CROHN DISEASE

This study tests whether a plant-based resistant starch, tailored to each child, can help restore a healthier gut microbiome in 100 kids with Crohn's disease or ulcerative colitis. Participants must have mild disease or be in remission. The goal is to boost butyrate production an…

This study tests whether a personalized diet supplement (a type of starch) can increase helpful gut bacteria in children with Crohn's disease. The goal is to see if this approach can help maintain remission and reduce the need for stronger medication. The study involves 45 childr…

This study looks at whether a special diet, called the Crohn's Disease Exclusion Diet (CDED), can help adults with active Crohn's disease feel better. Some participants will also get a liquid supplement, while others will add dairy products back early. The goal is to see which ap…

This study tests two different maintenance doses of the drug TEV-48574 given as a shot every 4 weeks in adults with moderate to severe ulcerative colitis or Crohn's disease. Participants must have completed a previous 14-week study of the same drug. The goal is to see if the drug…

This study looks at the long-term safety of the drug ustekinumab in children aged 2 to under 18 who have Crohn's disease, ulcerative colitis, or psoriatic arthritis. Participants must have already completed a prior study and shown benefit from the drug. The main goal is to track …

This study tests a new approach for people with Crohn's disease who have complex anal fistulas that did not heal with standard treatments. Doctors will take a small amount of the patient's own fat, break it into tiny pieces, and inject it around the fistula to help it close. The …

This study tests whether a plant-based starch, tailored to each child's needs, can improve gut health in 80 children with Crohn's disease or ulcerative colitis. The goal is to boost production of a helpful substance called butyrate and restore a healthier balance of gut bacteria.…

This study tests whether a computer dashboard (iDose) that helps doctors adjust infliximab doses is better than the usual approach for people with Crohn's disease or ulcerative colitis. About 124 adults and teens will be followed for a year to see if the tool leads to more sympto…

This study tests whether a special anti-inflammatory diet, adapted for Puerto Rican foods and preferences, can help people with Crohn's disease feel better and reduce inflammation. About 150 adults with mild to moderate Crohn's will follow either the DAIN diet or their usual diet…

This study tests a remote monitoring system (app and medication reminders) for people with inflammatory bowel disease (IBD) starting a new oral or injectable treatment. About 123 adults will use the system or standard care for 12 months to see if it improves medication adherence,…

This study tests a drug called guselkumab in 350 people with moderate to severe Crohn's disease who haven't responded well to other treatments. The goal is to see if it can reduce symptoms and heal the gut lining over 12 to 24 weeks. Participants receive either the drug or a plac…

This study tests whether injecting a patient's own concentrated platelets (PRP) after balloon dilation can prevent the colon from narrowing again in people with Crohn's disease. About 74 adults with a short colon stricture will receive either a high or low concentration of PRP. T…

This study tests a new imaging device called MSOT that uses light and sound to detect inflammation in the skin or gut. Researchers will check if it is safe and can spot inflammation in people with graft-versus-host disease, Crohn's disease, or colitis. About 100 adults will have …

This study looks at whether treating insomnia can improve the lives of people with Crohn's disease. Researchers will test a remote insomnia treatment in 83 adults with mild to moderate Crohn's. They want to see if better sleep can also help with pain and inflammation.

This study tests whether CoQ10, a natural supplement, can reduce fatigue in people with Crohn's disease. About 60 participants will take one of two doses of CoQ10 for 8 weeks, and healthy volunteers will take it for 2 weeks. The goal is to see if fatigue improves enough to justif…

This study looks at whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and quality of life in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for …

This study tests a thin probe inserted through the nose to measure how leaky the gut is. It involves 15 healthy adults and checks if the device can accurately measure electrical signals in the intestine. The goal is to see if this tool is feasible for future research on gut disea…

This study looks at whether the probiotic VSL#3 can change how bile acids are processed in people with Crohn's disease or ulcerative colitis. About 79 adults with stable, inactive disease will take the probiotic for 6 weeks. Researchers will measure bile acid levels in blood and …

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if this device can effectively detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's diseas…

This study looks at how diet and gut bacteria are linked to Crohn's disease in children. Researchers will follow 250 newly diagnosed children and 50 healthy kids, collecting stool, blood, and diet logs over a year. The goal is to create a computer algorithm that predicts which fo…

This study tests a program to help teenagers with Crohn's disease or ulcerative colitis move from pediatric to adult healthcare. About 90 teens aged 16 to 17.5 will either get standard care or a program with a personal navigator, online skills training, and education. The goal is…

This study aims to create a detailed 'atlas' of gut cells from people with Crohn's disease and healthy volunteers. Researchers will analyze tissue samples to see how cell types differ between diseased and healthy gut. The goal is to better understand what causes Crohn's and find …

This study takes small tissue samples (biopsies) from people having a routine endoscopy and grows them into mini-organs called organoids. These organoids mimic the real intestine and help researchers understand diseases like Crohn's and ulcerative colitis. The goal is to learn ho…

This study follows 100 children under 17 with Crohn's disease to see how the condition shows up, what treatments doctors choose, and how kids improve over time. Researchers will track symptoms and remission rates at 14 and 54 weeks. No new treatment is given—this is an observatio…

This study compares two ways of taking biopsies during colonoscopy in people with inflammatory bowel disease (IBD). About 1642 participants will be randomly assigned to either a limited biopsy approach or a more extensive random biopsy approach. The goal is to see which method fi…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study compares a faster, contrast-free MRI technique (diffusion-weighted) with the standard MRI for monitoring Crohn's disease activity in 140 adults. The goal is to see if the simpler scan works just as well, without bowel cleansing or gadolinium injection, making follow-up…

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…