Could a common antidepressant tame severe asthma?
NCT ID NCT06216535
First seen Feb 01, 2026 · Last updated Jun 23, 2026 · Updated 24 times
Summary
This study tests whether escitalopram, an antidepressant, can reduce severe asthma flare-ups in people with frequent attacks. Researchers will give either the drug or a placebo to 105 adults with moderate-to-severe asthma. The goal is to see if the drug lowers the number of attacks needing steroids or hospital visits.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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UT Southwestern, 1440 Empire Central, Ste. LD4.100
RECRUITINGDallas, Texas, 75247, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
escitalopram
What this could lead to
If it works, this could point toward a new way to prevent severe asthma attacks using a common antidepressant.
What could go wrong
This is a small, early-phase trial with only 105 participants. The drug may not reduce exacerbations, and side effects like nausea or drowsiness are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.