CROHN DISEASE

This study tests whether taking fecal transplants (processed stool from healthy donors) in capsule form can help control inflammation in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hund…

This study looks at two treatment paths for people with Crohn's disease that has caused narrowing (strictures) in the bowel. One group gets surgery early, while the other tries biologic drugs first and only has surgery if needed. The goal is to see which approach helps patients f…

This study aims to see if a computer program that calculates a personalized dose of infliximab based on blood tests can help children with Crohn's disease achieve deep remission better than the usual dosing method. About 180 children and young adults newly diagnosed with Crohn's …

This study looks at whether taking prebiotics (a type of fiber) can improve gut health in people with ulcerative colitis, a form of inflammatory bowel disease. About 70 adults with active symptoms will take a prebiotic supplement for 8 weeks. Researchers will track changes in sym…

This program provides early access to upadacitinib, an investigational drug, for people with Crohn's disease, ulcerative colitis, certain types of arthritis, or atopic dermatitis. It is for those who have no other suitable treatment options and cannot join a clinical trial. A doc…

This study tests whether adding a special nutrition drink to standard dietary advice helps people with inflammatory bowel disease (IBD) who are at risk of malnutrition. About 146 adults with Crohn's disease or ulcerative colitis will either receive only nutritional counseling or …

This study tests whether the experimental drug icotrokinra can reduce symptoms and intestinal inflammation in people with moderate-to-severe Crohn's disease. About 1,092 participants will receive either icotrokinra or a placebo. The goal is to see if the drug leads to clinical re…

This study looks at the long-term safety of a medicine called tulisokibart for people with moderate to severe Crohn's disease or ulcerative colitis. Participants who already took tulisokibart in an earlier study can join. The main goal is to see if the drug remains safe and toler…

This study tests whether the drug guselkumab can help people with Crohn's disease whose current treatment (ustekinumab) has stopped working. About 78 Chinese adults with active Crohn's will receive guselkumab and be followed for 48 weeks. The goal is to see if the drug can bring …

This pilot study tests whether combining a weight-loss medication (tirzepatide) with a special diet can help control mild Crohn's disease in people who are already on biologic therapy. The study includes 24 adults with a BMI of 27 or higher. The goal is to see if this approach is…

This study compares two treatments for children with Crohn's disease: a single drug (infliximab or an immunosuppressant) versus a combination of both. The goal is to see which approach better controls the disease and leads to remission. About 128 children aged 6 to 18 with active…

This study is for people with moderate-to-severe Crohn's disease who have a narrowed intestine causing blockages. Researchers are testing a treatment plan centered on the drug ustekinumab to see if it can improve symptoms, reduce inflammation, and help patients avoid surgery or t…

This study tests whether adding an experimental drug (LY4395089) to the existing treatment mirikizumab works better than mirikizumab alone for adults with moderate-to-severe Crohn's disease. About 60 participants will be followed for 62 weeks to see if the combination improves bo…

This early-phase study tests a new stem cell treatment for people with Crohn's disease who have complex anal fistulas that did not get better with standard care. The treatment uses donated fat-derived stem cells injected directly into the fistula to reduce inflammation and help i…

This study is testing whether a remote monitoring app can help people with active inflammatory bowel disease (Crohn's or ulcerative colitis) spend more time feeling well. About 290 adults whose disease is active enough to need a change in medication will use the app to track symp…

This study aims to see if robotic surgery is a safe and effective option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to the standard laparoscopic approach, looking at things like bloo…

This study tests whether statins, a common cholesterol-lowering drug, can prevent strictures (narrowing of the intestine) in adults with Crohn's disease. About 20 people who need surgery for strictures will take either statins or a placebo daily for 6-12 months. Researchers will …

This study tests whether a diet that removes refined and intolerant foods can help people with Crohn's disease stay in remission after bowel surgery. Researchers will track quality of life and nutrition in 35 participants. The goal is to develop a practical dietary plan for Chine…

This study tests whether a stem cell transplant followed by the drug vedolizumab can help people with severe Crohn's disease that hasn't responded to other treatments. About 50 adults with active Crohn's will receive high-dose chemotherapy, a stem cell transplant, and then vedoli…

This study is testing several new treatments for adults with moderate to severe ulcerative colitis or Crohn's disease. About 60 participants will be assigned to one of the treatment groups. The goal is to see if these treatments are safe and effective over at least 62 weeks.

This study tests whether treating Crohn's disease to a target of full gut wall healing (transmural healing) is better than treating symptoms alone. About 304 adults with moderate-to-severe Crohn's will be randomly assigned to one of two treatment strategies over 48 weeks. One gro…

This study tests whether combining two drugs (upadacitinib and ustekinumab) is more effective than increasing the dose of just one drug for people with Crohn's disease who didn't get better with standard treatment. About 214 adults with active Crohn's will be randomly assigned to…

This study tests whether guselkumab works better than risankizumab for people with moderate to severe Crohn's disease, a condition that causes painful gut inflammation. About 530 adults will receive one of the two drugs and be followed for a year. The main goal is to see who achi…

This study tests whether removing the mesentery (a fatty tissue near the intestine) during surgery for Crohn's disease is safe and helps prevent the disease from coming back. About 30 adults with Crohn's who are on biotherapy and need ileocolic surgery will take part. Researchers…

This study tests whether a stem cell transplant using the patient's own cells can 'reset' the immune system in teens and young adults (ages 13-28) with severe Crohn's disease that hasn't responded to other treatments. The approach removes overactive immune cells and replaces them…

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous treatment (anti-TNF drugs) stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and pr…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study is testing whether transplanting healthy gut bacteria (in capsule form) can take hold in the intestines of people with Crohn's disease and possibly reduce inflammation. Researchers will enroll 120 adults with active Crohn's to see if the donor microbes engraft and if s…

This study follows 900 children aged 6-17 newly diagnosed with Crohn's disease to see how well their intestines heal after one year of anti-TNF therapy. Researchers will use blood tests, stool samples, colonoscopy, and special MRI scans to track healing. The goal is to understand…

This study will collect images and videos from 10,000 patients who undergo capsule endoscopy (a pill-sized camera that takes pictures of the digestive tract). Researchers will use this data to train artificial intelligence to detect bowel diseases like Crohn's, celiac disease, an…

This study tests a new capsule camera attached to a string that takes pictures of the lower gut without sedation. About 30 adults who are healthy or have Lynch syndrome, Crohn disease, or inflammatory bowel disease will try it. The goal is to see if the capsule can get clear imag…

This study compares two ways to prevent Crohn's disease from returning after bowel surgery. One group gets biologic drugs right after surgery, while the other group only starts them if a scope shows signs of disease coming back. The goal is to see if the wait-and-see approach wor…

This study is testing a web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with the condition. The goal is to see if knowing their personal risk motivates them to make healthier lifestyle and diet changes that might …

This study tests whether far-infrared (fIR) therapy is safe and can help ease symptoms in people with Crohn's disease. Forty adults with active Crohn's will receive 10 fIR treatments, give blood and stool samples, and fill out questionnaires. Researchers will compare three differ…

This study tests whether a daily cranberry supplement can help restore healthy gut bacteria in adults with Crohn's disease. About 50 participants will take either the supplement or a placebo for 10 weeks. Researchers will track changes in gut bacteria, inflammation, and symptoms …

This study looks at whether an adapted diet, combined with a special liquid nutrition drink, can improve quality of life for adults with Crohn's disease during a flare-up. About 52 participants will either receive standard medical care or the diet plus partial enteral nutrition. …

This study tests a smartphone app called COBMINDEX to help people with Crohn's disease manage stress, fatigue, and pain. About 200 adults with stable Crohn's will use the app or work with a human therapist. The goal is to see if the app can improve quality of life and coping skil…

This study tests a low dose of Interleukin-2 (IL-2) in 30 people aged 12-80 with moderate-to-severe Crohn's disease. The goal is to find the safest and most effective dose to reduce symptoms. Participants will be monitored for side effects and changes in disease activity over 8 w…

This pilot study from the University of Michigan is testing whether changing sleep timing and using morning light therapy can improve symptoms and quality of life in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 68 adults wi…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…

This study aims to collect blood, stool, and tissue samples from 200 children with inflammatory bowel disease (IBD) or other gut disorders over three years. Researchers will use advanced genetic techniques to study how inflammation develops in the gut. The goal is to better under…

This study aims to find out if the unique mix of bacteria and fungi in the gut can predict how well a person with Crohn's disease will respond to therapy. Researchers will collect stool, blood, and tissue samples from 100 adults in British Columbia during routine colonoscopies an…

This study looks at the long-term safety of the drug ustekinumab compared to other biologic treatments in adults with Crohn's disease or ulcerative colitis. Researchers will use electronic health records from the Department of Defense to track rates of cancer, serious infections,…

This study looks at whether changes in sleep can act as an early warning sign for a flare-up in people with inflammatory bowel disease (IBD), such as Crohn's disease or ulcerative colitis. Researchers will track sleep quality and disease activity in 216 adults who are currently i…

This study looks at bone health in teenagers who were recently diagnosed with Crohn's disease. Researchers will use MRI scans to measure fat in the bone marrow and compare it to healthy teens. The goal is to understand if Crohn's disease affects bone strength early on, which coul…

This study is testing a new educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease). The tool helps patients understand immune checkpoint inhibitor drugs and their possible side effects. Researchers wil…

This study follows 575 adults with Crohn's disease who have had part of their intestine removed. Researchers collect medical history, blood, tissue, and stool samples to better understand why the disease often comes back after surgery. The goal is to create a more detailed classi…

This study aims to find a better way to detect scarring in the intestines of people with Crohn's disease. Researchers will use a special dye and PET/CT scans to see if they can identify early scarring and track how it worsens over time. The goal is to help develop new treatments …

This study is testing a new wireless capsule that you swallow to measure temperature inside your digestive tract. The goal is to see if it can help doctors find diseases like Crohn's disease. Ten healthy adults will take part to check if the capsule works correctly.

This study looks at how gut bacteria change the way immune cells use energy, which may be linked to inflammatory bowel disease (IBD). Researchers will test 45 people—healthy adults and those with IBD—using blood, urine, and stool samples. Healthy volunteers will take a short cour…

This study aims to identify markers in blood and tissue samples that may predict how patients with inflammatory bowel disease (IBD) respond to a type of medication called TNF-alpha inhibitors. Researchers will compare samples from 100 participants, including healthy controls and …

This study looks at how often people with active Crohn's disease have a problem called exocrine pancreatic insufficiency (EPI), where the pancreas doesn't make enough enzymes to digest food properly. Researchers will check 50 adults before and 14 weeks after they start a biologic…

This study follows 450 adults who have inflammatory bowel disease (IBD) but no symptoms yet. Researchers want to learn how the disease changes over time and what biological signs might predict future problems like pain, diarrhea, or complications. The goal is to better understand…

This study looks at how immune cells and inflammation might play a role in migraine. Researchers will compare 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The goal is to measure levels of certain …

This study is testing a special PET/MR scan that uses a radioactive tracer to detect scar tissue in the gut of people with Crohn's disease. The goal is to see if the scan can accurately tell the difference between scarred (fibrotic) and inflamed strictures, which could help docto…

This study looks at people with Crohn's disease that is hard to treat, meaning their symptoms don't improve much with standard drugs. Researchers will track 1,400 adults in China to see how common this condition is and how well advanced treatments work. The goal is to find out wh…

This study looks at the gut microbiome (bacteria, fungi, and viruses) in people with Crohn's disease, with or without arthritis, and compares them to healthy volunteers. The goal is to find biological markers that could help understand the link between these conditions. No treatm…

This study looks for tiny plastic particles (microplastics) in children with and without inflammatory bowel disease (IBD). Researchers will collect samples of gut tissue, stool, urine, and blood during routine medical procedures. The goal is to see if microplastics are present an…

This study is testing a new medical device that measures how nerves respond to inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The device checks three types of nerve fibers to help doctors better understand disease…