Chronic pain syndrome

This trial investigates whether adding a booster session and extended access to the rehabilitation team after standard interdisciplinary care can improve outcomes for people with chronic pain. Two hundred participants in Swedish primary healthcare will be randomly assigned to eit…

This trial is testing whether a person's genetic makeup can predict how well they respond to three common pain treatments: low-level laser therapy, therapeutic ultrasound, and prolotherapy (a dextrose injection). Researchers will recruit 80 people with myofascial pain and 80 with…

This trial tests whether a specific nerve block, called a subcostal anterior quadratus lumborum block, can prevent chronic neuropathic pain in people donating a kidney through laparoscopic surgery. Half of the 60 participants receive the block with a local anesthetic, while the o…

This study tests a new way of managing chronic pain by improving teamwork between pain clinics, GPs, and other services. About 386 adults referred to pain clinics in Norway will either get this new pathway or standard care. The goal is to see if better coordination and a clear 6-…

This study aimed to test a closed-loop spinal cord stimulation device to reduce spasticity and pain in people who had a stroke or brain injury. It was designed for adults with chronic neuropathic pain and spasticity lasting more than three months. However, the trial was withdrawn…

This study compares two telemedicine approaches for people with chronic pain and opioid misuse. One program provides standard medication management via remote visits, while the other adds a 12-week self-help program with phone-based coaching. The goal is to see which approach bet…

This study tests a type of spinal cord stimulation that uses low-level electrical pulses (below the sensation threshold) against the best available medical treatments for people with ongoing back and leg pain after back surgery. About 114 participants will be randomly assigned to…

Functional somatic disorders cause persistent physical symptoms that doctors cannot explain by other diseases. The DISTRESS trial evaluates a new clinic where internal medicine doctors, trained to recognize these disorders, examine patients and provide guidance to their general p…

This observational study is testing whether measuring the nociceptive flexion reflex (a spinal reflex) can predict which patients with chronic back or neck pain will get significant pain relief from interventional procedures like epidural injections or nerve blocks. Researchers w…

This study uses a device that combines magnetic stimulation and brain wave recording (TMS-EEG) to find biological markers for chronic pain. Researchers will measure brain responses in 100 adults with chronic pain and see if these signals can help diagnose pain types and predict h…

This study is testing whether an online course can help people with multiple sclerosis, long COVID, fibromyalgia, or cancer-related fatigue adopt healthier diets and self-care habits. Researchers will measure changes in quality of life, fatigue, and mental health. The goal is to …

This study is testing whether applying peppermint oil to the skin can reduce chronic pain and improve daily function in people with fibromyalgia. Researchers will also look at whether this treatment is cost-effective compared to standard care. About 175 adults with fibromyalgia w…

Researchers in Chile are testing whether adding neural mobilization, a physical therapy technique that targets nerve movement, to standard fibromyalgia care improves daily function and reduces pain more than standard care alone. The trial enrolls 20 women aged 18 and older with a…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests a low-cost training program for doctors and their patients with chronic pain. The program teaches team-based skills to manage pain and reduce reliance on opioids. About 1,188 participants (patients aged 14–80 and their doctors) will take part. The goal is to see …

Researchers are testing whether a virtual walking program can reduce chronic pain and psychological distress in people with severe mobility impairment, mostly from spinal cord injuries or polio. Participants wear a head-mounted display and use a controller to guide an avatar thro…

This study combines virtual reality with a gentle electrical pulse on the ear (called taVNS) to help people with chronic shoulder pain who are waiting for surgery. The goal is to see if this drug-free approach can reduce pain, anxiety, and depression. Only 10 people will take par…

This study tests a spinal cord stimulator that delivers fast-acting pain relief without the usual tingling sensation. About 177 adults with long-term back and limb pain will use the device. The main goal is to see if at least half of them get 50% or more pain reduction after 3 mo…

This study tests the long-term safety and effectiveness of an experimental drug called AXS-14 for people with fibromyalgia, a condition causing widespread pain and fatigue. About 300 adults who previously took part in a related study will receive AXS-14 for 52 weeks. Researchers …

This study tests a multidisciplinary program for adults with chronic back pain. Participants will attend group sessions on pain education, healthy habits, and emotional coping, plus do therapeutic exercises. The goal is to see if the program improves physical function, reduces fe…

This study tests a toolkit designed to help employees with chronic pain feel more confident managing their condition at work and stay productive. Over 600 workers from around 30 UK organizations will either use the toolkit or receive usual care. Researchers will measure work abil…

This study compares two ways to manage pain after total knee replacement: a continuous nerve catheter that delivers numbing medicine for days versus a single nerve block. Sixty-four adults scheduled for knee surgery will be randomly assigned to one of the two methods. Researchers…

This study tests a group-based parent training program called SPACE-Pain, originally developed for anxiety, to see if it is feasible and acceptable for parents of children aged 10-17 with chronic pain. The program teaches parents to reduce accommodation while staying warm and sup…

This study looks at whether a guided therapeutic writing program can help adult women with chronic pain and co-occurring mental health conditions. Participants will complete writing exercises focused on emotional processing and meaning-making over four weeks, then share their exp…

This study is testing a spinal cord stimulator that automatically adjusts its electrical pulses based on real-time nerve signals. The goal is to see if this smart device can better guide treatment for people with long-term pain in the trunk or limbs. The trial involves 250 partic…

This study compares two exercise programs for adults aged 65 and older living in residential care. One group does short, frequent 'exercise snacks' twice a day, while the other does longer, structured sessions a few times a week. Over 12 weeks, researchers will measure changes in…

This trial tests whether transcranial electrical stimulation (tES) — a safe, non-invasive technique that sends a mild electrical current through the scalp — can reduce pain and improve quality of life in children and adolescents aged 10 to 21 with juvenile fibromyalgia or other n…

This trial compares two pain medications, tramadol and tapentadol, to see which provides better pain relief after arthroscopic rotator cuff repair surgery. Adults aged 18-80 undergoing this elective shoulder surgery will receive one of the two drugs as part of a multimodal pain m…

This study tests two types of virtual reality therapy to see if they can reduce pain and improve daily function in people with chronic low back pain. Two hundred adults aged 18 to 85 with back pain lasting at least 6 months will use VR headsets for 8 weeks. Researchers will track…

This study tests a 12-week Pain Self-Management (PSM) program for people with chronic pain and opioid misuse or opioid use disorder. Researchers want to see if the program helps participants manage pain better and stay in treatment for opioid use. About 204 adults from primary ca…

This study tests two approaches to help people with opioid use disorder and chronic pain feel better. One is a pain self-management program with coaching and peer support. The other allows flexible dosing of buprenorphine based on pain levels. 268 adults from participating clinic…

This pilot trial tests whether Acceptance and Commitment Therapy (ACT), a type of talking therapy, can help disease-free cancer survivors manage chronic pain and reduce long-term opioid use. Participants attend six weekly virtual sessions with a psychologist. The study focuses on…

This study looks at whether offering yoga or physical therapy at opioid treatment programs can help people with chronic back pain and opioid use disorder feel better and use fewer opioids. About 180 adults will be randomly assigned to 12 weeks of yoga, physical therapy, or their …

This study tests whether microcurrent therapy—a very mild electrical stimulation—can reduce pain and improve daily life for people with fibromyalgia. About 50 adults will use a device at home alongside their usual pain care. The goal is to see if this simple, self-administered tr…

This trial tests whether slow intravenous ketamine infusions can safely reduce pain in people with fibromyalgia. Researchers will measure pain levels before and after treatment, and track how long any relief lasts. They will also look for traits that predict who responds best, ai…

This study compares three approaches for chronic back pain: Pain Reprocessing Therapy (PRT), Cognitive Behavioral Therapy (CBT), and usual care. Researchers want to see if PRT helps lower pain intensity and improve daily functioning. The trial enrolls 150 racially and ethnically …

This study tests whether combining virtual reality games with physical therapy can reduce chronic pain in children aged 7 to 21. Twenty participants with pain in the head, neck, or upper limbs will attend six weekly sessions. They will play VR games designed to encourage movement…

This study follows children aged 0 to 18 with chronic localized neuropathic pain who receive an 8% capsaicin patch as part of their routine care. Researchers will track whether the patch reduces pain and lessens the need for other pain treatments over six months. The goal is to s…

This study looked at whether taking a probiotic supplement for 8 weeks could reduce inflammation and pain in teenagers (ages 13-17) who have chronic pain and a body mass index at or above the 85th percentile. Researchers measured changes in a blood marker of inflammation (C-react…

This study tests a telehealth program called MCBMAP that combines counseling and skills training to help people with HIV reduce chronic pain and unhealthy drinking. The program is delivered entirely through video calls and online materials, making it easier for participants to jo…

This early study tests whether a non-invasive brain stimulation technique called TMS can help reduce pain, fatigue, and brain fog in people with fibromyalgia. About 30 adults will receive multiple TMS sessions and undergo MRI scans to see how the brain changes. The goal is to gat…

This phase 2 trial will test whether extended-release ketamine tablets can reduce pain in 65 adults with complex regional pain syndrome (CRPS), a chronic condition causing severe, often burning pain. Participants will take either 80 mg or 160 mg of ketamine daily for several week…

This study looks at whether combining mindfulness training (MBSR) with an open-label placebo—a pill that patients know has no active drug—is a practical way to help people with chronic pain. Researchers will randomly assign 45 adults to receive either mindfulness alone, the place…

This study tests an 8-week app-based breathing program that uses heart rate feedback to help people with chronic migraine. Thirty adults will use the app daily for 10 minutes, and researchers will track changes in migraine frequency and psychological well-being. The goal is to se…

This study tests whether watching a video of an avatar receiving acupuncture — and vividly imagining the treatment on oneself — can reduce chronic low back pain. Adults aged 18 to 60 with persistent back pain for over six months will either watch real or sham acupuncture imagery …

This study tests whether acceptance and commitment therapy (ACT) helps adults with chronic non-malignant pain (pain lasting 3+ months not caused by cancer). Sixty participants are randomly assigned to ACT, cognitive behavioral therapy (CBT), or standard medical care alone. Both A…

This study tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) and a smartphone care management app can help people with both opioid use disorder and chronic pain. About 127 adults already on buprenorphine treatment will try one or both tools. The …

This pilot study tests whether a 2-hour mindfulness training program, called Mindfulness-Oriented Recovery Enhancement (MORE), can help people living with both HIV and chronic pain. The study enrolls 40 adults with HIV who also have chronic pain and are willing to avoid new treat…

This study tests whether combining pain neuroscience education (teaching people how the brain processes pain) with therapeutic exercise helps people with fibromyalgia or chronic low back pain. Participants attend exercise sessions three times a week and one education session week…

This study tests whether an online pain coping skills training program can reduce joint, bone, and muscle pain in breast cancer survivors who take aromatase inhibitors (AIs). Participants are women who have completed primary cancer treatment and experience AI-related joint pain. …

This study tests a small implanted device that sends mild electrical pulses to nerves to relieve chronic pain from injury or surgery. About 89 adults with long-lasting pain in the back, shoulder, knee, or foot will either get the implant plus usual care or usual care alone. The g…

This study tests whether adding monthly booster sessions to standard cognitive behavioral therapy (CBT) helps people with chronic pain manage their symptoms better over 18 months. About 716 military health system beneficiaries with chronic pain will receive either standard CBT or…

This study tests whether two non-invasive brain stimulation techniques—transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound (TUS)—can reduce chronic pain in people with diabetic neuropathy. Participants, aged 40 to 80 with foot pain lasting at least 6 months…

This study tests a 9-week virtual group program that teaches mindfulness, yoga, nutrition, and self-massage to help people with chronic pain. It is being offered at Federally-Qualified Health Centers, which serve low-income patients. The goal is to see if the program can be succe…

This study tests whether a directed massage technique works better than a classic symmetrical massage for people with long-term back or neck pain that hasn't improved with other treatments. Fifty adults aged 18 to 80 will receive both types of massage, and researchers will measur…

This study looks at whether pre-recorded yoga videos are as helpful as live online yoga classes for veterans with chronic pain. About 98 veterans will take part, first attending a 5-session primer, then practicing yoga for 12 weeks either on their own with videos or in a live VA …

This study tests whether a very low dose of naltrexone, a drug usually used for addiction, can reduce pain and other symptoms in people with Complex Regional Pain Syndrome (CRPS). Forty adults with CRPS will receive either the drug or a placebo for six months. The main goal is to…

This study was designed to compare two types of nerve-blocking procedures for people with long-term knee pain from osteoarthritis. The goal was to see if targeting six nerves works better than the usual three nerves for reducing pain and improving daily function. The trial was wi…

This study tests a special nerve cap (Axoguard Large-Diameter Nerve Cap) in 15 adults who have had a limb injury or amputation. The cap is placed over the cut nerve end to protect it and may help reduce chronic nerve pain. The goal is to see if the cap is safe and works well befo…

This early-phase trial tests whether adding lacosamide, a drug normally used for seizures, can safely help people with chronic pancreatitis who still have abdominal pain despite taking opioids. The study involves 21 adults who will take lacosamide for 7 days alongside their usual…

This study tests Pain Reprocessing Therapy (PRT) for adults with chronic primary pain that may be due to a nociplastic pain mechanism. PRT includes education to reframe pain as a false alarm and specific techniques to reduce it. The trial involves 12 participants in Norwegian pri…

This Phase 3 trial tests whether a nurse-led phone program can help rural veterans better manage chronic pain. Over 600 participants will receive either the program or a one-time education session, and researchers will track pain interference for 12 months. The goal is to improve…

This study tests whether getting Chuna manual therapy every two weeks for 20 weeks helps people with mild but long-lasting neck pain feel better and have fewer flare-ups. 250 adults with neck pain for over a year will be split into two groups: one gets the hands-on therapy, the o…

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study compares two types of spinal cord stimulation—high frequency and burst—for treating chronic back and leg pain. Seven adults who are candidates for spinal cord stimulation will be randomly assigned to one waveform and tracked for at least 36 months. The goal is to see w…

This study tests a special spinal cord stimulator that automatically adjusts to your pain signals. It involves 70 adults with long-term pain in the back, arms, or legs. The goal is to see if the device safely reduces pain over time.

This study tests a small, battery-powered headband that delivers a gentle electrical pulse to the scalp to help reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is …

This study aimed to see if a one-hour session of inhaled nitrous oxide (laughing gas) could reduce pain in people with fibromyalgia. It was designed for adults aged 18-75 with moderate to severe pain. However, the study was withdrawn before any participants were enrolled, so no r…

This study tests whether a group program called Partners4Pain, which teaches mind-body skills like meditation, relaxation, and gentle exercises, can reduce pain and improve daily life for people with chronic back or neck pain. About 376 adults will be randomly assigned to either …

This study tests whether two 90-minute pain science education sessions can help 54 adults with fibromyalgia living in rural Spain. The sessions aim to change how patients think about pain, using simple language and metaphors. Researchers will measure pain sensitivity, daily funct…

This study tests a spinal cord stimulator (BurstDR) to relieve chronic pain from diabetic neuropathy. Twenty adults with long-lasting leg pain will try a temporary device for one week. If their pain drops by at least half, they can get a permanent implant. The study tracks pain l…

This study compares two minimally invasive procedures to treat chronic pelvic pain: laparoscopic presacral neurectomy and fluoroscopically guided nerve block. Sixty-two adults with pelvic cancer-related pain who still have significant pain despite standard treatment will be rando…

This study tests whether a type of pain education that teaches the brain's role in pain, combined with motivational interviewing, can reduce chronic pain in breast cancer survivors. 156 women who have finished primary treatment and still have pain will be randomly assigned to thi…

This study tests a treatment called Hypnosis Enhanced Cognitive Therapy (HYPCT) for people with new spinal cord injuries who are in rehab. It compares HYPCT to standard pain education to see if it can lower pain intensity and prevent chronic pain. Participants will attend four se…

This study looks at whether supervised physical activity helps people with fibromyalgia stay active longer than just getting advice. Fibromyalgia causes pain and fatigue, and inactivity can make symptoms worse. The study involves 330 adults who are currently sedentary. Researcher…

This study tests whether adding a non-invasive brain stimulation technique called rTMS to a three-week intensive pain rehabilitation program can help youth aged 10-18 with severe chronic pain. The goal is to see if the stimulation can reduce pain and improve daily function, mood,…

This study tests whether a nurse care management program can help rural adults with chronic pain feel better and function more in daily life. The program includes care coordination, cognitive behavioral therapy, and referrals to an exercise program. About 450 rural patients will …

This study tests whether online group cognitive behavioral therapy (CBT) is a practical way to help adults with cerebral palsy who have chronic pain. Fourteen participants will attend weekly virtual therapy sessions for 12 weeks. The main goal is to see if people will stick with …

This study tests a 24-week program called SC-POWR for 204 adults with opioid use disorder and chronic pain. Participants get medication, therapy, exercise (like Wii Fit and Tai Chi), and stress reduction (relaxation training and acupuncture). The goal is to reduce pain interferen…

This study aimed to see if a device called Sana could improve quality of life for people with fibromyalgia, a condition that causes long-term pain. Researchers planned to compare the active device to a sham (fake) device in adults aged 18 to 65 who had fibromyalgia symptoms for a…

This study is testing a new device that uses gentle vibrations on the belly, back, or temples to help people with chronic pain conditions like pelvic pain, abdominal pain, low back pain, or migraine. About 50 adults will try the real device or a placebo to see if it safely reduce…

This study tests whether virtual reality (VR) meditation can improve sleep and reduce anxiety in people with chronic pain and insomnia. About 30 adults with both conditions for at least 6 months will use VR meditation and track their sleep, pain, and mood. The goal is to see if t…

This study tests whether a digital version of cognitive behavioral therapy for insomnia (CBT-I) can improve sleep and reduce pain in 140 adults with chronic pain and insomnia. Participants will either receive the digital CBT-I program or digital sleep hygiene education. The goal …

This study is testing a new program led by physiotherapists to help teens and young adults (ages 12-25) who have had muscle or joint pain for at least 3 months. The program focuses on gradually increasing physical activity and reducing fear of movement. The goal is to see if this…

This study tests two telehealth-based treatments—brief pain education and 10 weeks of physical therapy—to help 500 adults with chronic low back pain. The goal is to improve pain management and reduce opioid use in community health centers. Participants receive sessions via phone …

This study explores whether low-intensity focused ultrasound (LIFU) can temporarily change brain activity to reduce chronic pain. Eighty adults with moderate-to-severe pain lasting at least 3 months will receive brain scans, pain tests, and questionnaires over 10 weeks. The goal …

This study is testing a full-spectrum cannabis extract containing CBD and THC in 36 women with fibromyalgia, a condition causing widespread pain, fatigue, and sleep problems. Participants will receive different doses over six months to see if it improves symptoms and quality of l…

This study tests whether stationary cycling (at a voluntary or assisted pace) and a type of psychotherapy called I-STOP can reduce drug cravings in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will try these approaches alone or toget…

This study looks at whether adding a mobile app that guides teens through physical exercise and mindfulness training can make standard pain rehabilitation more effective. About 60 teens aged 13-19 with long-term pain will either get the app plus a shorter hospital program, or the…

This study compares two types of nerve blocks—interscalene and suprascapular—for controlling pain after arthroscopic shoulder surgery. 84 adults having shoulder arthroscopy will receive one of the blocks, and researchers will measure pain levels and side effects. The goal is to f…

This study looks at whether a special type of massage therapy, designed to be sensitive to trauma and different cultures, can help refugees and asylum seekers who survived torture or war. About 50 people will either get their usual care plus this massage, or just usual care. The …

This study tests whether combining pain neuroscience education (teaching patients about how pain works) with a gradual, timed increase in physical activity can reduce chronic pain in breast cancer survivors. About 122 survivors who have finished cancer treatment will be randomly …

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study tests a small, implantable device that stimulates nerves to relieve chronic pain after injury or surgery. About 185 adults with peripheral neuralgia will either receive the stimulator plus standard medical care or standard care alone. The goal is to see if the device p…

This study tests whether an 8-week mindfulness yoga program, done mostly at home via video calls, can reduce the impact of fibromyalgia. Sixty-four adults with fibromyalgia are randomly assigned to either the yoga program or standard physiotherapy. The goal is to see if yoga impr…

This study planned to test whether a small vibrating bee with ice-pack wings, called Buzzy, could reduce pain during IV placement in adults with chronic pain who receive lidocaine infusions. Participants would have rated their pain and satisfaction after IV insertion. However, th…

This study tests whether a brief education and self-management program with home exercises can reduce pain and improve daily function in adults with long-lasting jaw pain (TMD) as effectively as more intensive hands-on physiotherapy. Forty adults aged 18–65 with jaw pain for at l…

This study explores whether shining specific colors of light into the eyes can help people with chronic low back pain or fibromyalgia feel less pain. Sixty adults will use a portable light device for 2 hours daily over 5 days. The goal is to see if this approach is practical and …

This study tests whether a nasal spray containing oxytocin, a natural hormone, can reduce pain and improve function in people with chronic pain. About 336 adults with nerve, muscle, or pelvic pain will try two doses of oxytocin and a placebo spray over several weeks. The goal is …

This study looks at whether slow breathing techniques can help women with fibromyalgia improve their heart rate control and exercise performance. About 159 women will be randomly assigned to breathe slowly (with or without a visual guide) or normally before doing arm curls. Resea…

This study tests whether yoga can reduce nerve pain caused by chemotherapy in cancer survivors. About 227 participants will either take yoga classes twice a week for 8 weeks, attend educational sessions, or receive standard care. Researchers will measure pain, balance, fall risk,…

This Mayo Clinic study tests whether a virtual reality meditation program called TRIPP can reduce the impact of fibromyalgia. Forty adults with fibromyalgia will use either the active VR meditation or a sham (fake) VR experience for two weeks each. Researchers will measure change…

This study tests a personalized yoga coaching program for people with lupus who have chronic pain. Fifteen participants work with a coach to create a yoga practice that fits their needs and limits. The goal is to see if the program is feasible and if it helps reduce pain. It is a…

This study tests whether daily listening to jazz music combined with mindfulness can reduce chronic pain and anxiety. About 90 adults with chronic pain and moderate-to-severe anxiety will listen to jazz recordings daily for 4 weeks. Researchers will measure changes in pain intens…

This study looks at whether a digital health program (Hinge Health) plus a wearable pain relief device (Enso) can help people with chronic low back pain feel better and move more easily. About 196 adults with back pain for at least 3 months will be randomly assigned to either the…

This study looks at whether a single session of mild electrical brain stimulation (tDCS) over the cerebellum can help reduce pain in women with fibromyalgia. About 92 right-handed women aged 18-65 with confirmed fibromyalgia and moderate-to-severe pain will receive the stimulatio…

This study looks at whether pranayama breathing exercises can help people with fibromyalgia feel less pain, anxiety, and sleep better. About 54 adults with fibromyalgia will practice these breathing techniques. The goal is to see if this gentle, low-cost approach can improve qual…

This study tests whether a combined therapy (Acceptance and Commitment Therapy plus Mindfulness-Based Relapse Prevention) can reduce how much pain interferes with daily life in veterans who have both chronic pain and opioid use disorder. About 157 veterans taking buprenorphine fo…

This study looks at adults with chronic pain who receive ketamine infusions at Stanford's Pain Management Center. Researchers want to understand which patients improve and what factors predict a good response. The goal is to better tailor this treatment to individuals.

This study planned to test whether virtual reality-based guided mindfulness meditation could help adults with anxiety, depression, stress, or pain feel better. Researchers wanted to see if using VR meditation was practical and if it improved mood and pain scores. However, the stu…

This study compares a multidisciplinary treatment (combining pain management, pelvic floor therapy, and mucosal care) with standard care for women suffering from chronic vulvar pain (vulvodynia) lasting at least 3 months. About 106 women aged 18 and older will participate. The go…

This study compares personalized electro-acupuncture and auricular-acupuncture against usual care for treating chronic pain in adults with musculoskeletal pain or fibromyalgia. Participants are split into three groups: two receive different acupuncture methods, and one receives s…

This study tests a program called COMPASS-NP for home care workers who have chronic pain. The program combines pain education, coping strategies, and safety tips, led by a trained peer. About 140 workers will take part to see if it reduces how much pain interferes with their work…

This study tests whether a single, two-hour pain relief skills session called Empowered Relief can reduce chronic pain after a cesarean delivery. Sixty women who still have moderate to severe pain six weeks after their C-section will attend the session and be followed for 12 week…

This study tests whether daily exposure to green LED light can reduce chronic pain. 55 adults with conditions like fibromyalgia or nerve pain will use a green or white light device at home for 2 hours each day over 3 months. Researchers will measure changes in pain levels, medica…

This study tests a treatment that combines two therapies (ACT and MBRP) to help people with both chronic pain and opioid use disorder. About 160 adults already on buprenorphine will be randomly assigned to either this combined therapy or their usual care. The goal is to see if th…

This study tests whether a single dose of ketamine, given while patients are sedated, can reduce chronic pain and depression symptoms. Forty adults with both conditions will receive either ketamine or a placebo (saline) during sedation with propofol. Researchers will track pain a…

This study tested whether two types of gentle brain stimulation (tDCS and TUS) can reduce pain and improve daily function in people with chronic knee osteoarthritis. 64 adults with persistent knee pain received either real or sham stimulation. Researchers measured changes in pain…

This study tests whether two types of gentle brain stimulation—tDCS and TUS—can reduce pain and improve daily function in people with chronic low back pain. Researchers will compare active stimulation to a sham (fake) treatment in 40 adults aged 18-85 who have had persistent back…

This trial gave multiple infusions of a patient's own stem cells to treat chronic muscle and joint pain that had lasted at least a year. The patient received six infusions over about 32 weeks, with safety checks and pain scores tracked throughout. The goal was to see if this appr…

This study looks at whether cannabis oil can help reduce pain and improve sleep and quality of life in people with fibromyalgia who have not found relief from other treatments. Researchers will track pain levels, side effects, and how well patients stick to the treatment. The goa…

This study tests whether a mindfulness program called MORE can help people with long-term cancer pain. 76 adults with a history of cancer and ongoing pain will either learn mindfulness skills or continue their usual care. The goal is to see if this approach is practical and helpf…

This study tests a psychological treatment called Pain Reprocessing Therapy (PRT) for people with chronic widespread pain, including fibromyalgia. PRT teaches patients that pain can come from 'stuck' brain patterns and helps them retrain their brain to stop sending false pain ala…

This study tests whether a gentle electrical brain stimulation device, used at home, can reduce chronic pain in people with rheumatoid arthritis whose inflammation is already well-controlled. Thirty-four participants will either receive real or sham stimulation over several sessi…

This study aims to find out if spinal cord stimulation (SCS) truly reduces pain or if the effect is just due to patients' expectations. Twenty-five adults with chronic pain who already have an SCS implant will take part in four test sessions. During each session, the stimulator w…

This study looks at whether the number of pain sites or the type of pain (constant vs. intermittent) is linked to physical function in people with knee osteoarthritis. Researchers will measure function with a chair stand test and pain with questionnaires and pain drawings. The go…

This early-phase study looks at whether a common blood pressure drug, hydrochlorothiazide, can affect chronic pain in people who already have a spinal cord stimulator implant. About 36 adults with chronic low back pain and high blood pressure will take the drug or a placebo for t…

This study explores whether wearable devices can continuously monitor physiological signals, sleep, and physical activity in adolescents with chronic musculoskeletal pain. The goal is to develop objective digital measures of pain that could improve diagnosis and treatment. Resear…

This study aims to find out whether a person's genes and clinical profile can predict who will develop acute or chronic pain after major surgery. Researchers will follow 10,000 patients for one year after their operation, tracking pain levels and daily functioning. The goal is to…

This study looks at how brain networks synchronize in people with fibromyalgia, a condition causing widespread pain. Researchers will use EEG and fMRI to measure brain activity and test a gentle brain stimulation technique called HD-tDCS. The goal is to understand pain processing…

This study is looking at why some people develop persistent pain after breast cancer surgery while others do not. Researchers will follow 220 adults undergoing breast cancer surgery, using questionnaires and a pain sensitivity test to identify risk factors. The goal is to find re…

This study asks how long a spinal cord stimulator (SCS) trial should last to accurately predict whether it will relieve chronic pain. People with chronic pain undergoing a standard SCS trial will fill out daily surveys about their pain and function. The goal is to find the shorte…

This study aims to improve how doctors diagnose and treat chronic muscle and joint pain by using simple questionnaires and pain sensitivity tests. Researchers will study 250 adults with conditions like osteoarthritis, fibromyalgia, chronic low back pain, or inflammatory arthritis…

This study compares three psychological treatments—CBT, ACT, and EAET—for adults with chronic back or neck pain. Researchers want to understand how each therapy works and which patients benefit most. 408 participants will receive weekly online therapy for 8 weeks and be followed …

This study investigates factors that may influence cognitive skills—like memory, attention, and problem-solving—in women diagnosed with fibromyalgia. Researchers will assess thinking abilities using a detailed cognitive test and measure how fibromyalgia affects daily life. The go…

This study explores how women with fibromyalgia experience pain using a smartphone app with animations and body maps. Participants will describe their pain by choosing and adjusting animations that match their sensations. The goal is to find better ways to measure pain quality an…

This study tests a new imaging method to see if white blood cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome. Participants receive their own white blood cells tagged with a radioactive tracer, then undergo a brain PET/MRI scan. Th…

This study surveys 350 adults with hemophilia to better understand chronic pain—its type, location, and impact on daily life. Participants fill out questionnaires about their pain history, medication use, and emotional well-being. The goal is to help doctors recognize and treat p…

This study aims to develop a screening test for a pain control mechanism called DNIC, which is often faulty in people with chronic pain. Researchers will use cameras to capture facial expressions during pain tests and apply artificial intelligence to see if they can automatically…

This study looks at how stress affects the brain and body in 70 teenagers (ages 11-17) with chronic widespread pain. Participants will have an MRI scan while experiencing mild heat pain, and provide saliva samples to measure stress hormones. The goal is to understand the link bet…

This study looks back at medical records of 200 adults with Complex Regional Pain Syndrome (CRPS) to see which pain treatments doctors actually use first and how well they work. Researchers want to find patterns that could help choose the best treatment for each person. No new tr…

This study planned to use Apple Watches to track physical activity, diet, and environment in children with complex regional pain syndrome (CRPS) to identify what triggers sudden severe pain. However, the study was withdrawn before enrolling any participants, so no data was collec…

This study reviewed the medical records of 2500 people who received hyperbaric oxygen therapy (HBOT) for conditions like traumatic brain injury, stroke, fibromyalgia, or age-related decline. Researchers compared computerized thinking and memory tests taken before and after treatm…

This study gathers opinions from 30 healthcare experts, including physiotherapists and midwives, to decide the best way to teach women about pain during and after childbirth. The goal is to create a standard pain education program that can be tested in future studies. No treatmen…

This study looks at how the nervous system becomes overly sensitive in people with different types of chronic pain. Researchers will assess 185 adults using questionnaires, thinking tests, and laser brain-wave measurements at the start and after one year. The goal is to better un…

This study aims to see if a short, 4-question Turkish version of the Pain Anxiety Symptom Scale is a reliable and valid tool for measuring pain-related anxiety. Researchers will enroll 350 adults aged 18-65 who have had chronic pain for at least 3 months. Participants will fill o…

This study is testing a Turkish version of a questionnaire that looks at how chronic pain conditions like fibromyalgia and back pain affect sexual function and satisfaction. Researchers will ask 170 people with chronic pain and a stable partner to fill out the survey. The goal is…

This pilot study looks at whether light, self-paced swimming is a tolerable activity for people with ME/CFS and related conditions like Long COVID and fibromyalgia. Participants will swim for 15-30 minutes at their own pace and track symptoms and heart rate variability using an a…

This observational study will follow 384 patients in Brazil who are using cannabis-based products (like CBD or THC oils) prescribed by their own doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients' quality of life,…

This study is investigating whether bruxism (teeth grinding or clenching) is associated with pelvic pain, erectile dysfunction, and anxiety in young men aged 18-30. Researchers will use questionnaires and physical exams to assess 100 participants. The goal is to better understand…

This study explores whether bruxism (teeth grinding or clenching) is related to pelvic floor dysfunction in young women aged 18-30. Researchers will use questionnaires and physical exams to assess jaw function, pelvic floor symptoms, and anxiety in 100 participants. The goal is t…

This study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …

This study looks at whether matching adults with chronic pain to specific psychological treatments—like cognitive behavioral therapy, mindfulness, or hypnosis—based on their personal traits (such as brain activity or thinking patterns) leads to better pain relief. Researchers wil…

This study is enrolling 120 adults with Complex Regional Pain Syndrome (CRPS) to see if certain blood clotting factors are linked to how well they respond to neridronic acid treatment. Researchers will measure pain levels before and after treatment. The goal is to find markers th…

This study follows 100 people with combat-related limb injuries to see if the mechanics of the injury—like force and direction—can predict who will develop chronic pain. Researchers will track pain levels at 3 and 6 months. The goal is to find early warning signs so doctors can s…

This study from Stanford University aims to find biological markers that can tell doctors whether a person with chronic musculoskeletal pain is likely to recover or develop long-term disability. Researchers will follow 250 adults aged 18-80, using questionnaires and possibly imag…

This study aims to validate a self-report questionnaire that people with Complex Regional Pain Syndrome (CRPS) can fill out at home. Researchers will compare the self-report results with in-person clinical exams to see if the questionnaire accurately measures symptom severity and…

This study reviews the medical records of 20 adults who had a limb amputated to relieve severe, long-lasting pain from complex regional pain syndrome (CRPS). Researchers want to measure how many days pass between the amputation and when patients first use a functional prosthetic …

This study uses a driving simulator to test whether people with chronic pain can drive safely while taking oral opioids. 450 participants with a valid driver's license will be tested on measures like weaving and reaction time. The goal is to provide better guidance to patients an…

This study looks at whether stressful or traumatic life events increase the chance of developing fibromyalgia. Researchers will follow 534 adults—some with rheumatic diseases and some healthy—for one year, checking for new fibromyalgia cases. The goal is to better understand how …

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study tests whether green light can reduce pain by looking at brain activity in 30 healthy adults. Participants are exposed to green or white light for two hours while researchers measure pain pathways and brain waves. The goal is to understand how green light works, not to …

This study looks at women who have both chronic pain conditions (central sensitization syndromes) and post-traumatic stress disorder (PTSD). First, researchers will identify different psychological patterns in these women. Then, they will test a personalized talk therapy approach…

This study looks at whether the dose of sufentanil, a strong painkiller given during non-major abdominal surgery, is linked to chronic pain 3 months after the operation. Researchers will interview 855 patients by phone to check for pain and its severity. The goal is to identify a…

This study aims to create a decision aid to help patients on long-term opioid therapy and their doctors have better conversations about safely reducing or stopping opioids. Researchers will interview patients and doctors to understand their experiences, then test the tool with 30…

This study was designed to explore what kinds of feelings (like touch or tingling) could be created by electrically stimulating the spinal cord in people with amputations who experience phantom limb pain. Researchers planned to work with patients who already had a spinal cord sti…

This study follows 275 teens aged 11–18 with chronic muscle or joint pain to find biological and behavioral markers that predict recovery versus ongoing pain. Researchers measure pain intensity and how much pain limits daily activities. The goal is to better understand why some t…