CROHN DISEASE

This study tests a drug called risankizumab in 260 adults with fibrostenotic Crohn's disease, a severe form where scarring narrows the intestines. Participants who have not improved with standard treatments will receive either the drug or a placebo. The goal is to see if risankiz…

This study tests a new drug, JNJ-78934804, against another drug (guselkumab) in 460 people with moderate to severe Crohn's disease. The goal is to see if it can reduce symptoms and heal the gut lining after 48 weeks. Participants must have had Crohn's for at least 12 weeks and ha…

This study will follow about 100 adults in Saudi Arabia who have moderate to severe Crohn's disease or ulcerative colitis and are starting guselkumab. Researchers want to see how long patients keep taking the medicine without stopping. The study does not give any treatment—it jus…

This study tests a device that filters inflammatory substances from the blood during flare-ups of Crohn's disease or ulcerative colitis. About 40 adults will either receive standard care alone or standard care plus the Efferon LPS filter. The goal is to see if the filter safely r…

This study tests a special day hospital program for people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. The program combines blood tests, doctor visits, education, and workshops in a single day. Researchers want to see if this approach helps …

This study tests if mirikizumab can shrink inflamed narrowings (strictures) in the small intestine caused by Crohn's disease. About 60 adults with at least one inflammatory stricture will receive the drug for several months. The main goal is to see if the stricture length improve…

This study will test if hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) helps people with over 30 different conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. About 100 participants will receive the treatment and repor…

This study tests whether adding a special diet (Crohn's Disease Exclusion Diet) to standard biologic therapy helps more adults with Crohn's disease achieve complete gut healing. About 185 participants in China will be randomly assigned to receive either the diet plus biologics or…

This study tests a self-management program for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal is to see if changing behaviors can improve health and quality of life. About 40 adults with active IBD will take part in the pr…

This study watches 50 adults with moderate-to-severe Crohn's disease or ulcerative colitis who are already starting guselkumab as part of their normal care. Researchers will track how long patients continue the drug and how they respond early on. No extra treatments or changes ar…

This study is developing a questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will interview 275 patients to identify key self-care behaviors, then test the questionnaire's accuracy. The goal is to give doctors a be…

This study looks at whether marking the stoma spot and teaching patients about it before surgery helps them feel better and have fewer problems afterward. About 100 adults who need a stoma (either planned or emergency) will join. Researchers will compare quality of life and early…