New drug duo takes on tough liver cancers
NCT ID NCT06789848
First seen Feb 28, 2026 · Last updated Jun 22, 2026 · Updated 15 times
Summary
This phase 2 trial is testing whether a combination of two immune-boosting drugs, ligufalimab and cadonilimab, can shrink advanced liver or bile duct cancers that have stopped responding to prior treatments. About 64 adults will receive the drugs by IV every three weeks. The main goal is to see how many patients' tumors shrink or disappear.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Texas Southwestern Medical Center
RECRUITINGDallas, Texas, 75390, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ligufalimab and Cadonilimab (two immune-boosting drugs given by IV)
What this could lead to
If it works, this could offer a new treatment option for people with advanced liver or bile duct cancers that have not responded to other therapies.
What could go wrong
This is an early phase 2 trial with only 64 participants, so results may not apply to everyone. The drugs can cause immune-related side effects, and the cancer may still grow.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.