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Can retraining the brain ease chronic pain? small trial hopes to find out

NCT ID NCT07287072

Symptom relief Sponsor: University of Oslo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests Pain Reprocessing Therapy (PRT) for adults with chronic primary pain that may be due to a nociplastic pain mechanism. PRT includes education to reframe pain as a false alarm and specific techniques to reduce it. The trial involves 12 participants in Norwegian primary care and measures pain intensity and physical function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pain Reprocessing Therapy (behavioral intervention)
What this could lead to
If successful, this could offer a new, effective treatment option for chronic pain patients in primary care, potentially reducing the need for specialist referrals.
What could go wrong
This is a very small pilot study with only 12 participants, so results may not apply broadly. The therapy is new and its long-term benefits are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 12 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2026

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 70 * On sick leave, or at risk of sick leave * Pain intensity corresponding to 3 (or more) on the NRS from the PROMIS-29. * Readiness to change, corresponding to the action stage from the readiness to change model, where they are ready to participate in their own change process Exclusion Criteria: * Structural causes for their pain (rheumatoid arthritis, cancer, etc.), * Severe psychiatric conditions (ongoing or previous psychotic disorders, suicidality, or severe depression/anxiety/bipolar disorder) * Illegal substance abuse, or known dependence on benzodiazepines or opioids * Ongoing litigation or compensation process related to the pain condition * Ongoing and severe psychosocial stressors (e.g. recent divorce etc.)

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Conditions

The condition(s) this trial relates to.

Chronic Pain chronic pain syndrome Nociplastic Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic primary pain Nociplastic pain

Contacts and locations

Locations

  • Ullevål sykehus

    Oslo, Norway

More trials for these conditions

Other studies related to the condition(s) this trial covers.