Ketamine may be safe for severe brain injury, tiny study hints
NCT ID NCT06062628
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 34 times
Summary
This early-phase study will give a single dose of ketamine to 10 adults with severe traumatic brain injury who already have monitors measuring brain pressure and oxygen levels. Researchers want to see if ketamine changes these readings, challenging the old belief that it raises brain pressure dangerously. The goal is to gather safety data for a possible new sedation option in intensive care.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Parkland Memorial Hospital
RECRUITINGDallas, Texas, 75235, United States
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Parkland Memorial Hospital
RECRUITINGDallas, Texas, 75235, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ketamine hydrochloride
What this could lead to
If it works, this could show that ketamine is safe to use in severe TBI, potentially offering a new sedation option that doesn't harm breathing.
What could go wrong
This is a very small pilot study (10 people) with no control group, so results may not apply broadly. Ketamine has long been thought to raise brain pressure, and this risk is still being tested.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.