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Which talk therapy works best for chronic pain? new study aims to find out

NCT ID NCT06044649

Knowledge-focused Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares three psychological treatments—CBT, ACT, and EAET—for adults with chronic back or neck pain. Researchers want to understand how each therapy works and which patients benefit most. 408 participants will receive weekly online therapy for 8 weeks and be followed for 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cognitive Behavioral Therapy, Acceptance and Commitment Therapy, Emotional Awareness and Expression Therapy
What this could lead to
If successful, this could help doctors match chronic pain patients to the most effective psychological therapy, improving pain management without drugs.
What could go wrong
This is a mechanistic study, not a treatment trial. It may not lead to new treatments, and results may not apply to all pain types or people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

408 people

The number who actually took part.

Started

Nov 2023

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Back/neck is primary pain location (e.g., back/neck pain greater than leg pain) * Pain for at least 3 months and experienced 4 or more days/week for the past 6 months * Pain intensity last week is \>= 3 (0 to 10 rating scale) * Pain interference last week is \>= 3 (0 to 10 rating scale) * At least age 18 * Lives in United States * Fluent in English * Has personal computer/tablet and internet access * Able to attend weekly sessions * Willing to be randomized * Seeking to improve their pain-related status via a psychological therapy Exclusion Criteria: Past 2 years (treated for or having experienced): * Complex regional pain syndrome * Epilepsy/seizure disorder * Autoimmune disease * Liver disease * Cancer * Heart disease * Substance dependence or use disorder * Schizophrenia or other psychotic disorder * Bipolar disorder * Obsessive-compulsive disorder * Borderline personality disorder * Suicide attempt or suicide intention or impulse Also: * Major medical procedure scheduled within next 9 months * Applied for/ litigating for pain-related disability/worker's compensation (past year). * Major life event/stressor in past 6 months * Cognitive impairment (screener score \<=4)

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Conditions

The condition(s) this trial relates to.

Back Pain Chronic Pain chronic pain syndrome Neck Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Back pain Chronic pain Neck pain

Contacts and locations

Locations

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

  • Wayne State University

    Detroit, Michigan, 48202, United States

More trials for these conditions

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