Scientists decode how food and microbes shape Crohn's in kids

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * CD study group - 'Consent form - Part 1' 1. Children with clinical suspicion for CD. 2. Between 6 and 18 years of age. 3. Naïve to any medical or nutritional intervention. CD study group - 'Consent form - Part 2' 1. Children with CD confirmed by endoscopy (and based on accepted criteria7) 2. Between 6 and 18 years of age. 3. Naïve to any medical or nutritional intervention. Control group undergoing endoscopy en between 6 and 18 years of age undergoing colonoscopy for non-specific abdominal pain or other non-inflammatory gastrointestinal conditions. Control group not undergoing colonoscopy 1. Children with no symptoms or signs of gastrointestinal disease and no known medical conditions. 2. Children between 6 and 18 years of age. These children will be recruited from general pediatric clinics (children attending for routine check-up), orthopedic clinics, ophthalmology clinics or schools. Exclusion Criteria: * CD study group 1. Chronic treatment with any drug upon enrolment and the use of systemic antibiotics, probiotics or proton pump inhibitors during 30 days prior to enrollment. 2. Morbid obesity (BMI \> 95th percentile for their age and gender). 3. Following particular dietary regimen/dietitian consultation/participation in another study. 4. Chronic use of steroids or immunomodulatory medications prior to CD diagnosis. 5. Any other chronic disease (e.g. HIV, Cushing disease, acromegaly, hyperthyroidism, etc.), cancer and recent anti-cancer therapy, neuro-psychiatric disorders, coagulation disorders, celiac disease or any other chronic GI disorder. 6. Gut-related surgery, including bariatric surgery. 7. Inability of the participant and nuclear family to follow and utilize the smartphone application. Control group not undergoing colonoscopy 1. Children with no symptoms or signs of gastrointestinal disease and no known medical conditions. 2. Children between 6 and 18 years of age. These children will be recruited from general pediatric clinics (children attending for routine check-up), orthopedic clinics, ophthalmology clinics or schools. Control group undergoing endoscopy 1. Any known chronic illness. 2. Following particular dietary regimen/dietitian consultation/participation in another study. 3. Chronic treatment with any drug upon enrolment and the use of systemic antibiotics, probiotics or proton pump inhibitors during 30 days prior to enrollment. 4. Gut-related surgery, including bariatric surgery.