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Mini-Guts in a dish: scientists probe why IBD tissue struggles to heal

NCT ID NCT06805890

NEW Knowledge-focused Sponsor: Assistance Publique Hopitaux De Marseille Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

Researchers collect small tissue samples from the inflamed and non-inflamed intestines of people with Crohn's disease or ulcerative colitis, as well as from people without inflammatory bowel disease. They grow these cells into tiny three-dimensional structures called organoids that mimic the intestinal lining. By exposing the organoids to inflammatory signals and testing how well they grow and repair, the team aims to understand why inflamed tissue heals poorly. The study does not test a treatment; it gathers knowledge that could inform future therapies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the approach works, it could help explain why the intestinal lining heals poorly in Crohn's disease and ulcerative colitis, which may guide future treatments that support tissue repair.
What could go wrong
This is a laboratory study of tissue samples, not a treatment tested in people. Organoids grown in dishes may not fully reflect what happens inside the human gut, so any insights could take years to translate into therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

For IBD group the inclusion criteria will be: * Patients of either sex aged 18 years or older * Patient that have read the information form and signed consent * Patient covered with health insurance * Patients with Crohn's Disease or ulcerative colitis in accordance with accepted clinical, endoscopic, histological and/or radiologic criteria, regardless of the level, severity of the disease or duration of disease progression. * Patients with colonic involvement of Crohn's disease or ulcerative colitis * Patients undergoing a screening colonoscopy in the context of IBD disease follow-up OR undergoing intestinal resection for IBD disease aggravation For control group the inclusion criteria will be: * Patients of either sex aged 18 years or older * Patient that have read the information form and signed consent * Patient covered with health insurance * Patients undergoing a screening colonoscopy in the context of a family history of colonic neoplasia, follow-up of colonic polyps or functional intestinal disorders OR undergoing intestinal resection for intestinal neoplasia, occlusive syndrome or colostomy The non-inclusion criteria for IBD group will be: * Contraindication to the anaesthetic or colonoscopy procedure * Patients without colonic involvement of Crohn's disease or ulcerative colitis * Patients of Adults without legal capacity * Patients in Health and Social Establishments * Persons in emergency situations * Persons deprived of their liberty * Non-affiliated to a social security scheme * Absence or refusal of the informed consent The non-inclusion criteria for control group will be: * IBD disease revealed during colonoscopy or gastrointestinal resection * Patient suffering from Immune-Mediated Inflammatory Diseases (IMIDs) * Contraindication to the anaesthetic or colonoscopy procedure * Patients of Adults without legal capacity * Patients in Health and Social Establishments * Persons in emergency situations * Persons deprived of their liberty * Non-affiliated to a social security scheme * Absence or refusal of the informed consent

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Conditions

The condition(s) this trial relates to.

Crohn disease inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Crohn disease Inflammatory bowel diseases (IBD) Ulcerative colitis (disorder)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Nord Hospital

    RECRUITING

    Marseille, 13915, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.