HIV infections

This early-stage trial will test a new HIV vaccine in 22 infants who were exposed to HIV during birth but are not infected. The vaccine is designed to train the immune system to recognize and fight HIV. The main goal is to see if the vaccine is safe and whether it triggers an imm…

Researchers are testing whether a two-drug injectable regimen can control HIV in adults who have not yet started treatment. The trial pairs an experimental drug called VH4011499 with cabotegravir, an existing injectable HIV medicine, and compares different dose combinations again…

This study looks at whether giving women living with HIV the option to collect their own HPV test samples at home or in their community, with help from health workers, increases how many get screened for cervical cancer. About 17,700 women will take part across multiple clinics. …

This study tests whether a self-applied cream (5-fluorouracil) after a heat procedure (thermal ablation) can clear HPV better than a placebo cream in 140 women with HIV in Kenya. Participants will use the cream every two weeks for 24 weeks and be followed for 48 weeks total. The …

This study tests whether two safe dietary supplements—a probiotic and blueberry extract—can reduce signs of accelerated aging in people with HIV who drink alcohol. Researchers will measure changes in immune cells and biological age markers. The trial involves 160 participants age…

This study tests a new robotic bronchoscopy system that uses real-time 3D imaging to help doctors biopsy lung nodules in people with HIV. The goal is to see if this robot-guided approach is more accurate and safer than current navigation methods. One hundred participants will be …

This study will test a rapid fingerstick test for HIV and syphilis in pregnant women who come to the emergency department without prior prenatal care. Researchers want to see if offering this test leads to more women being diagnosed and starting treatment right away. The goal is …

Researchers are testing a new injectable drug called VH5356136 to see if it is safe and how the body processes it. The trial enrolls about 160 healthy adults without HIV, ages 18 to 55. Participants receive a single dose of the drug or a placebo, and researchers monitor side effe…

Researchers are testing an experimental injectable drug called VH4367310 in healthy adults aged 18 to 55. The drug is a long-acting form of cabotegravir, a medicine already used to prevent HIV. This phase 1 trial gives a single increasing dose to measure how the body processes th…

This study looks at how to make HIV prevention pills (PrEP) easier for young people to get and keep using. Researchers will follow 1000 current or eligible PrEP users in Alabama and Botswana for 2 years. They will also create and test a decision-support toolkit to help patients a…

This study looks at whether long-acting HIV prevention shots and opioid use disorder medications can help people in prison who are about to be released. Researchers will enroll 450 adults at participating prisons and follow them to see if they stick with treatment and avoid HIV, …

This pilot trial tests a mobile app called Bandi, designed to support HIV prevention among young men who have sex with men in South Korea. Participants are randomly assigned to either the full app, which includes interactive health content, peer forums, a sexual health log, and a…

This study tests a mobile app called LOTUS designed to help people who use drugs engage with HIV prevention services like testing and PrEP. The app provides tips, reminders, peer support, and a way to ask healthcare professionals questions. The trial will enroll 40 participants t…

This study will test a smartphone app designed to help Black teenagers and young adults in Atlanta take their HIV prevention medication (PrEP) consistently. Researchers will work with 10 participants and their adult supporters to see if the app is easy to use and helpful. The goa…

This study tests whether a single daily pill that combines HIV prevention (PrEP) and birth control is easier for women to take consistently than taking two separate pills. About 300 women without HIV will try both approaches in a crossover design, and researchers will measure adh…

This study tests a tablet-based tool called PrEPwise, delivered by community health workers, to help Black women in eastern Virginia learn about and decide whether to start PrEP (a daily pill that prevents HIV). The trial will enroll 108 Black women who are eligible for PrEP and …

This study will test whether offering HIV prevention medication, routine STI testing, and a preventive antibiotic at retail pharmacies helps young women avoid infections. About 720 women aged 15 to 24 who visit pharmacies for birth control will take part. Researchers will check h…

This study looks at ways to improve care for teens and young adults who have experienced sexual assault. The goal is to offer same-day HIV prevention medicine and substance use support during their emergency room visit. Researchers will work with young people to design and test t…

This study aims to develop and pilot a program for people with HIV in South Africa who also face depression, trauma, and food insecurity. Researchers will first explore how these problems interact, then create a treatment called CBT-SA that combines therapy, nutrition support, an…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods (like the shot or implant) affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will join groups based on their contraceptive choice…

This study is testing a new program to help men living with HIV in Uganda feel more comfortable telling their sexual partners about their HIV status. The program includes education, counseling, and practice conversations. Researchers want to see if it helps more men share their s…

This study tests a method to help clinics prescribe long-acting injectable PrEP, a shot that prevents HIV. Researchers will work with 20 healthcare providers and staff to improve how they offer this option. The goal is to see if a simple, flexible strategy can increase the number…