HIV infections

This trial is testing two tuberculosis (TB) vaccines—VPM1002 and a repeat BCG vaccination—in pre-adolescents aged 8-14 who were vaccinated at birth. The goal is to see if these vaccines are safe and trigger a strong immune response in children both with and without HIV, and in th…

This early-stage trial tests three experimental mRNA vaccines designed to train the immune system to fight HIV. The study involves 96 healthy adults without HIV in South Africa. Researchers will check for side effects and measure whether the vaccines trigger specific immune cells…

This early-stage study tests two experimental mRNA vaccines designed to teach the body to make powerful antibodies that can neutralize many types of HIV. About 53 healthy adults without HIV will receive the vaccines to check safety and immune response. The goal is to see if the v…

This early-stage trial tests whether three experimental mRNA vaccines can safely teach the immune system to recognize and fight HIV. About 108 healthy, HIV-negative adults aged 18-55 will receive one of the vaccines. The main goal is to check for side effects and see if the vacci…

This study in Botswana tests whether giving three powerful antibodies by infusion can help children who started HIV treatment early keep the virus suppressed without taking daily antiretroviral pills. About 41 children aged 2 to 12 will receive the antibodies while stopping their…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This trial tests whether a structured improvement strategy, called SAIA, can help syringe service programs in the U.S. deliver more HIV testing and referrals to prevention and treatment services. The study will compare programs using SAIA with those continuing their usual practic…

This study tests a new HIV medicine, fostemsavir, in people whose HIV has become resistant to many other drugs. About 371 adults with multi-drug resistant HIV took part. The goal was to see if fostemsavir could lower the amount of virus in their blood. This is a disease control s…

This trial tests a smart pillbox that sends text alerts when a person misses their HIV medication. The alerts go to the user, a support person, and a case manager to help them get back on track. The study involves African American men who have sex with men and have trouble sticki…

This study tests a mobile app called Connections for people living with HIV who also have substance use disorders. The app provides resources, weekly check-ins, discussion rooms, and private messaging with peer mentors and care teams. Researchers want to see if using the app help…

This study tests a mobile app called WiseApp along with a smart pill dispenser to help Spanish-speaking people with HIV take their medication regularly. About 248 participants from New York City and the Dominican Republic will use the app for 12 months. The goal is to see if the …

This study tests a simplified, accelerated HIV care model called ACCELERATE. It combines rapid telehealth appointments, a pre-approved HIV medication, and a free 30-day starter supply to help people with HIV who have fallen out of care get back on track. The goal is to see if thi…

This Phase 3 trial tests whether people with HIV who are already well-controlled on daily pills can switch to a monthly injection of two drugs (cabotegravir and rilpivirine) and stay just as healthy. About 630 adults whose virus is suppressed on a standard three-drug pill regimen…

This study tests a new drug, VH3810109, given with another HIV medicine (cabotegravir) in adults whose HIV is already well-controlled. The goal is to see if this combination can keep the virus suppressed as well as standard treatments. About 185 participants will receive either t…

This study tests a long-acting injectable HIV medication (CAB LA + RPV LA) in people whose virus is still detectable despite taking daily oral pills. About 332 participants will either get the shots or continue standard oral therapy. The goal is to see if the injections can bette…

This study tests two drug combinations in 300 people with HIV who have gained weight or have high cholesterol. One part compares dapagliflozin (a diabetes drug) to a placebo for weight loss. The other compares a two-drug statin combo to a single statin for lowering cholesterol. T…

This Phase 3 trial tests whether switching from daily HIV pills to monthly injections of cabotegravir and rilpivirine can keep the virus suppressed in adults with HIV. About 618 participants who are already virally suppressed will either stay on their current pills or switch to t…

This early-stage study tests whether adding an experimental drug (VH3810109) with or without another drug (fostemsavir) to standard HIV therapy can reduce the hidden viral reservoir in people living with HIV. About 107 adults, either new to treatment or already on stable therapy,…

This study tests whether a simpler two-drug pill (dolutegravir/lamivudine) works as well as a standard three-drug pill (bictegravir/emtricitabine/tenofovir alafenamide) for adults with HIV who have never been treated. About 473 participants will take one of the two pills daily fo…

This early-stage study tests a new lab-made antibody called VH4527079 in healthy adults and people with HIV. The goal is to check if it is safe and how the body processes it when given as a single shot or multiple infusions. About 102 participants aged 18-55 will take part. This …

This study looks at whether a trained friend, family member, or partner can safely give long-acting HIV injections at home. It involves 1,000 people with HIV who are already on the injectable treatment and have the virus under control. The goal is to make it easier for people to …

This study looks at how safe and effective certain HIV medicines are for children and teens (ages 4 weeks to under 18 years) who already have the virus under control. Participants take a combination of drugs (atazanavir or darunavir boosted with cobicistat, plus emtricitabine/ten…

This study tests a program called PASEO that helps teenagers with HIV in Lima, Peru, successfully move from pediatric to adult HIV care. The program includes a helper who checks in monthly, peer support groups, education sessions, and mental health support. About 160 teens will t…

This study tests whether a two-drug combination (dolutegravir and lamivudine) is as safe and effective as the standard three-drug HIV treatment for children aged 2 to 15. About 386 children who already have undetectable HIV levels will take either the two-drug pill or their usual…

This study aimed to test a new solid tablet combining two HIV drugs (darunavir and ritonavir) for children aged 3 and older weighing 10-25 kg. The goal was to find the right dose and check safety and acceptability. However, the trial was withdrawn before any participants were enr…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This early-phase trial tests a combination of HIV GP160 protein and BCG vaccine (used for tuberculosis) in 20 HIV-positive people without AIDS symptoms. The goal is to see if the mix can activate the immune system to recognize and kill HIV. It is a small proof-of-concept study, n…

This study aimed to see if a personalized RNA vaccine, a powerful antibody (10-1074), and a drug called romidepsin could help people with HIV stop their daily antiretroviral pills while keeping the virus under control. The trial planned to enroll 56 adults with well-controlled HI…

This study tests a program that combines digital health tools (like medication reminders and online consultations) with social support to help people with HIV who struggle to take their medication regularly. Researchers will enroll 210 participants in Taiwan and track changes in …

This study compares different HPV tests to find the best way to screen for cervical cancer in women living with HIV in Latin America. Over 1,000 participants will provide cervical, vaginal, and urine samples, plus undergo colposcopy and biopsies. The goal is to identify which tes…

Researchers are testing whether repeat couples HIV testing and counseling helps male couples at high risk of HIV. The study enrolls couples who already took part in an earlier testing program. Couples are assigned by chance to either retest together or to individual HIV testing. …

This study tests whether peer-led support—either one-on-one, in a group, or both—can help transgender men who have sex with men start and continue taking PrEP, a daily pill that prevents HIV. Participants are randomly assigned to receive standard HIV prevention information, a tai…

This study tests whether adding a communication skills video and a substance use module to standard couples HIV testing can help male couples reduce drug use and risky sex. About 484 male couples are randomly assigned to receive standard testing alone or with one or both extra mo…

This study is checking the long-term safety and effectiveness of a long-acting injectable drug called cabotegravir (CAB LA) for preventing HIV. It includes about 3,500 people who already received CAB LA in earlier HIV prevention studies. Participants will continue getting the sho…

This pilot trial tests whether training Gancheros—people who provide injection services in exchange for money or drugs—can lower HIV, hepatitis C, and overdose risks among migrant Puerto Rican people who inject drugs in New York City. Gancheros will attend six sessions on prevent…

This study tests a program called ZAIMARA that brings together adolescent girls (ages 15-19) and their mother figures for a two-day workshop. The goal is to improve communication about HIV, sexually transmitted infections, and PrEP, and to increase HIV testing and prevention. Res…

This study tests a community-based approach to lower HIV rates among men who have sex with men (MSM) at highest risk in the southern United States. The strategy uses local coalitions to reduce barriers, promote testing, increase PrEP use, and improve care for those living with HI…

This study aims to see if mobile phone messages can help teens in Uganda prevent HIV and address related issues like mental health and alcohol use. Researchers will adapt an existing text and voice system to include HIV prevention info and mental health screening. About 200 adole…

This study tests a program called TIARAS, which combines a reward system for staying drug-free and on PrEP (HIV prevention pills or shots) with expressive writing about past trauma. The goal is to see if this approach lowers HIV risk in women who inject drugs. 219 women from Phil…

This study tests a new version of the HIV prevention drug cabotegravir given as a shot every 4 months. About 229 teens and adults at risk for HIV will receive the injection to see how well the drug stays in the body and if it is safe. The goal is to make HIV prevention easier by …

This study tests a mobile app called Combine to help gay, bisexual, and other men who have sex with men in rural southern US get tested for HIV and STIs and start taking PrEP (a daily pill that prevents HIV). About 473 men will use the app and be placed into one of four groups: s…

This study tests whether text reminders, commitment pledges, and planning prompts can help men who have sex with men stay on PrEP, a daily pill that prevents HIV. About 106 men in South Africa who are just starting PrEP will either get standard care or these extra nudges. The goa…

This large phase 3 study tests whether a long-acting injectable drug called cabotegravir, given every 2 months, is safe and effective for preventing HIV in women. Over 3,200 HIV-negative women are taking part, comparing the shot to daily oral Truvada. The goal is to see if the in…

This pilot study tests whether a 2-hour mindfulness training program, called Mindfulness-Oriented Recovery Enhancement (MORE), can help people living with both HIV and chronic pain. The study enrolls 40 adults with HIV who also have chronic pain and are willing to avoid new treat…

This study tests whether a 48-week exercise program can improve physical function and reduce disability in HIV-positive adults over 50 in Côte d'Ivoire. 180 participants will be split into three groups: supervised group exercise, home-based exercise with phone support, or health …

This pilot study tests whether an electronic health record tool can help doctors identify patients at higher risk for HIV and prescribe PrEP, a daily pill that prevents HIV. Researchers will roll out the tool in 2-3 community health centers and compare PrEP prescription rates to …

Researchers are testing a coaching program to help primary care clinics in rural West Virginia screen and treat opioid use disorder, HIV, and hepatitis C. The program includes group priority-setting, rapid-cycle improvement coaching, and provider training. Twenty clinics will tak…

This study talks to people living with HIV from diverse backgrounds to learn what helps or hinders them from getting oral health care and cancer prevention. Researchers will hold focus groups and use questionnaires to understand barriers and gather ideas for improvement. The goal…

Researchers are testing whether an online HIV stigma training can reduce stigmatizing attitudes and behaviors in nursing students. Third- and fourth-year nursing students will either take this training or a standard HIV epidemiology course. Before and after, the students will com…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study examines a program in two Boston-area jails designed to make HIV testing and treatment easier for people with opioid use disorder. Researchers will follow about 59 participants who are leaving jail within a month to see if they use HIV services, get tested, or take PrE…

This study looks at how HIV infection and aging impact the body's response to the Prevnar 13 vaccine, which protects against pneumococcal bacteria. Researchers will measure antibody levels in the lungs, nasal passages, and blood of participants aged 21-45 or 55-75, comparing thos…

This long-term study follows 7,500 adults with HIV who are taking antiretroviral therapy. Researchers track their health over time to understand complications, side effects, and how the infection evolves. The goal is to improve monitoring and care for people living with HIV.

This study tests a program where veteran peer workers provide education, healthcare navigation, and social support to 150 veterans with opioid use disorder who are not connected to VA healthcare. The goal is to reduce risky behaviors related to overdose and HIV/HCV infection. Res…

This study tests whether AI-powered X-ray analysis and portable molecular tests can help find tuberculosis (TB) and COVID-19 cases in African communities where many cases go undetected. Over 26,000 adults will be screened using these tools, and researchers will measure how quickl…

This study involves 65 healthy adults without HIV to see how well they tolerate two long-acting injections (cabotegravir and lenacapavir). Participants will receive both shots at different times and report on pain, bother, and overall satisfaction. The goal is to understand injec…

This study uses a special imaging scan (PET/CT) and a radioactive tracer to measure inflammation in the brain. Researchers will compare four groups: people with HIV and opioid use disorder, people with only one of these conditions, and healthy volunteers. The goal is to understan…

This study tests a program called CHIMES designed to help young Black gay and bisexual men living with HIV get better mental health care. The program includes posters, provider training, mental health screening, and case management. Researchers will track whether it leads to more…

This study asks people who have taken part in HIV clinical trials to give permission for their stored blood and tissue samples to be used in future research, including genetic testing. The goal is to have a large collection of samples ready for studies that haven't been planned y…