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120,000-Person study hopes to crack the code of chronic illness

NCT ID NCT04306939

Knowledge-focused Sponsor: University of Pittsburgh Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common disease mechanisms and potential new uses for existing drugs.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify new drug targets and ways to repurpose existing medications for multiple chronic diseases.
What could go wrong
This is an observational study, not a treatment trial. It is currently suspended, and results may take years to translate into actual therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2014

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients seen in a UPMC facility with available electronic health records

Ages

12 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Case Subjects * Clinical diagnosis of a chronic disease or disorder (ex. pancreatitis, hepatitis or fatty liver, inflammatory bowel disease, irritable bowel syndrome, diarrhea, constipation, chronic pain syndromes, diabetes, hypertension, cardiovascular disease, chronic kidney disease, chronic neurologic disorders, rheumatological disorders, endocrine disorders, chronic pulmonary diseases, sinorespiratory disorders, chronic skin diseases, cancers and related disorders) * Ability to read and write in English; * Ability to provide informed consent Control Subjects • UPMC patients age 12 years without a chronic disorder. Exclusion Criteria: * Chronic infectious disease as the primary medical problem * Less than 12 years of age * Inability of the subject to understand the protocol * Inability to the subject provide informed consent

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Conditions

The condition(s) this trial relates to.

acute pancreatitis celiac disease cholecystitis cholelithiasis chronic diarrheal disease Chronic Disease chronic kidney disease Chronic Pain chronic pain syndrome chronic pancreatitis chronic renal failure syndrome congenital bile acid synthesis defect constipation disorder Crohn disease cystic fibrosis diabetes mellitus Dyslipidemias exocrine pancreatic insufficiency Fibrosis gastritis hepatitis hyperlipidemia inflammatory bowel disease inherited lipid metabolism disorder irritable bowel syndrome metabolic dysfunction-associated steatohepatitis metabolic dysfunction-associated steatotic liver disease multiple sclerosis Pancreatic Cyst pancreatic intraductal papillary-mucinous neoplasm pancreatitis primary biliary cholangitis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute pancreatitis Bile acid synthesis defect Biliary cirrhosis Celiac disease Cholecystitis Cholelithiases Chronic disease Chronic kidney diseases Chronic pain Chronic pancreatitis Constipation - functional Constipation chronic idiopathic Crohn disease Cyst pancreas Cystic fibrosis Diabetes mellitus Diarrhea chronic Dyslipidemias Gastritis Hepatitis Inflammatory bowel diseases IPMN Irritable bowel syndrome Multiple sclerosis NASH - nonalcoholic steatohepatitis Pancreatic exocrine insufficiency Rheumatoid arthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Pittsburgh Medical Center

    Pittsburgh, Pennsylvania, 15213, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.