CROHN DISEASE

This study tested whether injecting donor stem cells into the wall of the vagina and rectum could safely heal abnormal tunnels (fistulas) that form in some women with Crohn's disease. About 20 women with a single fistula were to receive one injection of 75 million stem cells. The…

This study tested whether adding an experimental pill (BI 706321) to the standard Crohn's drug ustekinumab could better control moderate to severe Crohn's disease. About 49 adults were randomly assigned to receive either the combination or a placebo plus ustekinumab for 3 months,…

This study aimed to see if a computer program could help doctors give the right dose of infliximab to children and young adults with Crohn's disease. The program used blood test results to set each patient's dose, hoping to reach better drug levels than standard dosing. Only 6 pe…

This study tested the antifungal drug posaconazole in people with active Crohn's disease who carry a specific genetic risk (CARD9 S12N). The goal was to see if reducing a certain gut fungus could lower inflammation and improve symptoms. The trial was stopped early and only enroll…

This study tested whether the oral drug ozanimod could keep Crohn's disease under control in people with moderate-to-severe symptoms. About 550 participants who had already responded to an initial treatment were randomly assigned to receive ozanimod or a placebo for up to 52 week…

This study tested whether injecting donor stem cells into fistulas around the J-pouch could help people with Crohn's disease. The goal was to see if the treatment was safe and could close the abnormal tunnels. The study was stopped early, so results are limited.

This study tested a single injection of stem cells from donated bone marrow to treat fistulas (abnormal tunnels) in people with Crohn's disease. The goal was to see if it was safe and could help heal the fistulas. The trial was stopped early, but the results may still offer clues…

This study tested an oral medication called ozanimod to help people with moderate-to-severe Crohn's disease reach remission (fewer symptoms). About 625 adults with Crohn's who had not responded well to other treatments were randomly assigned to receive ozanimod or a placebo for 1…

This study compared two surgical methods for removing diseased intestine in people with Crohn's disease to see which better prevents the disease from returning. It involved 13 adults who needed surgery for Crohn's that didn't respond to medication. The trial was stopped early, so…

This study looked at the long-term safety and effectiveness of the oral drug ozanimod for people with moderate to severe Crohn's disease. It was an extension study for participants who completed earlier studies. The study was terminated early, so results are limited.

This study looked at whether an anti-inflammatory whole-food diet could help people with mild-to-moderate Crohn's disease feel better and enter remission. Researchers planned to compare the diet to usual eating habits in 28 adults aged 18-75. The study was stopped early, so resul…

This study aimed to see if the antibiotic rifaximin could reduce bloating in people with diabetic gastroparesis, a condition where the stomach empties slowly. Only 5 adults with diabetes and confirmed slow stomach emptying were enrolled. The trial was terminated early, so results…