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Zofran may ease nasty bowel prep for children needing colonoscopy

NCT ID NCT05439772

Symptom relief Sponsor: State University of New York - Downstate Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether giving ondansetron (Zofran) before drinking bowel-cleansing liquid helps children have a cleaner colon and feel less sick. 41 kids aged 2 to 20 took either ondansetron or a placebo before their colonoscopy. The study measured bowel cleanliness and symptoms like pain, bloating, nausea, and vomiting.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ondansetron (Zofran)
What this could lead to
If it works, ondansetron could make bowel preparation for colonoscopy more comfortable for children by reducing nausea and vomiting.
What could go wrong
This is a small pilot study with only 41 participants, so results may not apply to all children. Ondansetron can rarely cause heart rhythm problems in those with certain conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

41 people

The number who actually took part.

Started

Jan 2021

Finished

Jul 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 20 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>2, \<20 * clinically indicated for a colonoscopy Exclusion Criteria: * known arrhythmia or long QT

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Conditions

The condition(s) this trial relates to.

Abdominal Pain diarrheal disease Eosinophilic enteropathy eosinophilic gastroenteritis Gastrointestinal Hemorrhage inflammatory bowel disease Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Abdominal pain Diarrhea Eosinophilic gastroenteritis Hematochezia Inflammatory bowel diseases Weight loss

Contacts and locations

Locations

  • SUNY Downstate University Hospital of Brooklyn

    Brooklyn, New York, 11203, United States

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