INFLAMMATORY BOWEL DISEASES

This study tested whether adding the antibiotic minocycline to standard mesalamine treatment helps control mild-to-moderate ulcerative colitis. 46 adults took part. Researchers measured disease activity using a symptom score. The trial is complete, but results are not yet publish…

This study tested an experimental pill called MORF-057 in 39 adults with moderate to severe ulcerative colitis. The drug aims to reduce gut inflammation by blocking a specific protein. Researchers measured changes in colon tissue health and symptom scores after 12 weeks of treatm…

This study looked at whether transferring gut bacteria from healthy donors (fecal microbiota transplantation) can help people with mild-to-moderate ulcerative colitis. 102 participants received the transplant while staying on their usual medication. The goal was to see if it coul…

This study looked at 688 people in South Korea with ulcerative colitis, Crohn's disease, or pouchitis who received Kynteles (Vedolizumab) as part of their normal care. The main goal was to track side effects and see how many patients felt better after treatment. The results help …

This study looked at 150 adults with Crohn's disease to see if advanced imaging could predict how well the drug Ustekinumab controls inflammation. Researchers measured changes in the gut wall and compared them to standard tests. The goal was to improve treatment monitoring for th…

This study tested whether a blood test measuring proteins can help doctors choose the best treatment for people newly diagnosed with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. 300 patients were split into two groups: one where doctors had …

This study tested whether adding atorvastatin (a cholesterol-lowering drug) to standard mesalamine treatment improves quality of life and reduces inflammation in adults with ulcerative colitis. 54 participants completed the trial. The goal was to see if the drug's anti-inflammato…

This study looked at four substances in the blood (Osteoprotegerin, sRANKL, NFkB, and TFF3) to see if they could help diagnose inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. Researchers measured these markers in 70 newly diagnosed patient…

This study tested whether a diet that avoids certain inflammatory foods could lower the risk of developing Crohn's disease in healthy people who have a close relative with the condition. Twenty-nine participants followed the 'Tasty & Healthy' diet for 8 weeks. The main goal was t…

This study tested whether combining a fecal microbiota transplant (FMT) with the drug bezlotoxumab could prevent repeat Clostridium difficile infections in people with inflammatory bowel disease (IBD). Sixty-one adults with at least two prior C. diff infections were randomly assi…

This pilot study tested whether ondansetron (Zofran), a drug used for nausea, can improve bowel preparation for colonoscopy in children aged 2 to 20. 41 participants took either ondansetron or a placebo before drinking the bowel-cleansing solution. Researchers measured how clean …

This study looked at whether eating gluten-free for one week can reduce stomach symptoms and tiredness in people with ulcerative colitis. Fifteen adults with the condition ate a gluten-free diet plus special granola bars—first without gluten, then with high gluten. They filled ou…

This study looked at whether fenofibrate, a drug usually used for high cholesterol, can reduce inflammation and improve symptoms in people with mild to moderate ulcerative colitis. Sixty adults took part. The main goal was to see if the drug improved disease activity and quality …

This study looked at whether a short-term, low-calorie plant-based diet (called a fasting mimicking diet) could help reduce depressive symptoms in people with inflammatory bowel disease (IBD). 42 adults with mild-to-moderate depression and IBD completed three 5-day diet cycles. R…

This small study tested whether an AI-powered virtual reality app could safely provide mental health support to 22 adults with inflammatory bowel disease (IBD) who also had mild anxiety or depression. The goal was to see if the digital session was practical and acceptable, not to…

This study tested a comprehensive self-management program for people with inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease. The program included eight sessions covering topics like symptom tracking, relaxation, diet, and pain management. Research…

This study tested whether nurse coaching could help people with inflammatory bowel disease (IBD) better manage their symptoms, improve self-care, and enhance quality of life. Forty adults with IBD in remission participated. Researchers measured changes in symptom burden, self-car…

This study observed 92 adults with inflammatory bowel disease (Crohn's or ulcerative colitis) who were already receiving or starting vedolizumab. Researchers watched how patients and doctors chose between intravenous infusion or subcutaneous injection in everyday practice. The go…

This study analyzed data from over 8,700 pregnant women with inflammatory bowel disease (Crohn's or ulcerative colitis) to see how well doctors follow guidelines when prescribing antiTNFα drugs and whether the benefits outweigh the risks for both mother and baby. Researchers look…

This study looked at 211 adults with long-standing inflammatory bowel disease (IBD) to see which colonoscopy method finds precancerous growths better: high-definition white light or dye spraying. Participants had IBD for at least eight years. The goal was to improve cancer screen…

This study looked at tiny, lab-grown versions of the intestine called organoids, made from tissue samples of people with inflammatory bowel disease (Crohn's or ulcerative colitis), a genetic polyp condition (FAP), and healthy volunteers. The goal was to understand how intestinal …

This study looked at how being isolated during the COVID-19 pandemic affected the mental health of 232 people with inflammatory bowel disease (IBD). Researchers used questionnaires to measure depression, anxiety, and other psychological symptoms. The goal was to understand what f…

This completed study took extra biopsies from 40 people already having a colonoscopy to create a detailed map of the cells in the human colon. By analyzing gene activity and DNA structure in individual cells, researchers hope to better understand how colon diseases and type 2 dia…

This completed study looked at 115 people with inflammatory bowel disease (IBD) to see if their condition raises the risk of atherosclerosis, a hardening of the arteries that can lead to heart attacks and strokes. Researchers measured artery stiffness and thickness, and tracked h…

This study looked at whether giving extra nutrition through a vein in the arm (instead of a central line) helps people recover after colorectal surgery. 200 adults who had surgery for conditions like colorectal cancer or inflammatory bowel disease took part. The goal was to see i…

This study tested whether a transition coach could help 16-17 year olds with Juvenile Idiopathic Arthritis or Inflammatory Bowel Disease prepare for adult medical care. 27 teens took part in a coaching program to build self-management skills. The goal was to see if the program wa…

This study took small tissue samples from 16 people with or without inflammatory bowel disease during routine colonoscopies. Researchers grew these samples into mini-organs called organoids in the lab. They then tested how radiation and potential treatments affect these organoids…

This study looked at physical fitness in 100 children and teens (ages 10-17) with chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis, or unclassified colitis) and compared them to healthy kids of the same age, weight, and sex. Researchers measured cardiorespi…

This study looked at how hormonal birth control might help manage inflammatory bowel disease (IBD) symptoms that get worse during a woman's period. Researchers surveyed 50 women with IBD to understand their preferences for birth control and whether they would join a future trial.…

This study looked at how inflammatory bowel disease (IBD) affects oral health and daily life. Researchers compared 138 adults with IBD to people without IBD, using a questionnaire to measure oral health-related quality of life. The goal was to understand which factors, like medic…

This study aims to create a tool that helps nurses better assess and care for the sexual health needs of men with inflammatory bowel disease (IBD). The research involved 792 participants, including men with IBD and their partners, as well as healthcare professionals. The goal is …

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This study looked at how well two newer biologic drugs (ustekinumab and vedolizumab) work for Crohn's disease in 50 Chinese patients. Researchers checked for things like healing of the gut lining and symptom improvement, and also looked for side effects. The goal was to find out …

This study looked at whether taking a bowel-cleaning liquid before a capsule endoscopy helps doctors see the small intestine better and find more problems. 230 adults scheduled for the procedure were randomly assigned to get either a split dose, a single morning dose, or no speci…

This study looked at 40 children aged 6 to 17 with inflammatory bowel disease (Crohn's or ulcerative colitis) to understand how DNA that escapes from cells might make inflammation worse. Researchers analyzed blood, stool, and gut tissue samples to see if a specific pathway (cGAS-…

This study looked at gut bacteria in 15 people with inflammatory bowel disease (IBD) or Parkinson's disease, comparing them to healthy individuals. Researchers analyzed stool and blood samples to see which bacteria were present and whether bacteria were leaking from the gut into …

This early-stage study tested a new oral drug, IPG11406, in 66 healthy adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo. This research does not treat any disease but is a necessary first step before testing the drug in …