COLITIS, ULCERATIVE

This study is monitoring the safety and effectiveness of the drug Jyseleca (filgotinib) in Korean patients with rheumatoid arthritis or ulcerative colitis. About 2,040 participants will be followed for 24 weeks to track side effects and disease activity. The goal is to confirm th…

This study tests an oral medication called icotrokinra for people with moderate to severe ulcerative colitis, a chronic condition causing colon inflammation and ulcers. Researchers will see if the drug can bring about remission—meaning fewer bathroom trips, less bleeding, and hea…

This study tests a new medicine called MH002, which contains live bacteria that may help repair the gut in people with mild-to-moderate ulcerative colitis. About 204 adults whose symptoms are not well controlled by standard treatment will receive either MH002 or a placebo. The go…

This study looks at how well guselkumab works for Chinese adults with moderate-to-severe ulcerative colitis who have never taken biologic drugs before. Researchers will track changes in symptoms and quality of life over 48 weeks in a real-world setting. The goal is to see if this…

This study tests whether long-acting antibodies can help people with moderate to severe ulcerative colitis (UC). About 645 adults will receive the antibodies through an IV and then as shots under the skin. The goal is to see if these treatments reduce gut inflammation and lead to…

This study looks at the long-term safety of a medicine called tulisokibart for people with moderate to severe Crohn's disease or ulcerative colitis. Participants who already took tulisokibart in an earlier study can join. The main goal is to see if the drug remains safe and toler…

This study follows 300 adults with moderate to severe ulcerative colitis who are prescribed etrasimod as part of their regular care. Researchers will track symptom changes over 52 weeks using health questionnaires completed on a phone or computer. The goal is to see how well etra…

This program provides early access to the drug etrasimod for people with severe ulcerative colitis who have tried at least three other treatments without success or cannot use them. The goal is to offer a potential treatment option when no standard therapies are available. Patien…

This study is testing whether a carefully designed diet can change the gut bacteria of people with active ulcerative colitis and reduce disease activity. Researchers will enroll 20 adults with mild to moderate disease. Participants will follow the study diet and be monitored for …

This study will follow 500 people with Crohn's disease or ulcerative colitis who are starting guselkumab, a biologic drug. Researchers want to see how well the drug controls symptoms like diarrhea and rectal bleeding, and how it affects fatigue, quality of life, and work producti…

This study is tracking 220 adults in the UK with moderate to severe ulcerative colitis or Crohn's disease who are starting guselkumab, a biologic treatment. Researchers want to see how well the drug controls symptoms and helps patients achieve remission without needing steroids. …

This study tests an experimental drug called MK-8690 for people with moderate to severe ulcerative colitis, a chronic gut condition causing inflammation and symptoms like diarrhea and bleeding. About 100 adults will receive either the drug or a placebo to see if it can bring abou…

This study tests an oral drug called etrasimod in children aged 2 to under 12 with moderate to severe ulcerative colitis. The goal is to see if the drug can safely reduce inflammation and bring the disease under control. Participants will take the drug for up to 52 weeks, with an…

This study is testing several new treatments for adults with moderate to severe ulcerative colitis or Crohn's disease. About 60 participants will be assigned to one of the treatment groups. The goal is to see if these treatments are safe and effective over at least 62 weeks.

This study is for adults aged 18 to 65 with moderate to severe ulcerative colitis who are starting etrasimod as part of their regular care. Researchers will track symptom changes over 52 weeks using health questionnaires completed online. The goal is to see if etrasimod helps red…

This study tests an experimental drug called SAR441566 in about 204 adults with moderate-to-severe ulcerative colitis, a chronic bowel disease causing inflammation and symptoms like diarrhea and bleeding. The goal is to see if different doses can help patients achieve remission (…

This study tests an oral medication called ozanimod in 120 children aged 12-17 with moderate-to-severe ulcerative colitis who haven't improved with standard treatments. The goal is to see if the drug can safely bring the disease into remission (no symptoms) and keep it there. Par…

This study looks at the long-term safety of a drug called guselkumab in children who have Crohn's disease, ulcerative colitis, or juvenile psoriatic arthritis. About 196 kids who already completed a previous study and benefited from the drug will continue treatment. The main goal…

This study looks at the long-term safety of the drug ustekinumab compared to other biologic treatments in adults with Crohn's disease or ulcerative colitis. Researchers will use electronic health records from the Department of Defense to track rates of cancer, serious infections,…

This study looks at how well adults with chronic conditions like inflammatory bowel disease, high blood pressure, anemia, or multiple sclerosis accept and stick with two dietary supplements (Goodphyte IB Defense and Goodphyte Immunity). The supplements contain a natural enzyme th…

This study looks at why many people with ulcerative colitis have trouble sleeping and how that affects their disease. Researchers will track sleep quality, gut bacteria, and nerve activity in 152 patients. The goal is to understand the connection between the gut and brain to impr…

This study looks at how often people with Crohn's disease, ulcerative colitis, an ileostomy, or bile acid diarrhea have low magnesium levels. Magnesium is important for muscles, nerves, and heart health, but standard blood tests may miss a deficiency. Researchers will compare dif…

This study is testing a new medical device that measures how nerves respond to inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The device checks three types of nerve fibers to help doctors better understand disease…