CROHN DISEASE

This study looked at how well the drug upadacitinib works for Crohn's disease when it only affects the small bowel, compared to when it affects other parts of the digestive tract. Researchers reviewed records of 3 people with active Crohn's who took upadacitinib for 12 weeks. The…

This pilot study tested whether taking grape powder daily could improve gut health in adults with Crohn's disease, a type of inflammatory bowel disease. Twenty-one participants in remission took freeze-dried grape powder for a period. Researchers measured changes in gut bacteria …

This study looked at 688 people in South Korea with ulcerative colitis or Crohn's disease who were treated with Kynteles (vedolizumab) as part of their regular care. The main goal was to track side effects and see how many patients felt better after treatment. The results help do…

This study looked at whether ustekinumab (STELARA) is safe and effective for Chinese adults with moderate to severe Crohn's disease. 182 participants received the drug and were followed for 52 weeks. The main goals were to see if symptoms improved by week 8 and if gut healing occ…

This study tested a new drug called tulisokibart (PRA023) in 55 people with moderate to severe Crohn's disease who had not responded well to other treatments. The main goals were to check safety and see if the drug could improve gut healing and reduce symptoms. After 12 weeks, so…

This study tested an experimental drug called TEV-48574 in 290 adults with moderate to severe ulcerative colitis or Crohn's disease. The goal was to see if the drug could help patients achieve remission or reduce bowel inflammation after 14 weeks of treatment. Participants receiv…

This study tested whether a blood test measuring proteins can help doctors choose a more powerful treatment early for people newly diagnosed with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. 300 patients were split into two groups: one where…

This study looked at 108 adults with Crohn's disease whose symptoms returned while on standard ustekinumab treatment. Researchers gave them a stronger re-induction dose and then compared two maintenance schedules: every 8 weeks versus every 4 weeks. The goal was to see if the hig…

This study looked at 150 adults with Crohn's disease who were treated with ustekinumab, a targeted drug. Researchers used high-tech imaging to measure inflammation deep in the gut wall and checked if that helped predict how well the drug worked over 12 months. The goal was to see…

This study tested whether using a special monitor (ClearSight) to track blood flow during colorectal surgery could lower the chance of complications. 160 adults having surgery for colon polyps, colorectal cancer, or Crohn's disease took part. The goal was to see if this approach …

This study tested a medicine called ustekinumab in 101 children with moderate-to-severe Crohn's disease. The goal was to see if the drug could reduce symptoms and keep the disease under control. Children first received the drug through an IV, then some continued with injections t…

This study looked at 38 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) whose disease was under control with intravenous infliximab. Researchers switched them to a subcutaneous (under-the-skin) version to see if drug exposure, effectiveness, and quality of …

This study looked at how well a special diet (called CDED plus NEP) works for children aged 8 to 18 with active Crohn's disease in everyday medical practice. A total of 58 children took part. The goal was to see if the diet could help them feel better without needing steroids or …

This study tested a medicine called spesolimab in 27 adults with Crohn's disease who also have fistulas near the anus. Participants received either the drug or a placebo every 4 weeks for 24 weeks. The goal was to see if the drug helps close fistulas and understand how it works. …

This study tested whether taking fecal microbiota transplant (FMT) capsules could help prevent Crohn's disease from returning after surgery. 23 adults with Crohn's who had surgery received FMT either by capsules or colonoscopy. The goal was to see if the capsules could deliver th…

This small study tested whether an AI-powered virtual reality app could safely help people with inflammatory bowel disease (IBD) who also have mild to moderate anxiety or depression. Twenty-two adults with IBD used the app during a single session. The goal was to see if the appro…

This study looked at whether a short-term, plant-based low-calorie diet (called a fasting mimicking diet) could improve depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with IBD and mild-to-moderate depression completed three 5-day diet cycles. Resea…

This study looked at whether a tailored physical activity program could help children and teens with inflammatory bowel disease (IBD) improve their bone density. Kids with IBD often have weaker bones due to inflammation, medication, and low activity levels. Fifteen participants c…

This study involved 324 adults with conditions like Crohn's disease, arthritis, or psoriasis who switched from a standard to a higher-concentration adalimumab injection. Researchers measured injection site pain and how well patients stuck with the new treatment over 180 days. The…

This study tested a self-management program for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Researchers wanted to …

This study looked at whether differences in the BAFF gene are linked to getting Crohn's disease or how the disease behaves. Researchers compared 824 people with and without Crohn's. No treatment was given—the goal was simply to learn more about genetic risk factors.

This study looked at how having inflammatory bowel disease (Crohn's or ulcerative colitis) as a child affects work and education in adulthood. Researchers surveyed 343 adults who were diagnosed before age 17 to compare their employment and schooling with the general population. T…

This study looked at 250 people with or suspected of having Crohn's disease. It compared a quick MRI without any injected contrast dye to the standard longer MRI that requires a contrast injection. The goal was to see if the simpler scan could reliably tell a normal from an abnor…

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at 300 people with Crohn's disease to see if a computer analysis of CT scans could predict who would need surgery within a year of diagnosis. The goal was to create a tool that helps doctors decide on treatment earlier. The study did not test a new treatment, bu…

This study looked at 11 adults with Crohn's disease who had surgery to remove damaged intestine. Researchers compared two surgical methods—Kono-S and standard side-to-side—to see how each affected gut bacteria and immune cells. The goal was to learn more about the biological envi…

This study looked at how well two newer biologic drugs, Ustekinumab and Vedolizumab, work for Crohn's disease in 50 Chinese patients. Researchers checked if the drugs helped heal the gut lining and reduce symptoms, and also looked at side effects. The goal was to find out what fa…

This study looked at 63 people with Crohn's disease who had an anal fistula treated with anti-TNF drugs and seton drainage. Researchers wanted to see how often the fistula came back over the long term and what factors might increase the risk. The goal is to help doctors improve t…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (IBD) to understand how DNA that escapes from cells might worsen inflammation. Researchers analyzed blood, stool, and gut tissue samples to study a specific pathway called cGAS-STING. The goal was to id…

This study tested a new drug (AZD7798) in 9 adults with Crohn's disease to see how it changes inflammation in the small intestine. Researchers used special PET scans to measure these changes. The goal was to understand how the drug works in the body, not to treat the disease dire…

This study looked at 59 adults with Crohn's disease who had surgery to remove damaged parts of their intestine. Researchers tracked changes in certain immune cells (T cells) in the blood and gut over one year to see if they could predict when the disease would come back. The goal…