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New pill shows promise for ulcerative colitis sufferers

NCT ID NCT05611671

Disease control Sponsor: Morphic Therapeutic, Inc. (A Wholly Owned Subsidiary of Eli Lilly and Company) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests three different doses of an experimental drug called MORF-057 in 280 adults with moderate to severe ulcerative colitis, a chronic inflammatory bowel disease. The goal is to see if the drug can safely help patients achieve remission, meaning less bleeding, more normal bowel movements, and healed gut lining. Participants are randomly assigned to receive either MORF-057 or a placebo, and neither they nor their doctors know which group they are in.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

280 people

The number who actually took part.

Started

Nov 2022

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Has signs/symptoms of moderate to severe UC for at least 3 months prior to Screening * Has evidence of UC extending at least 15 cm from the anal verge * Demonstrated an inadequate response, loss of response, or intolerance to at least one of the following treatments: Oral aminosalicylates (e.g., mesalamine, sulfasalazine, olsalazine, or balsalazide), corticosteroids, immunosuppressants (e.g., azathioprine, 6-mercaptopurine, or methotrexate), advanced therapies for UC (e.g., biologic agents, Janus kinase \[JAK\] antagonists, or sphingosine-1-phosphate \[S1P\] receptor agonists) * Subject has no prior exposure to approved or investigational anti-integrin therapies * Agrees to abide by the study guidelines and requirements * Capable of giving signed informed consent Exclusion Criteria: * Diagnosed with indeterminate colitis, microscopic colitis, ischemic colitis, radiation colitis, or Crohn's disease or has clinical findings suggestive of Crohn's disease * Has positive findings on a subjective neurological screening questionnaire * Has a concurrent, clinically significant, serious, unstable comorbidity * Previous treatment with vedolizumab or other licensed or investigational integrin inhibitors * Participation in any other interventional study or received any investigational therapy within 30 days * Previous exposure to MORF-057 and/or a known hypersensitivity to drugs with a similar mechanism to MORF-057 * Unable to attend study visits or comply with study procedures

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Conditions

The condition(s) this trial relates to.

inflammatory bowel disease ulcerative colitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Colitis ulcerative Inflammatory bowel diseases

Contacts and locations

Locations

  • "Vita Longa" Non-Public Healthcare Facility, Limited Liability Company

    Katowice, 40-748, Poland

  • Acibadem City Clinic Multiprofile Hospital for Active Treatment Tokuda

    Sofia, 1407, Bulgaria

  • All India Institute of Medical Sciences

    New Delhi, 110029, India

  • Arizona Digestive Health - Sun City

    Sun City, Arizona, 85351, United States

  • Blacktown Hospital

    Blacktown, 2148, Australia

  • Bugat Pal Korhaz

    Gyöngyös, 3200, Hungary

  • CLINSANTE Clinical Research Centre Ewa Galczak-Nowak, Malgorzata Trzaska

    Bydgoszcz, 85-794, Poland

  • Center of Diagnosis and Treatment Provita

    Bucharest, 21494, Romania

  • Centre Hospitalier Universitaire de Nice - Hôpital l'Archet

    Nice, 06202, France

  • Centrum Medyczne Reuma Park

    Warsaw, 02-665, Poland

  • Changhua Christian Hospital

    Changhua, 50006, Taiwan

  • Charite - University Hospital Berlin

    Berlin, 10117, Germany

  • Chia-Yi Christian Hospital

    Chiayi City, 600, Taiwan

  • China Medical University Hospital

    Taichung, 404, Taiwan

  • Clinical Hospital Center Bezanijska Kosa

    Belgrade, 11000, Serbia

  • Cliniq s.r.o.

    Bratislava, 811 09, Slovakia

  • Clinoxus s.r.o., Outpatient Clinic Budejovicka

    Prague, 140 00, Czechia

  • Colentina Clinical Hospital

    Bucharest, 020125, Romania

  • Concord Repatriation General Hospital

    Concord, 2139, Australia

  • Curatio, Jsc

    Tbilisi, 0114, Georgia

  • Dayanand Medical College and Hospital

    Ludhiana, 141001, India

  • Digestive Diseases Center "Gastro"

    Riga, 1079, Latvia

  • Dong-A University Hospital

    Busan, 49201, South Korea

  • EMC Medical Institute Joint Stock Company, "Certus" Private Healthcare Facility Hospital No. 1

    Poznan, 60-309, Poland

  • EMC Medical Institute Joint Stock Company, EuroMediCare Specialist Outpatient Clinics in Wroclaw

    Wroclaw, 54-144, Poland

  • ENDOMED s.r.o.

    Košice, 04013, Slovakia

  • ETG Lublin

    Lublin, 20-412, Poland

  • ETG Zamość

    Zamość, 22-400, Poland

  • East Tallinn Central Hospital

    Tallinn, 10138, Estonia

  • Eminat, LLC - Miramar

    Miramar, Florida, 33027, United States

  • Endoscopy Limited Liability Company

    Sopot, 81-756, Poland

  • Far Eastern Memorial Hospital

    Taipei, 220, Taiwan

  • Fejer County St. Gyorgy University Teaching Hospital

    Székesfehérvár, H-8000, Hungary

  • Fejér Megyei Szent György Egyetemi Oktató Kórház

    Székesfehérvár, 8000, Hungary

  • Fiona Stanley Hospital

    Murdoch, 6150, Australia

  • Fortis Hospital

    Noida, 201301, India

  • Fortis Memorial Research Institute(FMRI)

    Gurgaon, 122002, India

  • Gastro Care Institute

    Lancaster, California, 93534, United States

  • Gastro LM s.r.o.

    Prešov, 08001, Slovakia

  • General Hospital "Djordje Joanovic"

    Zrenjanin, 23000, Serbia

  • Gleneagles Hospital

    Hyderabad, 500004, India

  • Government Medical College

    Thiruvananthapuram, 695011, India

  • Great Lakes Gastroenterology

    Mentor, Ohio, 44060, United States

  • H-T. Medical Center

    Tychy, 43-100, Poland

  • Hospital of Padova

    Padova, 35128, Italy

  • IP Clinic

    Lodz, 90-752, Poland

  • IRCCS Istituto Clinico Humanitas- Centro Malattie Infiammatorie Intestinali

    Rozzano, 20089, Italy

  • IRCCS Ospedale Casa Sollievo della Sofferenza

    San Giovanni Rotondo, 71013, Italy

  • IRCCS Ospedale San Raffaele

    Segrate, 20132, Italy

  • Innova Clinical Trials

    Coral Gables, Florida, 33145, United States

  • JSC Infectious Diseases, AIDS and Clinical Immunology Research Center

    Tbilisi, 0159, Georgia

  • Javorszky Odon Korhaz

    Vác, 2600, Hungary

  • Kaplan Medical Center, Institute of Gastroenterology and Liver Diseases

    Rehovot, 7661041, Israel

  • Krakow Medical Center

    Krakow, 31-501, Poland

  • Krankenhaus Waldfriede

    Berlin, 14163, Germany

  • Kyung Hee University Hospital

    Seoul, 02447, South Korea

  • LTD Aversi Clinic

    Tbilisi, 0160, Georgia

  • LTD The First Medical Center

    Tbilisi, 0180, Georgia

  • LV Venter OU

    Pärnu, 80010, Estonia

  • Liepaja Regional Hospital

    Liepāja, LV-3414, Latvia

  • Malkhaz Katsiashvili Multiprofile Emergency Medicine Center LLC

    Tbilisi, 0101, Georgia

  • Mater Adult Hospital Brisbane

    South Brisbane, 4101, Australia

  • Medical Center "CITO" Ltd.

    Tbilisi, 0179, Georgia

  • Medical Center "Rusemed" EOOD

    Rousse, 7005, Bulgaria

  • Medical University of Vienna

    Vienna, 1090, Austria

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • New health-CK, Kieltucki and partners g.p.

    Staszów, 28-200, Poland

  • OU Innomedica

    Tallinn, 10117, Estonia

  • Order Hospital Linz Ltd. - Hospital of Sisters of Mercy

    Linz, 4010, Austria

  • Ospedale Luigi Sacco

    Milan, 20157, Italy

  • Pauls Stradins Clinical Univeristy Hospital

    Riga, LV-1002, Latvia

  • PreventaMed, s.r.o.

    Olomouc, 77900, Czechia

  • Republican Panevezys Hospital

    Panevezys, 35144, Lithuania

  • Robert Wood Johnson University Medical School

    New Brunswick, New Jersey, 08901, United States

  • Royal Brisbane and Women's Hospital

    Herston, QLD 4029, Australia

  • S R Kalla Memorial Gastro and General Hospital

    Jaipur, 302006, India

  • SIDS Hospital and Research Centre

    Surat, 395002, India

  • Salzburg Regional Hospital

    Salzburg, 5020, Austria

  • Sawai Man Singh Medical College Hospital (SMS Hospital)

    Jaipur, 302004, India

  • Second Multiprofile Hospital for Active Treatment - Sofia

    Sofia, 2700, Bulgaria

  • Semmelweis Medical University

    Budapest, 1083, Hungary

  • Semmelweis University, Department of Internal Medicine and Haematology, Division of Internal Medicine and Gastroenterology

    Budapest, H-1088, Hungary

  • Shaare Zedek Medical Center, Digestive Diseases Institute

    Jerusalem, 91004, Israel

  • St. John Paul 2nd Municipal Hospital in Elblag

    Elblag, 82-300, Poland

  • TLC Clinical Research Inc.

    Los Angeles, California, 90048, United States

  • Taipei Veterans General Hospital

    Taipei, 112201, Taiwan

  • The University of Texas Health Science Center at Houston

    Houston, Texas, 77030, United States

  • Tri-Service General Hospital

    Neihu Taipei, 11490, Taiwan

  • Twoja Przychodnia - Szczecinskie Centrum Medyczne

    Szczecin, 71-434, Poland

  • Twoja Przychodnia Opolskie Centrum Medyczne

    Opole, 45 819, Poland

  • Twoja Przychodnia Pcm

    Poznan, 60-324, Poland

  • University Hospital Schleswig-Holstein

    Kiel, 24105, Germany

  • University Hospital Ulm

    Ulm, 89081, Germany

  • University Multiprofile Hospital for Active Treatment "ACIBADEM City Clinic"

    Sofia, 1202, Bulgaria

  • University Teaching Hospital No. 4 in Lublin

    Lublin, 20-090, Poland

  • University of Tartu

    Tartu, 51014, Estonia

  • Vilnius University Hospital Santaros Klinikos

    Vilnius, LT-08406, Lithuania

  • WIP Warsaw IBD Point Profesor Kierkus

    Warsaw, 04-501, Poland

  • West Tallinn Central Hospital

    Tallinn, 10617, Estonia

  • Yashoda Hospital

    Secunderabad, 500003, India

  • Yeungnam Univeristy Medical Center

    Daegu, 42415, South Korea

  • Zvezdara University Medical Center

    Belgrade, 11 000, Serbia

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