HIV INFECTIONS

This early-stage trial tests a new HIV vaccine in 22 infants who were exposed to HIV before birth but are not infected. The goal is to see if the vaccine is safe and helps the babies' immune systems fight HIV. The study is not yet recruiting and focuses on safety and immune respo…

This study tests two over-the-counter supplements to see if they can slow down immune aging in people with HIV who drink alcohol. The trial will involve 160 adults aged 40 and older. Participants will try each supplement for a period, and researchers will measure changes in immun…

This study tests a program called WeCare, which combines problem-solving therapy with support for HIV medication adherence. About 60 men who have sex with men in South Africa will take part. The goal is to see if the program reduces depression and anxiety, and helps participants …

This study tests whether a self-applied cream (5-fluorouracil) can help clear HPV after a standard procedure (thermal ablation) in women with HIV in Kenya. About 140 women will use either the cream or a placebo every other week for 6 months. The goal is to see if the cream improv…

This early-stage study tests a new experimental HIV drug, VH4770359, in 214 healthy adults aged 18 to 55. The main goal is to check if the drug is safe and how the body processes it. Results will help design future studies in people living with HIV.

This early-stage study tests whether dasatinib, a drug used for cancer, can lower the amount of hidden HIV in the body (the HIV reservoir). Fourteen adults with well-controlled HIV on standard therapy will take either dasatinib or a placebo daily for 12 weeks. The goal is to see …

This study tests an experimental drug called JL18008 in people with HIV whose immune systems haven't fully recovered despite standard treatment. About 30 adults will receive either the drug or a placebo as a weekly injection for 4 weeks, while continuing their regular HIV medicat…

This study offers continued access to an HIV treatment for up to 183 people who completed a previous ViiV Healthcare study and are still doing well on it. The goal is to keep providing the treatment while monitoring safety. Participants must have a doctor's confirmation that they…

This study will test three different pharmacy-based approaches to help young women prevent sexually transmitted infections (STIs) and HIV. About 720 women aged 15-24 who visit retail pharmacies for birth control will be offered HIV prevention medication, routine STI testing, and …

This study aims to improve care for teens and young adults who have experienced sexual assault by offering same-day HIV prevention medicine and substance use support. Researchers will work with survivors and community groups to design and test these services. About 90 participant…

This study tests a decision aid called PrEPwise to help Black women in Virginia learn about and start PrEP, a medicine that prevents HIV. Community health workers will deliver the tool during HIV testing visits. The goal is to see if the tool is acceptable and helps more women st…

This study looks at whether offering a rapid, combined HIV and syphilis test to pregnant women in the emergency department helps find more infections and start treatment sooner. About 1,400 pregnant women who have not had regular prenatal care will be included. The goal is to pre…

This study tests whether a smartphone app can help Black teenagers and young adults in Atlanta take their HIV prevention medication (PrEP) consistently. Ten participants will use the app and give feedback on how easy it is to use and whether it helps them communicate with a suppo…

This study tests whether long-acting HIV prevention shots and opioid use disorder medications work well for people in prison who are close to release. About 300 adults will receive these treatments and be followed to see how well they stick with them and whether they reduce HIV r…

This study compares how well women stick to a single daily pill that prevents both HIV and pregnancy versus taking two separate pills. About 300 women without HIV, aged 16-39, will try both methods in a crossover design. The goal is to see if a combined pill makes it easier to st…

This study tests a new program to help men living with HIV in Uganda share their status with partners. The program includes education, counseling, and role-playing. Researchers want to see if it helps more men disclose their HIV status compared to standard care. About 70 men will…

This study in South Africa, where HIV is most common, looks at how problems like depression, trauma, and not having enough food can make HIV worse. Researchers are developing a special therapy (CBT-SA) to help people with HIV handle these issues and stick to their medication. The…

This study looks at how a long-acting injectable HIV prevention drug (CAB-LA) and hormonal birth control methods affect each other in women. About 105 women who already use CAB-LA or no HIV prevention will choose to use an injectable contraceptive, an implant, or no hormonal birt…

This study explores whether an artificial intelligence chatbot can help increase HIV testing among men who have sex with men in Kuala Lumpur, Malaysia. Eighty participants will be randomly assigned to either receive automated, personalized messages about HIV testing or standard c…