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Antifungal drug trial targets gut fungus in Crohn's patients

NCT ID NCT04966585

First seen Feb 24, 2026 · Last updated May 20, 2026 · Updated 14 times

Summary

This study tested the antifungal drug posaconazole in people with active Crohn's disease who carry a specific genetic risk (CARD9 S12N). The goal was to see if reducing a certain gut fungus could lower inflammation and improve symptoms. The trial was stopped early and only enrolled 10 participants.

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Contacts and locations

Locations

  • Cedars-Sinai Medical Center (CSMC)

    Los Angeles, California, 90048, United States

  • Mayo Clinic

    Rochester, Minnesota, 55901, United States

Conditions

Explore the condition pages connected to this study.