INFLAMMATORY BOWEL DISEASES

This study tests whether a personalized diet supplement (a type of starch) can increase helpful gut bacteria in children with Crohn's disease. The goal is to see if this can help maintain remission and reduce the need for stronger medication. The study involves 45 children aged 8…

This study planned to test whether injecting stem cells from a donor's bone marrow into the pouch (a surgically created internal reservoir) could safely treat severe pouchitis that didn't respond to standard treatments. The trial was withdrawn before enrolling any participants, s…

This study tests whether using a computer dashboard to guide infliximab dosing is more effective and safer than standard dosing for people with Crohn's disease or ulcerative colitis. About 124 participants will receive either dashboard-guided or standard treatment, with the goal …

This study tests whether a plant-based resistant starch, tailored to each child's needs, can help restore a healthier balance of gut bacteria in children with Crohn's disease or ulcerative colitis. About 80 children will receive either the starch or a placebo for several months. …

This study tests a digital health system that reminds people with inflammatory bowel disease (IBD) to take their medication and lets them report symptoms. About 123 adults starting a new oral or injectable treatment will use the system or get standard care for 12 months. The goal…

This study tests three different doses of an experimental drug called MORF-057 in 280 adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The goal is to see if the drug can safely help patients achieve remission, meaning less bleeding, more no…

This study tests whether a plant-based starch, tailored to each child's needs, can help restore a healthier gut microbiome in children with inflammatory bowel disease (Crohn's or colitis). About 100 children with mild disease or in remission will receive the starch for 6 months. …

This study tests whether adding high-dose vitamin D3 to standard anti-TNF therapy can improve symptoms and reduce inflammation in people with active Crohn's disease or ulcerative colitis. About 100 adults starting anti-TNF treatment will receive either vitamin D3 or a placebo for…

This study looks at whether a virtual reality (VR) program can help people with inflammatory bowel disease (IBD) manage their pain. About 40 adults with IBD and abdominal pain will try the VR program at home for 4 weeks. Researchers want to see if it is easy to use and if it help…

This observational study will collect genetic and health information from 120,000 people with chronic conditions like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers will analyze how genes, lifestyle, and other factors affect disease progression and…

This registry is following over 2,200 adults with inflammatory bowel disease (IBD) across North America to see how approved treatments work in everyday practice. Researchers are collecting data on disease patterns, complications, and patient outcomes. The goal is to better unders…

This study looks at whether regular text message check-ins and the ability to text your IBD care team can improve disease management and quality of life. About 900 people with Crohn's disease or ulcerative colitis will take part. Some will get extra symptom surveys and texting ac…

This 5-year observational study is following 15,000 adults and children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, in real-world clinics. Researchers are collecting data on disease patterns, treatment use, and patient outcomes to bett…

This study tests a program to help teenagers with Crohn's disease or ulcerative colitis move from pediatric to adult healthcare. About 90 teens aged 16 to 17.5 will either get the program (which includes a navigator, skills training, and education) or standard care. The goal is t…

This study is collecting blood, stool, and urine samples from 1,000 people with Inflammatory Bowel Disease (IBD). Researchers will store these samples along with medical information to learn more about the disease and find ways to improve patient outcomes. The study does not invo…

This study aims to better understand what causes inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and other gut problems by analyzing blood and tissue samples from 1,000 patients. Researchers will use advanced lab techniques to track immune system changes over …

This study tests a thin probe inserted through the nose to measure how leaky the gut is. It involves 15 healthy adults and checks if the device can accurately measure electrical signals in the intestine. The goal is to see if this tool is feasible for future research on gut disea…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if the probe can detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerati…

This study looks at whether taking extra random biopsies during a colonoscopy helps find precancerous growths in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 1,600 participants will be randomly assigned to one of two biopsy…

This study aims to develop computer-generated metrics from standard tests like endoscopy and scans to better assess inflammatory bowel disease (IBD). Researchers will compare these computer metrics with human evaluations to see if they can improve accuracy. The study involves 200…

This study follows nearly 5,000 children with Crohn's disease, ulcerative colitis, or indeterminate colitis to monitor the long-term safety of their treatments, including the drug infliximab. Researchers collect information on side effects, disease activity, and quality of life o…