Blood filter device aims to tame severe IBD flares

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Crohn's disease (ICD-10: K50), extensive disease, with a chronic continuous or relapsing course during an exacerbation (flare), including: * Severe flare: CDAI ≥ 450 and/or SES-CD \> 15; * Moderate flare: CDAI 350-450 and/or SES-CD \> 7, steroid-refractory. * Ulcerative colitis (ICD-10: K51), with a chronic continuous or relapsing course during an exacerbation (flare), including: * Severe flare: Mayo score ≥ 10 and partial Mayo score ≥ 6; * Moderate flare: Mayo score 6-9 and partial Mayo score ≥ 3, steroid-refractory or steroid-dependent. * Presence of signs and symptoms of ulcerative colitis or Crohn's disease for at least 3 months prior to study enrollment. * The diagnosis must be confirmed by clinical and endoscopic findings and supported by a histopathology report * The patient's condition allows Efferon LPS therapy to be performed for at least 2 hours Exclusion Criteria: * Indeterminate colitis, radiation colitis, ischemic colitis,confirmed presence of megacolon, strictures, or stenosis causing symptoms of intestinal obstruction. * Expected need for bowel resection within 4 weeks after enrollment * Presence at hospitalization of a stoma, ileal pouch-anal anastomosis, or a fistula with purulent discharge (which, in the investigator's opinion, is likely to require surgical or medical intervention within 4 weeks after enrollment), or planned ileostomy or colostomy. * Partial or total colectomy, small bowel resection, or creation of a stoma (i.e., temporary or permanent colostomy, ileostomy, or other enterostomy) within 6 months prior to enrollment, or presence of an external or entero-enteric fistula with symptoms within 6 months prior to enrollment. * Suspected or diagnosed intra-abdominal or perianal abscess that has not been adequately treated. * Positive test for Clostridioides difficile toxin. * Positive test for infectious pathogens (including helminth eggs, parasites, or bacterial infections). * History of malignancy within the past 5 years, including solid tumors or hematologic malignancies (except for basal cell carcinoma of the skin, squamous cell carcinoma of the skin in situ, or cervical dysplasia/cancer that has been surgically excised with complete resolution), or colonic mucosal dysplasia that has not been completely removed. * End-stage renal disease. * Acute pulmonary embolism confirmed by imaging. * Acute myocardial infarction within the last 4 weeks. * Acute cerebrovascular accident (stroke) within the last 8 weeks. * Dementia. * Uncontrolled bleeding (acute blood loss within the last 24 hours). * History or current evidence of recurrent or chronic viral infection (e.g., hepatitis B virus, hepatitis C virus, or human immunodeficiency virus \[HIV\]). * Alcohol or drug dependence. * Any other condition that, in the investigator's opinion, would preclude the patient's participation in this study.