INFLAMMATORY BOWEL DISEASES

This study tests an experimental pill called MORF-057 (zotemtegrast) in 385 adults with moderate-to-severe Crohn's disease. The drug works by blocking a protein that drives gut inflammation. Participants will receive one of three doses of the drug or a placebo for 14 weeks to see…

This study is testing whether robotic surgery is a safe and effective option for people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will compare robotic surgery to standard laparoscopic surgery in 100 adults. The goal is to…

This study tests whether transplanting healthy donor stool into the gut can help people with ulcerative colitis reach remission without steroids. About 85 adults with active UC will receive either fecal transplants or a placebo. The goal is to see if a larger, definitive trial is…

This study tests whether a fecal microbiota transplant (FMT) can improve liver health in people with primary sclerosing cholangitis (PSC) and inflammatory bowel disease. About 58 adults will receive either FMT or a placebo. The main goal is to see if FMT lowers a key liver enzyme…

This study looks at how well newer inflammatory bowel disease (IBD) medications work in children whose previous anti-TNF treatment stopped working or didn't help. About 1,100 kids with Crohn's disease or ulcerative colitis will answer questions about their symptoms and health ove…

This study tests whether adding the antifungal drug fluconazole to standard IL-23 therapy (like risankizumab or ustekinumab) improves symptoms in people with mild to moderate Crohn's disease. Researchers will compare outcomes in 120 adults who receive either fluconazole or a plac…

This study tests whether adding fermented foods to the diet can reduce inflammation and improve quality of life in people with mild-to-moderate ulcerative colitis. About 21 adults with confirmed UC and active symptoms will eat fermented foods and be monitored for changes in a sto…

This study tests whether dapagliflozin, a drug already used for diabetes, can help people with mild-to-moderate ulcerative colitis (a type of inflammatory bowel disease). The goal is to see if it reduces inflammation and improves symptoms like diarrhea and abdominal pain. About 5…

This study tests whether long-acting antibodies can help people with moderate-to-severe ulcerative colitis, a chronic inflammatory bowel disease. About 645 adults will receive the antibodies through an IV infusion followed by regular shots under the skin. The goal is to reduce gu…

This study looks at whether checking and improving nutrition before surgery can help people with inflammatory bowel disease (IBD) recover better. About 150 adults having bowel surgery will be offered nutrition screening and special shakes. The goal is to see if this approach redu…

This study tests whether swallowing frozen capsules containing filtered or whole donor stool can safely bring ulcerative colitis into remission. About 129 adults with mild-to-moderate active disease who have not responded to standard treatments will take the capsules or a placebo…

This study looks at how well and how safely the drug mirikizumab works over a long period (about 3 years) in children and teenagers with moderate-to-severe ulcerative colitis or Crohn's disease. About 150 participants who have already been in earlier studies will continue treatme…

This study tests whether acupuncture can reduce the number of flare-ups in people with Crohn's disease who are currently in remission. About 106 participants will receive either real or sham acupuncture over several months. The goal is to see if this ancient practice can help kee…

This study tests an experimental drug called TQH3906 in adults with moderate-to-severe ulcerative colitis or Crohn's disease. About 135 participants will receive either the drug or a placebo for 12 weeks to see if it safely reduces inflammation and improves symptoms. The goal is …

This pilot study tests a new device called the Retro-TCE capsule, which is a small camera attached to a string that is inserted into the lower gut to take pictures without needing sedation. The study will enroll 30 people, including healthy volunteers and those with Lynch syndrom…

This study is testing a new web-based tool that gives personalized risk estimates for Crohn's disease to people who have a close family member with inflammatory bowel disease. The goal is to see if learning their personal risk motivates them to make healthy lifestyle changes, lik…

This study tests whether changing sleep timing and using morning light therapy can improve symptoms and quality of life in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. About 68 adults with active IBD symptoms will participate. Re…

This study tests if pentoxifylline, a drug already used for other conditions, can safely reduce symptoms of mild to moderate ulcerative colitis. About 60 adults will take the drug and be monitored for changes in bowel symptoms and quality of life. The goal is to see if this offer…

This study tests whether far-infrared (fIR) therapy is safe and can help ease symptoms in people with Crohn's disease. Forty adults with mild to moderate Crohn's will receive 10 fIR treatments. Researchers will compare three different intensities of fIR to a placebo to find the b…

This study tests a virtual group program that teaches teens with inflammatory bowel disease (IBD) coping skills and heart rate biofeedback to reduce stress, anxiety, and depression. About 128 participants aged 13–18 will be randomly assigned to the program or a waitlist. The goal…

This study tests whether virtual reality (VR)-guided brain-gut behavioral therapy can help manage pain in hospitalized adults with inflammatory bowel disease (IBD). Researchers want to see if the approach is practical and acceptable to patients. About 40 participants will try the…

This study tests a small device placed under the skin near the tailbone that sends mild signals to a nerve, aiming to reduce sudden bowel urgency in people with ulcerative colitis. About 137 adults with the condition will take part. The device is implanted in a same-day procedure…

This study aims to understand why many people with inflammatory bowel disease (IBD) continue to have abdominal pain even when their disease is in remission. Researchers will follow thousands of patients, using questionnaires, blood and stool samples, and heart rate recordings to …

This study uses health insurance claims data from Korea to count how many children under 18 have Crohn's disease or ulcerative colitis, and how their treatment changes as they grow. Researchers will look at patterns of medication use, hospital visits, and costs over several years…

This study looks at whether the unique mix of bacteria and fungi in the gut can predict how well Crohn's disease patients will respond to treatment. Researchers will collect stool, blood, and tissue samples from 100 adults during routine colonoscopies and track their health for a…

This study is testing a new device called a wireless thermal capsule, which is swallowed and measures temperature as it travels through the digestive tract. The goal is to see if it can reliably detect small temperature changes that might indicate inflammation from diseases like …

This early-phase study at Stanford University is testing the statin drug rosuvastatin in 15 people with primary sclerosing cholangitis (PSC), a liver disease with no cure. Researchers want to see how the drug changes bile acids and gut bacteria, hoping to better understand why PS…

This study aims to collect blood samples and medical data from 3000 people with autoimmune diseases like lupus, scleroderma, and myositis. Researchers will use these samples to identify new biomarkers and better understand the diseases. The goal is to support future research into…

This study collects tissue, blood, and stool samples from 200 children with inflammatory bowel disease (IBD) and children with other gut disorders. Researchers will use a technique called spatial transcriptomics to see which genes are active in different parts of the gut. The goa…

This study aims to identify biological markers that can predict how patients with inflammatory bowel disease (IBD) will respond to a type of medication called TNF-alpha inhibitors. Researchers will collect blood and tissue samples from 100 adults, including healthy controls and I…

This study is collecting health information and samples from 100 people with inflammatory bowel disease (IBD) when they change treatments. Researchers will use artificial intelligence to analyze this data and find patterns that could predict when a treatment change is needed. The…

This study surveys 400 adults with inflammatory bowel disease (IBD) from two medical centers to understand how social factors like insurance, income, and support affect medication adherence and quality of life. Researchers focus on Hispanic and Black patients, who often have wors…

This study is creating a large database to collect information on people with rare diseases like amyloidosis, sarcoidosis, and Gaucher disease. Researchers will track patients' health over time, including their symptoms, treatments, and outcomes. The goal is to improve diagnosis …

This study looks at how natural cannabis compounds (phytocannabinoids) affect immune cells from 100 people with chronic inflammatory diseases like rheumatoid arthritis, lupus, and Crohn's disease. Researchers will take a blood sample and expose the cells to different cannabis ext…

This study looks at how the immune system damages the gut in diseases like celiac disease and inflammatory bowel disease. Researchers will analyze immune cells and DNA from 200 adults to understand what goes wrong. The goal is to learn more about these conditions, not to test a n…

This study looks at whether a toxin called deoxynivalenol (DON), found in grains, might be a risk factor for inflammatory bowel disease (IBD). Researchers will measure DON levels in 100 people—some with Crohn's disease and others without IBD—to see how the body processes it. The …

This study looks at whether a non-invasive intestinal ultrasound can predict when Crohn's disease will come back in patients who are currently in deep remission. Researchers will follow 420 adults for 18 months to see who relapses and compare ultrasound results between those who …

This study collects DNA from 1200 patients receiving routine care at the University of Chicago. Researchers look for genetic differences that might affect how well a drug works or how likely it is to cause side effects. The goal is to see if giving this genetic information to doc…

This study is testing a new medical device that measures nerve responses to assess inflammation in children with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. The goal is to develop a more precise way to track disease activity and guide treat…

This study looks at how nutrition and body composition (like muscle and fat) impact the health of people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will follow 300 participants starting new medical treatments or having sur…