Can a common Anti-Nausea drug make colonoscopy prep easier for children?
NCT ID NCT05439772
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 38 times
Summary
This pilot study tested whether ondansetron (Zofran), a drug used for nausea, can improve bowel preparation for colonoscopy in children aged 2 to 20. 41 participants took either ondansetron or a placebo before drinking the bowel-cleansing solution. Researchers measured how clean the bowel was and how much discomfort children felt. The goal is to make the prep process less unpleasant.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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SUNY Downstate University Hospital of Brooklyn
Brooklyn, New York, 11203, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ondansetron (Zofran)
What this could lead to
If it works, ondansetron could make bowel preparation for colonoscopy more tolerable for children by reducing nausea and vomiting.
What could go wrong
This is a small pilot study with only 41 participants, so results may not apply to all children. The drug may not significantly improve bowel prep quality or symptoms.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.