INFLAMMATORY BOWEL DISEASES

This study tests whether taking frozen capsules containing filtered or whole stool from healthy donors can help people with mild-to-moderate active ulcerative colitis achieve remission. About 129 adults who have not responded to standard treatments will receive either the stool c…

This study looks at how well newer inflammatory bowel disease (IBD) drugs work in children whose previous treatment (anti-TNF) stopped working. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and provide stool samples over ti…

This study tests whether adding the antifungal drug fluconazole to standard IL-23 therapy helps people with Crohn's disease feel better. About 120 adults with mild-to-moderate Crohn's will be randomly assigned to receive either fluconazole or a placebo alongside their usual treat…

This study tests a new capsule camera attached to a string that takes pictures of the lower gut without needing sedation. About 30 healthy adults and people with Lynch syndrome or inflammatory bowel disease will try it. The goal is to see if the device can get clear images and be…

This study is testing a web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with the condition. The goal is to see if learning their personal risk motivates them to make healthy lifestyle and diet changes that might p…

This study tests whether adding fermented foods like yogurt, kimchi, and sauerkraut to the diet can reduce inflammation and improve quality of life in people with mild to moderate ulcerative colitis. About 21 adults with confirmed UC will eat fermented foods for a period while re…

This study tests whether pentoxifylline, a drug already used for other conditions, can safely reduce symptoms and improve quality of life in people with mild to moderate ulcerative colitis. About 60 adults will take the drug and be monitored for changes in disease activity and da…

This study tests a virtual group program that teaches teens with IBD coping skills and heart rate biofeedback to reduce stress, anxiety, and depression. About 128 teens aged 13-18 with IBD will be randomly assigned to the program or a waitlist. The goal is to see if the program i…

This study tests if far-infrared (fIR) therapy is safe and helpful for people with Crohn's disease. Forty adults will receive 10 treatments, give blood and stool samples, and fill out questionnaires. Researchers will compare three different intensities of fIR to a placebo to find…

This observational study aims to understand how nutrition and body composition impact clinical outcomes in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical therapy or unde…

This study looks at why the immune system damages the gut in diseases like celiac disease and inflammatory bowel disease. Researchers will analyze immune cells and DNA from 200 adults to understand how these diseases develop and progress. The goal is to learn more, not to test a …

This study looks at how statin therapy changes bile acids and gut bacteria in people with primary sclerosing cholangitis (PSC), a liver disease with no cure. Researchers will collect samples from 15 adults with PSC to understand the disease better. The goal is not to treat PSC di…

This study aims to find out if the unique mix of microbes in the gut can predict how well a person with Crohn's disease will respond to treatment. Researchers will collect stool, blood, and tissue samples from 100 adults in British Columbia, Canada, and track their health for 12 …

This study looks at whether robotic surgery is a good option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to the standard laparoscopic (keyhole) approach, measuring things like blood l…

This study looks at how social factors like insurance and medication adherence affect quality of life in Hispanic and Black patients with inflammatory bowel disease (IBD). Researchers will survey 400 adults with IBD to understand these links. The goal is to find ways to improve h…

This study is creating a large database to collect information from 380 people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track survival, treatments, and side effects over time. The goal is to better understand these conditions and improve…