INFLAMMATORY BOWEL DISEASES

This study tests an experimental drug called ATH-063 in 120 adults with moderate-to-severe ulcerative colitis who have not improved with biologic therapies. The goal is to see if the drug can reduce symptoms like diarrhea and bleeding and improve colon healing over 12 weeks. Part…

This study tests if xylitol, a common sweetener, can safely clear C. difficile bacteria from the gut in people with inflammatory bowel disease (IBD). About 99 adults with mild or inactive IBD will take either a low or high dose of xylitol or a placebo for four weeks. Researchers …

This study tests a blood-filtering device called Efferon LPS in 40 adults with Crohn's disease or ulcerative colitis during a flare-up. The device is designed to remove harmful substances from the blood to reduce inflammation. Participants will either receive standard care alone …

This pilot study will test a 24-week digital self-management program designed to help people with inflammatory bowel disease (IBD) manage their symptoms and improve their quality of life. The program is accessed via web or mobile device and includes modules to build long-term hab…

This study tests a dietary supplement called GenesiDol for managing muscle and joint pain in people with inflammatory bowel disease (IBD), like Crohn's disease or ulcerative colitis. About 40 adults with persistent pain will take the supplement for 8 weeks to see if it reduces pa…

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study tests whether a brain-training technique called neurofeedback can help reduce muscle and joint pain in people with inflammatory bowel disease (IBD). Researchers will enroll 80 adults with IBD who have persistent pain. Participants will use a special device to learn how…

This study tests whether duloxetine, a medication that affects brain signals, can reduce disability and psychological distress in adults with inflammatory bowel disease (IBD). About 32 participants will take duloxetine for a period, and researchers will measure changes in anxiety…

This study tests whether watching a short video tailored to their specific type of inflammatory bowel disease (IBD) helps patients better prepare their bowel for a colonoscopy. About 600 adults with ulcerative colitis or Crohn's disease will be randomly assigned to receive either…

This study looks at how anxiety, depression, and stress might cause advanced IBD treatments to stop working. Researchers will ask 450 people with IBD to fill out questionnaires about their mental health while they receive regular infusions. The goal is to understand if mental hea…

This study will check if low vitamin D levels are linked to more active disease in people with inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis. Researchers will measure vitamin D in 100 adults with IBD and compare it to their current disease act…

This study will check if certain blood cell measurements (platelet count, size, and shape) are linked to how active inflammatory bowel disease (IBD) is. Researchers will compare these blood test results with standard disease activity scores in 84 adults with IBD. The goal is to s…

This study aims to see if anemia (low red blood cells) can help predict how inflammatory bowel disease (IBD) will progress in patients. Researchers will follow 83 adults with IBD at Assiut University Hospitals in Egypt and track their hospitalization rates. The goal is to find a …

This study will use a detailed heart ultrasound technique called speckle tracking to look for early signs of heart trouble in 100 adults with inflammatory bowel disease (IBD). Researchers want to see if this method can catch heart changes before they become serious and how those …

This study follows 75 adults with Crohn's disease or ulcerative colitis who are starting guselkumab, a drug used for inflammatory bowel disease. Researchers want to see if the drug also helps with joint pain and stiffness linked to spondyloarthritis. Participants will report symp…

This study is building a new questionnaire to measure how well people with inflammatory bowel disease (IBD) take care of themselves. Researchers will talk to 275 adults with Crohn's disease or ulcerative colitis to understand their self-care habits, then test the questionnaire to…