menopausal women aged 55 and older. Researchers will compare D-mannose to a placebo over 12 months in 90 women who have had mul…

This study tests a program to help people in the Dallas County Jail get tested for HIV and learn about PrEP, a daily pill that prevents HIV. A patient navigator meets with interested individuals to discuss risk, offer testing, and connect them with community PrEP providers after …

This study tests whether a compound from green tea, EGCG, can lower the risk of liver cancer in people with liver cirrhosis. About 60 adults with cirrhosis but no prior liver cancer will take either EGCG or a placebo for several months. Researchers will measure changes in a blood…

This study tests whether an oral medication called mitoquinone can prevent healthy adults from getting COVID-19 after they have been in close contact with someone who has the virus. About 112 participants will be randomly assigned to receive either the drug or a placebo. The goal…

This study is testing whether helping people aged 70 and older keep their blood pressure under control can prevent memory loss and dementia. Researchers will compare a special care program (with decision support and team-based care) to usual care. About 4,000 participants with hi…

This study tests a new way to prevent heart failure in people with type 2 diabetes. Doctors will use a blood test (NT-proBNP) and a risk score to find high-risk patients, then start proven preventive medicines early. The goal is to see if this approach reduces heart failure or de…

This study looks at three different breathing treatments (IPPB, EzPAP, and Metaneb) to see which one helps the lungs expand and recover best after heart surgery. About 324 adults who had certain types of heart surgery will take part. The goal is to find out which therapy improves…

This study tests a non-invasive ear stimulation device (tAN) to see if it can lower pain and the need for opioid painkillers after lumbar spine surgery. About 20 adults having back surgery will either receive the real stimulation or a sham version. The goal is to offer a safer, d…

This study tests two different mixtures of common anesthesia drugs (propofol and etomidate) to see which one keeps blood pressure more stable and causes fewer side effects during endoscopy. About 200 adults with higher health risks will take part. The goal is to find a safer way …

This study tests whether a remote exercise program can improve exercise capacity and muscle health in 120 adults with heart failure with preserved ejection fraction (HFpEF) or those at risk. Participants will follow one of four lifestyle interventions from home. The goal is to he…

This small pilot study tests whether a non-invasive brain stimulation technique called tDCS, applied to the cerebellum, can improve social behaviors and mental flexibility in 15 women and girls aged 15–30 with anorexia nervosa. Participants will receive the stimulation while play…

This study tests whether a low dose of colchicine, a drug typically used for gout, can improve exercise capacity in people with a type of heart failure called HFpEF who also have signs of inflammation. About 60 participants will be randomly assigned to receive either colchicine o…

This study tests whether a mobile phone app can help people with kidney problems control body swelling by guiding daily adjustments to their water pill (diuretic) dose. Thirty participants will use the app for 90 days, entering daily weight and blood pressure readings. The app th…

This study looks at how the body handles phosphate in people with chronic kidney disease (stages 3-4). Researchers will test blood and urine to find new markers that show when phosphate levels are too high. The goal is to create a simple index to measure phosphate overload, which…

This study looks at how a drug called scopolamine affects brain activity during memory tasks. About 60 adults with epilepsy who are already having brain surgery for seizure monitoring will take part. They will receive either the drug or a saltwater solution on different days, the…

This study looks at whether eating too much phosphate—a common additive in processed foods—can reduce your ability to exercise and increase belly fat. Researchers will measure oxygen use during cycling and use special scans to see how muscles produce energy. The study involves 12…

This study looks at how well different cooling methods (like fans or cold water) can lower body temperature and reduce heart strain in healthy adults aged 65 and older during simulated heat waves. Researchers will measure changes in body temperature and heart function. The goal i…

This study is gathering information from 1,000 intensive care patients to learn what normal pupil measurements look like when using a special device called a pupillometer. The goal is to create a standard set of values for pupil size and reactivity, which can help doctors better …

This observational study aims to develop a new imaging method to measure how the brain uses energy and makes chemical messengers. Researchers will scan 28 healthy adults using a special MRI technique with a labeled substance called pyruvate. The goal is to create maps of brain me…

This study looks at how two common blood pressure drugs, propranolol and metoprolol, affect body temperature in healthy adults aged 65 and older during 3 hours of extreme heat. Researchers will measure changes in internal temperature and sweat rate. The goal is to understand if t…

This study is testing a new type of MRI scan that looks at how the heart uses energy. Researchers want to see if this scan can tell how much heart muscle is still working in people with severe heart disease. The study will compare the new MRI with standard PET and SPECT scans in …

This study looks at how a simulated burn injury (using a special material on the skin) affects how quickly the body cools down after exercise in hot conditions. Researchers will measure core temperature and heart rate in 28 healthy adults. The goal is to understand if burn surviv…

This study follows a large group of people with multiple sclerosis over many years to learn how the disease changes and how treatments work in real life. Participants fill out surveys twice a year about their health and lifestyle. The information is used only for research and is …

This study is testing a non-invasive eye scan called OCTA to see if it can detect signs of brain diseases like stroke and bleeding. Researchers will compare scans from 50 people with neurological conditions and healthy volunteers. The goal is to gather early data to support large…

This study collects health information from up to 10,000 people who received or were considered for radiation therapy at UT Southwestern since 2000. Researchers will compare outcomes like quality of life and side effects to national data. The goal is to learn which patients benef…

This study is looking for 1,000 people with lupus skin disease (cutaneous lupus) to help find the genes and proteins that cause it. By analyzing blood and skin samples, researchers hope to better understand the disease, improve diagnosis, and spark new drug development. Participa…

This study tests a new device that measures pressure inside the skull without surgery. A tiny pin on the head detects skull movements from each heartbeat to create a pressure waveform. Researchers will compare these readings to standard invasive measurements in 30 adults already …

This study looks at CT scans from 2,000 people to see if computer models can better predict how lung cancer will respond to treatment. Researchers will review medical records of patients treated for early-stage lung cancer and also use data from a national screening trial. The go…

This study looks at how natural changes in the female hormone estradiol might change the way the spinal cord adapts. Researchers will use mild electrical stimulation to test spinal responses in 50 healthy young adults. The goal is to understand basic biology, not to treat any dis…

This study is looking for 90 adults with Parkinson's disease or similar conditions (like multiple system atrophy or progressive supranuclear palsy) to test whether brain scans combined with artificial intelligence can help doctors tell these diseases apart and predict how fast th…

This study is testing whether a mild electrical current applied to the spine (called tsDCS) can improve leg reflexes, walking, and balance in people who have leg weakness after a stroke. About 100 adults who had a stroke more than 6 months ago will attend at least 15 sessions ove…

This study uses a special MRI technique to see how brain tumors use energy. Researchers want to learn more about tumor metabolism, not to treat the disease. About 25 adults with brain tumors will have one extra scan to help scientists understand these cancers better.