INFLAMMATORY BOWEL DISEASES

This study tests whether a plant-based resistant starch, tailored to each child, can help restore a healthier gut microbiome in 100 kids with Crohn's disease or ulcerative colitis. Participants must have mild disease or be in remission. The goal is to boost butyrate production an…

This study tests whether a personalized diet supplement (a type of starch) can increase helpful gut bacteria in children with Crohn's disease. The goal is to see if this approach can help maintain remission and reduce the need for stronger medication. The study involves 45 childr…

This study tests three doses of an experimental drug called MORF-057 against a placebo in 280 adults with moderate to severe ulcerative colitis. The goal is to see if the drug can safely reduce inflammation and bring about remission, meaning less bleeding, more normal bowel movem…

This study tests whether a plant-based starch, tailored to each child's needs, can improve gut health in 80 children with Crohn's disease or ulcerative colitis. The goal is to boost production of a helpful substance called butyrate and restore a healthier balance of gut bacteria.…

This study aimed to test if stem cells from donated bone marrow are safe and workable for people with severe pouchitis, a complication after colon surgery for inflammatory bowel disease. It was designed for adults aged 18-75 who had not responded to standard treatments. The study…

This study tests whether a computer dashboard (iDose) that helps doctors adjust infliximab doses is better than the usual approach for people with Crohn's disease or ulcerative colitis. About 124 adults and teens will be followed for a year to see if the tool leads to more sympto…

This study tests a remote monitoring system (app and medication reminders) for people with inflammatory bowel disease (IBD) starting a new oral or injectable treatment. About 123 adults will use the system or standard care for 12 months to see if it improves medication adherence,…

This study tests whether a virtual reality (VR) program can help manage pain in people with inflammatory bowel disease (IBD). About 40 adults with IBD and abdominal pain will use a VR headset at home for 4 weeks. The goal is to see if the program is easy to use and acceptable, an…

This study is testing a special thermal probe that measures temperature changes in the lining of the colon during a routine colonoscopy. The goal is to see if this device can effectively detect inflammation in people with inflammatory bowel disease (IBD), including Crohn's diseas…

This study tests a program to help teenagers with Crohn's disease or ulcerative colitis move from pediatric to adult healthcare. About 90 teens aged 16 to 17.5 will either get standard care or a program with a personal navigator, online skills training, and education. The goal is…

This study tests a thin probe inserted through the nose to measure how leaky the gut is. It involves 15 healthy adults and checks if the device can accurately measure electrical signals in the intestine. The goal is to see if this tool is feasible for future research on gut disea…

This study aims to better understand immune-related gut diseases like inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and functional gut disorders. Researchers will collect blood and tissue samples from 1,000 patients to analyze immune cells and find what driv…

This study looks at existing medical tests—like endoscopy, biopsies, and scans—from 200 people with inflammatory bowel disease (IBD). Researchers will use computers to create new measurements from these tests. The goal is to see if computer analysis can help doctors assess IBD mo…

This study compares two ways of taking biopsies during colonoscopy in people with inflammatory bowel disease (IBD). About 1642 participants will be randomly assigned to either a limited biopsy approach or a more extensive random biopsy approach. The goal is to see which method fi…

This study follows 15,000 adults and children (age 2+) with Crohn's disease, ulcerative colitis, or indeterminate colitis for up to 5 years. Researchers will collect data on how patients respond to treatments, side effects, and disease changes in everyday medical practice. The go…

This study is collecting blood, stool, and urine samples from 1,000 people with Inflammatory Bowel Disease (IBD) to learn more about the condition. Researchers hope this information will lead to better treatments and outcomes. Participants must be between 18 and 85 years old and …

This study is a large registry that follows over 2,200 adults with inflammatory bowel disease (IBD) across North America. It does not test new treatments but instead observes how approved therapies work in everyday practice, including their effectiveness, safety, and how the dise…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study looks at whether people with inflammatory bowel disease (IBD) have better outcomes and feel more in control of their health when they can text their medical team and regularly report symptoms via text surveys. About 900 participants will be split into two groups: one g…

This study is a long-term registry that follows nearly 5,000 children with inflammatory bowel disease (Crohn's, ulcerative colitis, or indeterminate colitis) to monitor their safety and health over time. Researchers collect information on side effects from treatments like inflixi…