INFLAMMATORY BOWEL DISEASES

This study tests whether adding the antifungal drug fluconazole to standard IL-23 therapy helps people with Crohn's disease feel better. About 120 adults with mild to moderate Crohn's will either get fluconazole or a placebo alongside their usual treatment. The goal is to see if …

This study tests whether long-acting antibodies can help people with moderate to severe ulcerative colitis (UC). About 645 adults will receive the antibodies through an IV and then as shots under the skin. The goal is to see if these treatments reduce gut inflammation and lead to…

This study looks at whether eating more fermented foods (like yogurt, kimchi, and sauerkraut) can reduce inflammation and improve quality of life in people with mild to moderate ulcerative colitis. About 21 adults with active symptoms will follow a fermented-food-supplemented die…

This study is testing whether fecal microbiota transplantation (FMT), or a 'poop transplant,' can help people with ulcerative colitis achieve remission without steroids. About 85 adults with active disease will receive either FMT or a placebo. The main goal is to see if a larger …

This study aims to see if robotic surgery is a safe and effective option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to the standard laparoscopic approach, looking at things like bloo…

This study tests whether dapagliflozin, a drug already used for diabetes, can help control symptoms of inflammatory bowel disease (IBD) like diarrhea and belly pain. Researchers will enroll 50 adults with mild-to-moderate ulcerative colitis to see if the drug reduces gut inflamma…

This study tests whether capsules containing frozen stool from healthy donors can help people with mild-to-moderate ulcerative colitis reach remission. About 129 adults who have not responded to standard treatments will take the capsules by mouth over several weeks. The goal is t…

This study tests a new drug called MORF-057 in adults with moderate to severe Crohn's disease, a condition that causes inflammation in the gut. About 385 people will receive either one of three doses of the drug or a placebo to see if it helps heal the gut lining and reduce sympt…

This study looks at how well and how safely the drug mirikizumab works over a long period (about 3 years) in children and teenagers with moderate-to-severe ulcerative colitis or Crohn's disease. About 150 participants who have already been in earlier studies will continue treatme…

This study looks at whether checking and improving nutrition before surgery can help people with inflammatory bowel disease (IBD) recover faster and have fewer problems after their operation. About 150 adults having IBD-related intestinal surgery will be offered nutritional shake…

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous treatment (anti-TNF drugs) stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and pr…

This study tests whether pentoxifylline, a drug usually used for blood flow problems, can safely reduce symptoms in people with mild-to-moderate ulcerative colitis. Researchers will measure changes in disease activity and quality of life over the trial period. The study aims to e…

This study tests a new capsule camera attached to a string that takes pictures of the lower gut without sedation. About 30 adults who are healthy or have Lynch syndrome, Crohn disease, or inflammatory bowel disease will try it. The goal is to see if the capsule can get clear imag…

This study is testing a web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with the condition. The goal is to see if knowing their personal risk motivates them to make healthier lifestyle and diet changes that might …

This study explores whether virtual reality (VR)-guided therapy can help manage pain for people hospitalized with inflammatory bowel disease (IBD). About 40 participants will try the VR program and report if it was helpful and easy to use. The goal is to see if this approach is a…

This study tests a virtual group program that teaches teens with inflammatory bowel disease (IBD) coping skills and uses heart rate biofeedback to help manage stress. About 128 teens aged 13-18 will either join the program right away or be placed on a waitlist. The goal is to see…

This study tests whether far-infrared (fIR) therapy is safe and can help ease symptoms in people with Crohn's disease. Forty adults with active Crohn's will receive 10 fIR treatments, give blood and stool samples, and fill out questionnaires. Researchers will compare three differ…

This study looks at why the immune system damages the gut in diseases like celiac disease and inflammatory bowel disease. Researchers will analyze immune cells from 200 adults to understand how these cells cause problems and sometimes lead to cancer. The goal is to learn more abo…

This study is testing a new wireless capsule that you swallow to measure temperature inside your digestive tract. The goal is to see if it can help doctors find diseases like Crohn's disease. Ten healthy adults will take part to check if the capsule works correctly.

This study is creating a large database to collect information about people with rare diseases like amyloidosis, sarcoidosis, and many others. Researchers will track patients' health, treatments, and outcomes over time. The goal is to better understand these conditions and improv…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…

This study aims to find out if the unique mix of bacteria and fungi in the gut can predict how well a person with Crohn's disease will respond to therapy. Researchers will collect stool, blood, and tissue samples from 100 adults in British Columbia during routine colonoscopies an…

This study looks at how social factors like insurance and medication adherence impact quality of life in Hispanic and Black patients with inflammatory bowel disease (IBD). Researchers will survey 400 adults with IBD to understand these links. The goal is to find ways to improve c…

This study looks at whether a toxin called deoxynivalenol (DON), often found in grains, might be an environmental risk factor for inflammatory bowel diseases like Crohn's and colitis. Researchers will measure DON levels in 100 people—some with Crohn's disease and some without—who…

This study is creating a large collection of blood samples and medical information from 3000 people with autoimmune diseases like lupus, scleroderma, and myositis. The goal is to help researchers find new markers and develop better treatments. Participants will not receive any ex…

This study looks at whether a non-invasive intestinal ultrasound can predict when Crohn's disease will come back in patients who are currently in deep remission. Researchers will follow 420 adults for 18 months to see who relapses and compare ultrasound results between those who …

This study looks at how statins, a common cholesterol medicine, change bile acids and gut bacteria in people with primary sclerosing cholangitis (PSC), a rare liver disease with no cure. Researchers will collect samples from 15 adults with PSC to understand the disease better. Th…

This study looks at how natural cannabis compounds (like CBD and THC) affect immune cells from 100 people with chronic inflammatory diseases such as rheumatoid arthritis, lupus, and inflammatory bowel disease. Researchers will take a blood sample and expose the cells to different…

This study uses health records to find out how many children under 18 in Korea develop Crohn's disease or ulcerative colitis each year, and how many are living with these conditions. It will also look at what treatments children receive as they grow, and how often they visit the …

This study collects DNA samples from 1200 adults receiving routine care at the University of Chicago. Researchers test for genetic differences that could affect how patients respond to certain medications, including risk of side effects. The results are shared with their doctors,…

This study is collecting health information and samples from 100 people with inflammatory bowel disease (IBD) who are changing their treatment. Researchers will use artificial intelligence to analyze this data and find patterns that could predict when a treatment change is needed…

This study is testing a new medical device that measures how nerves respond to inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The device checks three types of nerve fibers to help doctors better understand disease…