HIV INFECTIONS

This study tested the safety and immune response of two experimental HIV vaccine candidates in healthy adults who do not have HIV. The 127 participants received different versions of the vaccines, which were mixed with substances called adjuvants designed to boost the body's reac…

This study tested a vaccine designed to strengthen the immune system's response to cytomegalovirus (CMV) in adults who have both HIV and CMV. 90 participants, all with well-controlled HIV on stable medication, received either two doses of the experimental vaccine or a placebo. Th…

This study tested the safety and immune response of several experimental HIV vaccines in healthy adults who do not have HIV. The main goal was to see if the vaccine shots were safe and if they could trigger the body to produce antibodies that might fight the virus. Researchers en…

This early-stage study tested the safety and immune response of a new HIV vaccine approach in 46 healthy adults without HIV. Participants received synthetic DNA injections, some with an additional protein boost, to see if they could trigger specific immune responses against HIV. …

This early-stage study tested the safety and immune response of an experimental HIV vaccine in healthy infants born to mothers with HIV. The study enrolled 38 mother-infant pairs, with infants receiving up to five vaccine doses starting in their first week of life. The main goals…

This early-stage study tested a new experimental HIV vaccine in 51 healthy, HIV-negative adults. The main goals were to check if the vaccine was safe and to see if it could stimulate the immune system to produce antibodies that might fight HIV. Researchers tested different doses …

This study tested how well the Moderna COVID-19 vaccine worked in adults with a higher risk of severe illness, including people living with HIV. Over 14,000 participants in Eastern and Southern Africa received either two or three doses, depending on whether they had a prior COVID…

This was a small, early-stage study to check the safety and immune response of a new HIV vaccine in healthy adults. It involved 24 participants who received either the vaccine or a placebo. The main goal was to see if the vaccine was safe and if it triggered an immune response, n…

This study tested whether the standard hepatitis A vaccine is safe and works well for people living with HIV, including children as young as 1. About 400 participants received the vaccine, and researchers checked their blood for protective antibodies and monitored for any side ef…

This early-stage study tested the safety and immune response of a new experimental HIV vaccine in healthy adults. Thirty-four participants received either the vaccine or a placebo to see if it was well-tolerated and could trigger an immune defense against HIV. The goal was to gat…

This study tested two different combinations of HIV medications to see how well they control the virus and how safe they are. It involved 61 people with HIV who had not taken this specific type of medication before. The goal was to compare the effectiveness and side effects of th…

This study tested if adding a new drug called enfuvirtide (FUZEON®) to standard HIV therapy could better control a rare and severe brain infection called PML in people with HIV. It involved 30 patients in France who received the intensified drug combination for 6 months, followed…

This study tested if combining four common heart failure medications into a single daily pill helps patients take their medicine more consistently. Researchers worked with 35 adults who have a specific type of heart failure, including some who also have HIV. The goal was to see i…

This study tested whether people living with HIV can safely donate kidneys to other HIV-positive patients who need transplants. Researchers followed three HIV-positive kidney donors to monitor their health after donation, checking for complications, kidney function changes, and H…

This study tested whether adding financial incentives for treatment improved HIV care for people who inject drugs and men who have sex with men in India. Researchers compared standard care centers to centers that also offered incentives, tracking whether people started medication…

This study tested long-acting injectable HIV medications in children and adolescents whose HIV was already well-controlled with daily pills. The goal was to find the right dose and see if getting shots every month or two was safe, tolerable, and kept the virus suppressed. Researc…

This study tested whether a mobile health clinic could better connect people who inject drugs with opioid addiction to essential care. It compared delivering addiction medication and HIV treatment/prevention directly in a mobile unit to providing referrals to community clinics. T…

This early-stage study tested whether a personalized vaccine made from a person's own white blood cells is safe and can boost the immune system against HIV. The study involved 40 adults with HIV who were already taking effective HIV medications. Researchers compared different met…

This study looked back at the medical records of 800 people living with HIV to compare how well two different medication regimens worked. It specifically focused on people who face significant life challenges, like unstable housing or food insecurity, to see if a two-drug regimen…

This study tested two experimental oral drugs designed to block HIV by targeting the virus's capsid. It involved 44 adults with HIV who had never taken antiviral medication before. Participants received one of the drugs or a placebo for 10 days so researchers could measure how mu…

This early-stage study tested the safety and initial effects of an experimental antibody called VRC01 in adults recently diagnosed with HIV. Participants received either the antibody alone, the antibody plus standard antiretroviral therapy (ART), or a placebo plus ART. The main g…

This study tested a support program to help young Black and Hispanic adults with HIV take their daily medication more consistently. Participants were randomly assigned to either have weekly video calls with a trained peer coach or to use a self-guided online education website. Th…

This study tested a counseling program that involves the family and friends of people receiving treatment for opioid addiction and HIV in Tanzania. The goal was to see if this social support approach is practical and acceptable for helping patients stay in their methadone treatme…

This study tested if a cholesterol-lowering injection called alirocumab could reduce heart disease risk in people living with HIV. It involved 118 adults aged 40+ with well-controlled HIV and either existing heart disease or significant risk factors. Participants received either …

This study tested a new strategy to help people with HIV in Ukraine who had fallen out of medical care. Researchers used health data to identify 160 people who had missed appointments and then actively helped them reconnect with clinics and start treatment. The goal was to see if…

This study looked at whether people living with HIV prefer to receive their long-acting injection treatment at a general hospital day unit or at a specialized HIV clinic. Researchers enrolled 90 participants who were already prescribed this injectable medication and randomly assi…

This study tested a short video shown in clinic waiting rooms. The goal was to help people with HIV start their medication, take it consistently, and stay connected to their medical care. Researchers measured if the video helped by looking at medical records from over 4,000 patie…

This study tested a new experimental HIV vaccine called Trimer 4571 in people already living with HIV who were on stable, effective medication. The main goals were to check if the vaccine was safe and to see if it could help the body's immune system produce powerful antibodies ag…

This study provided continued access to the HIV medication dolutegravir for children and adolescents who had successfully completed earlier clinical trials. It aimed to ensure these young patients could keep receiving their effective treatment until the drug became commercially a…

This study tested a single-tablet HIV medication in children and teens. It aimed to find the right dose, check how the body processes the drug, and see if it was safe and effective at controlling the virus. The study included 129 young people, from ages 2 to 18, who were either n…

This study tested a simpler, two-drug HIV treatment in teenagers who had never taken HIV medication before. The goal was to see if taking fewer drugs could still effectively control the virus for up to three years while potentially reducing long-term side effects. Thirty-two adol…

This study tested a new system to help people who use substances take their daily HIV prevention pill (PrEP) more consistently. Participants used a special 'digital pill' that sends a signal when swallowed, paired with a smartphone app that provided reminders and support. The goa…

This early-phase study tested a personalized vaccine made from a patient's own immune cells and inactivated HIV. The goal was to see if it was safe and could help control the virus after participants temporarily stopped their standard antiretroviral medication. Eleven people with…

This study tested whether sending trained community health workers to visit pregnant women at home could improve health for both mothers and their babies. It followed nearly 1,500 women in rural South Africa for a year after giving birth. The program aimed to help with challenges…

This study tested a new support program for clinics to improve care for adults with multiple long-term conditions like HIV, diabetes, and high blood pressure. Over 1,800 participants in South Africa either received standard care or the new ENHANCE program, which included special …

This study tested a new strategy using faster, on-site tests to screen pregnant women for several sexually transmitted infections (STIs) in Zimbabwe. The goal was to see if this approach was practical, accepted by patients, and could lead to better and quicker treatment. Research…

This study tested new, faster HIV tests that give results during a clinic visit. The goal was to see if these quick tests help connect people to treatment if they have HIV, or to prevention medication if they don't, much sooner than standard lab tests. Researchers enrolled 419 ad…

This study tested a new screening strategy in Guatemala. It used rapid, on-site tests to check pregnant women for syphilis and HIV during prenatal visits. The goal was to see if this approach could find more infections faster, so treatment could start sooner to protect both mothe…

This study aimed to find people with undiagnosed HIV who were already in the hospital. Researchers tested 300 patients at a hospital in Milan who showed certain health conditions or reported risky behaviors. The goal was to see how common hidden HIV infections are in this setting…

This study tested a new, faster HIV test for babies and young children in Zambia. The goal was to see if getting test results right away, at the community clinic, would help more HIV-positive infants start life-saving antiretroviral therapy (ART) sooner. Researchers also wanted t…

This study tested whether a digital, community-led program could help reduce the risk of HIV and hepatitis C in rural areas heavily affected by the opioid crisis. Over 500 people from Appalachia and the Midwest were assigned to either try the new digital program or receive standa…

This early-stage study tested a vaginal ring designed to be worn for 90 days to help prevent HIV infection. Researchers enrolled 49 healthy, HIV-negative women to check how much of the drug tenofovir entered their bodies and to monitor safety. Participants were randomly assigned …

This study tested a soccer-based program called SKILLZ to improve health for teenage girls in Zambia. The program aimed to increase HIV testing, use of contraception and prevention methods, and help girls living with HIV stay in care. Researchers compared an enhanced version of t…

This study tested if watching a short, culturally tailored online soap opera could encourage HIV prevention behaviors in Latina women. Researchers enrolled 95 women in North Carolina to watch four episodes about HIV risks and prevention. The goal was to see if the show increased …

This study tested a new hospital checklist designed to help people who inject drugs get better care. The goal was to connect 60 rural patients with addiction treatment and HIV prevention medications like PrEP during their hospital stay. Researchers wanted to see if this simple re…

This study aimed to understand how women who inject drugs view and use a long-acting injectable medication (CAB-LA) to prevent HIV, compared to daily oral pills. Researchers followed 144 women over six months to see which method they chose, how well they stuck with it, and what f…

This study tested if a peer-driven program could help more Black and Hispanic/Latino men who have sex with men start taking PrEP, a daily pill that prevents HIV. In the program, trained participants educated friends in their social networks about PrEP and encouraged them to get a…

This study tested a mobile pop-up clinic in Seattle to provide healthcare to women who inject drugs and exchange sex. The van offered HIV prevention medication (PrEP), treatment for opioid addiction, and rapid testing for sexually transmitted infections. Researchers wanted to see…

This study tested a new way to encourage male partners of pregnant women to get tested for HIV. Researchers gave some women a standard invitation for their partner to get tested at a clinic, and gave other women that invitation plus a take-home oral HIV test kit for their partner…

This study tested whether a smartphone app called GeoPassport, combined with peer mentor support and small rewards, could help men and transgender women leaving jail access important health services. The goal was to see if this approach helped people get HIV prevention medication…

This study tested different ways for clinics to offer a long-acting injection (called cabotegravir or Apretude) to prevent HIV. It involved 370 Black cisgender and transgender women without HIV, as well as clinic staff. The main goal was to see which clinic strategies worked best…

This study tested whether offering HIV prevention medication (PrEP) and STI testing through community outreach could reach men who have sex with men who might not otherwise access healthcare. Researchers used both digital apps and physical community spaces to connect with 209 par…

This study aimed to understand the safety and how a daily HIV prevention pill builds up in the body of Kenyan women. Researchers gave 54 HIV-negative women different weekly doses of the pill under direct observation for up to 18 weeks. The goal was to measure drug levels in the b…

This study tested a digital health program designed to help male couples in the U.S. work together to prevent HIV and sexually transmitted infections (STIs). Over 16 months, 778 men in relationships used an online toolkit to create and follow personalized prevention plans and agr…

This study tested whether barbershops could be effective places to help prevent HIV. Researchers worked with 18 barbershops in Uganda to see if barbers could provide HIV education and self-test kits to their male customers. The goal was to see if this approach was practical and a…

This large study tested whether a long-acting injection given every two months (cabotegravir) works as well as or better than a daily oral pill (Truvada) to prevent HIV infection. It enrolled over 4,500 HIV-negative men and transgender women who have sex with men and are at high …

This study tested a program where trained peer guides helped women on probation in San Francisco get connected to HIV prevention services. The goal was to see if this support could reduce the stigma these women face and make it easier for them to start and stay on a daily pill ca…

This study created and tested a toolkit for healthcare clinics to help more Black women in the South start and stay on HIV prevention medication (PrEP). It focused on two clinics in Mississippi and aimed to address specific barriers these women face, including domestic violence. …

This project aimed to make HIV prevention services more accessible by integrating them into existing family planning clinics in Kenya. The program trained family planning staff to screen young women for HIV risk and offer PrEP medication to prevent infection. Researchers evaluate…

This study tested a training program for doctors in Alabama to help them better prevent HIV in young women. The program taught doctors how to have comfortable conversations about sexual health and prescribe PrEP, a daily pill that prevents HIV. Researchers wanted to see if the tr…

This study aimed to find the best ways for clinics to offer a long-acting injection for HIV prevention. It involved 287 HIV-negative men and transgender men, who received the shot, and clinic staff who administered it. Researchers compared two different support strategies for cli…

This study tested different ways to help young gay couples communicate about HIV prevention and get tested together. Researchers compared a program with communication skills training and couple's HIV testing against standard individual testing. The goal was to see which approach …

This early-stage study tested the safety and how the body processes two new long-acting injection formulations of cabotegravir, a medication used for HIV prevention. The study involved 56 healthy adult volunteers who received a single injection. Researchers monitored participants…

This study tested two different phone counseling approaches to help smokers with HIV quit. Researchers compared standard smoking cessation advice with a newer method that focuses on understanding feelings that lead to smoking and finding alternative activities. The study involved…

This study explored whether Tai Chi, a gentle mind-body exercise, could help adults living with HIV manage their chronic pain. Researchers tested the program's feasibility and how well it was received by participants, comparing it to a general health education course. The goal wa…

This study looked at whether medical cannabis could help reduce nerve pain and inflammation in people living with HIV. Researchers followed 35 adults with HIV and nerve pain who were already certified for medical cannabis use. Over 14 weeks, they compared how different ratios of …

This study aimed to understand how well COVID-19 vaccines protect people aged 55 and older who are living with HIV. Researchers followed 75 participants for a year, comparing immune responses in people with HIV to those without. The study did not give vaccines but observed people…

This study aimed to understand how aging affects specific enzymes in the body that help activate a common HIV prevention and treatment medication. Researchers collected blood and colon tissue samples from 21 adults of different ages, comparing those taking the drug to those who w…

This study observed 200 transgender and non-binary adults living with HIV across Europe over 18 months. Researchers collected health data and survey responses to understand how well HIV treatment works in this community and identify barriers to care. The goal is to gather informa…

This project aimed to plan and test ideas for reducing stigma against people who use drugs in clinics that provide HIV prevention and care. Researchers worked with 51 healthcare workers from community health centers. They developed and tested a training program and explored poten…

This study tested whether taking a 28-day break from cannabis affects mood, pain, sleep, inflammation, and HIV levels in people living with HIV who use cannabis regularly. Researchers paid 25 participants money as an incentive to stop using cannabis for one month and tracked thei…

This study aimed to understand how the body processes HIV and tuberculosis medications during pregnancy and after birth. Researchers observed 205 pregnant and breastfeeding women who were already taking these medications for their health care. They measured drug levels in the mot…

This study tested a new public discussion method to improve the consent process for clinical research, especially for teens in sensitive HIV prevention studies. Researchers gathered 128 people, including teens, parents, and community members, to debate different consent models. T…

This small, early-stage study tested whether a single dose of the cancer drug pembrolizumab is safe for people with well-controlled HIV. The main goal was to check for safety, not to treat HIV. Researchers also wanted to see if the drug could help reveal if the virus was hiding i…

This study looked at people taking PrEP, a daily pill to prevent HIV, to see if using it for a long time changes their sexual behaviors or their chances of getting other sexually transmitted infections (STIs). Researchers compared 248 people in France who had been on PrEP for ove…

This study aimed to find out how many people held in a specific French detention center had HIV, hepatitis B, or hepatitis C. Researchers used rapid tests to screen 350 detainees, as many come from regions where these infections are common and may not know their status. The goal …

This study aimed to understand how different vaginal infections and bacteria might affect when a baby is born. Researchers followed 603 pregnant women in South Africa, testing them for common infections and analyzing their vaginal bacteria at two points during pregnancy. The main…

This was the first study in humans for a new drug called VH4524184, which is being developed for HIV. The main goal was to check if the drug is safe and to see how the body processes it. The study involved 84 healthy volunteers who received either the drug or a placebo, and resea…

This study aims to gather information on how well a cancer treatment called CAR T-cell therapy works for people living with HIV who also have certain blood cancers. Researchers will collect standard medical data from about 30 patients who have already received this therapy. The g…

This early study tested how a new HIV drug candidate behaves in healthy adults. Researchers examined how the body absorbs different tablet forms, whether food affects absorption, and how it interacts with other common medications. The study involved 126 healthy volunteers to gath…

This study aimed to understand how many people with HIV develop cancer and what types of cancer they get. Researchers collected information from 462 patients at US clinics to see patterns in cancer care and learn why some patients do or don't join cancer treatment trials. The stu…

This study aimed to understand how THC, the main active compound in cannabis, changes how immune cells work at a genetic level. Researchers gave THC to 56 people, some with HIV and some without, to measure changes in their genes and immune proteins. The goal was to gather basic k…

This study aimed to understand how HIV and tuberculosis (TB) medications are processed by the body during pregnancy and after birth. Researchers followed over 1,500 pregnant and postpartum women who were already taking these medications for their care. By measuring drug levels in…